Table 1. Open in new tab Baseline...

Numbers

All patients

Normal

1-vessel (excl. LM)

2-vessel (excl. LM)

3-vessel (excl. LM)

Left main stem (LM)

p-Value

Angiographic findings %, (n)

2776

20.9 (580)

23.1 (641)

18.1 (503)

29.4 (815)

8.5 (237)

< 0.001

Clinical characteristics

Age, years, mean, (range), SD

2776

58 (19–88) SD 11

53 (19–86) SD 11

56 (25–86) SD 11

58 (32–85) SD 10

60 (34–85) SD 10

63 (37–88) SD 10

<0.001

Male, %, (n)

2776

58.4 (1621)

53.3 (309)

58.5 (375)

56.3 (283)

60.5 (493)

67.9 (161)

0.002

BMI, kg/m², mean, (range), SD

2360

26.4 (15.4–74.5) SD 4.4

26.8 (16.9–74.5) SD 5.3

26.5 (17.3–52.8) SD 4.3

26.5 (16.9–43.5) SD 4.2

26.2 (15.4 –42.5) SD 4.2

26.1 (16.2–40.3) SD 4.1

0.137

Smoker, current, %, (n)

2254

15.0 (339)

14.3 (64)

16.9 (98)

19.0 (80)

13.2 (82)

8.3 (15)

<0.001

Systolic blood pressure, mm Hg, mean, (range), SD

2575

136 (84–220) SD 18

134 (84–200) SD 18

136 (90–214) SD 18

136 (90–210) SD 17

138 (85–220) SD18

137 (100–190) SD 17

0.001

Diastolic blood pressure, mm Hg, mean, (range), SD

2575

73 (40–115) SD 10

74 (40–105) SD 10

73 (50–115) SD10

74 (48–110) SD 10

72 (40–108) SD 10

71 (40–102) SD 10

<0.001

Hypertension, treated, %, (n)

2639

80.4 (2121)

68.7 (375)

80.3 (480)

82.6 (398)

85.5 (671)

86.4 (197)

<0.001

Antihypertensive medication, %, (n)

2766

80.5 (2236)

82.9 (481)

79.7 (511)

80.5 (405)

79.4 (647)

81.0 (192)

0.788

Hyperlipidaemia, treated, %, (n)

2247

68.0 (1528)

60.4 (271)

62.2 (361)

69.9 (290)

74.4 (462)

79.4 (143)

<0.001

Atrial fibrillation, %, (n)

2776

5.2 (144)

6.9 (40)

4.2 (27)

3.0 (15)

5.6 (46)

6.8 (16)

0.025

Previous disease, %, (n)

Myocardialinfarction

2776

38.5 (1069)

15.9 (92)

33.2 (213)

42.5 (214)

51.2 (417)

56.1 (133)

<0.001

Any CAD

2776

58.0 (1610)

31.6 (183)

52.6 (337)

63.6 (320)

72.3 (589)

76.4 (181)

<0.001

Previous PCI

2617

5.8 (153)

2.6 (14)

5.7 (35)

7.1 (34)

7.4 (56)

6.3 (14)

0.022

Previous CABG

2776

10.5 (291)

1.2 (7)

3.0 (19)

5.0 (25)

21.3 (174)

27.8 (66)

<0.001

Previous angina

2776

35.4 (982)

19.8 (115)

28.7 (184)

35.6 (179)

47.5 (387)

49.4 (117)

<0.001

Heart failure

2776

14.9 (414)

11.4 (66)

7.8 (50)

13.5 (68)

21.1 (172)

24.5 (58)

<0.001

Stroke

2776

8.3 (231)

5.7 (33)

6.2 (40)

8.5 (43)

9.9 (81)

14.3 (34)

<0.001

Renal insufficiency

2776

11.0 (306)

12.9 (75)

9.7 (62)

11.7 (59)

11.0 (90)

8.4 (20)

0.266

Peripheral artery disease^a

2776

16.3 (452)

9.1 (53)

10.5 (67)

17.5 (88)

22.3 (182)

26.2 (62)

