Table 1 Open in new tab Clinical...

Aβ− CU

Aβ− MCI

Aβ+ CU

Aβ+ MCI

Comparison P-value

127

Age ± SD

71.1 ± 9.4

71.5 ± 9.1

77.8 ± 6.9

73.3 ± 7.6

73.0 ± 9.2

Aβ− CU and Aβ+ CU^***

Aβ− MCI and Aβ+ CU^***

Aβ+ CU and Aβ+ MCI^*

Aβ+ CU and AD^**

Sex, female/male

40/48

27/31

37/28

38/43

67/60

n.s.

Education ± SD, years

15.3 ± 2.8

15.7 ± 3.0

15.2 ± 3.6

15.8 ± 3.1

14.3 ± 3.1

Aβ+ MCI and AD^**

MMSE ± SD

29.4 ± 0.8

28.2 ± 2.3

28.4 ± 2.2

27.1 ± 2.6

22.6 ± 3.0

Aβ− CU and Aβ− MCI^*

Aβ− CU and Aβ+ MCI^***

Aβ− CU and AD^***

Aβ− MCI and Aβ+ MCI^*

Aβ− MCI and AD^***

Aβ+ CU and Aβ+ MCI^*

Aβ+ CU and AD^***

Aβ+ MCI and AD^***

APOE ε4 alleles (0/1/2)

70/14/1

42/13/1

33/28/4

32/33/14

38/62/25^a

Aβ− CU and Aβ+ CU^***

Aβ− CU and Aβ+ MCI^***

Aβ− CU and AD^***

Aβ− MCI and Aβ+ CU^**

Aβ− MCI and Aβ+ MCI^***

Aβ− MCI and AD^***

Aβ+ CU and AD^**

Baseline tau

Temporal meta-ROI SUVR (mean ± SD)

1.15 ± 0.08

1.14 ± 0.09

1.24 ± 0.13

1.32 ± 0.36

1.73 ± 0.36

Aβ− CU and Aβ+ MCI^***

Aβ− CU and AD^***

Aβ− MCI and Aβ+ MCI^***

Aβ− MCI and AD^***

Aβ+ CU and Aβ+ MCI^***

Aβ+ CU and AD^***

Aβ+ MCI and AD^***

Neocortical ROI SUVR (mean ± SD)

1.06 ± 0.07

1.04 ± 0.08

1.10 ± 0.08

1.20 ± 0.23

1.36 ± 0.30

Aβ− CU and Aβ+ MCI^***

Aβ− CU and AD^***

Aβ− MCI and Aβ+ MCI^***

Aβ− MCI and AD^***

Aβ+ CU and Aβ+ MCI^*

Aβ+ CU and AD^***

Aβ+ MCI and AD^***

Baseline tau %/year

Temporal meta-ROI %/year (mean ± SD)

0.4 ± 2.7

−0.4 ± 2.3

1.2 ± 2.8

3.0 ± 5.3

2.9 ± 5.7

Aβ− CU and Aβ+ MCI^***

Aβ− CU and AD^***

Aβ− MCI and Aβ+ MCI^***

Aβ− MCI and AD^***

Neocortical ROI %/year, mean ± SD

0.5 ± 2.9

−0.3 ± 2.9

0.8 ± 2.6

2.2 ± 5.0

2.9 ± 5.1

Aβ− CU and AD^***

Aβ− MCI and Aβ+ MCI^**

Aβ− MCI and AD^***

Aβ+ CU and AD^**

Tau slopes

Temporal meta-ROI (SUVR/year), mean ± SD

0.004 ± 0.031

−0.005 ± 0.027

0.016 ± 0.036

0.052 ± 0.098

0.049 ± 0.114

Aβ− CU and Aβ+ MCI^**

Aβ− CU and AD^***

Aβ− MCI and Aβ+ MCI^***

Aβ− MCI and AD^***

Neocortical ROI (SUVR/year), mean ± SD

0.005 ± 0.030

−0.003 ± 0.029

0.009 ± 0.029

0.031 ± 0.076

0.041 ± 0.080

Aβ− CU and Aβ+ MCI^*

Aβ− CU and AD^***

Aβ− MCI and Aβ+ MCI^**

Aβ− MCI and AD^***

Aβ+ CU and AD^**

Table 1

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Clinical characteristics of participants

