| . | Survivors . | Non-survivors . | p . |
|---|---|---|---|
| N | 922 | 116 | |
| Age, years | 51.6 ± 10.3 | 56.3 ± 11.8 | <0.001 |
| Sex, men, N (%) | 302 (32.7) | 63 (54.3) | <0.001 |
| Locality, urban, N (%) | 412 (44.7) | 65 (56.0) | 0.021 |
| Body mass index, kg/m2 | 25.2 ± 7.00 | 22.7 ± 6.73 | <0.001 |
| Waist circumference, cm | 80.7 ± 13.0 | 79.1 ± 14.5 | 0.26 |
| Systolic blood pressure, mmHg | 135 ± 24.1 | 144 ± 28.4 | <0.001 |
| Diastolic blood pressure, mmHg | 88.3 ± 14.1 | 91.3 ± 16.1 | 0.033 |
| Biochemical variables | |||
| Insulin-like growth factor-1, ng/ml | 48.5 (6.5; 124) | 45.8 (7.20; 111) | 0.50 |
| IGFBP-3, ng/ml | 1353 (91.8; 5677) | 1431 (185; 5150) | 0.64 |
| Glucose, mmol/l | 4.92 (3.50; 7.10) | 4.74 (3.30; 6.70) | 0.12 |
| Glycated haemoglobin, % | 5.67 (4.90; 6.80) | 5.45 (4.50; 6.60) | 0.004 |
| Total cholesterol, mmol/l | 5.23 ± 1.34 | 4.78 ± 1.33 | <0.001 |
| HDL-cholesterol, mmol/l | 1.59 ± 0.62 | 1.56 ± 1.32 | 0.69 |
| Triglycerides, mmol/l | 1.17 (0.57; 2.77) | 1.08 (0.56; 2.35) | 0.079 |
| C-reactive protein, mg/l | 3.16 (0.25; 35.4) | 5.21 (0.43; 53.2) | <0.001 |
| Interleukin-6, pg/ml | 2.80 (0.75; 17.1) | 5.24 (0.75; 33.9) | <0.001 |
| γ-glutamyl transferase, U/l | 55.6 (19.9; 354) | 78.3 (21.0; 488) | <0.001 |
| Creatinine clearance, ml/min | 94.2 (56.3; 168) | 83.6 (39.7; 152) | 0.002 |
| Urinary albumin–creatinine ratio | 0.29 (0.11; 1.07) | 0.33 (0.11; 1.10) | 0.20 |
| Physical activity index | 7.34 ± 1.87 | 6.41 ± 1.85 | <0.001 |
| Self-reported diabetes, N (%) | 12 (1.30) | 1 (0.86) | 0.76 |
| Self-reported tobacco use, N (%) | 487 (52.8) | 78 (67.2) | 0.003 |
| Self-reported alcohol use, N (%) | 377 (40.9) | 61 (52.6) | 0.016 |
| Anti-hypertensive medication, N (%) | 166 (18.0) | 30 (25.9) | 0.042 |
| . | Survivors . | Non-survivors . | p . |
|---|---|---|---|
| N | 922 | 116 | |
| Age, years | 51.6 ± 10.3 | 56.3 ± 11.8 | <0.001 |
| Sex, men, N (%) | 302 (32.7) | 63 (54.3) | <0.001 |
| Locality, urban, N (%) | 412 (44.7) | 65 (56.0) | 0.021 |
| Body mass index, kg/m2 | 25.2 ± 7.00 | 22.7 ± 6.73 | <0.001 |
| Waist circumference, cm | 80.7 ± 13.0 | 79.1 ± 14.5 | 0.26 |
| Systolic blood pressure, mmHg | 135 ± 24.1 | 144 ± 28.4 | <0.001 |
| Diastolic blood pressure, mmHg | 88.3 ± 14.1 | 91.3 ± 16.1 | 0.033 |
| Biochemical variables | |||
| Insulin-like growth factor-1, ng/ml | 48.5 (6.5; 124) | 45.8 (7.20; 111) | 0.50 |
| IGFBP-3, ng/ml | 1353 (91.8; 5677) | 1431 (185; 5150) | 0.64 |
| Glucose, mmol/l | 4.92 (3.50; 7.10) | 4.74 (3.30; 6.70) | 0.12 |