<0.001

Diabetes-related variables

HbA1c, mmol/mol, mean, (range), SD

2638

66.7 (26–145) SD 14.1

65.6 (29–123) SD 14.8

66.8 (26–145) SD 14.3

67.4 (28–130) SD 13.7

67.2 (33–133) SD 13.5

65.7 (33–110) SD 13.9

0.162

Diabetes duration, years, mean, (range), SD

2776

35 (0–76) SD 14

29 (0–76) SD 14

33 (0–69) SD 14

35 (0–73) SD 14

39 (5–70) SD 13

42 (8–75) SD 14

<0.001

Debute age, years, mean, (range), SD

2776

23 (0–50) SD 13

24 (0–50) SD 14

23 (1–50) SD 13

23 (0–50) SD 13

21 (1–50) SD 13

22 (0–50) SD 14

0.001

Creatinine, µmol/l, mean, (range), SD

2524

121 (24–1013) SD 128

140 (34–1013) SD 177

113 (24–938) SD 114

118 (37–872) SD 117

117 (40–971) SD 107

114 (45–761) SD 96

0.003

LDL, mg/dl, mean, (range), SD

1840

2.7 (0.5–7.3) SD 0.9

2.6 (0.6–6.0) SD 0.8

2.7 (0.9–7.3) SD 0.9

2.7 (0.5–7.3) SD 0.9

2.7 (0.6–6.0) SD 0.9

2.7 (0.7–7.0) SD 0.9

0.275

HDL, mg/dl, mean, (range), SD

1861

1.52 (0.43–3.97) SD 0.49

1.60 (0.43–3.8) SD 0.52

1.53 (0.60–3.40) SD 0.48

1.46 (0.52–2.80) SD 0.45

1.52 (0.64–3.97) SD 0.50

1.45 (0.59–3.56) SD 0.48

0.002

Triglycerides, mg/dl, mean, (range), SD

1859

1.39 (0.30–14.10) SD 1.02

1.27 (0.30–9.60) SD 0.87

1.44 (0.38–11.20), SD 1.11

1.47 (0.30–10.0) SD1.02

1.40 (0.40–13.0) SD 0.96

1.43 (0.40–14.10) SD 1.27

0.064

Retinopathy, %, (n)

2776

66.1 (1836)

60.0 (348)

63.8 (409)

65.8 (331)

71.2 (580)

70.9 (168)

<0.001

Never hypo-glycaemia, %, (n)

596

89.8 (535)

90.6 (126)

93.8 (151)

89.7 (96)

85.0 (119)

87.8 (43)

0.121

Pump, %, (n)

2033

12.2 (248)

17.6 (77)

12.0 (59)

9.7 (35)

12.3 (71)

3.6 (6)

<0.001

Never physical activity, %, (n)

1378

15.2 (209)

12.9 (38)

14.2 (50)

14.2 (33)

17.5 (68)

18.5 (20)

0.255

Micro albuminuria, %, (n)

2276

46.8 (1065)

40.1 (190)

42.7 (223)

49.9 (205)

51.0 (346)

52.9 (101)

<0.001

Macro albuminuria, %, (n)

2318

23.5 (544)

23.4 (110)

20.6 (109)

24.6 (103)

24.3 (169)

25.7 (53)

0.478

Angio indication, %, (n)

2752

<0.001

Stable

31.3 (862)

22.6 (129)

27.7 (177)

30.8 (154)

38.7 (311)

38.4 (91)

NSTE-ACS

37.5 (1032)

23.8 (136)

37.2 (238)

41.2 (206)

42.3 (340)

47.3 (112)

STEMI

10.2 (280)

2.1 (12)

17.7 (113)

12.8 (64)

9.6 (77)

5.9 (14)

Chest pain

5.4 (135)

19.1 (109)

1.7 (11)

1.6 (8)

0.7 (6)

0.4 (1)

Silent IHD

2.9 (81)

4.2 (24)

2.7 (17)

3.6 (18)

2.4 (19)

1.3 (3)

Arrhythmia

1.3 (36)

4.5 (26)

0.6 (4)

0.6 (3)

0.2 (2)

0.4 (1)

Valvular

3.6 (98)

8.0 (46)

4.2 (27)

2.4 (12)

1.0 (8)

2.1 (5)

Heart failure

3.6 (100)

7.5 (43)

2.8 (18)

2.8 (14)

2.5 (20)

2.1 (5)

Aorta aneurysm

0 (1)

0.2 (1)

0 (0)

Cardiac arrest

0.4 (10)

0.5 (3)

0.3 (2)

0.4 (2)

0.2 (2)

0.4 (1)

Stent

Numbers, mean, (range), SD

993

1.2 (0–5) SD 0.9

0.3 (0–3) SD 0.7

1.1 (0–4) SD 0.7

1.3 (0–4) SD 0.9

1.3 (0–5) SD 1.1

1.3 (0–5) SD 1.3

<0.001

Complete revascularisation after PCI, %, (n)

876

58.8 (515)

77.8 (7)

90.2 (360)

40.6 (103)

20.7 (36)

22.5 (9)

<0.001

Primary decision after angiography, %, (n)

2698

<0.001

No therapy

9.7 (263)

38.8 (222)

3.2 (20)

1.6 (8)

1.1 (9)

1.8 (4)

Medical

19.5 (525)

39.7 (227)

15.6 (98)

11.1 (54)

14.8 (116)

13.2 (30)

CABG

19.8 (535)

0 (0)

1.4 (9)

11.3 (55)

44.1 (346)

55.1 (125)

PCI

36.2 (976)

3.8 (22)

68.6 (430)

58.2 (284)

25.3 (198)

18.5 (42)

Numbers

All patients

Normal

1-vessel (excl. LM)

2-vessel (excl. LM)

3-vessel (excl. LM)