	Aβ− CU	Aβ− MCI	Aβ+ CU	Aβ+ MCI	AD	Comparison P-value
n	88	58	65	81	127
Age ± SD	71.1 ± 9.4	71.5 ± 9.1	77.8 ± 6.9	73.3 ± 7.6	73.0 ± 9.2	Aβ− CU and Aβ+ CU^* Aβ− MCI and Aβ+ CU^* Aβ+ CU and Aβ+ MCI^* Aβ+ CU and AD^**
Sex, female/male	40/48	27/31	37/28	38/43	67/60	n.s.
Education ± SD, years	15.3 ± 2.8	15.7 ± 3.0	15.2 ± 3.6	15.8 ± 3.1	14.3 ± 3.1	Aβ+ MCI and AD^**
MMSE ± SD	29.4 ± 0.8	28.2 ± 2.3	28.4 ± 2.2	27.1 ± 2.6	22.6 ± 3.0	Aβ− CU and Aβ− MCI^* Aβ− CU and Aβ+ MCI^* Aβ− CU and AD^* Aβ− MCI and Aβ+ MCI^* Aβ− MCI and AD^*** Aβ+ CU and Aβ+ MCI^* Aβ+ CU and AD^* Aβ+ MCI and AD^*
APOE ε4 alleles (0/1/2)	70/14/1	42/13/1	33/28/4	32/33/14	38/62/25^a	Aβ− CU and Aβ+ CU^* Aβ− CU and Aβ+ MCI^* Aβ− CU and AD^* Aβ− MCI and Aβ+ CU^ Aβ− MCI and Aβ+ MCI^* Aβ− MCI and AD^* Aβ+ CU and AD^**
Baseline tau
Temporal meta-ROI SUVR (mean ± SD)	1.15 ± 0.08	1.14 ± 0.09	1.24 ± 0.13	1.32 ± 0.36	1.73 ± 0.36	Aβ− CU and Aβ+ MCI^* Aβ− CU and AD^* Aβ− MCI and Aβ+ MCI^* Aβ− MCI and AD^* Aβ+ CU and Aβ+ MCI^* Aβ+ CU and AD^* Aβ+ MCI and AD^***
Neocortical ROI SUVR (mean ± SD)	1.06 ± 0.07	1.04 ± 0.08	1.10 ± 0.08	1.20 ± 0.23	1.36 ± 0.30	Aβ− CU and Aβ+ MCI^* Aβ− CU and AD^* Aβ− MCI and Aβ+ MCI^* Aβ− MCI and AD^* Aβ+ CU and Aβ+ MCI^* Aβ+ CU and AD^* Aβ+ MCI and AD^*
Baseline tau %/year
Temporal meta-ROI %/year (mean ± SD)	0.4 ± 2.7	−0.4 ± 2.3	1.2 ± 2.8	3.0 ± 5.3	2.9 ± 5.7	Aβ− CU and Aβ+ MCI^* Aβ− CU and AD^* Aβ− MCI and Aβ+ MCI^* Aβ− MCI and AD^*
Neocortical ROI %/year, mean ± SD	0.5 ± 2.9	−0.3 ± 2.9	0.8 ± 2.6	2.2 ± 5.0	2.9 ± 5.1	Aβ− CU and AD^* Aβ− MCI and Aβ+ MCI^ Aβ− MCI and AD^* Aβ+ CU and AD^
Tau slopes
Temporal meta-ROI (SUVR/year), mean ± SD	0.004 ± 0.031	−0.005 ± 0.027	0.016 ± 0.036	0.052 ± 0.098	0.049 ± 0.114	Aβ− CU and Aβ+ MCI^ Aβ− CU and AD^* Aβ− MCI and Aβ+ MCI^* Aβ− MCI and AD^*
Neocortical ROI (SUVR/year), mean ± SD	0.005 ± 0.030	−0.003 ± 0.029	0.009 ± 0.029	0.031 ± 0.076	0.041 ± 0.080	Aβ− CU and Aβ+ MCI^* Aβ− CU and AD^* Aβ− MCI and Aβ+ MCI^ Aβ− MCI and AD^* Aβ+ CU and AD^

