Table 2 Open in new tab Univariate Cox...

	RFS-first	OS
Age at the first surgery (years)	0.987	0.962–1.013	0.315	1.018	0.968–1.071	0.484
Male sex	1.987	0.929–4.251	0.077	2.692	0.789–9.184	0.114
Tumour size >15 cm	0.584	0.274–2.244	0.163	0.402	0.120–1.135	0.140
Tumour laterality (right side)	0.678	0.316–1.454	0.318	0.895	0.259–3.100	0.861
Multifocal disease	1.858	0.814–4.245	0.141	1.855	0.532–6.472	0.332
Preoperative biopsy	1.132	0.576–2.226	0.719	1.298	0.423–3.983	0.684
Diagnosis of liposarcoma before surgery	0.508	0.231–1.121	0.094	0.467	0.135–1.619	0.230
Lymph node metastasis	1.124	0.151–8.371	0.909	0.046	0.000–137600	0.685
Other organ resection	1.590	0.619–4.079	0.335	1.864	0.392–8.849	0.434
Significant post-operative complications	0.709	0.414–1.216	0.211	0.839	0.295–2.387	0.742
R0 resection	0.423	0.187–0.956	0.039	0.319	0.068–1.483	0.145
Well-differentiated subtype	0.289	0.127–0.656	0.003	0.190	0.048–0.749	0.018
Adjuvant therapy	0.571	0.198–1.642	0.298	0.408	0.052–3.208	0.394

RFS-first

Hazard ratio

95% CI

P value

Hazard ratio

95% CI

P value

Age at the first surgery (years)

0.987

0.962–1.013

0.315

1.018

0.968–1.071

0.484

Male sex

1.987

0.929–4.251

0.077

2.692

0.789–9.184

0.114

Tumour size >15 cm

0.584

0.274–2.244

0.163

0.402

0.120–1.135

0.140

Tumour laterality (right side)

0.678

0.316–1.454

0.318

0.895

0.259–3.100

0.861

Multifocal disease

1.858

0.814–4.245

0.141

1.855

0.532–6.472

0.332

Preoperative biopsy

1.132

0.576–2.226

0.719

1.298

0.423–3.983

0.684

Diagnosis of liposarcoma before surgery

0.508

0.231–1.121

0.094

0.467

0.135–1.619

0.230

Lymph node metastasis

1.124

0.151–8.371

0.909

0.046

0.000–137600

0.685

Other organ resection

1.590

0.619–4.079

0.335

1.864

0.392–8.849

0.434

Significant post-operative complications

0.709

0.414–1.216

0.211

0.839

0.295–2.387

0.742

R0 resection

0.423

0.187–0.956

0.039

0.319

0.068–1.483

0.145

Well-differentiated subtype

0.289

0.127–0.656

0.003

0.190

0.048–0.749

0.018

Adjuvant therapy

0.571

0.198–1.642

0.298

0.408

0.052–3.208

0.394

	RFS-first	OS
Age at the first surgery (years)	0.987	0.962–1.013	0.315	1.018	0.968–1.071	0.484
Male sex	1.987	0.929–4.251	0.077	2.692	0.789–9.184	0.114
Tumour size >15 cm	0.584	0.274–2.244	0.163	0.402	0.120–1.135	0.140
Tumour laterality (right side)	0.678	0.316–1.454	0.318	0.895	0.259–3.100	0.861
Multifocal disease	1.858	0.814–4.245	0.141	1.855	0.532–6.472	0.332
Preoperative biopsy	1.132	0.576–2.226	0.719	1.298	0.423–3.983	0.684
Diagnosis of liposarcoma before surgery	0.508	0.231–1.121	0.094	0.467	0.135–1.619	0.230
Lymph node metastasis	1.124	0.151–8.371	0.909	0.046	0.000–137600	0.685
Other organ resection	1.590	0.619–4.079	0.335	1.864	0.392–8.849	0.434
Significant post-operative complications	0.709	0.414–1.216	0.211	0.839	0.295–2.387	0.742
R0 resection	0.423	0.187–0.956	0.039	0.319	0.068–1.483	0.145
Well-differentiated subtype	0.289	0.127–0.656	0.003	0.190	0.048–0.749	0.018
Adjuvant therapy	0.571	0.198–1.642	0.298	0.408	0.052–3.208	0.394

Table 2

Open in new tab

Univariate Cox regression analysis of RFS after the first surgery (RFS-first) and OS

	RFS-first			OS
	Hazard ratio	95% CI	P value	Hazard ratio	95% CI	P value
Age at the first surgery (years)	0.987	0.962–1.013	0.315	1.018	0.968–1.071	0.484
Male sex	1.987	0.929–4.251	0.077	2.692	0.789–9.184	0.114
Tumour size >15 cm	0.584	0.274–2.244	0.163	0.402	0.120–1.135	0.140
Tumour laterality (right side)	0.678	0.316–1.454	0.318	0.895	0.259–3.100	0.861
Multifocal disease	1.858	0.814–4.245	0.141	1.855	0.532–6.472	0.332
Preoperative biopsy	1.132	0.576–2.226	0.719	1.298	0.423–3.983	0.684
Diagnosis of liposarcoma before surgery	0.508	0.231–1.121	0.094	0.467	0.135–1.619	0.230
Lymph node metastasis	1.124	0.151–8.371	0.909	0.046	0.000–137600	0.685
Other organ resection	1.590	0.619–4.079	0.335	1.864	0.392–8.849	0.434
Significant post-operative complications	0.709	0.414–1.216	0.211	0.839	0.295–2.387	0.742
R0 resection	0.423	0.187–0.956	0.039	0.319	0.068–1.483	0.145
Well-differentiated subtype	0.289	0.127–0.656	0.003	0.190	0.048–0.749	0.018
Adjuvant therapy	0.571	0.198–1.642	0.298	0.408	0.052–3.208	0.394

	RFS-first			OS
	Hazard ratio	95% CI	P value	Hazard ratio	95% CI	P value
Age at the first surgery (years)	0.987	0.962–1.013	0.315	1.018	0.968–1.071	0.484
Male sex	1.987	0.929–4.251	0.077	2.692	0.789–9.184	0.114
Tumour size >15 cm	0.584	0.274–2.244	0.163	0.402	0.120–1.135	0.140
Tumour laterality (right side)	0.678	0.316–1.454	0.318	0.895	0.259–3.100	0.861
Multifocal disease	1.858	0.814–4.245	0.141	1.855	0.532–6.472	0.332
Preoperative biopsy	1.132	0.576–2.226	0.719	1.298	0.423–3.983	0.684
Diagnosis of liposarcoma before surgery	0.508	0.231–1.121	0.094	0.467	0.135–1.619	0.230
Lymph node metastasis	1.124	0.151–8.371	0.909	0.046	0.000–137600	0.685
Other organ resection	1.590	0.619–4.079	0.335	1.864	0.392–8.849	0.434
Significant post-operative complications	0.709	0.414–1.216	0.211	0.839	0.295–2.387	0.742
R0 resection	0.423	0.187–0.956	0.039	0.319	0.068–1.483	0.145
Well-differentiated subtype	0.289	0.127–0.656	0.003	0.190	0.048–0.749	0.018
Adjuvant therapy	0.571	0.198–1.642	0.298	0.408	0.052–3.208	0.394

RFS, recurrence-free survival; OS, overall survival; CI, confidence interval.

A significant post-operative complication was defined as a complication observed within 30 days after surgery with Clavien–Dindo Grade ≥2. Adjuvant therapy includes chemotherapy, radiation therapy or both performed before or after surgery.

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