Table 3 Open in new tab Post-dialysis...

	hs-TnI	galectin-3	hFABP
Sex (female)	1.337	0.091, 2.584	0.036	−1.226	−2.342, −0.110	0.031	−2.333	−3.608, −1.059	<0.001
Ethnicity (non-Caucasian)	−1.297	−2.899, 0.304	0.11	−0.647	−2.111, 0.818	0.39	−1.879	−3.535, −0.223	0.026
Diabetes	1.650	0.356, 2.945	0.012	2.096	0.934, 3.257	<0.001	1.263	−0.060, 2.587	0.061
Coronary artery disease	−1.953	−3.400, −0.506	0.008	0.247	−1.043, 1.536	0.71	0.282	−1.189, 1.754	0.71
Residual renal function	0.242	−1.202, 1.685	0.74	−1.768	−3.084, −0.452	0.008	−0.727	−2.233, 0.779	0.34
Hemodialysis treatment time (per minute)	−0.025	−0.048, −0.003	0.025	−0.009	−0.017, −0.001	0.020	−0.011	−0.022, −0.001	0.039
Exeltra 190^*	−0.955	−2.656, 0.746	0.27	−2.512	−3.659, −1.364	<0.001	−4.905	−6.372, −3.439	<0.001
Ultrafiltration (per L)	0.991	0.528, 1.453	<0.001	1.053	0.887, 1.220	<0.001	1.877	1.647, 2.106	<0.001
Total blood processed (per L)	0.017	−0.032, 0.066	0.49	−0.139	−0.156, −0.122	<0.001	−0.072	−0.095, −0.049	<0.001
Intradialytic hypotension (SBP < 90 mm Hg)	−0.402	−1.411, 0.607	0.44	−0.119	−0.459, 0.220	0.49	−0.522	−0.997, −0.047	0.031
Pre-dialysis biomarker (per unit/volume)	1.128	1.122, 1.133	<0.001	0.235	0.223, 0.246	<0.001	0.637	0.623, 0.650	<0.001

	hs-TnI	galectin-3	hFABP
Sex (female)	1.337	0.091, 2.584	0.036	−1.226	−2.342, −0.110	0.031	−2.333	−3.608, −1.059	<0.001
Ethnicity (non-Caucasian)	−1.297	−2.899, 0.304	0.11	−0.647	−2.111, 0.818	0.39	−1.879	−3.535, −0.223	0.026
Diabetes	1.650	0.356, 2.945	0.012	2.096	0.934, 3.257	<0.001	1.263	−0.060, 2.587	0.061
Coronary artery disease	−1.953	−3.400, −0.506	0.008	0.247	−1.043, 1.536	0.71	0.282	−1.189, 1.754	0.71
Residual renal function	0.242	−1.202, 1.685	0.74	−1.768	−3.084, −0.452	0.008	−0.727	−2.233, 0.779	0.34
Hemodialysis treatment time (per minute)	−0.025	−0.048, −0.003	0.025	−0.009	−0.017, −0.001	0.020	−0.011	−0.022, −0.001	0.039
Exeltra 190^*	−0.955	−2.656, 0.746	0.27	−2.512	−3.659, −1.364	<0.001	−4.905	−6.372, −3.439	<0.001
Ultrafiltration (per L)	0.991	0.528, 1.453	<0.001	1.053	0.887, 1.220	<0.001	1.877	1.647, 2.106	<0.001
Total blood processed (per L)	0.017	−0.032, 0.066	0.49	−0.139	−0.156, −0.122	<0.001	−0.072	−0.095, −0.049	<0.001
Intradialytic hypotension (SBP < 90 mm Hg)	−0.402	−1.411, 0.607	0.44	−0.119	−0.459, 0.220	0.49	−0.522	−0.997, −0.047	0.031
Pre-dialysis biomarker (per unit/volume)	1.128	1.122, 1.133	<0.001	0.235	0.223, 0.246	<0.001	0.637	0.623, 0.650	<0.001

Table 3

Post-dialysis cardiac biomarker multivariate linear regression models.

