Table 2.
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Echocardiographic Parameters of 849 People Living With Human Immunodeficiency Virus and Uninfected Study Participants

VariableHIV-Uninfected (n = 461)PLWH, ART-Naive (n = 388)P Valuea
Systolic measures
 Left ventricular function
  Ejection fraction, %66.4 (8.9)66.4 (8.8).720
  End diastolic volume, mL61.2 (20.0)61.4 (19.5).154
  End diastolic volume index, mL/m236.0 (11.4)36.7 (11.4).108
  End systolic volume, mL20.6 (9.2)20.6 (9.0).484
  End systolic volume index, mL/m212.1 (5.4)12.3 (5.4).427
 Right ventricular function
  TAPSE, cm2.2 (0.4)2.2 (0.4).874
Structural measures
 Left atrial/ventricular chamber size
  Diastolic diameter, cm4.2 (0.5)4.2 (0.5).833
  LV mass, g119.5 (32.3)122.0 (34.5)<.0001
  Relative wall thickness0.43 (0.13)0.45 (0.13).105
  Left atrial volume, mL33.3 (12.7)33.7 (20.0).108
  Left atrial volume index, mL/m219.5 (7.2)20.1 (12.8).077
Diastolic measures
 Pulse Doppler at mitral valve
  E wave velocity, m/s0.79 (0.17)0.76 (0.16).066
  A wave velocity, m/s0.53 (0.17)0.55 (0.16).001
  E wave deceleration time, ms195.3 (43.4)196.1 (46.7).638
  E/A ratio1.62 (0.6)1.47 (0.5)<.0001
 Tissue Doppler
  Lateral e′ wave, cm/s14.4 (3.2)14.0 (3.1).003
  Septal e′ wave, cm/s10.7 (2.6)10.0 (2.4)<.0001
  Average E/e′6.7 (1.8)6.8 (1.8).006
VariableHIV-Uninfected (n = 461)PLWH, ART-Naive (n = 388)P Valuea
Systolic measures
 Left ventricular function
  Ejection fraction, %66.4 (8.9)66.4 (8.8).720
  End diastolic volume, mL61.2 (20.0)61.4 (19.5).154
  End diastolic volume index, mL/m236.0 (11.4)36.7 (11.4).108
  End systolic volume, mL20.6 (9.2)20.6 (9.0).484
  End systolic volume index, mL/m212.1 (5.4)12.3 (5.4).427
 Right ventricular function
  TAPSE, cm2.2 (0.4)2.2 (0.4).874
Structural measures
 Left atrial/ventricular chamber size
  Diastolic diameter, cm4.2 (0.5)4.2 (0.5).833
  LV mass, g119.5 (32.3)122.0 (34.5)<.0001
  Relative wall thickness0.43 (0.13)0.45 (0.13).105
  Left atrial volume, mL33.3 (12.7)33.7 (20.0).108
  Left atrial volume index, mL/m219.5 (7.2)20.1 (12.8).077
Diastolic measures
 Pulse Doppler at mitral valve
  E wave velocity, m/s0.79 (0.17)0.76 (0.16).066
  A wave velocity, m/s0.53 (0.17)0.55 (0.16).001
  E wave deceleration time, ms195.3 (43.4)196.1 (46.7).638
  E/A ratio1.62 (0.6)1.47 (0.5)<.0001
 Tissue Doppler
  Lateral e′ wave, cm/s14.4 (3.2)14.0 (3.1).003
  Septal e′ wave, cm/s10.7 (2.6)10.0 (2.4)<.0001
  Average E/e′6.7 (1.8)6.8 (1.8).006

Data are presented as mean (standard deviation).

Abbreviations: ART, antiretroviral therapy; HIV, human immunodeficiency virus; PLWH, people living with human immunodeficiency virus; TAPSE, tricuspid annular plane systolic excursion.

aLinear regression (adjusted for age, sex, systolic blood pressure, and body mass index) (P < .05 in bold).

