Table 4. Open in new tab Incidence and...

Table 4.

Incidence and Adjusted Hazard Ratio of Viral Infection Stratified by Duration of Angiotensin Receptor Blocker or Angiotensin-converting-Enzyme Inhibitor Therapy in Patients With Hypertension

Medication Exposed	No.	Event	Person-years	Rate^a	Adjusted HR (95% CI)^b
ARB^c
Non-ARB	20 207	1301	145 307	8.95	1.00
≤ 120 d	3792	192	26 017	7.38	0.82 (.70–.96)*
121–500 d	5499	225	37 708	5.97	0.70 (.61–.80)***
500–1200 d	5315	158	39 873	3.96	0.47 (.40–.55)***
> 1200 d	5601	148	53 809	2.75	0.31 (.26–.37)***
ACEI^c
Non-ACEI	18 029	1142	147 866	7.72	1.00
≤ 50 d	2535	195	20 430	9.54	1.23 (1.05–1.43)**
51–150 d	5254	293	42 918	6.83	0.92 (.81–1.04)
151–550 d	5091	259	42 409	6.11	0.87 (.76–1.00)*
> 550 d	5149	190	47 880	3.97	0.50 (.43–.59)***

Medication Exposed	No.	Event	Person-years	Rate^a	Adjusted HR (95% CI)^b
ARB^c
Non-ARB	20 207	1301	145 307	8.95	1.00
≤ 120 d	3792	192	26 017	7.38	0.82 (.70–.96)*
121–500 d	5499	225	37 708	5.97	0.70 (.61–.80)***
500–1200 d	5315	158	39 873	3.96	0.47 (.40–.55)***
> 1200 d	5601	148	53 809	2.75	0.31 (.26–.37)***
ACEI^c
Non-ACEI	18 029	1142	147 866	7.72	1.00
≤ 50 d	2535	195	20 430	9.54	1.23 (1.05–1.43)**
51–150 d	5254	293	42 918	6.83	0.92 (.81–1.04)
151–550 d	5091	259	42 409	6.11	0.87 (.76–1.00)*
> 550 d	5149	190	47 880	3.97	0.50 (.43–.59)***

Abbreviations: ACEI, angiotensin-converting enzyme inhibitor; ARB, angiotensin receptor blocker; CI, confidence interval; HR, hazard ratio.

^aRate is incidence rate per 1000 person-years.

^bMultivariable analysis including age, sex, urbanization level, monthly income, comorbidities, and medications.

^cThe cumulative use days are partitioned in to 4 segments by quartile.

*P < .05.

**P < .01.

***P < .001.

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