Univariate Cox-regression hazard ratio’s of currently used predictors and echocardiographic derives indices of RV structure and function including the RV ɛ-area loop characteristics
| . | Univariate HR (95% CI) . | P-value . |
|---|---|---|
| Age (years) | 1.023 (1.002–1.044) | 0.03 |
| Sex (male) | 2.191 (1.210–3.968) | 0.01 |
| NT-ProBNP (>1400 ng/L) | 3.215 (1.727–5.982) | <0.01 |
| 6M-WD (<165 m) | 2.873 (1.005–8.209) | <0.01 |
| RA area (>26 cm2) | 1.310 (0.676–2.537) | 0.42 |
| RVEDA (>26.8 cm2) | 2.777 (1.405–5.488) | <0.01 |
| RVESA (>16.9 cm2) | 3.690 (1.775–7.669) | <0.01 |
| RVFAC (<25.5 %) | 5.429 (2.973–9.914) | <0.01 |
| TAPSE (<1.95 cm) | 2.199 (1.202–4.022) | 0.01 |
| ESslope (>−1.695 %/cm) | 2.658 (1.125–6.282) | 0.03 |
| Sslope (>−1.62 %/cm) | 2.124 (1.161–3.886) | 0.01 |
| Peak ɛ (>−14.45 %) | 3.400 (1.858–6.222) | <0.01 |
| UNCOUP_ED (<1.025) | 1.840 (1.025–3.301) | 0.04 |
| UNCOUP_LD (<2.035) | 1.362 (0.745–2.491) | 0.32 |
| UNCOUP (<0.805) | 1.557 (0.861–2.813) | 0.14 |
| EDslope (<0.95 %/cm) | 1.800 (1.000–3.238) | 0.05 |
| LDslope (<2.465 %/cm) | 2.684 (1.198–6.014) | 0.02 |
| . | Univariate HR (95% CI) . | P-value . |
|---|---|---|
| Age (years) | 1.023 (1.002–1.044) | 0.03 |
| Sex (male) | 2.191 (1.210–3.968) | 0.01 |
| NT-ProBNP (>1400 ng/L) | 3.215 (1.727–5.982) | <0.01 |
| 6M-WD (<165 m) | 2.873 (1.005–8.209) | <0.01 |
| RA area (>26 cm2) | 1.310 (0.676–2.537) | 0.42 |
| RVEDA (>26.8 cm2) | 2.777 (1.405–5.488) | <0.01 |
| RVESA (>16.9 cm2) | 3.690 (1.775–7.669) | <0.01 |
| RVFAC (<25.5 %) | 5.429 (2.973–9.914) | <0.01 |
| TAPSE (<1.95 cm) | 2.199 (1.202–4.022) | 0.01 |
| ESslope (>−1.695 %/cm) | 2.658 (1.125–6.282) | 0.03 |
| Sslope (>−1.62 %/cm) | 2.124 (1.161–3.886) | 0.01 |
| Peak ɛ (>−14.45 %) | 3.400 (1.858–6.222) | <0.01 |
| UNCOUP_ED (<1.025) | 1.840 (1.025–3.301) | 0.04 |
| UNCOUP_LD (<2.035) | 1.362 (0.745–2.491) | 0.32 |
| UNCOUP (<0.805) | 1.557 (0.861–2.813) | 0.14 |
| EDslope (<0.95 %/cm) | 1.800 (1.000–3.238) | 0.05 |
| LDslope (<2.465 %/cm) | 2.684 (1.198–6.014) | 0.02 |
6M-WD, 6 min walking distance; CI, confidence interval; HR, hazard ratio; RVEDA, right ventricular end-diastolic area; RVESA, right ventricular end-systolic area; RVFAC, right ventricular fractional area change; TAPSE, tricuspid annular plane systolic excursion.
Univariate Cox-regression hazard ratio’s of currently used predictors and echocardiographic derives indices of RV structure and function including the RV ɛ-area loop characteristics
| . | Univariate HR (95% CI) . | P-value . |
|---|---|---|
| Age (years) | 1.023 (1.002–1.044) | 0.03 |
| Sex (male) | 2.191 (1.210–3.968) | 0.01 |
| NT-ProBNP (>1400 ng/L) | 3.215 (1.727–5.982) | <0.01 |
| 6M-WD (<165 m) | 2.873 (1.005–8.209) | <0.01 |
| RA area (>26 cm2) | 1.310 (0.676–2.537) | 0.42 |
| RVEDA (>26.8 cm2) | 2.777 (1.405–5.488) | <0.01 |
| RVESA (>16.9 cm2) | 3.690 (1.775–7.669) | <0.01 |
| RVFAC (<25.5 %) | 5.429 (2.973–9.914) | <0.01 |
| TAPSE (<1.95 cm) | 2.199 (1.202–4.022) | 0.01 |
| ESslope (>−1.695 %/cm) | 2.658 (1.125–6.282) | 0.03 |
| Sslope (>−1.62 %/cm) | 2.124 (1.161–3.886) | 0.01 |
| Peak ɛ (>−14.45 %) | 3.400 (1.858–6.222) | <0.01 |
| UNCOUP_ED (<1.025) | 1.840 (1.025–3.301) | 0.04 |
| UNCOUP_LD (<2.035) | 1.362 (0.745–2.491) | 0.32 |
| UNCOUP (<0.805) | 1.557 (0.861–2.813) | 0.14 |
| EDslope (<0.95 %/cm) | 1.800 (1.000–3.238) | 0.05 |
| LDslope (<2.465 %/cm) | 2.684 (1.198–6.014) | 0.02 |
| . | Univariate HR (95% CI) . | P-value . |
|---|---|---|
| Age (years) | 1.023 (1.002–1.044) | 0.03 |
| Sex (male) | 2.191 (1.210–3.968) | 0.01 |
| NT-ProBNP (>1400 ng/L) | 3.215 (1.727–5.982) | <0.01 |
| 6M-WD (<165 m) | 2.873 (1.005–8.209) | <0.01 |
| RA area (>26 cm2) | 1.310 (0.676–2.537) | 0.42 |
| RVEDA (>26.8 cm2) | 2.777 (1.405–5.488) | <0.01 |
| RVESA (>16.9 cm2) | 3.690 (1.775–7.669) | <0.01 |
| RVFAC (<25.5 %) | 5.429 (2.973–9.914) | <0.01 |
| TAPSE (<1.95 cm) | 2.199 (1.202–4.022) | 0.01 |
| ESslope (>−1.695 %/cm) | 2.658 (1.125–6.282) | 0.03 |
| Sslope (>−1.62 %/cm) | 2.124 (1.161–3.886) | 0.01 |
| Peak ɛ (>−14.45 %) | 3.400 (1.858–6.222) | <0.01 |
| UNCOUP_ED (<1.025) | 1.840 (1.025–3.301) | 0.04 |
| UNCOUP_LD (<2.035) | 1.362 (0.745–2.491) | 0.32 |
| UNCOUP (<0.805) | 1.557 (0.861–2.813) | 0.14 |
| EDslope (<0.95 %/cm) | 1.800 (1.000–3.238) | 0.05 |
| LDslope (<2.465 %/cm) | 2.684 (1.198–6.014) | 0.02 |
6M-WD, 6 min walking distance; CI, confidence interval; HR, hazard ratio; RVEDA, right ventricular end-diastolic area; RVESA, right ventricular end-systolic area; RVFAC, right ventricular fractional area change; TAPSE, tricuspid annular plane systolic excursion.
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