| Any infection: UK Biobank . | ||||
|---|---|---|---|---|
| . | CC (n = 6345) . | TC/TT (n = 1281) . | Rate ratio (95% CI) . | P . |
| Any infection | 1188 (18.72%) | 285 (22.23%) | 0.96 (0.82–1.13) | 0.61 |
| Number of infections per subject | 0.27 | 0.30 | 0.95 (0.83–1.08) | 0.42 |
| Any infection: iPSYCH | ||||
| CC (n = 217) | TC/TT (n = 64) | Rate ratio (95% CI) | P | |
| Any infection | 112 (51.6%) | 33 (51.6%) | 0.97 (0.65–1.45) | 0.88 |
| Av. observation years per subject | 7.2 | 7.5 | ||
| Type of infection: UK Biobank | ||||
| CC (n = 6345) | TC/TT (n = 1281) | Rate ratio (95% CI) | P | |
| Bacterial infection | 593 (9.35%) | 139 (10.85%) | 0.94 (0.75–1.18) | 0.61 |
| Viral infection | 275 (4.33%) | 59 (4.61%) | 1.03 (0.73–1.45) | 0.88 |
| Other infection | 366 (5.77%) | 86 (6.71%) | 0.89 (0.67–1.20) | 0.46 |
| Site of infection: UK Biobank | ||||
| CC (n = 6345) | TC/TT (n = 1281) | Rate ratio (95% CI) | P | |
| Respiratory | 384 (6.05%) | 88 (6.87%) | 0.96 (0.72–1.28) | 0.79 |
| Skin | 235 (3.70%) | 60 (4.68%) | 0.85 (0.60–1.21) | 0.38 |
| Gastrointestinal | 208 (3.28%) | 50 (3.90%) | 0.98 (0.67–1.43) | 0.91 |
| Sepsis | 66 (1.04%) | 13 (1.01%) | 1.11 (0.54–2.27) | 0.78 |
| Hepatitis | 58 (1.34%) | 13 (1.01%) | 1.00 (0.48–2.07) | 0.99 |
| Any infection: UK Biobank . | ||||
|---|---|---|---|---|
| . | CC (n = 6345) . | TC/TT (n = 1281) . | Rate ratio (95% CI) . | P . |
| Any infection | 1188 (18.72%) | 285 (22.23%) | 0.96 (0.82–1.13) | 0.61 |
| Number of infections per subject | 0.27 | 0.30 | 0.95 (0.83–1.08) | 0.42 |
| Any infection: iPSYCH | ||||
| CC (n = 217) | TC/TT (n = 64) | Rate ratio (95% CI) | P | |
| Any infection | 112 (51.6%) | 33 (51.6%) | 0.97 (0.65–1.45) | 0.88 |
| Av. observation years per subject | 7.2 | 7.5 | ||
| Type of infection: UK Biobank | ||||
| CC (n = 6345) | TC/TT (n = 1281) | Rate ratio (95% CI) | P | |
| Bacterial infection | 593 (9.35%) | 139 (10.85%) | 0.94 (0.75–1.18) | 0.61 |
| Viral infection | 275 (4.33%) | 59 (4.61%) | 1.03 (0.73–1.45) | 0.88 |
| Other infection | 366 (5.77%) | 86 (6.71%) | 0.89 (0.67–1.20) | 0.46 |
| Site of infection: UK Biobank | ||||
| CC (n = 6345) | TC/TT (n = 1281) | Rate ratio (95% CI) | P | |
| Respiratory | 384 (6.05%) | 88 (6.87%) | 0.96 (0.72–1.28) | 0.79 |
| Skin | 235 (3.70%) | 60 (4.68%) | 0.85 (0.60–1.21) | 0.38 |
| Gastrointestinal | 208 (3.28%) | 50 (3.90%) | 0.98 (0.67–1.43) | 0.91 |
| Sepsis | 66 (1.04%) | 13 (1.01%) | 1.11 (0.54–2.27) | 0.78 |
| Hepatitis | 58 (1.34%) | 13 (1.01%) | 1.00 (0.48–2.07) | 0.99 |
Association between Duffy-null genotyoe and risk of infection in individuals with Black African/Caribbean ethnicity in (i) the UK Biobank sample and (ii) the iPSYCH sample. Only sites of infection that were present in at least 1% of controls were included. Details of analysis conducted in whole UK Biobank sample (all ethnicities) are given in Supplementary Material, Table S5.
