Demographics, Tumor Location, Treatment, and Outcome in 17 Patients With Pineal Parenchymal Tumor of Intermediate Differentiation
| Case . | Sex . | Age at diagnosis, y . | DWI signal . | Contrast enhancement . | Dissemination at diagnosis . | Extent of resection . | Radiation regimen . | Adjuvant chemotherapy . | PFS, mo . | OS, mo . |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | M | 15 | High | Homogeneous | Yes | Biopsy | CS-IMRT + focal | Yes | 25.6 | 68.1 |
| 2 | F | 20 | No/Mild | Patchy | No | STR | CS-IMRT | No | – | +131.3 |
| 3 | M | 20 | No/Mild | Patchy (mild) | No | STR | Focal proton | No | – | +24 |
| 4 | M | 27 | a | Homogeneous | Yes | Biopsy | CS-IMRT | Yes | 63.2 | 101 |
| 5 | F | 29 | No/Mild | Homogenous (mild) | No | GTR | CS-IMRT | No | – | +148.5 |
| 6 | M | 30 | High | Homogeneous | No | GTR | None | No | – | 0.1 |
| 7 | M | 31 | No/Mild | Heterogeneous (patchy) | No | GTR | CS-P | No | 16.8 | +39.3 |
| 8 | M | 36 | Mild | Patchy (mild) | No | GTR | CS-P | No | – | +66.5 |
| 9 | F | 37 | High | Homogeneous | No | STR | CS-IMRT | Yes | 159.5 | +162.8 |
| 10 | F | 37 | No/Mild | Patchy | No | GTR | CS-P | No | – | +63.4 |
| 11 | M | 40 | High | Homogeneous | No | GTR | CS-P | No | – | +48.5 |
| 12 | F | 41 | No | Patchy | Yes | Biopsy | CS-P | Yes | – | +12.4 |
| 13 | M | 43 | a | Homogeneous | No | STR | SRS | No | – | +28.6 |
| 14 | F | 48 | No | Homogeneous | No | STR | CS-IMRT | No | 20.9 | 20.9 |
| 15 | F | 51 | a | a | No | STR | SRS | No | – | 4.1 |
| 16 | F | 56 | a | Homogeneous | No | a | CS-IMRT + SRS | No | 16.5 | 33.3 |
| 17 | M | 57 | No/Mild | Homogeneous | No | GTR | None | No | 12.7 | +111 |
| Case . | Sex . | Age at diagnosis, y . | DWI signal . | Contrast enhancement . | Dissemination at diagnosis . | Extent of resection . | Radiation regimen . | Adjuvant chemotherapy . | PFS, mo . | OS, mo . |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | M | 15 | High | Homogeneous | Yes | Biopsy | CS-IMRT + focal | Yes | 25.6 | 68.1 |
| 2 | F | 20 | No/Mild | Patchy | No | STR | CS-IMRT | No | – | +131.3 |
| 3 | M | 20 | No/Mild | Patchy (mild) | No | STR | Focal proton | No | – | +24 |
| 4 | M | 27 | a | Homogeneous | Yes | Biopsy | CS-IMRT | Yes | 63.2 | 101 |
| 5 | F | 29 | No/Mild | Homogenous (mild) | No | GTR | CS-IMRT | No | – | +148.5 |
| 6 | M | 30 | High | Homogeneous | No | GTR | None | No | – | 0.1 |
| 7 | M | 31 | No/Mild | Heterogeneous (patchy) | No | GTR | CS-P | No | 16.8 | +39.3 |
| 8 | M | 36 | Mild | Patchy (mild) | No | GTR | CS-P | No | – | +66.5 |
| 9 | F | 37 | High | Homogeneous | No | STR | CS-IMRT | Yes | 159.5 | +162.8 |
| 10 | F | 37 | No/Mild | Patchy | No | GTR | CS-P | No | – | +63.4 |
| 11 | M | 40 | High | Homogeneous | No | GTR | CS-P | No | – | +48.5 |
| 12 | F | 41 | No | Patchy | Yes | Biopsy | CS-P | Yes | – | +12.4 |
| 13 | M | 43 | a | Homogeneous | No | STR | SRS | No | – | +28.6 |
| 14 | F | 48 | No | Homogeneous | No | STR | CS-IMRT | No | 20.9 | 20.9 |
| 15 | F | 51 | a | a | No | STR | SRS | No | – | 4.1 |
| 16 | F | 56 | a | Homogeneous | No | a | CS-IMRT + SRS | No | 16.5 | 33.3 |
| 17 | M | 57 | No/Mild | Homogeneous | No | GTR | None | No | 12.7 | +111 |
Abbreviations: CS-IMRT, craniospinal irradiation with intensity modulated radiation therapy; CS-P, craniospinal irradiation with proton therapy; DWI, diffusion-weighted imaging; F, female; GTR, gross total resection; M, male; mo, months; OS, overall survival; PFS, progression-free survival; SRS, stereotactic radiosurgery; STR, subtotal resection.
aUnknown.
