Events at follow-up in patients grouped according to concordance and discordance between estimated glomerular filtration rate based on the Berlin Initiative Study-1 equation with respect to the CKD-EPI equation.
| Criterion . | Total . | CKD-EPI and BIS-1 > 60a . | BIS-1 <60 but CKD-EPI >60 . | CKD-EPI and BIS-1 <60 . |
|---|---|---|---|---|
| Patients, n (%) | 7787 (100%) | 3448 (44.8%) | 1573 (20.2%) | 2766 (35.5%) |
| Death, n (%)* | 883 (11.3%) | 261 (7.6%) | 142 (9%) | 480 (17%) |
| Unadjusted HR (95% CI) | 1 | 1.20 (0.98–1.47) | 2.35 (2.02–2.74) | |
| p-value | – | 0.08 | <0.0001 | |
| Adjusted HRb (95% CI) | 1 | 1.13 (0.92–1.39) | 2.01 (1.72–2.35) | |
| p-value | – | 0.134 | <0.0001 | |
| Death or CV hospitalization (%)* | 2200 (28.3%) | 724 (21.0%) | 428 (27%) | 1048 (38%) |
| Unadjusted HR (95% CI) | 1 | 1.35 (1.20–1.53) | 2.01 (1.82–2.20) | |
| p-value | – | <0.0001 | <0.0001 | |
| Adjusted HRb (95% CI) | 1 | 1.26 (1.11–1.42) | 1.69 (1.53–1.86) | |
| p-value | – | <0.0001 | <0.0001 | |
| Death or all-cause hospitalization (%)* | 3761 (48.3%) | 1432 (41.5%) | 744 (47%) | 1585 (57%) |
| Unadjusted HR (95% CI) | 1 | 1.18 (1.08–1.30) | 1.58 (1.47–1.69) | |
| p-value | – | <0.0001 | <0.0001 | |
| Adjusted HRb (95% CI) | 1 | 1.12 (1.03–1.22) | 1.40 (1.33–1.53) | |
| p-value | – | 0.012 | <0.0001 |
| Criterion . | Total . | CKD-EPI and BIS-1 > 60a . | BIS-1 <60 but CKD-EPI >60 . | CKD-EPI and BIS-1 <60 . |
|---|---|---|---|---|
| Patients, n (%) | 7787 (100%) | 3448 (44.8%) | 1573 (20.2%) | 2766 (35.5%) |
| Death, n (%)* | 883 (11.3%) | 261 (7.6%) | 142 (9%) | 480 (17%) |
| Unadjusted HR (95% CI) | 1 | 1.20 (0.98–1.47) | 2.35 (2.02–2.74) | |
| p-value | – | 0.08 | <0.0001 | |
| Adjusted HRb (95% CI) | 1 | 1.13 (0.92–1.39) | 2.01 (1.72–2.35) | |
| p-value | – | 0.134 | <0.0001 | |
| Death or CV hospitalization (%)* | 2200 (28.3%) | 724 (21.0%) | 428 (27%) | 1048 (38%) |
| Unadjusted HR (95% CI) | 1 | 1.35 (1.20–1.53) | 2.01 (1.82–2.20) | |
| p-value | – | <0.0001 | <0.0001 | |
| Adjusted HRb (95% CI) | 1 | 1.26 (1.11–1.42) | 1.69 (1.53–1.86) | |
| p-value | – | <0.0001 | <0.0001 | |
| Death or all-cause hospitalization (%)* | 3761 (48.3%) | 1432 (41.5%) | 744 (47%) | 1585 (57%) |
| Unadjusted HR (95% CI) | 1 | 1.18 (1.08–1.30) | 1.58 (1.47–1.69) | |
| p-value | – | <0.0001 | <0.0001 | |
| Adjusted HRb (95% CI) | 1 | 1.12 (1.03–1.22) | 1.40 (1.33–1.53) | |
| p-value | – | 0.012 | <0.0001 |
BIS-1: Berlin Initiative Study-1; CV: cardiovascular; HR: hazard ratio; CI: confidence interval.
p < 0.0001.
Reference group for adjusted HRs: CKD-EPI and BIS-1 >60 mL/min/1.73 m2.
Adjusted for gender, prior myocardial infarction, heart failure, peripheral artery disease/stroke, diabetes and persistent/permanent atrial fibrillation.