	Aβ− CU	Aβ− MCI	Aβ+ CU	Aβ+ MCI	AD	Comparison P-value
n	88	58	65	81	127
Age ± SD	71.1 ± 9.4	71.5 ± 9.1	77.8 ± 6.9	73.3 ± 7.6	73.0 ± 9.2	Aβ− CU and Aβ+ CU^* Aβ− MCI and Aβ+ CU^* Aβ+ CU and Aβ+ MCI^* Aβ+ CU and AD^**
Sex, female/male	40/48	27/31	37/28	38/43	67/60	n.s.
Education ± SD, years	15.3 ± 2.8	15.7 ± 3.0	15.2 ± 3.6	15.8 ± 3.1	14.3 ± 3.1	Aβ+ MCI and AD^**
MMSE ± SD	29.4 ± 0.8	28.2 ± 2.3	28.4 ± 2.2	27.1 ± 2.6	22.6 ± 3.0	Aβ− CU and Aβ− MCI^* Aβ− CU and Aβ+ MCI^* Aβ− CU and AD^* Aβ− MCI and Aβ+ MCI^* Aβ− MCI and AD^*** Aβ+ CU and Aβ+ MCI^* Aβ+ CU and AD^* Aβ+ MCI and AD^*
APOE ε4 alleles (0/1/2)	70/14/1	42/13/1	33/28/4	32/33/14	38/62/25^a	Aβ− CU and Aβ+ CU^* Aβ− CU and Aβ+ MCI^* Aβ− CU and AD^* Aβ− MCI and Aβ+ CU^ Aβ− MCI and Aβ+ MCI^* Aβ− MCI and AD^* Aβ+ CU and AD^**
Baseline tau
Temporal meta-ROI SUVR (mean ± SD)	1.15 ± 0.08	1.14 ± 0.09	1.24 ± 0.13	1.32 ± 0.36	1.73 ± 0.36	Aβ− CU and Aβ+ MCI^* Aβ− CU and AD^* Aβ− MCI and Aβ+ MCI^* Aβ− MCI and AD^* Aβ+ CU and Aβ+ MCI^* Aβ+ CU and AD^* Aβ+ MCI and AD^***
Neocortical ROI SUVR (mean ± SD)	1.06 ± 0.07	1.04 ± 0.08	1.10 ± 0.08	1.20 ± 0.23	1.36 ± 0.30	Aβ− CU and Aβ+ MCI^* Aβ− CU and AD^* Aβ− MCI and Aβ+ MCI^* Aβ− MCI and AD^* Aβ+ CU and Aβ+ MCI^* Aβ+ CU and AD^* Aβ+ MCI and AD^*
Baseline tau %/year
Temporal meta-ROI %/year (mean ± SD)	0.4 ± 2.7	−0.4 ± 2.3	1.2 ± 2.8	3.0 ± 5.3	2.9 ± 5.7	Aβ− CU and Aβ+ MCI^* Aβ− CU and AD^* Aβ− MCI and Aβ+ MCI^* Aβ− MCI and AD^*
Neocortical ROI %/year, mean ± SD	0.5 ± 2.9	−0.3 ± 2.9	0.8 ± 2.6	2.2 ± 5.0	2.9 ± 5.1	Aβ− CU and AD^* Aβ− MCI and Aβ+ MCI^ Aβ− MCI and AD^* Aβ+ CU and AD^
Tau slopes
Temporal meta-ROI (SUVR/year), mean ± SD	0.004 ± 0.031	−0.005 ± 0.027	0.016 ± 0.036	0.052 ± 0.098	0.049 ± 0.114	Aβ− CU and Aβ+ MCI^ Aβ− CU and AD^* Aβ− MCI and Aβ+ MCI^* Aβ− MCI and AD^*
Neocortical ROI (SUVR/year), mean ± SD	0.005 ± 0.030	−0.003 ± 0.029	0.009 ± 0.029	0.031 ± 0.076	0.041 ± 0.080	Aβ− CU and Aβ+ MCI^* Aβ− CU and AD^* Aβ− MCI and Aβ+ MCI^ Aβ− MCI and AD^* Aβ+ CU and AD^

Aβ− = amyloid-β-negative; Aβ+ = amyloid-β-positive; AD = Alzheimer’s disease dementia; CU = cognitively unimpaired; n.s. = not significant; ROI = region of interest.

P < 0.05;

P < 0.01;

***

P < 0.001.

^aAPOE status not available for two individuals.

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