Table 1.

Summary of intracranial control following WBRT + SRS or SIB

StudyTreatment1-Year Outcomes
Local ControlDistant Brain Control
RTOG 95–084WBRT71%67%
WBRT + SRS82%73%
EORTC 229525SRS70%56%
WBRT + SRS87%72%
MDACC6SRS67%45%
WBRT + SRS100%73%
JROSG-99–17SRS 76%37%
WBRT + SRS90%58%
Alliance N05748SRS73%70%
WBRT + SRS90%92%
Summary of WBRT + SRS Arms82–100%58–92%
Popp et al9HA-WBRT 30 Gy/12 fx + SIB 51Gy/42Gy/12 fx for metastases/resection cavities98%69%
Westover et al3HA-WBRT 20 Gy/10 fx + SIB 40 Gy/10 fx for metastases91%87%
StudyTreatment1-Year Outcomes
Local ControlDistant Brain Control
RTOG 95–084WBRT71%67%
WBRT + SRS82%73%
EORTC 229525SRS70%56%
WBRT + SRS87%72%
MDACC6SRS67%45%
WBRT + SRS100%73%
JROSG-99–17SRS 76%37%
WBRT + SRS90%58%
Alliance N05748SRS73%70%
WBRT + SRS90%92%
Summary of WBRT + SRS Arms82–100%58–92%
Popp et al9HA-WBRT 30 Gy/12 fx + SIB 51Gy/42Gy/12 fx for metastases/resection cavities98%69%
Westover et al3HA-WBRT 20 Gy/10 fx + SIB 40 Gy/10 fx for metastases91%87%
Table 1.

Summary of intracranial control following WBRT + SRS or SIB

StudyTreatment1-Year Outcomes
Local ControlDistant Brain Control
RTOG 95–084WBRT71%67%
WBRT + SRS82%73%
EORTC 229525SRS70%56%
WBRT + SRS87%72%
MDACC6SRS67%45%
WBRT + SRS100%73%
JROSG-99–17SRS 76%37%
WBRT + SRS90%58%
Alliance N05748SRS73%70%
WBRT + SRS90%92%
Summary of WBRT + SRS Arms82–100%58–92%
Popp et al9HA-WBRT 30 Gy/12 fx + SIB 51Gy/42Gy/12 fx for metastases/resection cavities98%69%
Westover et al3HA-WBRT 20 Gy/10 fx + SIB 40 Gy/10 fx for metastases91%87%
StudyTreatment1-Year Outcomes
Local ControlDistant Brain Control
RTOG 95–084WBRT71%67%
WBRT + SRS82%73%
EORTC 229525SRS70%56%
WBRT + SRS87%72%
MDACC6SRS67%45%
WBRT + SRS100%73%
JROSG-99–17SRS 76%37%
WBRT + SRS90%58%
Alliance N05748SRS73%70%
WBRT + SRS90%92%
Summary of WBRT + SRS Arms82–100%58–92%
Popp et al9HA-WBRT 30 Gy/12 fx + SIB 51Gy/42Gy/12 fx for metastases/resection cavities98%69%
Westover et al3HA-WBRT 20 Gy/10 fx + SIB 40 Gy/10 fx for metastases91%87%
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