Events at follow-up in patients grouped according to concordance and discordance between estimated glomerular filtration rate based on the Berlin Initiative Study-1 equation with respect to the CKD-EPI equation.
| Criterion . | Total . | CKD-EPI and BIS-1 > 60a . | BIS-1 <60 but CKD-EPI >60 . | CKD-EPI and BIS-1 <60 . |
|---|---|---|---|---|
| Patients, n (%) | 7787 (100%) | 3448 (44.8%) | 1573 (20.2%) | 2766 (35.5%) |
| Death, n (%)* | 883 (11.3%) | 261 (7.6%) | 142 (9%) | 480 (17%) |
| Unadjusted HR (95% CI) | 1 | 1.20 (0.98–1.47) | 2.35 (2.02–2.74) | |
| p-value | – | 0.08 | <0.0001 | |
| Adjusted HRb (95% CI) | 1 | 1.13 (0.92–1.39) | 2.01 (1.72–2.35) | |
| p-value | – | 0.134 | <0.0001 | |
| Death or CV hospitalization (%)* | 2200 (28.3%) | 724 (21.0%) | 428 (27%) | 1048 (38%) |
| Unadjusted HR (95% CI) | 1 | 1.35 (1.20–1.53) | 2.01 (1.82–2.20) | |
| p-value | – | <0.0001 | <0.0001 | |
| Adjusted HRb (95% CI) | 1 | 1.26 (1.11–1.42) | 1.69 (1.53–1.86) | |
| p-value | – | <0.0001 | <0.0001 | |
| Death or all-cause hospitalization (%)* | 3761 (48.3%) | 1432 (41.5%) | 744 (47%) | 1585 (57%) |
| Unadjusted HR (95% CI) | 1 | 1.18 (1.08–1.30) | 1.58 (1.47–1.69) | |
| p-value | – | <0.0001 | <0.0001 | |
| Adjusted HRb (95% CI) | 1 | 1.12 (1.03–1.22) | 1.40 (1.33–1.53) | |
| p-value | – | 0.012 | <0.0001 |
| Criterion . | Total . | CKD-EPI and BIS-1 > 60a . | BIS-1 <60 but CKD-EPI >60 . | CKD-EPI and BIS-1 <60 . |
|---|---|---|---|---|
| Patients, n (%) | 7787 (100%) | 3448 (44.8%) | 1573 (20.2%) | 2766 (35.5%) |
| Death, n (%)* | 883 (11.3%) | 261 (7.6%) | 142 (9%) | 480 (17%) |
| Unadjusted HR (95% CI) | 1 | 1.20 (0.98–1.47) | 2.35 (2.02–2.74) | |
| p-value | – | 0.08 | <0.0001 | |
| Adjusted HRb (95% CI) | 1 | 1.13 (0.92–1.39) | 2.01 (1.72–2.35) | |
| p-value | – | 0.134 | <0.0001 | |
| Death or CV hospitalization (%)* | 2200 (28.3%) | 724 (21.0%) | 428 (27%) | 1048 (38%) |
| Unadjusted HR (95% CI) | 1 | 1.35 (1.20–1.53) | 2.01 (1.82–2.20) | |
| p-value | – | <0.0001 | <0.0001 | |
| Adjusted HRb (95% CI) | 1 | 1.26 (1.11–1.42) | 1.69 (1.53–1.86) | |
| p-value | – | <0.0001 | <0.0001 | |
| Death or all-cause hospitalization (%)* | 3761 (48.3%) | 1432 (41.5%) | 744 (47%) | 1585 (57%) |
| Unadjusted HR (95% CI) | 1 | 1.18 (1.08–1.30) | 1.58 (1.47–1.69) | |
| p-value | – | <0.0001 | <0.0001 | |
| Adjusted HRb (95% CI) | 1 | 1.12 (1.03–1.22) | 1.40 (1.33–1.53) | |
| p-value | – | 0.012 | <0.0001 |
BIS-1: Berlin Initiative Study-1; CV: cardiovascular; HR: hazard ratio; CI: confidence interval.
p < 0.0001.
Reference group for adjusted HRs: CKD-EPI and BIS-1 >60 mL/min/1.73 m2.
Adjusted for gender, prior myocardial infarction, heart failure, peripheral artery disease/stroke, diabetes and persistent/permanent atrial fibrillation.
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