| Characteristic . | Influenza Vaccination . | . |
|---|---|---|
| ccIIV4 (n = 92 187) | Egg-derived IIV4 (n = 1 261 675) | |
| Age, y | ||
| Missing, No. | 1 | 43 |
| Mean (95% CI) | 55.6 (55.5–55.8) | 38.7 (38.6–38.7) |
| Median (SD) | 59.0 (18.6) | 42 (24.4) |
| Age group, No. | ||
| 4–17 | 7465 | 404 510 |
| 18–64 | 55 104 | 693 014 |
| 65–75 | 17 554 | 103 741 |
| ≥ 75 | 12 064 | 60 410 |
| Female sex | 53 952 (58.5) | 709 626 (56.2) |
| Geographical regiona | ||
| Missing, No. | 7 | 275 |
| Boston | 8181 (9) | 74 327 (6) |
| New York | 659 (1) | 57 081 (5) |
| Philadelphia | 9744 (11) | 167 908 (13) |
| Atlanta | 53 751 (58) | 325 913 (26) |
| Chicago | 7649 (8) | 251 584 (20) |
| Dallas | 6302 (7) | 77 201 (6) |
| Kansas City | 1637 (2) | 105 975 (8) |
| Denver | 99 (< 1) | 17 476 (1) |
| San Francisco | 3854 (4) | 149 088 (12) |
| Seattle | 305 (< 1) | 34 856 (3) |
| Race/ethnicity | ||
| Missing, No. | 0 | 0 |
| White | 70 283 (76.2) | 812 931 (64.4) |
| Black | 7176 (7.8) | 90 351 (7.2) |
| Hispanic | 4261 (4.6) | 123 077 (9.8) |
| Other | 10 467 (11.4) | 235 316 (18.7) |
| Comorbidity category | ||
| Myocardial infarctionb | 1443 (1.6) | 9375 (0.7) |
| Congestive heart failure | 1309 (1.4) | 12 334 (1) |
| Peripheral vascular diseaseb | 3979 (4.3) | 26 727 (2.1) |
| Cerebrovascular disease | 819 (0.9) | 5397 (0.4) |
| Dementia | 2 (< 1) | 18 (< 1) |
| COPDb | 12 190 (13.2) | 95 393 (7.6) |
| Rheumatic disease | 1025 (1.1) | 7768 (0.6) |
| Peptic ulcer disease | 4 (< 1) | 16 (< 1) |
| Mild liver disease | 3642 (4.0) | 33 212 (2.6) |
| Diabetes without complicationsb | 16 587 (18.0) | 142 483 (11.3) |
| Diabetes with chronic complication | 4 (< 1) | 14 (< 1) |
| Hemiplegia or paraplegia | 115 (0.1) | 1551 (0.1) |
| Renal diseaseb | 1183 (1.3) | 4310 (0.3) |
| Any malignancy, including lymphoma and leukemia, except malignant neoplasm of skin | 1968 (2.1) | 15 669 (1.2) |
| Moderate or severe liver disease | 224 (0.2) | 1903 (0.2) |
| Metastatic solid tumor | 0 | 0 |
| HIV/AIDS | 315 (0.3) | 2983 (0.2) |
| Characteristic . | Influenza Vaccination . | . |
|---|---|---|
| ccIIV4 (n = 92 187) | Egg-derived IIV4 (n = 1 261 675) | |
| Age, y | ||
| Missing, No. | 1 | 43 |
| Mean (95% CI) | 55.6 (55.5–55.8) | 38.7 (38.6–38.7) |
| Median (SD) | 59.0 (18.6) | 42 (24.4) |
| Age group, No. | ||
| 4–17 | 7465 | 404 510 |
| 18–64 | 55 104 | 693 014 |
| 65–75 | 17 554 | 103 741 |
| ≥ 75 | 12 064 | 60 410 |
| Female sex | 53 952 (58.5) | 709 626 (56.2) |
| Geographical regiona | ||
| Missing, No. | 7 | 275 |
| Boston | 8181 (9) | 74 327 (6) |
| New York | 659 (1) | 57 081 (5) |
| Philadelphia | 9744 (11) | 167 908 (13) |
| Atlanta | 53 751 (58) | 325 913 (26) |
| Chicago | 7649 (8) | 251 584 (20) |
| Dallas | 6302 (7) | 77 201 (6) |
| Kansas City | 1637 (2) | 105 975 (8) |
| Denver | 99 (< 1) | 17 476 (1) |
| San Francisco | 3854 (4) | 149 088 (12) |
| Seattle | 305 (< 1) | 34 856 (3) |
| Race/ethnicity | ||
| Missing, No. | 0 | 0 |
| White | 70 283 (76.2) | 812 931 (64.4) |
| Black | 7176 (7.8) | 90 351 (7.2) |
| Hispanic | 4261 (4.6) | 123 077 (9.8) |
| Other | 10 467 (11.4) | 235 316 (18.7) |