Left main stem (LM)

p-Value

Angiographic findings %, (n)

2776

20.9 (580)

23.1 (641)

18.1 (503)

29.4 (815)

8.5 (237)

< 0.001

Clinical characteristics

Age, years, mean, (range), SD

2776

58 (19–88) SD 11

53 (19–86) SD 11

56 (25–86) SD 11

58 (32–85) SD 10

60 (34–85) SD 10

63 (37–88) SD 10

<0.001

Male, %, (n)

2776

58.4 (1621)

53.3 (309)

58.5 (375)

56.3 (283)

60.5 (493)

67.9 (161)

0.002

BMI, kg/m², mean, (range), SD

2360

26.4 (15.4–74.5) SD 4.4

26.8 (16.9–74.5) SD 5.3

26.5 (17.3–52.8) SD 4.3

26.5 (16.9–43.5) SD 4.2

26.2 (15.4 –42.5) SD 4.2

26.1 (16.2–40.3) SD 4.1

0.137

Smoker, current, %, (n)

2254

15.0 (339)

14.3 (64)

16.9 (98)

19.0 (80)

13.2 (82)

8.3 (15)

<0.001

Systolic blood pressure, mm Hg, mean, (range), SD

2575

136 (84–220) SD 18

134 (84–200) SD 18

136 (90–214) SD 18

136 (90–210) SD 17

138 (85–220) SD18

137 (100–190) SD 17

0.001

Diastolic blood pressure, mm Hg, mean, (range), SD

2575

73 (40–115) SD 10

74 (40–105) SD 10

73 (50–115) SD10

74 (48–110) SD 10

72 (40–108) SD 10

71 (40–102) SD 10

<0.001

Hypertension, treated, %, (n)

2639

80.4 (2121)

68.7 (375)

80.3 (480)

82.6 (398)

85.5 (671)

86.4 (197)

<0.001

Antihypertensive medication, %, (n)

2766

80.5 (2236)

82.9 (481)

79.7 (511)

80.5 (405)

79.4 (647)

81.0 (192)

0.788

Hyperlipidaemia, treated, %, (n)

2247

68.0 (1528)

60.4 (271)

62.2 (361)

69.9 (290)

74.4 (462)

79.4 (143)

<0.001

Atrial fibrillation, %, (n)

2776

5.2 (144)

6.9 (40)

4.2 (27)

3.0 (15)

5.6 (46)

6.8 (16)

0.025

Previous disease, %, (n)

Myocardialinfarction

2776

38.5 (1069)

15.9 (92)

33.2 (213)

42.5 (214)

51.2 (417)

56.1 (133)

<0.001

Any CAD

2776

58.0 (1610)

31.6 (183)

52.6 (337)

63.6 (320)

72.3 (589)

76.4 (181)

<0.001

Previous PCI

2617

5.8 (153)

2.6 (14)

5.7 (35)

7.1 (34)

7.4 (56)

6.3 (14)

0.022

Previous CABG

2776

10.5 (291)

1.2 (7)

3.0 (19)

5.0 (25)

21.3 (174)

27.8 (66)

<0.001

Previous angina

2776

35.4 (982)

19.8 (115)

28.7 (184)

35.6 (179)

47.5 (387)

49.4 (117)

<0.001

Heart failure

2776

14.9 (414)

11.4 (66)

7.8 (50)

13.5 (68)

21.1 (172)

24.5 (58)

<0.001

Stroke

2776

8.3 (231)

5.7 (33)

6.2 (40)

8.5 (43)

9.9 (81)

14.3 (34)

<0.001

Renal insufficiency

2776

11.0 (306)

12.9 (75)

9.7 (62)

11.7 (59)

11.0 (90)

8.4 (20)

0.266

Peripheral artery disease^a

2776

16.3 (452)

9.1 (53)

10.5 (67)

17.5 (88)

22.3 (182)

26.2 (62)

