Laboratory Results for a Confirmed Case of Heartland Virus Disease, by Date of Specimen
| Parameter (Normal Range) . | 12 Sep 2019 . | 16 Sep 2019 . | 17 Sep 2019 . | 18 Sep 2019 . | 23 Sep 2019 . | 10 Oct 2019 . | 6 Nov 2019 . | 8 Nov 2019 . |
|---|---|---|---|---|---|---|---|---|
| Platelets, × 1000/µL (140–440) | 97 | 61 | 68 | 76 | 169 | 165 | … | 192 |
| WBC count, × 1000/µL (4.5–11) | 2.5 | 2.54 | 4.08 | 3.29 | 3.33 | 4.52 | … | 6.34 |
| Neutrophils, × 1000/µL (1.78–5.38) | 1.5 | 0.82 | 1.74 | 1.22 | 1.32 | 1.64 | … | 3.97 |
| Lymphocytes, × 1000/µL (0.7–3.1) | 0.8 | 1.51 | 2.00 | 1.71 | 1.67 | 2.24 | … | 1.79 |
| Creatinine, mg/dL (0.70–1.30) | 1.46 | 1.13 | … | 1.08 | 1.01 | 1.02 | … | 1.21 |
| AST, units/L (13–40) | 141 | 223 | … | 147 | 89 | 67 | … | 29 |
| ALT, units/L (10–49) | 108 | 152 | … | 117 | 107 | 95 | … | 32 |
| Ehrlichia chaffeensis IgG titer (< 1:64) | Negative | … | … | … | … | … | … | … |
| E. chaffeensis IgM titer (< 1:20) | Negative | … | … | … | … | … | … | … |
| Lyme IgG/IgM antibody (< 0.91) | Negative | … | … | … | … | … | … | … |
| Lyme IgM quantitative (< 0.80) | Negative | … | … | … | … | … | … | … |
| RMSF IgM (< 0.90) | 0.18 | … | … | … | … | … | … | … |
| HRTV RT-PCR | … | … | … | Negativea | … | … | … | … |
| HRTV PRNT | … | … | … | Negativea | … | … | 1:2560b | … |
| HRTV IgM MIA | … | … | … | Positivec | … | … | … | … |
| HRTV IgG MIA | … | … | … | Positivec | … | … | … | … |
| Parameter (Normal Range) . | 12 Sep 2019 . | 16 Sep 2019 . | 17 Sep 2019 . | 18 Sep 2019 . | 23 Sep 2019 . | 10 Oct 2019 . | 6 Nov 2019 . | 8 Nov 2019 . |
|---|---|---|---|---|---|---|---|---|
| Platelets, × 1000/µL (140–440) | 97 | 61 | 68 | 76 | 169 | 165 | … | 192 |
| WBC count, × 1000/µL (4.5–11) | 2.5 | 2.54 | 4.08 | 3.29 | 3.33 | 4.52 | … | 6.34 |
| Neutrophils, × 1000/µL (1.78–5.38) | 1.5 | 0.82 | 1.74 | 1.22 | 1.32 | 1.64 | … | 3.97 |
| Lymphocytes, × 1000/µL (0.7–3.1) | 0.8 | 1.51 | 2.00 | 1.71 | 1.67 | 2.24 | … | 1.79 |
| Creatinine, mg/dL (0.70–1.30) | 1.46 | 1.13 | … | 1.08 | 1.01 | 1.02 | … | 1.21 |
| AST, units/L (13–40) | 141 | 223 | … | 147 | 89 | 67 | … | 29 |
| ALT, units/L (10–49) | 108 | 152 | … | 117 | 107 | 95 | … | 32 |
| Ehrlichia chaffeensis IgG titer (< 1:64) | Negative | … | … | … | … | … | … | … |
| E. chaffeensis IgM titer (< 1:20) | Negative | … | … | … | … | … | … | … |
| Lyme IgG/IgM antibody (< 0.91) | Negative | … | … | … | … | … | … | … |
| Lyme IgM quantitative (< 0.80) | Negative | … | … | … | … | … | … | … |
| RMSF IgM (< 0.90) | 0.18 | … | … | … | … | … | … | … |
| HRTV RT-PCR | … | … | … | Negativea | … | … | … | … |
| HRTV PRNT | … | … | … | Negativea | … | … | 1:2560b | … |
| HRTV IgM MIA | … | … | … | Positivec | … | … | … | … |
| HRTV IgG MIA | … | … | … | Positivec | … | … | … | … |
All tests on 12 September were conducted by LabCorp; all HRTV tests were conducted by the Centers for Disease Control and Prevention; all other tests were conducted by Cookeville Regional Medical Center Clinical Laboratory. For hematology and chemistry results, shown are only those assays for which an abnormal result was obtained.
Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; HRTV, Heartland virus; IgG, immunoglobulin G; IgM, immunoglobulin M; MIA, microsphere immunoassay; PRNT, plaque reduction neutralization test; RMSF, Rocky Mountain spotted fever; RT-PCR, reverse-transcription polymerase chain reaction; WBC, white blood cell.
aResults returned on 29 October 2019.
bResults returned on 27 November 2019.
cResults returned on 2 November 2019.
