Adjusted HR for all-cause mortality according to percentage use of dialysate potassium other than 2 mmol/L and medication prescriptionsa
| Dialysate potassium . | Person-years . | HR (95% CI) . | P-value . |
|---|---|---|---|
| Percentage of <2 mmol/L use per centreb (ref 0%) | 26 661 | ||
| 0–2% | 10 735 | 0.89 (0.81–0.98) | 0.01 |
| >2% | 9034 | 1 (0.92–1.1) | 0.9 |
| Percentage of 3 mmol/L use per centreb (ref 0–10%) | 16 443 | ||
| 10–30% | 17 237 | 0.87 (0.8–0.95) | 0.002 |
| >30% | 12 750 | 0.97 (0.89–1.05) | 0.4 |
| Percentage of 4 mmol/L use per centreb (ref 0%) | 43 228 | ||
| 0–2% | 1279 | 1 (0.82–1.21) | 0.9 |
| >2% | 1923 | 0.91 (0.77–1.08) | 0.2 |
| Potassium binders, g/dayb (ref 0) | 26 247 | ||
| <4 | 4615 | 1.22 (1.14–1.32) | <0.001 |
| 4–8 | 3859 | 0.6 (0.54–0.66) | <0.001 |
| ≥8 | 4117 | 0.25 (0.22–0.29) | <0.001 |
| Potassium, mg/dayb (ref 0) | 45 321 | ||
| <200 | 537 | 1.25 (1.03–1.51) | 0.02 |
| 200–400 | 194 | 1.17 (0.88–1.55) | 0.2 |
| ≥400 | 378 | 0.9 (0.71–1.13) | 0.3 |
| Missing medications | 7590 | 0.97 (0.91–1.05) | 0.4 |
| Dialysate potassium . | Person-years . | HR (95% CI) . | P-value . |
|---|---|---|---|
| Percentage of <2 mmol/L use per centreb (ref 0%) | 26 661 | ||
| 0–2% | 10 735 | 0.89 (0.81–0.98) | 0.01 |
| >2% | 9034 | 1 (0.92–1.1) | 0.9 |
| Percentage of 3 mmol/L use per centreb (ref 0–10%) | 16 443 | ||
| 10–30% | 17 237 | 0.87 (0.8–0.95) | 0.002 |
| >30% | 12 750 | 0.97 (0.89–1.05) | 0.4 |
| Percentage of 4 mmol/L use per centreb (ref 0%) | 43 228 | ||
| 0–2% | 1279 | 1 (0.82–1.21) | 0.9 |
| >2% | 1923 | 0.91 (0.77–1.08) | 0.2 |
| Potassium binders, g/dayb (ref 0) | 26 247 | ||
| <4 | 4615 | 1.22 (1.14–1.32) | <0.001 |
| 4–8 | 3859 | 0.6 (0.54–0.66) | <0.001 |
| ≥8 | 4117 | 0.25 (0.22–0.29) | <0.001 |
| Potassium, mg/dayb (ref 0) | 45 321 | ||
| <200 | 537 | 1.25 (1.03–1.51) | 0.02 |
| 200–400 | 194 | 1.17 (0.88–1.55) | 0.2 |
| ≥400 | 378 | 0.9 (0.71–1.13) | 0.3 |
| Missing medications | 7590 | 0.97 (0.91–1.05) | 0.4 |
HRs were adjusted for HDF, number of sessions per week, vascular access, dialysis time >4 h, as time-dependent variables, as well as for age, sex, respiratory failure, heart failure, cirrhosis, cancer, arrhythmia, arterial disease (stroke, transient ischaemic attack, coronary insufficiency, aneurysm abdominal aorta or arteritis of the lower limbs), obesity, mobility, initial nephropathy, emergency dialysis start, CKD-EPI >10 mL/min/1.73 m2, haemoglobin level, classes of albuminaemia. Cox models were stratified by dialysis unit type.
Time-dependent variable.
