Multivariable-adjusted associations between plasma MDA concentration and cardiovascular mortality risk in 604 RTRs
| Models . | HR per 1-SD increment . | 95% CI . | P-value . |
|---|---|---|---|
| Cardiovascular mortality | |||
| Model 1 | 1.31 | 1.03‒1.67 | 0.03 |
| Model 2 | 1.39 | 1.05‒1.83 | 0.02 |
| Model 3 | 1.43 | 1.11‒1.85 | 0.01 |
| Model 4 | 1.39 | 1.04‒1.85 | 0.02 |
| Model 5 | 1.40 | 1.06‒1.85 | 0.02 |
| Model 6 | 1.41 | 1.06‒1.88 | 0.02 |
| Non-cardiovascular mortality | |||
| Model 1 | 1.13 | 0.90‒1.41 | 0.31 |
| Model 2 | 1.14 | 0.88‒1.49 | 0.33 |
| Model 3 | 1.18 | 0.92‒1.52 | 0.19 |
| Model 4 | 1.12 | 0.89‒1.51 | 0.28 |
| Model 5 | 1.12 | 0.86‒1.45 | 0.42 |
| Model 6 | 1.16 | 0.89‒1.52 | 0.27 |
| Models . | HR per 1-SD increment . | 95% CI . | P-value . |
|---|---|---|---|
| Cardiovascular mortality | |||
| Model 1 | 1.31 | 1.03‒1.67 | 0.03 |
| Model 2 | 1.39 | 1.05‒1.83 | 0.02 |
| Model 3 | 1.43 | 1.11‒1.85 | 0.01 |
| Model 4 | 1.39 | 1.04‒1.85 | 0.02 |
| Model 5 | 1.40 | 1.06‒1.85 | 0.02 |
| Model 6 | 1.41 | 1.06‒1.88 | 0.02 |
| Non-cardiovascular mortality | |||
| Model 1 | 1.13 | 0.90‒1.41 | 0.31 |
| Model 2 | 1.14 | 0.88‒1.49 | 0.33 |
| Model 3 | 1.18 | 0.92‒1.52 | 0.19 |
| Model 4 | 1.12 | 0.89‒1.51 | 0.28 |
| Model 5 | 1.12 | 0.86‒1.45 | 0.42 |
| Model 6 | 1.16 | 0.89‒1.52 | 0.27 |
In total, 110 (18%) patients died, of which 44 (40%) deaths were due to cardiovascular causes. Model 1: crude model. Model 2: Model 1 + adjustment for age, sex, time since transplantation, eGFR and proteinuria status. Model 3: Model 2 + adjustment for cardiovascular risk factors included in the Framingham score. Model 4: Model 2 + adjustment for cardiovascular risk factors proposed by the WHO. Model 5: Model 2 + adjustment for cardiovascular history. Model 6: Model 2 + adjustment for type of donor and immunosuppressive therapy.
Multivariable-adjusted associations between plasma MDA concentration and cardiovascular mortality risk in 604 RTRs
| Models . | HR per 1-SD increment . | 95% CI . | P-value . |
|---|---|---|---|
| Cardiovascular mortality | |||
| Model 1 | 1.31 | 1.03‒1.67 | 0.03 |
| Model 2 | 1.39 | 1.05‒1.83 | 0.02 |
| Model 3 | 1.43 | 1.11‒1.85 | 0.01 |
| Model 4 | 1.39 | 1.04‒1.85 | 0.02 |
| Model 5 | 1.40 | 1.06‒1.85 | 0.02 |
| Model 6 | 1.41 | 1.06‒1.88 | 0.02 |
| Non-cardiovascular mortality | |||
| Model 1 | 1.13 | 0.90‒1.41 | 0.31 |
| Model 2 | 1.14 | 0.88‒1.49 | 0.33 |
| Model 3 | 1.18 | 0.92‒1.52 | 0.19 |
| Model 4 | 1.12 | 0.89‒1.51 | 0.28 |
| Model 5 | 1.12 | 0.86‒1.45 | 0.42 |
| Model 6 | 1.16 | 0.89‒1.52 | 0.27 |
| Models . | HR per 1-SD increment . | 95% CI . | P-value . |
|---|---|---|---|
| Cardiovascular mortality | |||
| Model 1 | 1.31 | 1.03‒1.67 | 0.03 |
| Model 2 | 1.39 | 1.05‒1.83 | 0.02 |
| Model 3 | 1.43 | 1.11‒1.85 | 0.01 |
| Model 4 | 1.39 | 1.04‒1.85 | 0.02 |
| Model 5 | 1.40 | 1.06‒1.85 | 0.02 |
| Model 6 | 1.41 | 1.06‒1.88 | 0.02 |
| Non-cardiovascular mortality | |||
| Model 1 | 1.13 | 0.90‒1.41 | 0.31 |
| Model 2 | 1.14 | 0.88‒1.49 | 0.33 |
| Model 3 | 1.18 | 0.92‒1.52 | 0.19 |
| Model 4 | 1.12 | 0.89‒1.51 | 0.28 |
| Model 5 | 1.12 | 0.86‒1.45 | 0.42 |
| Model 6 | 1.16 | 0.89‒1.52 | 0.27 |
In total, 110 (18%) patients died, of which 44 (40%) deaths were due to cardiovascular causes. Model 1: crude model. Model 2: Model 1 + adjustment for age, sex, time since transplantation, eGFR and proteinuria status. Model 3: Model 2 + adjustment for cardiovascular risk factors included in the Framingham score. Model 4: Model 2 + adjustment for cardiovascular risk factors proposed by the WHO. Model 5: Model 2 + adjustment for cardiovascular history. Model 6: Model 2 + adjustment for type of donor and immunosuppressive therapy.
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