Table 2.
Open in new tab

Echocardiographic Parameters of 849 People Living With Human Immunodeficiency Virus and Uninfected Study Participants

VariableHIV-Uninfected (n = 461)PLWH, ART-Naive (n = 388)P Valuea
Systolic measures
 Left ventricular function
  Ejection fraction, %66.4 (8.9)66.4 (8.8).720
  End diastolic volume, mL61.2 (20.0)61.4 (19.5).154
  End diastolic volume index, mL/m236.0 (11.4)36.7 (11.4).108
  End systolic volume, mL20.6 (9.2)20.6 (9.0).484
  End systolic volume index, mL/m212.1 (5.4)12.3 (5.4).427
 Right ventricular function
  TAPSE, cm2.2 (0.4)2.2 (0.4).874
Structural measures
 Left atrial/ventricular chamber size
  Diastolic diameter, cm4.2 (0.5)4.2 (0.5).833
  LV mass, g119.5 (32.3)122.0 (34.5)<.0001
  Relative wall thickness0.43 (0.13)0.45 (0.13).105
  Left atrial volume, mL33.3 (12.7)33.7 (20.0).108
  Left atrial volume index, mL/m219.5 (7.2)20.1 (12.8).077
Diastolic measures
 Pulse Doppler at mitral valve
  E wave velocity, m/s0.79 (0.17)0.76 (0.16).066
  A wave velocity, m/s0.53 (0.17)0.55 (0.16).001
  E wave deceleration time, ms195.3 (43.4)196.1 (46.7).638
  E/A ratio1.62 (0.6)1.47 (0.5)<.0001
 Tissue Doppler
  Lateral e′ wave, cm/s14.4 (3.2)14.0 (3.1).003
  Septal e′ wave, cm/s10.7 (2.6)10.0 (2.4)<.0001
  Average E/e′6.7 (1.8)6.8 (1.8).006
VariableHIV-Uninfected (n = 461)PLWH, ART-Naive (n = 388)P Valuea
Systolic measures
 Left ventricular function
  Ejection fraction, %66.4 (8.9)66.4 (8.8).720
  End diastolic volume, mL61.2 (20.0)61.4 (19.5).154
  End diastolic volume index, mL/m236.0 (11.4)36.7 (11.4).108
  End systolic volume, mL20.6 (9.2)20.6 (9.0).484
  End systolic volume index, mL/m212.1 (5.4)12.3 (5.4).427
 Right ventricular function
  TAPSE, cm2.2 (0.4)2.2 (0.4).874
Structural measures
 Left atrial/ventricular chamber size
  Diastolic diameter, cm4.2 (0.5)4.2 (0.5).833
  LV mass, g119.5 (32.3)122.0 (34.5)<.0001
  Relative wall thickness0.43 (0.13)0.45 (0.13).105
  Left atrial volume, mL33.3 (12.7)33.7 (20.0).108
  Left atrial volume index, mL/m219.5 (7.2)20.1 (12.8).077
Diastolic measures
 Pulse Doppler at mitral valve
  E wave velocity, m/s0.79 (0.17)0.76 (0.16).066
  A wave velocity, m/s0.53 (0.17)0.55 (0.16).001
  E wave deceleration time, ms195.3 (43.4)196.1 (46.7).638
  E/A ratio1.62 (0.6)1.47 (0.5)<.0001
 Tissue Doppler
  Lateral e′ wave, cm/s14.4 (3.2)14.0 (3.1).003
  Septal e′ wave, cm/s10.7 (2.6)10.0 (2.4)<.0001
  Average E/e′6.7 (1.8)6.8 (1.8).006

Data are presented as mean (standard deviation).

Abbreviations: ART, antiretroviral therapy; HIV, human immunodeficiency virus; PLWH, people living with human immunodeficiency virus; TAPSE, tricuspid annular plane systolic excursion.

aLinear regression (adjusted for age, sex, systolic blood pressure, and body mass index) (P < .05 in bold).

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