<0.001

Diabetes-related variables

HbA1c, mmol/mol, mean, (range), SD

2638

66.7 (26–145) SD 14.1

65.6 (29–123) SD 14.8

66.8 (26–145) SD 14.3

67.4 (28–130) SD 13.7

67.2 (33–133) SD 13.5

65.7 (33–110) SD 13.9

0.162

Diabetes duration, years, mean, (range), SD

2776

35 (0–76) SD 14

29 (0–76) SD 14

33 (0–69) SD 14

35 (0–73) SD 14

39 (5–70) SD 13

42 (8–75) SD 14

<0.001

Debute age, years, mean, (range), SD

2776

23 (0–50) SD 13

24 (0–50) SD 14

23 (1–50) SD 13

23 (0–50) SD 13

21 (1–50) SD 13

22 (0–50) SD 14

0.001

Creatinine, µmol/l, mean, (range), SD

2524

121 (24–1013) SD 128

140 (34–1013) SD 177

113 (24–938) SD 114

118 (37–872) SD 117

117 (40–971) SD 107

114 (45–761) SD 96

0.003

LDL, mg/dl, mean, (range), SD

1840

2.7 (0.5–7.3) SD 0.9

2.6 (0.6–6.0) SD 0.8

2.7 (0.9–7.3) SD 0.9

2.7 (0.5–7.3) SD 0.9

2.7 (0.6–6.0) SD 0.9

2.7 (0.7–7.0) SD 0.9

0.275

HDL, mg/dl, mean, (range), SD

1861

1.52 (0.43–3.97) SD 0.49

1.60 (0.43–3.8) SD 0.52

1.53 (0.60–3.40) SD 0.48

1.46 (0.52–2.80) SD 0.45

1.52 (0.64–3.97) SD 0.50

1.45 (0.59–3.56) SD 0.48

0.002

Triglycerides, mg/dl, mean, (range), SD

1859

1.39 (0.30–14.10) SD 1.02

1.27 (0.30–9.60) SD 0.87

1.44 (0.38–11.20), SD 1.11

1.47 (0.30–10.0) SD1.02

1.40 (0.40–13.0) SD 0.96

1.43 (0.40–14.10) SD 1.27

0.064

Retinopathy, %, (n)

2776

66.1 (1836)

60.0 (348)

63.8 (409)

65.8 (331)

71.2 (580)

70.9 (168)

<0.001

Never hypo-glycaemia, %, (n)

596

89.8 (535)

90.6 (126)

93.8 (151)

89.7 (96)

85.0 (119)

87.8 (43)

0.121

Pump, %, (n)

2033

12.2 (248)

17.6 (77)

12.0 (59)

9.7 (35)

12.3 (71)

3.6 (6)

<0.001

Never physical activity, %, (n)

1378

15.2 (209)

12.9 (38)

14.2 (50)

14.2 (33)

17.5 (68)

18.5 (20)

0.255

Micro albuminuria, %, (n)

2276

46.8 (1065)

40.1 (190)

42.7 (223)

49.9 (205)

51.0 (346)

52.9 (101)

<0.001

Macro albuminuria, %, (n)

2318

23.5 (544)

23.4 (110)

20.6 (109)

24.6 (103)

24.3 (169)

25.7 (53)

0.478

Angio indication, %, (n)

2752

<0.001

Stable

31.3 (862)

22.6 (129)

27.7 (177)

30.8 (154)

38.7 (311)

38.4 (91)

NSTE-ACS

37.5 (1032)

23.8 (136)

37.2 (238)

41.2 (206)

42.3 (340)

47.3 (112)

STEMI

10.2 (280)

2.1 (12)

17.7 (113)

12.8 (64)

9.6 (77)

5.9 (14)

Chest pain

5.4 (135)

19.1 (109)

1.7 (11)

1.6 (8)

0.7 (6)

0.4 (1)

Silent IHD

2.9 (81)

4.2 (24)

2.7 (17)

3.6 (18)

2.4 (19)

1.3 (3)

Arrhythmia

1.3 (36)

4.5 (26)

0.6 (4)

0.6 (3)

0.2 (2)

0.4 (1)

Valvular

3.6 (98)

8.0 (46)

4.2 (27)

2.4 (12)

1.0 (8)

2.1 (5)

Heart failure

3.6 (100)

7.5 (43)

2.8 (18)

2.8 (14)

2.5 (20)

2.1 (5)

Aorta aneurysm

0 (1)

0.2 (1)

0 (0)

Cardiac arrest

0.4 (10)

0.5 (3)

0.3 (2)

0.4 (2)

0.2 (2)

0.4 (1)

Stent

Numbers, mean, (range), SD

993

1.2 (0–5) SD 0.9

0.3 (0–3) SD 0.7

1.1 (0–4) SD 0.7

1.3 (0–4) SD 0.9

1.3 (0–5) SD 1.1

1.3 (0–5) SD 1.3

<0.001

Complete revascularisation after PCI, %, (n)

876

58.8 (515)

77.8 (7)

90.2 (360)

40.6 (103)

20.7 (36)

22.5 (9)

<0.001

Primary decision after angiography, %, (n)

2698

<0.001

No therapy

9.7 (263)

38.8 (222)

3.2 (20)

1.6 (8)

1.1 (9)

1.8 (4)

Medical

19.5 (525)

39.7 (227)

15.6 (98)

11.1 (54)

14.8 (116)

13.2 (30)

CABG

19.8 (535)

0 (0)

1.4 (9)

11.3 (55)

44.1 (346)

55.1 (125)

PCI

36.2 (976)

3.8 (22)

68.6 (430)

58.2 (284)

25.3 (198)

18.5 (42)

Table 1.

Open in new tab

Baseline characteristics by affected coronary vessels at the coronary angiogram.

