Table 2 Open in new tab LVEF during SB...

	Baseline	Final (Week 12)
1	62	84	22	70	8	46	66	20	57	11
2	67	72	5	69	2	38	70	32	72	34
3	68	70	2	68	0	37	66	29	64	27
4	60	65	5	62	2	40	60	20	50	10
5	68	76	8	66	−2	33	68	35	66	33
6	60	82	22	62	2	51	58	7	49	−2
7	65	70	5	66	1	28	72	44	63	35
8	55	76	21	58	3	48	61	13	62	14
9	55	68	13	62	7	42	76	34	62	20
10	63	75	12	68	5	48	54	6	55	7
11	60	80	20	62	2	46	52	6	62	16
Mean	62.1 ± 4.6	74.4 ± 6	12.3 ± 7.8*	64.8 ± 3.8	2.7 ± 2.9	41.5 ± 7.1	63.9 ± 7.6	22.4 ± 13.3*	60.2 ± 6.9	18.6 ± 12.3*
			R = 0.8, P = 0.003		R = 0.54 P = 0.09			R = −0.9, P < 0.001		R = −0.88, P < 0.001

Baseline

Final (Week 12)

No PVCs (Echo-1)

CI: 200 ms (Echo–2)

CI: 350 ms (Echo-3)

No PVCs (Echo-1)

CI: 200 ms (Echo-2)

CI: 350 ms (Echo-3)

Animal

SB LVEF

SB post-PVC LVEF

PESP LVEF (delta)

SB post-PVC LVEF

PESP LVEF (delta)

SB LVEF

SB post-PVC LVEF

PESP LVEF (delta)

SB post-PVC LVEF

PESP LVEF (delta)

−2

Mean

62.1 ± 4.6

74.4 ± 6

12.3 ± 7.8*

64.8 ± 3.8

2.7 ± 2.9

41.5 ± 7.1

63.9 ± 7.6

22.4 ± 13.3*

60.2 ± 6.9

18.6 ± 12.3*

R = 0.8, P = 0.003

R = 0.54 P = 0.09

R = −0.9, P < 0.001

R = −0.88, P < 0.001

	Baseline	Final (Week 12)
1	62	84	22	70	8	46	66	20	57	11
2	67	72	5	69	2	38	70	32	72	34
3	68	70	2	68	0	37	66	29	64	27
4	60	65	5	62	2	40	60	20	50	10
5	68	76	8	66	−2	33	68	35	66	33
6	60	82	22	62	2	51	58	7	49	−2
7	65	70	5	66	1	28	72	44	63	35
8	55	76	21	58	3	48	61	13	62	14
9	55	68	13	62	7	42	76	34	62	20
10	63	75	12	68	5	48	54	6	55	7
11	60	80	20	62	2	46	52	6	62	16
Mean	62.1 ± 4.6	74.4 ± 6	12.3 ± 7.8*	64.8 ± 3.8	2.7 ± 2.9	41.5 ± 7.1	63.9 ± 7.6	22.4 ± 13.3*	60.2 ± 6.9	18.6 ± 12.3*
			R = 0.8, P = 0.003		R = 0.54 P = 0.09			R = −0.9, P < 0.001		R = −0.88, P < 0.001

Table 2

Open in new tab

LVEF during SB without ectopy and SB post-PVC at 200 and 350 ms coupling intervals before (baseline) and after the development of PVC-CM (Week 12 bigeminal PVCs)

	Baseline					Final (Week 12)
	No PVCs (Echo-1)	CI: 200 ms (Echo–2)		CI: 350 ms (Echo-3)		No PVCs (Echo-1)	CI: 200 ms (Echo-2)		CI: 350 ms (Echo-3)
Animal	SB LVEF	SB post-PVC LVEF	PESP LVEF (delta)	SB post-PVC LVEF	PESP LVEF (delta)	SB LVEF	SB post-PVC LVEF	PESP LVEF (delta)	SB post-PVC LVEF	PESP LVEF (delta)
1	62	84	22	70	8	46	66	20	57	11
2	67	72	5	69	2	38	70	32	72	34
3	68	70	2	68	0	37	66	29	64	27
4	60	65	5	62	2	40	60	20	50	10
5	68	76	8	66	−2	33	68	35	66	33
6	60	82	22	62	2	51	58	7	49	−2
7	65	70	5	66	1	28	72	44	63	35
8	55	76	21	58	3	48	61	13	62	14
9	55	68	13	62	7	42	76	34	62	20
10	63	75	12	68	5	48	54	6	55	7
11	60	80	20	62	2	46	52	6	62	16
Mean	62.1 ± 4.6	74.4 ± 6	12.3 ± 7.8*	64.8 ± 3.8	2.7 ± 2.9	41.5 ± 7.1	63.9 ± 7.6	22.4 ± 13.3*	60.2 ± 6.9	18.6 ± 12.3*
			R = 0.8, P = 0.003		R = 0.54 P = 0.09			R = −0.9, P < 0.001		R = −0.88, P < 0.001

	Baseline					Final (Week 12)
	No PVCs (Echo-1)	CI: 200 ms (Echo–2)		CI: 350 ms (Echo-3)		No PVCs (Echo-1)	CI: 200 ms (Echo-2)		CI: 350 ms (Echo-3)
Animal	SB LVEF	SB post-PVC LVEF	PESP LVEF (delta)	SB post-PVC LVEF	PESP LVEF (delta)	SB LVEF	SB post-PVC LVEF	PESP LVEF (delta)	SB post-PVC LVEF	PESP LVEF (delta)
1	62	84	22	70	8	46	66	20	57	11
2	67	72	5	69	2	38	70	32	72	34
3	68	70	2	68	0	37	66	29	64	27
4	60	65	5	62	2	40	60	20	50	10
5	68	76	8	66	−2	33	68	35	66	33
6	60	82	22	62	2	51	58	7	49	−2
7	65	70	5	66	1	28	72	44	63	35
8	55	76	21	58	3	48	61	13	62	14
9	55	68	13	62	7	42	76	34	62	20
10	63	75	12	68	5	48	54	6	55	7
11	60	80	20	62	2	46	52	6	62	16
Mean	62.1 ± 4.6	74.4 ± 6	12.3 ± 7.8*	64.8 ± 3.8	2.7 ± 2.9	41.5 ± 7.1	63.9 ± 7.6	22.4 ± 13.3*	60.2 ± 6.9	18.6 ± 12.3*
			R = 0.8, P = 0.003		R = 0.54 P = 0.09			R = −0.9, P < 0.001		R = −0.88, P < 0.001

PESP LVEF (%) = SB post-PVC LVEF (%) − SB LVEF without ectopy (%); correlation coefficient (Pearson, R) between PESP LVEF at 200 ms/350 ms and final LVEF.

CI, coupling interval; CM, cardiomyopathy; LVEF, left ventricular ejection fraction; PESP, post-extrasystolic potentiation; PVC, premature ventricular contraction; SB, sinus beat. *P value <0.05

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