	hs-TnI			galectin-3			hFABP
	ß	95% CI	P-value	ß	95% CI	P-value	ß	95% CI	P-value
Sex (female)	1.337	0.091, 2.584	0.036	−1.226	−2.342, −0.110	0.031	−2.333	−3.608, −1.059	<0.001
Ethnicity (non-Caucasian)	−1.297	−2.899, 0.304	0.11	−0.647	−2.111, 0.818	0.39	−1.879	−3.535, −0.223	0.026
Diabetes	1.650	0.356, 2.945	0.012	2.096	0.934, 3.257	<0.001	1.263	−0.060, 2.587	0.061
Coronary artery disease	−1.953	−3.400, −0.506	0.008	0.247	−1.043, 1.536	0.71	0.282	−1.189, 1.754	0.71
Residual renal function	0.242	−1.202, 1.685	0.74	−1.768	−3.084, −0.452	0.008	−0.727	−2.233, 0.779	0.34
Hemodialysis treatment time (per minute)	−0.025	−0.048, −0.003	0.025	−0.009	−0.017, −0.001	0.020	−0.011	−0.022, −0.001	0.039
Exeltra 190^*	−0.955	−2.656, 0.746	0.27	−2.512	−3.659, −1.364	<0.001	−4.905	−6.372, −3.439	<0.001
Ultrafiltration (per L)	0.991	0.528, 1.453	<0.001	1.053	0.887, 1.220	<0.001	1.877	1.647, 2.106	<0.001
Total blood processed (per L)	0.017	−0.032, 0.066	0.49	−0.139	−0.156, −0.122	<0.001	−0.072	−0.095, −0.049	<0.001
Intradialytic hypotension (SBP < 90 mm Hg)	−0.402	−1.411, 0.607	0.44	−0.119	−0.459, 0.220	0.49	−0.522	−0.997, −0.047	0.031
Pre-dialysis biomarker (per unit/volume)	1.128	1.122, 1.133	<0.001	0.235	0.223, 0.246	<0.001	0.637	0.623, 0.650	<0.001

	hs-TnI			galectin-3			hFABP
	ß	95% CI	P-value	ß	95% CI	P-value	ß	95% CI	P-value
Sex (female)	1.337	0.091, 2.584	0.036	−1.226	−2.342, −0.110	0.031	−2.333	−3.608, −1.059	<0.001
Ethnicity (non-Caucasian)	−1.297	−2.899, 0.304	0.11	−0.647	−2.111, 0.818	0.39	−1.879	−3.535, −0.223	0.026
Diabetes	1.650	0.356, 2.945	0.012	2.096	0.934, 3.257	<0.001	1.263	−0.060, 2.587	0.061
Coronary artery disease	−1.953	−3.400, −0.506	0.008	0.247	−1.043, 1.536	0.71	0.282	−1.189, 1.754	0.71
Residual renal function	0.242	−1.202, 1.685	0.74	−1.768	−3.084, −0.452	0.008	−0.727	−2.233, 0.779	0.34
Hemodialysis treatment time (per minute)	−0.025	−0.048, −0.003	0.025	−0.009	−0.017, −0.001	0.020	−0.011	−0.022, −0.001	0.039
Exeltra 190^*	−0.955	−2.656, 0.746	0.27	−2.512	−3.659, −1.364	<0.001	−4.905	−6.372, −3.439	<0.001
Ultrafiltration (per L)	0.991	0.528, 1.453	<0.001	1.053	0.887, 1.220	<0.001	1.877	1.647, 2.106	<0.001
Total blood processed (per L)	0.017	−0.032, 0.066	0.49	−0.139	−0.156, −0.122	<0.001	−0.072	−0.095, −0.049	<0.001
Intradialytic hypotension (SBP < 90 mm Hg)	−0.402	−1.411, 0.607	0.44	−0.119	−0.459, 0.220	0.49	−0.522	−0.997, −0.047	0.031
Pre-dialysis biomarker (per unit/volume)	1.128	1.122, 1.133	<0.001	0.235	0.223, 0.246	<0.001	0.637	0.623, 0.650	<0.001

hs-TnI, high sensitivity troponin I; hFABP, heart-type fatty acid binding protein;

$ß$ ⁠, beta coefficient; CI, confidence interval; SBP, systolic blood pressure.

Estimates were also adjusted for age, heart failure, cerebrovascular disease, peripheral vascular disease, hemodialysis frequency >3x weekly, Toray but these are not shown (see Supplemental Table 5 for all parameter estimates).

β coefficients represent the change in biomarker over a hemodialysis treatment.

Changes are presented as per unit of the exposure where applicable.

(hemodialysis time, ultrafiltration volume, total blood processed, pre-dialysis biomarker).

comparator hemodialysis membrane is Revaclear 300/Revaclear 400.

Mean (SD) hemodialysis treatment time was 201 (35.6) min.

Mean (SD) ultrafiltration volume was 2.46 (1.06) L.

Mean (SD) total blood processed was 64.7 (14.2) L.

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