	Numbers	All patients	Normal	1-vessel (excl. LM)	2-vessel (excl. LM)	3-vessel (excl. LM)	Left main stem (LM)	p-Value
Angiographic findings %, (n)	2776		20.9 (580)	23.1 (641)	18.1 (503)	29.4 (815)	8.5 (237)	< 0.001
Clinical characteristics
Age, years, mean, (range), SD	2776	58 (19–88) SD 11	53 (19–86) SD 11	56 (25–86) SD 11	58 (32–85) SD 10	60 (34–85) SD 10	63 (37–88) SD 10	<0.001
Male, %, (n)	2776	58.4 (1621)	53.3 (309)	58.5 (375)	56.3 (283)	60.5 (493)	67.9 (161)	0.002
BMI, kg/m², mean, (range), SD	2360	26.4 (15.4–74.5) SD 4.4	26.8 (16.9–74.5) SD 5.3	26.5 (17.3–52.8) SD 4.3	26.5 (16.9–43.5) SD 4.2	26.2 (15.4 –42.5) SD 4.2	26.1 (16.2–40.3) SD 4.1	0.137
Smoker, current, %, (n)	2254	15.0 (339)	14.3 (64)	16.9 (98)	19.0 (80)	13.2 (82)	8.3 (15)	<0.001
Systolic blood pressure, mm Hg, mean, (range), SD	2575	136 (84–220) SD 18	134 (84–200) SD 18	136 (90–214) SD 18	136 (90–210) SD 17	138 (85–220) SD18	137 (100–190) SD 17	0.001
Diastolic blood pressure, mm Hg, mean, (range), SD	2575	73 (40–115) SD 10	74 (40–105) SD 10	73 (50–115) SD10	74 (48–110) SD 10	72 (40–108) SD 10	71 (40–102) SD 10	<0.001
Hypertension, treated, %, (n)	2639	80.4 (2121)	68.7 (375)	80.3 (480)	82.6 (398)	85.5 (671)	86.4 (197)	<0.001
Antihypertensive medication, %, (n)	2766	80.5 (2236)	82.9 (481)	79.7 (511)	80.5 (405)	79.4 (647)	81.0 (192)	0.788
Hyperlipidaemia, treated, %, (n)	2247	68.0 (1528)	60.4 (271)	62.2 (361)	69.9 (290)	74.4 (462)	79.4 (143)	<0.001
Atrial fibrillation, %, (n)	2776	5.2 (144)	6.9 (40)	4.2 (27)	3.0 (15)	5.6 (46)	6.8 (16)	0.025
Previous disease, %, (n)
Myocardialinfarction	2776	38.5 (1069)	15.9 (92)	33.2 (213)	42.5 (214)	51.2 (417)	56.1 (133)	<0.001
Any CAD	2776	58.0 (1610)	31.6 (183)	52.6 (337)	63.6 (320)	72.3 (589)	76.4 (181)	<0.001
Previous PCI	2617	5.8 (153)	2.6 (14)	5.7 (35)	7.1 (34)	7.4 (56)	6.3 (14)	0.022
Previous CABG	2776	10.5 (291)	1.2 (7)	3.0 (19)	5.0 (25)	21.3 (174)	27.8 (66)	<0.001
Previous angina	2776	35.4 (982)	19.8 (115)	28.7 (184)	35.6 (179)	47.5 (387)	49.4 (117)	<0.001
Heart failure	2776	14.9 (414)	11.4 (66)	7.8 (50)	13.5 (68)	21.1 (172)	24.5 (58)	<0.001
Stroke	2776	8.3 (231)	5.7 (33)	6.2 (40)	8.5 (43)	9.9 (81)	14.3 (34)	<0.001
Renal insufficiency	2776	11.0 (306)	12.9 (75)	9.7 (62)	11.7 (59)	11.0 (90)	8.4 (20)	0.266
Peripheral artery disease^a	2776	16.3 (452)	9.1 (53)	10.5 (67)	17.5 (88)	22.3 (182)	26.2 (62)	<0.001
Diabetes-related variables
HbA1c, mmol/mol, mean, (range), SD	2638	66.7 (26–145) SD 14.1	65.6 (29–123) SD 14.8	66.8 (26–145) SD 14.3	67.4 (28–130) SD 13.7	67.2 (33–133) SD 13.5	65.7 (33–110) SD 13.9	0.162
Diabetes duration, years, mean, (range), SD	2776	35 (0–76) SD 14	29 (0–76) SD 14	33 (0–69) SD 14	35 (0–73) SD 14	39 (5–70) SD 13	42 (8–75) SD 14	<0.001
