Table 1. Open in new tab Ciprofloxacin...

Table 1.

Ciprofloxacin susceptibility and relative fitness of relevant strains

Strain	Relevant genotype^a	MIC_Cip (mg/L)	Fitness ± SD^b
CH1464	WT	0.015	1.00 ± 0.01
CH6295	marR I18fs	0.06	0.81 ± 0.02
CH6300	marR C51fs	0.045	0.78 ± 0.02
CH6971	marR I18fs, ΔmarA (4.8 kb)	0.015	0.94 ± 0.03
CH7278	marR I18fs, lon ntC-26T	0.03	0.93 ± 0.01
CH6970	marR I18fs, arcA P58R	0.06	0.96 ± 0.02

Strain	Relevant genotype^a	MIC_Cip (mg/L)	Fitness ± SD^b
CH1464	WT	0.015	1.00 ± 0.01
CH6295	marR I18fs	0.06	0.81 ± 0.02
CH6300	marR C51fs	0.045	0.78 ± 0.02
CH6971	marR I18fs, ΔmarA (4.8 kb)	0.015	0.94 ± 0.03
CH7278	marR I18fs, lon ntC-26T	0.03	0.93 ± 0.01
CH6970	marR I18fs, arcA P58R	0.06	0.96 ± 0.02

See Table S1 for details on ΔmarA deletions. Number in parentheses shows total size of deletion. All isolates with the marR I18fs mutation also carry an mngA duplication (nt −49 to −44) mutation in the chromosome.

Competitive fitness ± SD relative to the WT (CH1464).

This Feature Is Available To Subscribers Only