Demographics, Tumor Location, Treatment, and Outcome in 17 Patients With Pineal Parenchymal Tumor of Intermediate Differentiation
| Case . | Sex . | Age at diagnosis, y . | DWI signal . | Contrast enhancement . | Dissemination at diagnosis . | Extent of resection . | Radiation regimen . | Adjuvant chemotherapy . | PFS, mo . | OS, mo . |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | M | 15 | High | Homogeneous | Yes | Biopsy | CS-IMRT + focal | Yes | 25.6 | 68.1 |
| 2 | F | 20 | No/Mild | Patchy | No | STR | CS-IMRT | No | – | +131.3 |
| 3 | M | 20 | No/Mild | Patchy (mild) | No | STR | Focal proton | No | – | +24 |
| 4 | M | 27 | a | Homogeneous | Yes | Biopsy | CS-IMRT | Yes | 63.2 | 101 |
| 5 | F | 29 | No/Mild | Homogenous (mild) | No | GTR | CS-IMRT | No | – | +148.5 |
| 6 | M | 30 | High | Homogeneous | No | GTR | None | No | – | 0.1 |
| 7 | M | 31 | No/Mild | Heterogeneous (patchy) | No | GTR | CS-P | No | 16.8 | +39.3 |
| 8 | M | 36 | Mild | Patchy (mild) | No | GTR | CS-P | No | – | +66.5 |
| 9 | F | 37 | High | Homogeneous | No | STR | CS-IMRT | Yes | 159.5 | +162.8 |
| 10 | F | 37 | No/Mild | Patchy | No | GTR | CS-P | No | – | +63.4 |
| 11 | M | 40 | High | Homogeneous | No | GTR | CS-P | No | – | +48.5 |
| 12 | F | 41 | No | Patchy | Yes | Biopsy | CS-P | Yes | – | +12.4 |
| 13 | M | 43 | a | Homogeneous | No | STR | SRS | No | – | +28.6 |
| 14 | F | 48 | No | Homogeneous | No | STR | CS-IMRT | No | 20.9 | 20.9 |
| 15 | F | 51 | a | a | No | STR | SRS | No | – | 4.1 |
| 16 | F | 56 | a | Homogeneous | No | a | CS-IMRT + SRS | No | 16.5 | 33.3 |
| 17 | M | 57 | No/Mild | Homogeneous | No | GTR | None | No | 12.7 | +111 |
| Case . | Sex . | Age at diagnosis, y . | DWI signal . | Contrast enhancement . | Dissemination at diagnosis . | Extent of resection . | Radiation regimen . | Adjuvant chemotherapy . | PFS, mo . | OS, mo . |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | M | 15 | High | Homogeneous | Yes | Biopsy | CS-IMRT + focal | Yes | 25.6 | 68.1 |
| 2 | F | 20 | No/Mild | Patchy | No | STR | CS-IMRT | No | – | +131.3 |
| 3 | M | 20 | No/Mild | Patchy (mild) | No | STR | Focal proton | No | – | +24 |
| 4 | M | 27 | a | Homogeneous | Yes | Biopsy | CS-IMRT | Yes | 63.2 | 101 |
| 5 | F | 29 | No/Mild | Homogenous (mild) | No | GTR | CS-IMRT | No | – | +148.5 |
| 6 | M | 30 | High | Homogeneous | No | GTR | None | No | – | 0.1 |
| 7 | M | 31 | No/Mild | Heterogeneous (patchy) | No | GTR | CS-P | No | 16.8 | +39.3 |
| 8 | M | 36 | Mild | Patchy (mild) | No | GTR | CS-P | No | – | +66.5 |
| 9 | F | 37 | High | Homogeneous | No | STR | CS-IMRT | Yes | 159.5 | +162.8 |
| 10 | F | 37 | No/Mild | Patchy | No | GTR | CS-P | No | – | +63.4 |
| 11 | M | 40 | High | Homogeneous | No | GTR | CS-P | No | – | +48.5 |
| 12 | F | 41 | No | Patchy | Yes | Biopsy | CS-P | Yes | – | +12.4 |
| 13 | M | 43 | a | Homogeneous | No | STR | SRS | No | – | +28.6 |
| 14 | F | 48 | No | Homogeneous | No | STR | CS-IMRT | No | 20.9 | 20.9 |
| 15 | F | 51 | a | a | No | STR | SRS | No | – | 4.1 |
| 16 | F | 56 | a | Homogeneous | No | a | CS-IMRT + SRS | No | 16.5 | 33.3 |
| 17 | M | 57 | No/Mild | Homogeneous | No | GTR | None | No | 12.7 | +111 |
Abbreviations: CS-IMRT, craniospinal irradiation with intensity modulated radiation therapy; CS-P, craniospinal irradiation with proton therapy; DWI, diffusion-weighted imaging; F, female; GTR, gross total resection; M, male; mo, months; OS, overall survival; PFS, progression-free survival; SRS, stereotactic radiosurgery; STR, subtotal resection.
aUnknown.
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