| Any infection: UK Biobank . | ||||
|---|---|---|---|---|
| . | CC (n = 6345) . | TC/TT (n = 1281) . | Rate ratio (95% CI) . | P . |
| Any infection | 1188 (18.72%) | 285 (22.23%) | 0.96 (0.82–1.13) | 0.61 |
| Number of infections per subject | 0.27 | 0.30 | 0.95 (0.83–1.08) | 0.42 |
| Any infection: iPSYCH | ||||
| CC (n = 217) | TC/TT (n = 64) | Rate ratio (95% CI) | P | |
| Any infection | 112 (51.6%) | 33 (51.6%) | 0.97 (0.65–1.45) | 0.88 |
| Av. observation years per subject | 7.2 | 7.5 | ||
| Type of infection: UK Biobank | ||||
| CC (n = 6345) | TC/TT (n = 1281) | Rate ratio (95% CI) | P | |
| Bacterial infection | 593 (9.35%) | 139 (10.85%) | 0.94 (0.75–1.18) | 0.61 |
| Viral infection | 275 (4.33%) | 59 (4.61%) | 1.03 (0.73–1.45) | 0.88 |
| Other infection | 366 (5.77%) | 86 (6.71%) | 0.89 (0.67–1.20) | 0.46 |
| Site of infection: UK Biobank | ||||
| CC (n = 6345) | TC/TT (n = 1281) | Rate ratio (95% CI) | P | |
| Respiratory | 384 (6.05%) | 88 (6.87%) | 0.96 (0.72–1.28) | 0.79 |
| Skin | 235 (3.70%) | 60 (4.68%) | 0.85 (0.60–1.21) | 0.38 |
| Gastrointestinal | 208 (3.28%) | 50 (3.90%) | 0.98 (0.67–1.43) | 0.91 |
| Sepsis | 66 (1.04%) | 13 (1.01%) | 1.11 (0.54–2.27) | 0.78 |
| Hepatitis | 58 (1.34%) | 13 (1.01%) | 1.00 (0.48–2.07) | 0.99 |
| Any infection: UK Biobank . | ||||
|---|---|---|---|---|
| . | CC (n = 6345) . | TC/TT (n = 1281) . | Rate ratio (95% CI) . | P . |
| Any infection | 1188 (18.72%) | 285 (22.23%) | 0.96 (0.82–1.13) | 0.61 |
| Number of infections per subject | 0.27 | 0.30 | 0.95 (0.83–1.08) | 0.42 |
| Any infection: iPSYCH | ||||
| CC (n = 217) | TC/TT (n = 64) | Rate ratio (95% CI) | P | |
| Any infection | 112 (51.6%) | 33 (51.6%) | 0.97 (0.65–1.45) | 0.88 |
| Av. observation years per subject | 7.2 | 7.5 | ||
| Type of infection: UK Biobank | ||||
| CC (n = 6345) | TC/TT (n = 1281) | Rate ratio (95% CI) | P | |
| Bacterial infection | 593 (9.35%) | 139 (10.85%) | 0.94 (0.75–1.18) | 0.61 |
| Viral infection | 275 (4.33%) | 59 (4.61%) | 1.03 (0.73–1.45) | 0.88 |
| Other infection | 366 (5.77%) | 86 (6.71%) | 0.89 (0.67–1.20) | 0.46 |
| Site of infection: UK Biobank | ||||
| CC (n = 6345) | TC/TT (n = 1281) | Rate ratio (95% CI) | P | |
| Respiratory | 384 (6.05%) | 88 (6.87%) | 0.96 (0.72–1.28) | 0.79 |
| Skin | 235 (3.70%) | 60 (4.68%) | 0.85 (0.60–1.21) | 0.38 |
| Gastrointestinal | 208 (3.28%) | 50 (3.90%) | 0.98 (0.67–1.43) | 0.91 |
| Sepsis | 66 (1.04%) | 13 (1.01%) | 1.11 (0.54–2.27) | 0.78 |
| Hepatitis | 58 (1.34%) | 13 (1.01%) | 1.00 (0.48–2.07) | 0.99 |
Association between Duffy-null genotyoe and risk of infection in individuals with Black African/Caribbean ethnicity in (i) the UK Biobank sample and (ii) the iPSYCH sample. Only sites of infection that were present in at least 1% of controls were included. Details of analysis conducted in whole UK Biobank sample (all ethnicities) are given in Supplementary Material, Table S5.
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