| Low ANC group . | Comparative group (ANC 2.0–7.5 × 109/L) . | . | . | . | |||||
|---|---|---|---|---|---|---|---|---|---|
| Genotype . | ANC range (109/L) . | Number of subjects (N) . | Number with infections (N%) . | Genotype . | Number of subjects (N) . | Number with infections (N%) . | RR (95% CI) . | SE . | P . |
| CC | <1.0 | 39 | 11 (28.21%) | CC | 5523 | 1039 (18.81%) | 1.46 (0.80–2.67) | 0.31 | 0.214 |
| TC/TT | 444 715 | 87 295 (19.63%) | 1.28 (0.70–2.34) | 0.31 | 0.419 | ||||
| CC | 1.0–1.5 | 323 | 71 (21.98%) | CC | 5523 | 1039 (18.81%) | 1.17 (0.92–1.48) | 0.12 | 0.212 |
| TC/TT | 444 715 | 87 295 (19.63%) | 1.03 (0.79–1.33) | 0.13 | 0.848 | ||||
| CC | 1.5–2.0 | 1115 | 194 (17.40%) | CC | 5523 | 1039 (18.81%) | 0.94 (0.81–1.10) | 0.08 | 0.442 |
| TC/TT | 444 715 | 87 295 (19.63%) | 0.80 (0.66–0.97) | 0.10 | 0.021 | ||||
| TC/TT | <1.0 | 718 | 169 (23.54%) | TC/TT | 444 715 | 87 295 (19.63%) | 1.21 (1.04–1.41) | 0.08 | 0.012 |
| TC/TT | 1.0–1.5 | 990 | 239 (24.14%) | TC/TT | 444 715 | 87 295 (19.63%) | 1.25 (1.10–1.42) | 0.06 | 5.72 × 10−4 |
| TC/TT | 1.5–2.0 | 5659 | 1064 (18.80%) | TC/TT | 444 715 | 87 295 (19.63%) | 0.98 (0.93–1.05) | 0.03 | 0.618 |
| Low ANC group . | Comparative group (ANC 2.0–7.5 × 109/L) . | . | . | . | |||||
|---|---|---|---|---|---|---|---|---|---|
| Genotype . | ANC range (109/L) . | Number of subjects (N) . | Number with infections (N%) . | Genotype . | Number of subjects (N) . | Number with infections (N%) . | RR (95% CI) . | SE . | P . |
| CC | <1.0 | 39 | 11 (28.21%) | CC | 5523 | 1039 (18.81%) | 1.46 (0.80–2.67) | 0.31 | 0.214 |
| TC/TT | 444 715 | 87 295 (19.63%) | 1.28 (0.70–2.34) | 0.31 | 0.419 | ||||
| CC | 1.0–1.5 | 323 | 71 (21.98%) | CC | 5523 | 1039 (18.81%) | 1.17 (0.92–1.48) | 0.12 | 0.212 |
| TC/TT | 444 715 | 87 295 (19.63%) | 1.03 (0.79–1.33) | 0.13 | 0.848 | ||||
| CC | 1.5–2.0 | 1115 | 194 (17.40%) | CC | 5523 | 1039 (18.81%) | 0.94 (0.81–1.10) | 0.08 | 0.442 |
| TC/TT | 444 715 | 87 295 (19.63%) | 0.80 (0.66–0.97) | 0.10 | 0.021 | ||||
| TC/TT | <1.0 | 718 | 169 (23.54%) | TC/TT | 444 715 | 87 295 (19.63%) | 1.21 (1.04–1.41) | 0.08 | 0.012 |
| TC/TT | 1.0–1.5 | 990 | 239 (24.14%) | TC/TT | 444 715 | 87 295 (19.63%) | 1.25 (1.10–1.42) | 0.06 | 5.72 × 10−4 |
| TC/TT | 1.5–2.0 | 5659 | 1064 (18.80%) | TC/TT | 444 715 | 87 295 (19.63%) | 0.98 (0.93–1.05) | 0.03 | 0.618 |
Association of infection in individuals with the CC genotype and a low ANC in contrast to individuals with the CC and TC/TT genotype with a normal ANC (2.0–7.5 × 109/L). Columns represent firstly for low ANC groups: genotype at rs2814778, ANC range, number of subjects in said group and number of infections. The comparative group consisted of individuals with an ANC in the range of 2.0–7.5 × 109/L and columns represent: genotype at rs2814778, number of subjects and number of infections. RR, rate ratio, in reference to low ANC group; SE, standard error; P = association P-value.