| Glycated haemoglobin, % | 5.67 (4.90; 6.80) | 5.45 (4.50; 6.60) | 0.004 |
| Total cholesterol, mmol/l | 5.23 ± 1.34 | 4.78 ± 1.33 | <0.001 |
| HDL-cholesterol, mmol/l | 1.59 ± 0.62 | 1.56 ± 1.32 | 0.69 |
| Triglycerides, mmol/l | 1.17 (0.57; 2.77) | 1.08 (0.56; 2.35) | 0.079 |
| C-reactive protein, mg/l | 3.16 (0.25; 35.4) | 5.21 (0.43; 53.2) | <0.001 |
| Interleukin-6, pg/ml | 2.80 (0.75; 17.1) | 5.24 (0.75; 33.9) | <0.001 |
| γ-glutamyl transferase, U/l | 55.6 (19.9; 354) | 78.3 (21.0; 488) | <0.001 |
| Creatinine clearance, ml/min | 94.2 (56.3; 168) | 83.6 (39.7; 152) | 0.002 |
| Urinary albumin–creatinine ratio | 0.29 (0.11; 1.07) | 0.33 (0.11; 1.10) | 0.20 |
| Physical activity index | 7.34 ± 1.87 | 6.41 ± 1.85 | <0.001 |
| Self-reported diabetes, N (%) | 12 (1.30) | 1 (0.86) | 0.76 |
| Self-reported tobacco use, N (%) | 487 (52.8) | 78 (67.2) | 0.003 |
| Self-reported alcohol use, N (%) | 377 (40.9) | 61 (52.6) | 0.016 |
| Anti-hypertensive medication, N (%) | 166 (18.0) | 30 (25.9) | 0.042 |
Values are mean ± standard deviation or geometric mean (5th and 95th percentile intervals) for logarithmically transformed variables.
IGFBP-3: insulin-like growth factor binding protein-3; HDL: high-density lipoprotein
| . | Survivors . | Non-survivors . | p . |
|---|---|---|---|
| N | 922 | 116 | |
| Age, years | 51.6 ± 10.3 | 56.3 ± 11.8 | <0.001 |
| Sex, men, N (%) | 302 (32.7) | 63 (54.3) | <0.001 |
| Locality, urban, N (%) | 412 (44.7) | 65 (56.0) | 0.021 |
| Body mass index, kg/m2 | 25.2 ± 7.00 | 22.7 ± 6.73 | <0.001 |
| Waist circumference, cm | 80.7 ± 13.0 | 79.1 ± 14.5 | 0.26 |
| Systolic blood pressure, mmHg | 135 ± 24.1 | 144 ± 28.4 | <0.001 |
| Diastolic blood pressure, mmHg | 88.3 ± 14.1 | 91.3 ± 16.1 | 0.033 |
| Biochemical variables | |||
| Insulin-like growth factor-1, ng/ml | 48.5 (6.5; 124) | 45.8 (7.20; 111) | 0.50 |
| IGFBP-3, ng/ml | 1353 (91.8; 5677) | 1431 (185; 5150) | 0.64 |
| Glucose, mmol/l | 4.92 (3.50; 7.10) | 4.74 (3.30; 6.70) | 0.12 |
| Glycated haemoglobin, % | 5.67 (4.90; 6.80) | 5.45 (4.50; 6.60) | 0.004 |
| Total cholesterol, mmol/l | 5.23 ± 1.34 | 4.78 ± 1.33 | <0.001 |
| HDL-cholesterol, mmol/l | 1.59 ± 0.62 | 1.56 ± 1.32 | 0.69 |
| Triglycerides, mmol/l | 1.17 (0.57; 2.77) | 1.08 (0.56; 2.35) | 0.079 |
| C-reactive protein, mg/l | 3.16 (0.25; 35.4) | 5.21 (0.43; 53.2) | <0.001 |
| Interleukin-6, pg/ml | 2.80 (0.75; 17.1) | 5.24 (0.75; 33.9) | <0.001 |
| γ-glutamyl transferase, U/l | 55.6 (19.9; 354) | 78.3 (21.0; 488) | <0.001 |