Debute age, years, mean, (range), SD	2776	23 (0–50) SD 13	24 (0–50) SD 14	23 (1–50) SD 13	23 (0–50) SD 13	21 (1–50) SD 13	22 (0–50) SD 14	0.001
Creatinine, µmol/l, mean, (range), SD	2524	121 (24–1013) SD 128	140 (34–1013) SD 177	113 (24–938) SD 114	118 (37–872) SD 117	117 (40–971) SD 107	114 (45–761) SD 96	0.003
LDL, mg/dl, mean, (range), SD	1840	2.7 (0.5–7.3) SD 0.9	2.6 (0.6–6.0) SD 0.8	2.7 (0.9–7.3) SD 0.9	2.7 (0.5–7.3) SD 0.9	2.7 (0.6–6.0) SD 0.9	2.7 (0.7–7.0) SD 0.9	0.275
HDL, mg/dl, mean, (range), SD	1861	1.52 (0.43–3.97) SD 0.49	1.60 (0.43–3.8) SD 0.52	1.53 (0.60–3.40) SD 0.48	1.46 (0.52–2.80) SD 0.45	1.52 (0.64–3.97) SD 0.50	1.45 (0.59–3.56) SD 0.48	0.002
Triglycerides, mg/dl, mean, (range), SD	1859	1.39 (0.30–14.10) SD 1.02	1.27 (0.30–9.60) SD 0.87	1.44 (0.38–11.20), SD 1.11	1.47 (0.30–10.0) SD1.02	1.40 (0.40–13.0) SD 0.96	1.43 (0.40–14.10) SD 1.27	0.064
Retinopathy, %, (n)	2776	66.1 (1836)	60.0 (348)	63.8 (409)	65.8 (331)	71.2 (580)	70.9 (168)	<0.001
Never hypo-glycaemia, %, (n)	596	89.8 (535)	90.6 (126)	93.8 (151)	89.7 (96)	85.0 (119)	87.8 (43)	0.121
Pump, %, (n)	2033	12.2 (248)	17.6 (77)	12.0 (59)	9.7 (35)	12.3 (71)	3.6 (6)	<0.001
Never physical activity, %, (n)	1378	15.2 (209)	12.9 (38)	14.2 (50)	14.2 (33)	17.5 (68)	18.5 (20)	0.255
Micro albuminuria, %, (n)	2276	46.8 (1065)	40.1 (190)	42.7 (223)	49.9 (205)	51.0 (346)	52.9 (101)	<0.001
Macro albuminuria, %, (n)	2318	23.5 (544)	23.4 (110)	20.6 (109)	24.6 (103)	24.3 (169)	25.7 (53)	0.478
Angio indication, %, (n)	2752							<0.001
Stable		31.3 (862)	22.6 (129)	27.7 (177)	30.8 (154)	38.7 (311)	38.4 (91)
NSTE-ACS		37.5 (1032)	23.8 (136)	37.2 (238)	41.2 (206)	42.3 (340)	47.3 (112)
STEMI		10.2 (280)	2.1 (12)	17.7 (113)	12.8 (64)	9.6 (77)	5.9 (14)
Chest pain		5.4 (135)	19.1 (109)	1.7 (11)	1.6 (8)	0.7 (6)	0.4 (1)
Silent IHD		2.9 (81)	4.2 (24)	2.7 (17)	3.6 (18)	2.4 (19)	1.3 (3)
Arrhythmia		1.3 (36)	4.5 (26)	0.6 (4)	0.6 (3)	0.2 (2)	0.4 (1)
Valvular		3.6 (98)	8.0 (46)	4.2 (27)	2.4 (12)	1.0 (8)	2.1 (5)
Heart failure		3.6 (100)	7.5 (43)	2.8 (18)	2.8 (14)	2.5 (20)	2.1 (5)
Aorta aneurysm		0 (1)	0.2 (1)	0 (0)	0 (0)	0 (0)	0 (0)
Cardiac arrest		0.4 (10)	0.5 (3)	0.3 (2)	0.4 (2)	0.2 (2)	0.4 (1)
Stent
Numbers, mean, (range), SD	993	1.2 (0–5) SD 0.9	0.3 (0–3) SD 0.7	1.1 (0–4) SD 0.7	1.3 (0–4) SD 0.9	1.3 (0–5) SD 1.1	1.3 (0–5) SD 1.3	<0.001
Complete revascularisation after PCI, %, (n)	876	58.8 (515)	77.8 (7)	90.2 (360)	40.6 (103)	20.7 (36)	22.5 (9)	<0.001
Primary decision after angiography, %, (n)	2698							<0.001
No therapy		9.7 (263)	38.8 (222)	3.2 (20)	1.6 (8)	1.1 (9)	1.8 (4)
Medical		19.5 (525)	39.7 (227)	15.6 (98)	11.1 (54)	14.8 (116)	13.2 (30)
CABG		19.8 (535)	0 (0)	1.4 (9)	11.3 (55)	44.1 (346)	55.1 (125)
PCI		36.2 (976)	3.8 (22)	68.6 (430)	58.2 (284)	25.3 (198)	18.5 (42)