| Comorbidity category | ||
| Myocardial infarctionb | 1443 (1.6) | 9375 (0.7) |
| Congestive heart failure | 1309 (1.4) | 12 334 (1) |
| Peripheral vascular diseaseb | 3979 (4.3) | 26 727 (2.1) |
| Cerebrovascular disease | 819 (0.9) | 5397 (0.4) |
| Dementia | 2 (< 1) | 18 (< 1) |
| COPDb | 12 190 (13.2) | 95 393 (7.6) |
| Rheumatic disease | 1025 (1.1) | 7768 (0.6) |
| Peptic ulcer disease | 4 (< 1) | 16 (< 1) |
| Mild liver disease | 3642 (4.0) | 33 212 (2.6) |
| Diabetes without complicationsb | 16 587 (18.0) | 142 483 (11.3) |
| Diabetes with chronic complication | 4 (< 1) | 14 (< 1) |
| Hemiplegia or paraplegia | 115 (0.1) | 1551 (0.1) |
| Renal diseaseb | 1183 (1.3) | 4310 (0.3) |
| Any malignancy, including lymphoma and leukemia, except malignant neoplasm of skin | 1968 (2.1) | 15 669 (1.2) |
| Moderate or severe liver disease | 224 (0.2) | 1903 (0.2) |
| Metastatic solid tumor | 0 | 0 |
| HIV/AIDS | 315 (0.3) | 2983 (0.2) |
Data are presented as no. (%), unless otherwise indicated.
Abbreviations: ccIIV4, quadrivalent, inactivated cell-derived influenza vaccine; CI, confidence interval; COPD, chronic obstructive pulmonary disease; HIV, human immunodeficiency virus; IIV4, quadrivalent inactivated influenza vaccine; SD, standard deviation.
aInformation for geographic region (as defined by the Department of Health and Human Services) was available for all (100%) participants in the ccIIV4 group and for 99.9% (n = 1 261 206) of the egg-derived IIV4 group.
bAt least 1.5-fold difference between exposure groups.
| Characteristic . | Influenza Vaccination . | . |
|---|---|---|
| ccIIV4 (n = 92 187) | Egg-derived IIV4 (n = 1 261 675) | |
| Age, y | ||
| Missing, No. | 1 | 43 |
| Mean (95% CI) | 55.6 (55.5–55.8) | 38.7 (38.6–38.7) |
| Median (SD) | 59.0 (18.6) | 42 (24.4) |
| Age group, No. | ||
| 4–17 | 7465 | 404 510 |
| 18–64 | 55 104 | 693 014 |
| 65–75 | 17 554 | 103 741 |
| ≥ 75 | 12 064 | 60 410 |
| Female sex | 53 952 (58.5) | 709 626 (56.2) |
| Geographical regiona | ||
| Missing, No. | 7 | 275 |
| Boston | 8181 (9) | 74 327 (6) |
| New York | 659 (1) | 57 081 (5) |
| Philadelphia | 9744 (11) | 167 908 (13) |
| Atlanta | 53 751 (58) | 325 913 (26) |
| Chicago | 7649 (8) | 251 584 (20) |
| Dallas | 6302 (7) | 77 201 (6) |
| Kansas City | 1637 (2) | 105 975 (8) |
| Denver | 99 (< 1) | 17 476 (1) |
| San Francisco | 3854 (4) | 149 088 (12) |
| Seattle | 305 (< 1) | 34 856 (3) |
| Race/ethnicity | ||
| Missing, No. | 0 | 0 |
| White | 70 283 (76.2) | 812 931 (64.4) |
| Black | 7176 (7.8) | 90 351 (7.2) |
| Hispanic | 4261 (4.6) | 123 077 (9.8) |
| Other | 10 467 (11.4) | 235 316 (18.7) |
| Comorbidity category | ||
| Myocardial infarctionb | 1443 (1.6) | 9375 (0.7) |
| Congestive heart failure | 1309 (1.4) | 12 334 (1) |
| Peripheral vascular diseaseb | 3979 (4.3) | 26 727 (2.1) |
| Cerebrovascular disease | 819 (0.9) | 5397 (0.4) |
| Dementia | 2 (< 1) | 18 (< 1) |
| COPDb | 12 190 (13.2) | 95 393 (7.6) |
| Rheumatic disease | 1025 (1.1) | 7768 (0.6) |
| Peptic ulcer disease | 4 (< 1) | 16 (< 1) |
| Mild liver disease | 3642 (4.0) | 33 212 (2.6) |
