Table 2

Performance comparison of the Fold-LTR-TCP with other state-of-the-art methods on LE benchmark dataset via 2-fold cross-validation

MethodsAccuracySource
PSI-Blast4.0%[39]
HMMER4.4%[39]
SAM-T983.4%[39]
BLASTLINK6.9%[39]
SSEARCH5.6%[39]
SSHMM6.9%[39]
THREADER14.6%[39]
Fugue12.5%[64]
RAPTOR25.4%[64]
SPARKS28.7%[64]
SP330.8%[64]
FOLDpro26.5%[64]
HHpred25.2%[62]
SP430.8%[62]
SP537.9%[62]
BoostThreader42.6%[62]
SPARKS-X45.2%[62]
RF-Fold40.8%[62]
DN-Fold33.6%[62]
RFDN-Fold37.7%[62]
DN-FoldS33.3%[62]
DN-FoldR27.4%[62]
FFAS-3D35.8%[61]
HH-fold42.1%[61]
TA-fold53.9%[61]
dRHP-PseRA34.9%[65]
MT-fold59.1%[65]
DeepFRpro66.0%[34]
DeepSVM-fold67.3%[35]
Fold-LTR-TCP73.2%This study
MethodsAccuracySource
PSI-Blast4.0%[39]
HMMER4.4%[39]
SAM-T983.4%[39]
BLASTLINK6.9%[39]
SSEARCH5.6%[39]
SSHMM6.9%[39]
THREADER14.6%[39]
Fugue12.5%[64]
RAPTOR25.4%[64]
SPARKS28.7%[64]
SP330.8%[64]
FOLDpro26.5%[64]
HHpred25.2%[62]
SP430.8%[62]
SP537.9%[62]
BoostThreader42.6%[62]
SPARKS-X45.2%[62]
RF-Fold40.8%[62]
DN-Fold33.6%[62]
RFDN-Fold37.7%[62]
DN-FoldS33.3%[62]
DN-FoldR27.4%[62]
FFAS-3D35.8%[61]
HH-fold42.1%[61]
TA-fold53.9%[61]
dRHP-PseRA34.9%[65]
MT-fold59.1%[65]
DeepFRpro66.0%[34]
DeepSVM-fold67.3%[35]
Fold-LTR-TCP73.2%This study

The bold values represent the proposed method achieving the top performance.

Table 2

Performance comparison of the Fold-LTR-TCP with other state-of-the-art methods on LE benchmark dataset via 2-fold cross-validation

MethodsAccuracySource
PSI-Blast4.0%[39]
HMMER4.4%[39]
SAM-T983.4%[39]
BLASTLINK6.9%[39]
SSEARCH5.6%[39]
SSHMM6.9%[39]
THREADER14.6%[39]
Fugue12.5%[64]
RAPTOR25.4%[64]
SPARKS28.7%[64]
SP330.8%[64]
FOLDpro26.5%[64]
HHpred25.2%[62]
SP430.8%[62]
SP537.9%[62]
BoostThreader42.6%[62]
SPARKS-X45.2%[62]
RF-Fold40.8%[62]
DN-Fold33.6%[62]
RFDN-Fold37.7%[62]
DN-FoldS33.3%[62]
DN-FoldR27.4%[62]
FFAS-3D35.8%[61]
HH-fold42.1%[61]
TA-fold53.9%[61]
dRHP-PseRA34.9%[65]
MT-fold59.1%[65]
DeepFRpro66.0%[34]
DeepSVM-fold67.3%[35]
Fold-LTR-TCP73.2%This study
MethodsAccuracySource
PSI-Blast4.0%[39]
HMMER4.4%[39]
SAM-T983.4%[39]
BLASTLINK6.9%[39]
SSEARCH5.6%[39]
SSHMM6.9%[39]
THREADER14.6%[39]
Fugue12.5%[64]
RAPTOR25.4%[64]
SPARKS28.7%[64]
SP330.8%[64]
FOLDpro26.5%[64]
HHpred25.2%[62]
SP430.8%[62]
SP537.9%[62]
BoostThreader42.6%[62]
SPARKS-X45.2%[62]
RF-Fold40.8%[62]
DN-Fold33.6%[62]
RFDN-Fold37.7%[62]
DN-FoldS33.3%[62]
DN-FoldR27.4%[62]
FFAS-3D35.8%[61]
HH-fold42.1%[61]
TA-fold53.9%[61]
dRHP-PseRA34.9%[65]
MT-fold59.1%[65]
DeepFRpro66.0%[34]
DeepSVM-fold67.3%[35]
Fold-LTR-TCP73.2%This study

The bold values represent the proposed method achieving the top performance.

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