	Numbers	All patients	Normal	1-vessel (excl. LM)	2-vessel (excl. LM)	3-vessel (excl. LM)	Left main stem (LM)	p-Value
Angiographic findings %, (n)	2776		20.9 (580)	23.1 (641)	18.1 (503)	29.4 (815)	8.5 (237)	< 0.001
Clinical characteristics
Age, years, mean, (range), SD	2776	58 (19–88) SD 11	53 (19–86) SD 11	56 (25–86) SD 11	58 (32–85) SD 10	60 (34–85) SD 10	63 (37–88) SD 10	<0.001
Male, %, (n)	2776	58.4 (1621)	53.3 (309)	58.5 (375)	56.3 (283)	60.5 (493)	67.9 (161)	0.002
BMI, kg/m², mean, (range), SD	2360	26.4 (15.4–74.5) SD 4.4	26.8 (16.9–74.5) SD 5.3	26.5 (17.3–52.8) SD 4.3	26.5 (16.9–43.5) SD 4.2	26.2 (15.4 –42.5) SD 4.2	26.1 (16.2–40.3) SD 4.1	0.137
Smoker, current, %, (n)	2254	15.0 (339)	14.3 (64)	16.9 (98)	19.0 (80)	13.2 (82)	8.3 (15)	<0.001
Systolic blood pressure, mm Hg, mean, (range), SD	2575	136 (84–220) SD 18	134 (84–200) SD 18	136 (90–214) SD 18	136 (90–210) SD 17	138 (85–220) SD18	137 (100–190) SD 17	0.001
Diastolic blood pressure, mm Hg, mean, (range), SD	2575	73 (40–115) SD 10	74 (40–105) SD 10	73 (50–115) SD10	74 (48–110) SD 10	72 (40–108) SD 10	71 (40–102) SD 10	<0.001
Hypertension, treated, %, (n)	2639	80.4 (2121)	68.7 (375)	80.3 (480)	82.6 (398)	85.5 (671)	86.4 (197)	<0.001
Antihypertensive medication, %, (n)	2766	80.5 (2236)	82.9 (481)	79.7 (511)	80.5 (405)	79.4 (647)	81.0 (192)	0.788
Hyperlipidaemia, treated, %, (n)	2247	68.0 (1528)	60.4 (271)	62.2 (361)	69.9 (290)	74.4 (462)	79.4 (143)	<0.001
Atrial fibrillation, %, (n)	2776	5.2 (144)	6.9 (40)	4.2 (27)	3.0 (15)	5.6 (46)	6.8 (16)	0.025
Previous disease, %, (n)
Myocardialinfarction	2776	38.5 (1069)	15.9 (92)	33.2 (213)	42.5 (214)	51.2 (417)	56.1 (133)	<0.001
Any CAD	2776	58.0 (1610)	31.6 (183)	52.6 (337)	63.6 (320)	72.3 (589)	76.4 (181)	<0.001
Previous PCI	2617	5.8 (153)	2.6 (14)	5.7 (35)	7.1 (34)	7.4 (56)	6.3 (14)	0.022
Previous CABG	2776	10.5 (291)	1.2 (7)	3.0 (19)	5.0 (25)	21.3 (174)	27.8 (66)	<0.001
Previous angina	2776	35.4 (982)	19.8 (115)	28.7 (184)	35.6 (179)	47.5 (387)	49.4 (117)	<0.001
Heart failure	2776	14.9 (414)	11.4 (66)	7.8 (50)	13.5 (68)	21.1 (172)	24.5 (58)	<0.001
Stroke	2776	8.3 (231)	5.7 (33)	6.2 (40)	8.5 (43)	9.9 (81)	14.3 (34)	<0.001
Renal insufficiency	2776	11.0 (306)	12.9 (75)	9.7 (62)	11.7 (59)	11.0 (90)	8.4 (20)	0.266
Peripheral artery disease^a	2776	16.3 (452)	9.1 (53)	10.5 (67)	17.5 (88)	22.3 (182)	26.2 (62)	<0.001
Diabetes-related variables
HbA1c, mmol/mol, mean, (range), SD	2638	66.7 (26–145) SD 14.1	65.6 (29–123) SD 14.8	66.8 (26–145) SD 14.3	67.4 (28–130) SD 13.7	67.2 (33–133) SD 13.5	65.7 (33–110) SD 13.9	0.162
Diabetes duration, years, mean, (range), SD	2776	35 (0–76) SD 14	29 (0–76) SD 14	33 (0–69) SD 14	35 (0–73) SD 14	39 (5–70) SD 13	42 (8–75) SD 14	<0.001
Debute age, years, mean, (range), SD	2776	23 (0–50) SD 13	24 (0–50) SD 14	23 (1–50) SD 13	23 (0–50) SD 13	21 (1–50) SD 13	22 (0–50) SD 14	0.001
Creatinine, µmol/l, mean, (range), SD	2524	121 (24–1013) SD 128	140 (34–1013) SD 177	113 (24–938) SD 114	118 (37–872) SD 117	117 (40–971) SD 107	114 (45–761) SD 96	0.003