| Diabetes without complicationsb | 16 587 (18.0) | 142 483 (11.3) |
| Diabetes with chronic complication | 4 (< 1) | 14 (< 1) |
| Hemiplegia or paraplegia | 115 (0.1) | 1551 (0.1) |
| Renal diseaseb | 1183 (1.3) | 4310 (0.3) |
| Any malignancy, including lymphoma and leukemia, except malignant neoplasm of skin | 1968 (2.1) | 15 669 (1.2) |
| Moderate or severe liver disease | 224 (0.2) | 1903 (0.2) |
| Metastatic solid tumor | 0 | 0 |
| HIV/AIDS | 315 (0.3) | 2983 (0.2) |
| Characteristic . | Influenza Vaccination . | . |
|---|---|---|
| ccIIV4 (n = 92 187) | Egg-derived IIV4 (n = 1 261 675) | |
| Age, y | ||
| Missing, No. | 1 | 43 |
| Mean (95% CI) | 55.6 (55.5–55.8) | 38.7 (38.6–38.7) |
| Median (SD) | 59.0 (18.6) | 42 (24.4) |
| Age group, No. | ||
| 4–17 | 7465 | 404 510 |
| 18–64 | 55 104 | 693 014 |
| 65–75 | 17 554 | 103 741 |
| ≥ 75 | 12 064 | 60 410 |
| Female sex | 53 952 (58.5) | 709 626 (56.2) |
| Geographical regiona | ||
| Missing, No. | 7 | 275 |
| Boston | 8181 (9) | 74 327 (6) |
| New York | 659 (1) | 57 081 (5) |
| Philadelphia | 9744 (11) | 167 908 (13) |
| Atlanta | 53 751 (58) | 325 913 (26) |
| Chicago | 7649 (8) | 251 584 (20) |
| Dallas | 6302 (7) | 77 201 (6) |
| Kansas City | 1637 (2) | 105 975 (8) |
| Denver | 99 (< 1) | 17 476 (1) |
| San Francisco | 3854 (4) | 149 088 (12) |
| Seattle | 305 (< 1) | 34 856 (3) |
| Race/ethnicity | ||
| Missing, No. | 0 | 0 |
| White | 70 283 (76.2) | 812 931 (64.4) |
| Black | 7176 (7.8) | 90 351 (7.2) |
| Hispanic | 4261 (4.6) | 123 077 (9.8) |
| Other | 10 467 (11.4) | 235 316 (18.7) |
| Comorbidity category | ||
| Myocardial infarctionb | 1443 (1.6) | 9375 (0.7) |
| Congestive heart failure | 1309 (1.4) | 12 334 (1) |
| Peripheral vascular diseaseb | 3979 (4.3) | 26 727 (2.1) |
| Cerebrovascular disease | 819 (0.9) | 5397 (0.4) |
| Dementia | 2 (< 1) | 18 (< 1) |
| COPDb | 12 190 (13.2) | 95 393 (7.6) |
| Rheumatic disease | 1025 (1.1) | 7768 (0.6) |
| Peptic ulcer disease | 4 (< 1) | 16 (< 1) |
| Mild liver disease | 3642 (4.0) | 33 212 (2.6) |
| Diabetes without complicationsb | 16 587 (18.0) | 142 483 (11.3) |
| Diabetes with chronic complication | 4 (< 1) | 14 (< 1) |
| Hemiplegia or paraplegia | 115 (0.1) | 1551 (0.1) |
| Renal diseaseb | 1183 (1.3) | 4310 (0.3) |
| Any malignancy, including lymphoma and leukemia, except malignant neoplasm of skin | 1968 (2.1) | 15 669 (1.2) |
| Moderate or severe liver disease | 224 (0.2) | 1903 (0.2) |
| Metastatic solid tumor | 0 | 0 |
| HIV/AIDS | 315 (0.3) | 2983 (0.2) |
Data are presented as no. (%), unless otherwise indicated.
Abbreviations: ccIIV4, quadrivalent, inactivated cell-derived influenza vaccine; CI, confidence interval; COPD, chronic obstructive pulmonary disease; HIV, human immunodeficiency virus; IIV4, quadrivalent inactivated influenza vaccine; SD, standard deviation.
aInformation for geographic region (as defined by the Department of Health and Human Services) was available for all (100%) participants in the ccIIV4 group and for 99.9% (n = 1 261 206) of the egg-derived IIV4 group.
bAt least 1.5-fold difference between exposure groups.
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