| Creatinine clearance, ml/min | 94.2 (56.3; 168) | 83.6 (39.7; 152) | 0.002 |
| Urinary albumin–creatinine ratio | 0.29 (0.11; 1.07) | 0.33 (0.11; 1.10) | 0.20 |
| Physical activity index | 7.34 ± 1.87 | 6.41 ± 1.85 | <0.001 |
| Self-reported diabetes, N (%) | 12 (1.30) | 1 (0.86) | 0.76 |
| Self-reported tobacco use, N (%) | 487 (52.8) | 78 (67.2) | 0.003 |
| Self-reported alcohol use, N (%) | 377 (40.9) | 61 (52.6) | 0.016 |
| Anti-hypertensive medication, N (%) | 166 (18.0) | 30 (25.9) | 0.042 |
| . | Survivors . | Non-survivors . | p . |
|---|---|---|---|
| N | 922 | 116 | |
| Age, years | 51.6 ± 10.3 | 56.3 ± 11.8 | <0.001 |
| Sex, men, N (%) | 302 (32.7) | 63 (54.3) | <0.001 |
| Locality, urban, N (%) | 412 (44.7) | 65 (56.0) | 0.021 |
| Body mass index, kg/m2 | 25.2 ± 7.00 | 22.7 ± 6.73 | <0.001 |
| Waist circumference, cm | 80.7 ± 13.0 | 79.1 ± 14.5 | 0.26 |
| Systolic blood pressure, mmHg | 135 ± 24.1 | 144 ± 28.4 | <0.001 |
| Diastolic blood pressure, mmHg | 88.3 ± 14.1 | 91.3 ± 16.1 | 0.033 |
| Biochemical variables | |||
| Insulin-like growth factor-1, ng/ml | 48.5 (6.5; 124) | 45.8 (7.20; 111) | 0.50 |
| IGFBP-3, ng/ml | 1353 (91.8; 5677) | 1431 (185; 5150) | 0.64 |
| Glucose, mmol/l | 4.92 (3.50; 7.10) | 4.74 (3.30; 6.70) | 0.12 |
| Glycated haemoglobin, % | 5.67 (4.90; 6.80) | 5.45 (4.50; 6.60) | 0.004 |
| Total cholesterol, mmol/l | 5.23 ± 1.34 | 4.78 ± 1.33 | <0.001 |
| HDL-cholesterol, mmol/l | 1.59 ± 0.62 | 1.56 ± 1.32 | 0.69 |
| Triglycerides, mmol/l | 1.17 (0.57; 2.77) | 1.08 (0.56; 2.35) | 0.079 |
| C-reactive protein, mg/l | 3.16 (0.25; 35.4) | 5.21 (0.43; 53.2) | <0.001 |
| Interleukin-6, pg/ml | 2.80 (0.75; 17.1) | 5.24 (0.75; 33.9) | <0.001 |
| γ-glutamyl transferase, U/l | 55.6 (19.9; 354) | 78.3 (21.0; 488) | <0.001 |
| Creatinine clearance, ml/min | 94.2 (56.3; 168) | 83.6 (39.7; 152) | 0.002 |
| Urinary albumin–creatinine ratio | 0.29 (0.11; 1.07) | 0.33 (0.11; 1.10) | 0.20 |
| Physical activity index | 7.34 ± 1.87 | 6.41 ± 1.85 | <0.001 |
| Self-reported diabetes, N (%) | 12 (1.30) | 1 (0.86) | 0.76 |
| Self-reported tobacco use, N (%) | 487 (52.8) | 78 (67.2) | 0.003 |
| Self-reported alcohol use, N (%) | 377 (40.9) | 61 (52.6) | 0.016 |
| Anti-hypertensive medication, N (%) | 166 (18.0) | 30 (25.9) | 0.042 |
Values are mean ± standard deviation or geometric mean (5th and 95th percentile intervals) for logarithmically transformed variables.
IGFBP-3: insulin-like growth factor binding protein-3; HDL: high-density lipoprotein
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