LDL, mg/dl, mean, (range), SD	1840	2.7 (0.5–7.3) SD 0.9	2.6 (0.6–6.0) SD 0.8	2.7 (0.9–7.3) SD 0.9	2.7 (0.5–7.3) SD 0.9	2.7 (0.6–6.0) SD 0.9	2.7 (0.7–7.0) SD 0.9	0.275
HDL, mg/dl, mean, (range), SD	1861	1.52 (0.43–3.97) SD 0.49	1.60 (0.43–3.8) SD 0.52	1.53 (0.60–3.40) SD 0.48	1.46 (0.52–2.80) SD 0.45	1.52 (0.64–3.97) SD 0.50	1.45 (0.59–3.56) SD 0.48	0.002
Triglycerides, mg/dl, mean, (range), SD	1859	1.39 (0.30–14.10) SD 1.02	1.27 (0.30–9.60) SD 0.87	1.44 (0.38–11.20), SD 1.11	1.47 (0.30–10.0) SD1.02	1.40 (0.40–13.0) SD 0.96	1.43 (0.40–14.10) SD 1.27	0.064
Retinopathy, %, (n)	2776	66.1 (1836)	60.0 (348)	63.8 (409)	65.8 (331)	71.2 (580)	70.9 (168)	<0.001
Never hypo-glycaemia, %, (n)	596	89.8 (535)	90.6 (126)	93.8 (151)	89.7 (96)	85.0 (119)	87.8 (43)	0.121
Pump, %, (n)	2033	12.2 (248)	17.6 (77)	12.0 (59)	9.7 (35)	12.3 (71)	3.6 (6)	<0.001
Never physical activity, %, (n)	1378	15.2 (209)	12.9 (38)	14.2 (50)	14.2 (33)	17.5 (68)	18.5 (20)	0.255
Micro albuminuria, %, (n)	2276	46.8 (1065)	40.1 (190)	42.7 (223)	49.9 (205)	51.0 (346)	52.9 (101)	<0.001
Macro albuminuria, %, (n)	2318	23.5 (544)	23.4 (110)	20.6 (109)	24.6 (103)	24.3 (169)	25.7 (53)	0.478
Angio indication, %, (n)	2752							<0.001
Stable		31.3 (862)	22.6 (129)	27.7 (177)	30.8 (154)	38.7 (311)	38.4 (91)
NSTE-ACS		37.5 (1032)	23.8 (136)	37.2 (238)	41.2 (206)	42.3 (340)	47.3 (112)
STEMI		10.2 (280)	2.1 (12)	17.7 (113)	12.8 (64)	9.6 (77)	5.9 (14)
Chest pain		5.4 (135)	19.1 (109)	1.7 (11)	1.6 (8)	0.7 (6)	0.4 (1)
Silent IHD		2.9 (81)	4.2 (24)	2.7 (17)	3.6 (18)	2.4 (19)	1.3 (3)
Arrhythmia		1.3 (36)	4.5 (26)	0.6 (4)	0.6 (3)	0.2 (2)	0.4 (1)
Valvular		3.6 (98)	8.0 (46)	4.2 (27)	2.4 (12)	1.0 (8)	2.1 (5)
Heart failure		3.6 (100)	7.5 (43)	2.8 (18)	2.8 (14)	2.5 (20)	2.1 (5)
Aorta aneurysm		0 (1)	0.2 (1)	0 (0)	0 (0)	0 (0)	0 (0)
Cardiac arrest		0.4 (10)	0.5 (3)	0.3 (2)	0.4 (2)	0.2 (2)	0.4 (1)
Stent
Numbers, mean, (range), SD	993	1.2 (0–5) SD 0.9	0.3 (0–3) SD 0.7	1.1 (0–4) SD 0.7	1.3 (0–4) SD 0.9	1.3 (0–5) SD 1.1	1.3 (0–5) SD 1.3	<0.001
Complete revascularisation after PCI, %, (n)	876	58.8 (515)	77.8 (7)	90.2 (360)	40.6 (103)	20.7 (36)	22.5 (9)	<0.001
Primary decision after angiography, %, (n)	2698							<0.001
No therapy		9.7 (263)	38.8 (222)	3.2 (20)	1.6 (8)	1.1 (9)	1.8 (4)
Medical		19.5 (525)	39.7 (227)	15.6 (98)	11.1 (54)	14.8 (116)	13.2 (30)
CABG		19.8 (535)	0 (0)	1.4 (9)	11.3 (55)	44.1 (346)	55.1 (125)
PCI		36.2 (976)	3.8 (22)	68.6 (430)	58.2 (284)	25.3 (198)	18.5 (42)

BMI: body mass index; CAD: coronary artery disease; CABG: coronary artery bypass graft; HbA1c: glycated haemoglobin; IHD: ischaemic heart disease; LM: left main-vessel disease; LDL: low density lipoprotein; HDL: high density lipoprotein; NSTE-ACS: non-ST-elevation acute coronary syndrome; PCI: percutaneous coronary intervention; SD: standard deviation; STEMI: ST-elevation myocardial infarction.

Hospitalisation for.

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