Laboratory Results for a Confirmed Case of Heartland Virus Disease, by Date of Specimen
| Parameter (Normal Range) . | 12 Sep 2019 . | 16 Sep 2019 . | 17 Sep 2019 . | 18 Sep 2019 . | 23 Sep 2019 . | 10 Oct 2019 . | 6 Nov 2019 . | 8 Nov 2019 . |
|---|---|---|---|---|---|---|---|---|
| Platelets, × 1000/µL (140–440) | 97 | 61 | 68 | 76 | 169 | 165 | … | 192 |
| WBC count, × 1000/µL (4.5–11) | 2.5 | 2.54 | 4.08 | 3.29 | 3.33 | 4.52 | … | 6.34 |
| Neutrophils, × 1000/µL (1.78–5.38) | 1.5 | 0.82 | 1.74 | 1.22 | 1.32 | 1.64 | … | 3.97 |
| Lymphocytes, × 1000/µL (0.7–3.1) | 0.8 | 1.51 | 2.00 | 1.71 | 1.67 | 2.24 | … | 1.79 |
| Creatinine, mg/dL (0.70–1.30) | 1.46 | 1.13 | … | 1.08 | 1.01 | 1.02 | … | 1.21 |
| AST, units/L (13–40) | 141 | 223 | … | 147 | 89 | 67 | … | 29 |
| ALT, units/L (10–49) | 108 | 152 | … | 117 | 107 | 95 | … | 32 |
| Ehrlichia chaffeensis IgG titer (< 1:64) | Negative | … | … | … | … | … | … | … |
| E. chaffeensis IgM titer (< 1:20) | Negative | … | … | … | … | … | … | … |
| Lyme IgG/IgM antibody (< 0.91) | Negative | … | … | … | … | … | … | … |
| Lyme IgM quantitative (< 0.80) | Negative | … | … | … | … | … | … | … |
| RMSF IgM (< 0.90) | 0.18 | … | … | … | … | … | … | … |
| HRTV RT-PCR | … | … | … | Negativea | … | … | … | … |
| HRTV PRNT | … | … | … | Negativea | … | … | 1:2560b | … |
| HRTV IgM MIA | … | … | … | Positivec | … | … | … | … |
| HRTV IgG MIA | … | … | … | Positivec | … | … | … | … |
| Parameter (Normal Range) . | 12 Sep 2019 . | 16 Sep 2019 . | 17 Sep 2019 . | 18 Sep 2019 . | 23 Sep 2019 . | 10 Oct 2019 . | 6 Nov 2019 . | 8 Nov 2019 . |
|---|---|---|---|---|---|---|---|---|
| Platelets, × 1000/µL (140–440) | 97 | 61 | 68 | 76 | 169 | 165 | … | 192 |
| WBC count, × 1000/µL (4.5–11) | 2.5 | 2.54 | 4.08 | 3.29 | 3.33 | 4.52 | … | 6.34 |
| Neutrophils, × 1000/µL (1.78–5.38) | 1.5 | 0.82 | 1.74 | 1.22 | 1.32 | 1.64 | … | 3.97 |
| Lymphocytes, × 1000/µL (0.7–3.1) | 0.8 | 1.51 | 2.00 | 1.71 | 1.67 | 2.24 | … | 1.79 |
| Creatinine, mg/dL (0.70–1.30) | 1.46 | 1.13 | … | 1.08 | 1.01 | 1.02 | … | 1.21 |
| AST, units/L (13–40) | 141 | 223 | … | 147 | 89 | 67 | … | 29 |
| ALT, units/L (10–49) | 108 | 152 | … | 117 | 107 | 95 | … | 32 |
| Ehrlichia chaffeensis IgG titer (< 1:64) | Negative | … | … | … | … | … | … | … |
| E. chaffeensis IgM titer (< 1:20) | Negative | … | … | … | … | … | … | … |
| Lyme IgG/IgM antibody (< 0.91) | Negative | … | … | … | … | … | … | … |
| Lyme IgM quantitative (< 0.80) | Negative | … | … | … | … | … | … | … |
| RMSF IgM (< 0.90) | 0.18 | … | … | … | … | … | … | … |
| HRTV RT-PCR | … | … | … | Negativea | … | … | … | … |
| HRTV PRNT | … | … | … | Negativea | … | … | 1:2560b | … |
| HRTV IgM MIA | … | … | … | Positivec | … | … | … | … |
| HRTV IgG MIA | … | … | … | Positivec | … | … | … | … |
All tests on 12 September were conducted by LabCorp; all HRTV tests were conducted by the Centers for Disease Control and Prevention; all other tests were conducted by Cookeville Regional Medical Center Clinical Laboratory. For hematology and chemistry results, shown are only those assays for which an abnormal result was obtained.
Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; HRTV, Heartland virus; IgG, immunoglobulin G; IgM, immunoglobulin M; MIA, microsphere immunoassay; PRNT, plaque reduction neutralization test; RMSF, Rocky Mountain spotted fever; RT-PCR, reverse-transcription polymerase chain reaction; WBC, white blood cell.
aResults returned on 29 October 2019.
bResults returned on 27 November 2019.
cResults returned on 2 November 2019.
This PDF is available to Subscribers Only
View Article Abstract & Purchase OptionsFor full access to this pdf, sign in to an existing account, or purchase an annual subscription.
