Multi-variable Cox proportional hazards model to test the association of the quantitative metrics of tricuspid regurgitation severity with either the risk of hospitalization for congestive heart failure or the composite endpoint of death or hospitalization for congestive heart failure.
| Variables . | Hazard ratioa . | 95% CI . | P-value for CHF . | Hazard ratioa . | 95% CI . | P-value for composite outcome . |
|---|---|---|---|---|---|---|
| VCavg (6 vs. 1 mm) | 8.662 | (2.199–34.110) | <0.0001 | 9.750 | (2.764–34.391) | <0.0001 |
| EROA (0.25 vs. 0.01 cm2) | 10.549 | (2.600–42.796) | <0.0001 | 11.223 | (3.207–39.273) | <0.0001 |
| RegVol (26 vs. 0.65 mL) | 16.568 | (3.924–69.960) | <0.0001 | 15.983 | (4.547–56.187) | <0.0001 |
| RegFr (44% vs. 1%) | 19.303 | (4.538–82.110) | <0.0001 | 19.599 | (5.261–73.009) | <0.0001 |
| Variables . | Hazard ratioa . | 95% CI . | P-value for CHF . | Hazard ratioa . | 95% CI . | P-value for composite outcome . |
|---|---|---|---|---|---|---|
| VCavg (6 vs. 1 mm) | 8.662 | (2.199–34.110) | <0.0001 | 9.750 | (2.764–34.391) | <0.0001 |
| EROA (0.25 vs. 0.01 cm2) | 10.549 | (2.600–42.796) | <0.0001 | 11.223 | (3.207–39.273) | <0.0001 |
| RegVol (26 vs. 0.65 mL) | 16.568 | (3.924–69.960) | <0.0001 | 15.983 | (4.547–56.187) | <0.0001 |
| RegFr (44% vs. 1%) | 19.303 | (4.538–82.110) | <0.0001 | 19.599 | (5.261–73.009) | <0.0001 |
The HR for continuous variables was obtained by contrasting the hazard estimated at the first and third quartiles values observed in the sample. All parameters’ relationship with the time to event was significantly non-linear (P < 0.05).
CI, confidence interval; CHF, hospitalization for congestive heart failure; EROA, effective regurgitant orifice area; RegFr, regurgitant fraction; RegVol, regurgitant volume; VCavg, vena contracta width.
Hazard ratios were computed as the ratio between the hazard at the III quartile vs. the hazard at the I quartile.
Multi-variable Cox proportional hazards model to test the association of the quantitative metrics of tricuspid regurgitation severity with either the risk of hospitalization for congestive heart failure or the composite endpoint of death or hospitalization for congestive heart failure.
| Variables . | Hazard ratioa . | 95% CI . | P-value for CHF . | Hazard ratioa . | 95% CI . | P-value for composite outcome . |
|---|---|---|---|---|---|---|
| VCavg (6 vs. 1 mm) | 8.662 | (2.199–34.110) | <0.0001 | 9.750 | (2.764–34.391) | <0.0001 |
| EROA (0.25 vs. 0.01 cm2) | 10.549 | (2.600–42.796) | <0.0001 | 11.223 | (3.207–39.273) | <0.0001 |
| RegVol (26 vs. 0.65 mL) | 16.568 | (3.924–69.960) | <0.0001 | 15.983 | (4.547–56.187) | <0.0001 |
| RegFr (44% vs. 1%) | 19.303 | (4.538–82.110) | <0.0001 | 19.599 | (5.261–73.009) | <0.0001 |
| Variables . | Hazard ratioa . | 95% CI . | P-value for CHF . | Hazard ratioa . | 95% CI . | P-value for composite outcome . |
|---|---|---|---|---|---|---|
| VCavg (6 vs. 1 mm) | 8.662 | (2.199–34.110) | <0.0001 | 9.750 | (2.764–34.391) | <0.0001 |
| EROA (0.25 vs. 0.01 cm2) | 10.549 | (2.600–42.796) | <0.0001 | 11.223 | (3.207–39.273) | <0.0001 |
| RegVol (26 vs. 0.65 mL) | 16.568 | (3.924–69.960) | <0.0001 | 15.983 | (4.547–56.187) | <0.0001 |
| RegFr (44% vs. 1%) | 19.303 | (4.538–82.110) | <0.0001 | 19.599 | (5.261–73.009) | <0.0001 |
The HR for continuous variables was obtained by contrasting the hazard estimated at the first and third quartiles values observed in the sample. All parameters’ relationship with the time to event was significantly non-linear (P < 0.05).
CI, confidence interval; CHF, hospitalization for congestive heart failure; EROA, effective regurgitant orifice area; RegFr, regurgitant fraction; RegVol, regurgitant volume; VCavg, vena contracta width.
Hazard ratios were computed as the ratio between the hazard at the III quartile vs. the hazard at the I quartile.
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