The two-gene combinations with highest frequency in T1 stage cancers for early diagnosis
| Cancer . | Gene 1 . | Gene 2 . | Co-frequency . |
|---|---|---|---|
| BLCA | SPOCD1 | ALOX5 | 100% |
| BLCA | SPOCD1 | C10orf116 | 100% |
| BLCA | SPOCD1 | CARD11 | 100% |
| BLCA | SPOCD1 | FER1L4 | 100% |
| BLCA | SPOCD1 | LOC284837 | 100% |
| BLCA | SPOCD1 | LRP11 | 100% |
| BLCA | SPOCD1 | MYCL1 | 100% |
| BLCA | SPOCD1 | PM20D1 | 100% |
| BLCA | SPOCD1 | PROM2 | 100% |
| BLCA | SPOCD1 | PVRL1 | 100% |
| BLCA | SPOCD1 | SNCG | 100% |
| BLCA | SPOCD1 | TINAGL1 | 100% |
| BLCA | SPOCD1 | ZNF626 | 100% |
| BRCA | PRLR | ZG16B | 79% |
| CESC | CDKN2A | SMC1B | 89% |
| CHOL | CLDN10 | TMEM156 | 89% |
| CHOL | CLDN10 | UCA1 | 89% |
| CHOL | CLDN10 | UNC13D | 89% |
| CHOL | IL8 | UNC13D | 89% |
| COAD | ACSL5 | GPX2 | 100% |
| COAD | ACSL5 | OLFM4 | 100% |
| ESCA | TM4SF20 | DUOX2 | 74% |
| ESCA | TM4SF20 | REG4 | 74% |
| HNSC | LY6K | PVRL1 | 94% |
| KIRC | BTNL9 | HMOX1 | 89% |
| KIRC | CDH6 | GPR4 | 89% |
| KIRC | HMOX1 | FLT1 | 89% |
| KIRC | HMOX1 | GPR4 | 89% |
| KIRP | LRRK2 | CRYAB | 88% |
| KIRP | LRRK2 | GALNT14 | 88% |
| LIHC | CDHR5 | TMEM37 | 88% |
| LUSC | DAPL1 | PVRL1 | 76% |
| PAAD | CHST4 | TMPRSS3 | 86% |
| PAAD | CLDN10 | DUOX2 | 86% |
| PAAD | CLDN10 | TMPRSS3 | 86% |
| SKCM | AP1S2 | VGF | 90% |
| SKCM | APOD | RGS20 | 90% |
| THCA | DAPL1 | DIRAS3 | 90% |
| Cancer . | Gene 1 . | Gene 2 . | Co-frequency . |
|---|---|---|---|
| BLCA | SPOCD1 | ALOX5 | 100% |
| BLCA | SPOCD1 | C10orf116 | 100% |
| BLCA | SPOCD1 | CARD11 | 100% |
| BLCA | SPOCD1 | FER1L4 | 100% |
| BLCA | SPOCD1 | LOC284837 | 100% |
| BLCA | SPOCD1 | LRP11 | 100% |
| BLCA | SPOCD1 | MYCL1 | 100% |
| BLCA | SPOCD1 | PM20D1 | 100% |
| BLCA | SPOCD1 | PROM2 | 100% |
| BLCA | SPOCD1 | PVRL1 | 100% |
| BLCA | SPOCD1 | SNCG | 100% |
| BLCA | SPOCD1 | TINAGL1 | 100% |
| BLCA | SPOCD1 | ZNF626 | 100% |
| BRCA | PRLR | ZG16B | 79% |
| CESC | CDKN2A | SMC1B | 89% |
| CHOL | CLDN10 | TMEM156 | 89% |
| CHOL | CLDN10 | UCA1 | 89% |
| CHOL | CLDN10 | UNC13D | 89% |
| CHOL | IL8 | UNC13D | 89% |
| COAD | ACSL5 | GPX2 | 100% |
| COAD | ACSL5 | OLFM4 | 100% |
| ESCA | TM4SF20 | DUOX2 | 74% |
| ESCA | TM4SF20 | REG4 | 74% |
| HNSC | LY6K | PVRL1 | 94% |
| KIRC | BTNL9 | HMOX1 | 89% |
| KIRC | CDH6 | GPR4 | 89% |
| KIRC | HMOX1 | FLT1 | 89% |
| KIRC | HMOX1 | GPR4 | 89% |
| KIRP | LRRK2 | CRYAB | 88% |
| KIRP | LRRK2 | GALNT14 | 88% |
| LIHC | CDHR5 | TMEM37 | 88% |
| LUSC | DAPL1 | PVRL1 | 76% |
| PAAD | CHST4 | TMPRSS3 | 86% |
| PAAD | CLDN10 | DUOX2 | 86% |
| PAAD | CLDN10 | TMPRSS3 | 86% |
| SKCM | AP1S2 | VGF | 90% |
| SKCM | APOD | RGS20 | 90% |
| THCA | DAPL1 | DIRAS3 | 90% |
Co-frequency denotes the frequency of high expression of one of the two genes in the cancer type. Note: the complete list of two-gene combinations, including 87 combinations in READ and 215 combinations in KICH, appears in Supplementary Table S5.
