Receiver operating characteristic curve analysis of serum biomarkers for the diagnosis of macrophage activation syndrome
| . | SLE . | JDM . | KD . | s-JIA . | ||||
|---|---|---|---|---|---|---|---|---|
| . | AUC . | Cut-off value . | AUC . | Cut-off value . | AUC . | Cut-off value . | AUC . | Cut-off value . |
| Neopterin, nmol/l | 0.875 | 26 | 0.938 | 31 | 0.948 | 28.6 | 0.937 | 23.8 |
| IL-18, pg/ml | 0.85 | 1380 | 1 | 856.5 | 0.962 | 720 | 0.897 | 71500 |
| IL-6, pg/ml | 0.6125 | 4 | 0.9688 | 4 | 0.6643 | 61 | 0.6636 | 24 |
| sTNFR-I, pg/ml | 0.975 | 2510 | 0.9688 | 1530 | 0.6095 | 3635 | 0.6989 | 3105 |
| sTNFR-II, pg/ml | 0.9 | 19 500 | 0.906 | 10 165 | 0.974 | 11 780 | 0.956 | 14000 |
| sTNFR-II/I | 0.575 | 5.277 | 0.5625 | 4.961 | 0.9857 | 5.196 | 0.9316 | 4.299 |
| . | SLE . | JDM . | KD . | s-JIA . | ||||
|---|---|---|---|---|---|---|---|---|
| . | AUC . | Cut-off value . | AUC . | Cut-off value . | AUC . | Cut-off value . | AUC . | Cut-off value . |
| Neopterin, nmol/l | 0.875 | 26 | 0.938 | 31 | 0.948 | 28.6 | 0.937 | 23.8 |
| IL-18, pg/ml | 0.85 | 1380 | 1 | 856.5 | 0.962 | 720 | 0.897 | 71500 |
| IL-6, pg/ml | 0.6125 | 4 | 0.9688 | 4 | 0.6643 | 61 | 0.6636 | 24 |
| sTNFR-I, pg/ml | 0.975 | 2510 | 0.9688 | 1530 | 0.6095 | 3635 | 0.6989 | 3105 |
| sTNFR-II, pg/ml | 0.9 | 19 500 | 0.906 | 10 165 | 0.974 | 11 780 | 0.956 | 14000 |
| sTNFR-II/I | 0.575 | 5.277 | 0.5625 | 4.961 | 0.9857 | 5.196 | 0.9316 | 4.299 |
AUC: area under the receiver operating characteristic curve; KD: Kawasaki disease; s-JIA: systemic JIA; sTNFR: soluble TNF receptor.
Receiver operating characteristic curve analysis of serum biomarkers for the diagnosis of macrophage activation syndrome
| . | SLE . | JDM . | KD . | s-JIA . | ||||
|---|---|---|---|---|---|---|---|---|
| . | AUC . | Cut-off value . | AUC . | Cut-off value . | AUC . | Cut-off value . | AUC . | Cut-off value . |
| Neopterin, nmol/l | 0.875 | 26 | 0.938 | 31 | 0.948 | 28.6 | 0.937 | 23.8 |
| IL-18, pg/ml | 0.85 | 1380 | 1 | 856.5 | 0.962 | 720 | 0.897 | 71500 |
| IL-6, pg/ml | 0.6125 | 4 | 0.9688 | 4 | 0.6643 | 61 | 0.6636 | 24 |
| sTNFR-I, pg/ml | 0.975 | 2510 | 0.9688 | 1530 | 0.6095 | 3635 | 0.6989 | 3105 |
| sTNFR-II, pg/ml | 0.9 | 19 500 | 0.906 | 10 165 | 0.974 | 11 780 | 0.956 | 14000 |
| sTNFR-II/I | 0.575 | 5.277 | 0.5625 | 4.961 | 0.9857 | 5.196 | 0.9316 | 4.299 |
| . | SLE . | JDM . | KD . | s-JIA . | ||||
|---|---|---|---|---|---|---|---|---|
| . | AUC . | Cut-off value . | AUC . | Cut-off value . | AUC . | Cut-off value . | AUC . | Cut-off value . |
| Neopterin, nmol/l | 0.875 | 26 | 0.938 | 31 | 0.948 | 28.6 | 0.937 | 23.8 |
| IL-18, pg/ml | 0.85 | 1380 | 1 | 856.5 | 0.962 | 720 | 0.897 | 71500 |
| IL-6, pg/ml | 0.6125 | 4 | 0.9688 | 4 | 0.6643 | 61 | 0.6636 | 24 |
| sTNFR-I, pg/ml | 0.975 | 2510 | 0.9688 | 1530 | 0.6095 | 3635 | 0.6989 | 3105 |
| sTNFR-II, pg/ml | 0.9 | 19 500 | 0.906 | 10 165 | 0.974 | 11 780 | 0.956 | 14000 |
| sTNFR-II/I | 0.575 | 5.277 | 0.5625 | 4.961 | 0.9857 | 5.196 | 0.9316 | 4.299 |
AUC: area under the receiver operating characteristic curve; KD: Kawasaki disease; s-JIA: systemic JIA; sTNFR: soluble TNF receptor.
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