Multi-variable Cox proportional hazards model to select the variables associated with either the hospitalization for congestive heart failure or the composite endpoint of death or hospitalization for congestive heart failure.
| Variables . | Hazard ratio . | 95% CI . | P-value for CHFa . | Hazard ratio . | 95% CI . | P-value for composite outcomea . |
|---|---|---|---|---|---|---|
| Age (years) | 1.022 | (1.008–1.036) | 0.002 | 1.023 | (1.01–1.036) | 0.001 |
| NYHA class (2 vs. 1) | 2.652 | (1.486–4.73) | 0.002 | 2.173 | (1.267–3.725) | 0.011 |
| NYHA class (3 vs. 1) | 1.328 | (0.655–2.697) | 1.162 | (0.596–2.262) | ||
| LV ejection fraction (%) | 0.972 | (0.942–1.002) | 0.067 | 0.971 | (0.944–1) | 0.049 |
| PASP (mm Hg) | 1.023 | (1.013–1.032) | <0.001 | 1.022 | (1.012–1.032) | <0.001 |
| TR severityb (moderate vs. mild) | 5.309 | (2.291–12.307) | 0.000 | 4.995 | (2.359–10.577) | 0.000 |
| TR severityb (severe vs. mild) | 17.918 | (7.942–40.426) | 15.697 | (7.557–32.605) | ||
| Model | 0.000 | 0.000 |
| Variables . | Hazard ratio . | 95% CI . | P-value for CHFa . | Hazard ratio . | 95% CI . | P-value for composite outcomea . |
|---|---|---|---|---|---|---|
| Age (years) | 1.022 | (1.008–1.036) | 0.002 | 1.023 | (1.01–1.036) | 0.001 |
| NYHA class (2 vs. 1) | 2.652 | (1.486–4.73) | 0.002 | 2.173 | (1.267–3.725) | 0.011 |
| NYHA class (3 vs. 1) | 1.328 | (0.655–2.697) | 1.162 | (0.596–2.262) | ||
| LV ejection fraction (%) | 0.972 | (0.942–1.002) | 0.067 | 0.971 | (0.944–1) | 0.049 |
| PASP (mm Hg) | 1.023 | (1.013–1.032) | <0.001 | 1.022 | (1.012–1.032) | <0.001 |
| TR severityb (moderate vs. mild) | 5.309 | (2.291–12.307) | 0.000 | 4.995 | (2.359–10.577) | 0.000 |
| TR severityb (severe vs. mild) | 17.918 | (7.942–40.426) | 15.697 | (7.557–32.605) | ||
| Model | 0.000 | 0.000 |
The HR for continuous variables was obtained by contrasting the hazard estimated at the first and third quartiles values observed in the sample.
CI, confidence interval; CHF, hospitalization for congestive heart failure; LV, left ventricular; NYHA, New York Heart Association; PASP, pulmonary artery systolic pressure; TR, tricuspid regurgitation.
P-values refer to the ANOVA.
Multi-parametric definition as recommended by current guidelines.15,16
Multi-variable Cox proportional hazards model to select the variables associated with either the hospitalization for congestive heart failure or the composite endpoint of death or hospitalization for congestive heart failure.
| Variables . | Hazard ratio . | 95% CI . | P-value for CHFa . | Hazard ratio . | 95% CI . | P-value for composite outcomea . |
|---|---|---|---|---|---|---|
| Age (years) | 1.022 | (1.008–1.036) | 0.002 | 1.023 | (1.01–1.036) | 0.001 |
| NYHA class (2 vs. 1) | 2.652 | (1.486–4.73) | 0.002 | 2.173 | (1.267–3.725) | 0.011 |
| NYHA class (3 vs. 1) | 1.328 | (0.655–2.697) | 1.162 | (0.596–2.262) | ||
| LV ejection fraction (%) | 0.972 | (0.942–1.002) | 0.067 | 0.971 | (0.944–1) | 0.049 |
| PASP (mm Hg) | 1.023 | (1.013–1.032) | <0.001 | 1.022 | (1.012–1.032) | <0.001 |
| TR severityb (moderate vs. mild) | 5.309 | (2.291–12.307) | 0.000 | 4.995 | (2.359–10.577) | 0.000 |
| TR severityb (severe vs. mild) | 17.918 | (7.942–40.426) | 15.697 | (7.557–32.605) | ||
| Model | 0.000 | 0.000 |
| Variables . | Hazard ratio . | 95% CI . | P-value for CHFa . | Hazard ratio . | 95% CI . | P-value for composite outcomea . |
|---|---|---|---|---|---|---|
| Age (years) | 1.022 | (1.008–1.036) | 0.002 | 1.023 | (1.01–1.036) | 0.001 |
| NYHA class (2 vs. 1) | 2.652 | (1.486–4.73) | 0.002 | 2.173 | (1.267–3.725) | 0.011 |
| NYHA class (3 vs. 1) | 1.328 | (0.655–2.697) | 1.162 | (0.596–2.262) | ||
| LV ejection fraction (%) | 0.972 | (0.942–1.002) | 0.067 | 0.971 | (0.944–1) | 0.049 |
| PASP (mm Hg) | 1.023 | (1.013–1.032) | <0.001 | 1.022 | (1.012–1.032) | <0.001 |
| TR severityb (moderate vs. mild) | 5.309 | (2.291–12.307) | 0.000 | 4.995 | (2.359–10.577) | 0.000 |
| TR severityb (severe vs. mild) | 17.918 | (7.942–40.426) | 15.697 | (7.557–32.605) | ||
| Model | 0.000 | 0.000 |
The HR for continuous variables was obtained by contrasting the hazard estimated at the first and third quartiles values observed in the sample.
CI, confidence interval; CHF, hospitalization for congestive heart failure; LV, left ventricular; NYHA, New York Heart Association; PASP, pulmonary artery systolic pressure; TR, tricuspid regurgitation.
P-values refer to the ANOVA.
Multi-parametric definition as recommended by current guidelines.15,16
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