Table 2 Open in new tab Results of...

Coefficient	Estimate ± SE	T-value	P-value
Temporal meta-region of interest
APOE ε4 status	−0.0027 ± 0.0085	−0.315	0.753
Amyloid-β status	0.0298 ± 0.0107	2.785	0.006^**
Age	−0.0012 ± 0.0005	−2.494	0.013^*
Sex	0.0220 ± 0.0077	2.855	0.005^**
Baseline tau	0.0577 ± 0.0151	3.827	<0.001^***
Study Avid 05	0.015 ± 0.010	1.472	0.141
Study Exp 3	0.008 ± 0.017	0.465	0.642
Study BF	0.020 ± 0.013	1.551	0.122
CU	0.009 ± 0.017	0.530	0.596
MCI	0.016 ± 0.016	1.011	0.312
Neocortical region of interest
APOE ε4 status	−0.0025 ± 0.0062	−0.398	0.691
Amyloid-β status	0.0145 ± 0.0062	1.865	0.062
Age	−0.0005 ± 0.0004	−1.501	0.134
Sex	0.0164 ± 0.0057	2.903	0.004^**
Baseline tau	0.0801 ± 0.0160	5.014	<0.001^***
Study Avid 05	0.012 ± 0.008	1.604	0.109
Study Exp 3	0.009 ± 0.013	0.727	0.468
Study BF	0.015 ± 0.010	1.549	0.122
CU	−0.003 ± 0.012	−0.259	0.796
MCI	0.001 ± 0.011	0.073	0.942

Coefficient	Estimate ± SE	T-value	P-value
Temporal meta-region of interest
APOE ε4 status	−0.0027 ± 0.0085	−0.315	0.753
Amyloid-β status	0.0298 ± 0.0107	2.785	0.006^**
Age	−0.0012 ± 0.0005	−2.494	0.013^*
Sex	0.0220 ± 0.0077	2.855	0.005^**
Baseline tau	0.0577 ± 0.0151	3.827	<0.001^***
Study Avid 05	0.015 ± 0.010	1.472	0.141
Study Exp 3	0.008 ± 0.017	0.465	0.642
Study BF	0.020 ± 0.013	1.551	0.122
CU	0.009 ± 0.017	0.530	0.596
MCI	0.016 ± 0.016	1.011	0.312
Neocortical region of interest
APOE ε4 status	−0.0025 ± 0.0062	−0.398	0.691
Amyloid-β status	0.0145 ± 0.0062	1.865	0.062
Age	−0.0005 ± 0.0004	−1.501	0.134
Sex	0.0164 ± 0.0057	2.903	0.004^**
Baseline tau	0.0801 ± 0.0160	5.014	<0.001^***
Study Avid 05	0.012 ± 0.008	1.604	0.109
Study Exp 3	0.009 ± 0.013	0.727	0.468
Study BF	0.015 ± 0.010	1.549	0.122
CU	−0.003 ± 0.012	−0.259	0.796
MCI	0.001 ± 0.011	0.073	0.942

Table 2

Results of linear models for tau accumulation

Coefficient	Estimate ± SE	T-value	P-value
Temporal meta-region of interest
APOE ε4 status	−0.0027 ± 0.0085	−0.315	0.753
Amyloid-β status	0.0298 ± 0.0107	2.785	0.006^**
Age	−0.0012 ± 0.0005	−2.494	0.013^*
Sex	0.0220 ± 0.0077	2.855	0.005^**
Baseline tau	0.0577 ± 0.0151	3.827	<0.001^***
Study Avid 05	0.015 ± 0.010	1.472	0.141
Study Exp 3	0.008 ± 0.017	0.465	0.642
Study BF	0.020 ± 0.013	1.551	0.122
CU	0.009 ± 0.017	0.530	0.596
MCI	0.016 ± 0.016	1.011	0.312
Neocortical region of interest
APOE ε4 status	−0.0025 ± 0.0062	−0.398	0.691
Amyloid-β status	0.0145 ± 0.0062	1.865	0.062
Age	−0.0005 ± 0.0004	−1.501	0.134
Sex	0.0164 ± 0.0057	2.903	0.004^**
Baseline tau	0.0801 ± 0.0160	5.014	<0.001^***
Study Avid 05	0.012 ± 0.008	1.604	0.109
Study Exp 3	0.009 ± 0.013	0.727	0.468
Study BF	0.015 ± 0.010	1.549	0.122
CU	−0.003 ± 0.012	−0.259	0.796
MCI	0.001 ± 0.011	0.073	0.942

Coefficient	Estimate ± SE	T-value	P-value
Temporal meta-region of interest
APOE ε4 status	−0.0027 ± 0.0085	−0.315	0.753
Amyloid-β status	0.0298 ± 0.0107	2.785	0.006^**
Age	−0.0012 ± 0.0005	−2.494	0.013^*
Sex	0.0220 ± 0.0077	2.855	0.005^**
Baseline tau	0.0577 ± 0.0151	3.827	<0.001^***
Study Avid 05	0.015 ± 0.010	1.472	0.141
Study Exp 3	0.008 ± 0.017	0.465	0.642
Study BF	0.020 ± 0.013	1.551	0.122
CU	0.009 ± 0.017	0.530	0.596
MCI	0.016 ± 0.016	1.011	0.312
Neocortical region of interest
APOE ε4 status	−0.0025 ± 0.0062	−0.398	0.691
Amyloid-β status	0.0145 ± 0.0062	1.865	0.062
Age	−0.0005 ± 0.0004	−1.501	0.134
Sex	0.0164 ± 0.0057	2.903	0.004^**
Baseline tau	0.0801 ± 0.0160	5.014	<0.001^***
Study Avid 05	0.012 ± 0.008	1.604	0.109
Study Exp 3	0.009 ± 0.013	0.727	0.468
Study BF	0.015 ± 0.010	1.549	0.122
CU	−0.003 ± 0.012	−0.259	0.796
MCI	0.001 ± 0.011	0.073	0.942

Linear models were analysed for each region using the slopes of tau accumulation. Statistical model: Tau slopes ∼ APOE ε4 status + amyloid-β status + age + sex + study + diagnosis + baseline tau SUVR. CU = cognitively unimpaired; SE = standard error. Values in bold represent statistically significant effects.

P < 0.05;

P < 0.01;

***

P < 0.001.

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