Adjusted HR for all-cause mortality according to percentage use of dialysate potassium other than 2 mmol/L and medication prescriptionsa
| Dialysate potassium . | Person-years . | HR (95% CI) . | P-value . |
|---|---|---|---|
| Percentage of <2 mmol/L use per centreb (ref 0%) | 26 661 | ||
| 0–2% | 10 735 | 0.89 (0.81–0.98) | 0.01 |
| >2% | 9034 | 1 (0.92–1.1) | 0.9 |
| Percentage of 3 mmol/L use per centreb (ref 0–10%) | 16 443 | ||
| 10–30% | 17 237 | 0.87 (0.8–0.95) | 0.002 |
| >30% | 12 750 | 0.97 (0.89–1.05) | 0.4 |
| Percentage of 4 mmol/L use per centreb (ref 0%) | 43 228 | ||
| 0–2% | 1279 | 1 (0.82–1.21) | 0.9 |
| >2% | 1923 | 0.91 (0.77–1.08) | 0.2 |
| Potassium binders, g/dayb (ref 0) | 26 247 | ||
| <4 | 4615 | 1.22 (1.14–1.32) | <0.001 |
| 4–8 | 3859 | 0.6 (0.54–0.66) | <0.001 |
| ≥8 | 4117 | 0.25 (0.22–0.29) | <0.001 |
| Potassium, mg/dayb (ref 0) | 45 321 | ||
| <200 | 537 | 1.25 (1.03–1.51) | 0.02 |
| 200–400 | 194 | 1.17 (0.88–1.55) | 0.2 |
| ≥400 | 378 | 0.9 (0.71–1.13) | 0.3 |
| Missing medications | 7590 | 0.97 (0.91–1.05) | 0.4 |
| Dialysate potassium . | Person-years . | HR (95% CI) . | P-value . |
|---|---|---|---|
| Percentage of <2 mmol/L use per centreb (ref 0%) | 26 661 | ||
| 0–2% | 10 735 | 0.89 (0.81–0.98) | 0.01 |
| >2% | 9034 | 1 (0.92–1.1) | 0.9 |
| Percentage of 3 mmol/L use per centreb (ref 0–10%) | 16 443 | ||
| 10–30% | 17 237 | 0.87 (0.8–0.95) | 0.002 |
| >30% | 12 750 | 0.97 (0.89–1.05) | 0.4 |
| Percentage of 4 mmol/L use per centreb (ref 0%) | 43 228 | ||
| 0–2% | 1279 | 1 (0.82–1.21) | 0.9 |
| >2% | 1923 | 0.91 (0.77–1.08) | 0.2 |
| Potassium binders, g/dayb (ref 0) | 26 247 | ||
| <4 | 4615 | 1.22 (1.14–1.32) | <0.001 |
| 4–8 | 3859 | 0.6 (0.54–0.66) | <0.001 |
| ≥8 | 4117 | 0.25 (0.22–0.29) | <0.001 |
| Potassium, mg/dayb (ref 0) | 45 321 | ||
| <200 | 537 | 1.25 (1.03–1.51) | 0.02 |
| 200–400 | 194 | 1.17 (0.88–1.55) | 0.2 |
| ≥400 | 378 | 0.9 (0.71–1.13) | 0.3 |
| Missing medications | 7590 | 0.97 (0.91–1.05) | 0.4 |
HRs were adjusted for HDF, number of sessions per week, vascular access, dialysis time >4 h, as time-dependent variables, as well as for age, sex, respiratory failure, heart failure, cirrhosis, cancer, arrhythmia, arterial disease (stroke, transient ischaemic attack, coronary insufficiency, aneurysm abdominal aorta or arteritis of the lower limbs), obesity, mobility, initial nephropathy, emergency dialysis start, CKD-EPI >10 mL/min/1.73 m2, haemoglobin level, classes of albuminaemia. Cox models were stratified by dialysis unit type.
Time-dependent variable.
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