The two-gene combinations with highest frequency in T1 stage cancers for early diagnosis
| Cancer . | Gene 1 . | Gene 2 . | Co-frequency . |
|---|---|---|---|
| BLCA | SPOCD1 | ALOX5 | 100% |
| BLCA | SPOCD1 | C10orf116 | 100% |
| BLCA | SPOCD1 | CARD11 | 100% |
| BLCA | SPOCD1 | FER1L4 | 100% |
| BLCA | SPOCD1 | LOC284837 | 100% |
| BLCA | SPOCD1 | LRP11 | 100% |
| BLCA | SPOCD1 | MYCL1 | 100% |
| BLCA | SPOCD1 | PM20D1 | 100% |
| BLCA | SPOCD1 | PROM2 | 100% |
| BLCA | SPOCD1 | PVRL1 | 100% |
| BLCA | SPOCD1 | SNCG | 100% |
| BLCA | SPOCD1 | TINAGL1 | 100% |
| BLCA | SPOCD1 | ZNF626 | 100% |
| BRCA | PRLR | ZG16B | 79% |
| CESC | CDKN2A | SMC1B | 89% |
| CHOL | CLDN10 | TMEM156 | 89% |
| CHOL | CLDN10 | UCA1 | 89% |
| CHOL | CLDN10 | UNC13D | 89% |
| CHOL | IL8 | UNC13D | 89% |
| COAD | ACSL5 | GPX2 | 100% |
| COAD | ACSL5 | OLFM4 | 100% |
| ESCA | TM4SF20 | DUOX2 | 74% |
| ESCA | TM4SF20 | REG4 | 74% |
| HNSC | LY6K | PVRL1 | 94% |
| KIRC | BTNL9 | HMOX1 | 89% |
| KIRC | CDH6 | GPR4 | 89% |
| KIRC | HMOX1 | FLT1 | 89% |
| KIRC | HMOX1 | GPR4 | 89% |
| KIRP | LRRK2 | CRYAB | 88% |
| KIRP | LRRK2 | GALNT14 | 88% |
| LIHC | CDHR5 | TMEM37 | 88% |
| LUSC | DAPL1 | PVRL1 | 76% |
| PAAD | CHST4 | TMPRSS3 | 86% |
| PAAD | CLDN10 | DUOX2 | 86% |
| PAAD | CLDN10 | TMPRSS3 | 86% |
| SKCM | AP1S2 | VGF | 90% |
| SKCM | APOD | RGS20 | 90% |
| THCA | DAPL1 | DIRAS3 | 90% |
| Cancer . | Gene 1 . | Gene 2 . | Co-frequency . |
|---|---|---|---|
| BLCA | SPOCD1 | ALOX5 | 100% |
| BLCA | SPOCD1 | C10orf116 | 100% |
| BLCA | SPOCD1 | CARD11 | 100% |
| BLCA | SPOCD1 | FER1L4 | 100% |
| BLCA | SPOCD1 | LOC284837 | 100% |
| BLCA | SPOCD1 | LRP11 | 100% |
| BLCA | SPOCD1 | MYCL1 | 100% |
| BLCA | SPOCD1 | PM20D1 | 100% |
| BLCA | SPOCD1 | PROM2 | 100% |
| BLCA | SPOCD1 | PVRL1 | 100% |
| BLCA | SPOCD1 | SNCG | 100% |
| BLCA | SPOCD1 | TINAGL1 | 100% |
| BLCA | SPOCD1 | ZNF626 | 100% |
| BRCA | PRLR | ZG16B | 79% |
| CESC | CDKN2A | SMC1B | 89% |
| CHOL | CLDN10 | TMEM156 | 89% |
| CHOL | CLDN10 | UCA1 | 89% |
| CHOL | CLDN10 | UNC13D | 89% |
| CHOL | IL8 | UNC13D | 89% |
| COAD | ACSL5 | GPX2 | 100% |
| COAD | ACSL5 | OLFM4 | 100% |
| ESCA | TM4SF20 | DUOX2 | 74% |
| ESCA | TM4SF20 | REG4 | 74% |
| HNSC | LY6K | PVRL1 | 94% |
| KIRC | BTNL9 | HMOX1 | 89% |
| KIRC | CDH6 | GPR4 | 89% |
| KIRC | HMOX1 | FLT1 | 89% |
| KIRC | HMOX1 | GPR4 | 89% |
| KIRP | LRRK2 | CRYAB | 88% |
| KIRP | LRRK2 | GALNT14 | 88% |
| LIHC | CDHR5 | TMEM37 | 88% |
| LUSC | DAPL1 | PVRL1 | 76% |
| PAAD | CHST4 | TMPRSS3 | 86% |
| PAAD | CLDN10 | DUOX2 | 86% |
| PAAD | CLDN10 | TMPRSS3 | 86% |
| SKCM | AP1S2 | VGF | 90% |
| SKCM | APOD | RGS20 | 90% |
| THCA | DAPL1 | DIRAS3 | 90% |
Co-frequency denotes the frequency of high expression of one of the two genes in the cancer type. Note: the complete list of two-gene combinations, including 87 combinations in READ and 215 combinations in KICH, appears in Supplementary Table S5.
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