| Low ANC group . | Comparative group (ANC 2.0–7.5 × 109/L) . | . | . | . | |||||
|---|---|---|---|---|---|---|---|---|---|
| Genotype . | ANC range (109/L) . | Number of subjects (N) . | Number with infections (N%) . | Genotype . | Number of subjects (N) . | Number with infections (N%) . | RR (95% CI) . | SE . | P . |
| CC | <1.0 | 39 | 11 (28.21%) | CC | 5523 | 1039 (18.81%) | 1.46 (0.80–2.67) | 0.31 | 0.214 |
| TC/TT | 444 715 | 87 295 (19.63%) | 1.28 (0.70–2.34) | 0.31 | 0.419 | ||||
| CC | 1.0–1.5 | 323 | 71 (21.98%) | CC | 5523 | 1039 (18.81%) | 1.17 (0.92–1.48) | 0.12 | 0.212 |
| TC/TT | 444 715 | 87 295 (19.63%) | 1.03 (0.79–1.33) | 0.13 | 0.848 | ||||
| CC | 1.5–2.0 | 1115 | 194 (17.40%) | CC | 5523 | 1039 (18.81%) | 0.94 (0.81–1.10) | 0.08 | 0.442 |
| TC/TT | 444 715 | 87 295 (19.63%) | 0.80 (0.66–0.97) | 0.10 | 0.021 | ||||
| TC/TT | <1.0 | 718 | 169 (23.54%) | TC/TT | 444 715 | 87 295 (19.63%) | 1.21 (1.04–1.41) | 0.08 | 0.012 |
| TC/TT | 1.0–1.5 | 990 | 239 (24.14%) | TC/TT | 444 715 | 87 295 (19.63%) | 1.25 (1.10–1.42) | 0.06 | 5.72 × 10−4 |
| TC/TT | 1.5–2.0 | 5659 | 1064 (18.80%) | TC/TT | 444 715 | 87 295 (19.63%) | 0.98 (0.93–1.05) | 0.03 | 0.618 |
| Low ANC group . | Comparative group (ANC 2.0–7.5 × 109/L) . | . | . | . | |||||
|---|---|---|---|---|---|---|---|---|---|
| Genotype . | ANC range (109/L) . | Number of subjects (N) . | Number with infections (N%) . | Genotype . | Number of subjects (N) . | Number with infections (N%) . | RR (95% CI) . | SE . | P . |
| CC | <1.0 | 39 | 11 (28.21%) | CC | 5523 | 1039 (18.81%) | 1.46 (0.80–2.67) | 0.31 | 0.214 |
| TC/TT | 444 715 | 87 295 (19.63%) | 1.28 (0.70–2.34) | 0.31 | 0.419 | ||||
| CC | 1.0–1.5 | 323 | 71 (21.98%) | CC | 5523 | 1039 (18.81%) | 1.17 (0.92–1.48) | 0.12 | 0.212 |
| TC/TT | 444 715 | 87 295 (19.63%) | 1.03 (0.79–1.33) | 0.13 | 0.848 | ||||
| CC | 1.5–2.0 | 1115 | 194 (17.40%) | CC | 5523 | 1039 (18.81%) | 0.94 (0.81–1.10) | 0.08 | 0.442 |
| TC/TT | 444 715 | 87 295 (19.63%) | 0.80 (0.66–0.97) | 0.10 | 0.021 | ||||
| TC/TT | <1.0 | 718 | 169 (23.54%) | TC/TT | 444 715 | 87 295 (19.63%) | 1.21 (1.04–1.41) | 0.08 | 0.012 |
| TC/TT | 1.0–1.5 | 990 | 239 (24.14%) | TC/TT | 444 715 | 87 295 (19.63%) | 1.25 (1.10–1.42) | 0.06 | 5.72 × 10−4 |
| TC/TT | 1.5–2.0 | 5659 | 1064 (18.80%) | TC/TT | 444 715 | 87 295 (19.63%) | 0.98 (0.93–1.05) | 0.03 | 0.618 |
Association of infection in individuals with the CC genotype and a low ANC in contrast to individuals with the CC and TC/TT genotype with a normal ANC (2.0–7.5 × 109/L). Columns represent firstly for low ANC groups: genotype at rs2814778, ANC range, number of subjects in said group and number of infections. The comparative group consisted of individuals with an ANC in the range of 2.0–7.5 × 109/L and columns represent: genotype at rs2814778, number of subjects and number of infections. RR, rate ratio, in reference to low ANC group; SE, standard error; P = association P-value.
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