Overview of analytes included as part of biomarker analyses for the African-PREDICT study, Potchefstroom, South Africa, 2013–2017.
| Biomarker laboratory analyses performed in South Africa and in international laboratories |
| Serum: albumin, total protein, liver enzymes, billirubin, uric acid, apolipoprotein A and B, calcium, chloride, cholesterol (high density, low density), triglycerides, creatinine, cystatin C, C-reactive protein, interleukin-6, tumour necrosis factor-α, iron, potassium, magnesium, sodium, phosphate, selenium, urea, cotinine, renin, aldosterone, testosterone, dehydroepiandrosterone sulfate, human sex hormone-binding globulin, cortisol, N-terminal prohormone B-type natriuretic peptide, MB isoenzyme of creatinine kinase, insulin, parathyroid hormone, 25-hydroxyvitamin D, angiotensin-converting enzyme, adiponectin, leptin, glutathione reductase, total antioxidant status, reactive oxygen species (serum peroxides), myeloperoxidase, cellular adhesion molecules, p-selectin, ADAMTS13, growth differentiating factor-15, insulin-like growth factor 1, insulin-like growth factor binding protein-3, tetrahydrobiopterin, renin–angiotensin system-Fingerprint including 10 peptides† |
| Sodium fluoride plasma: glucose |
| Citrated plasma: Von Willbrand factor, plasma clot turbidimetry and lysis |
| Stabilyte plasma: total fibrinogen, γ′ fibrinogen, plasminogen activator inhibitor-1 |
| EDTA plasma: prorenin, monocyte chemotactic protein-1, symmetric and asymmetric dimethylarginines (SDMA, ADMA),† arginine,† homoarginine,† 21-multiplex T-cell inflammatory cytokines† |
| EDTA whole blood: full blood count, blood group, glycated haemoglobin, superoxide dismutase, glutathione peroxidase, total glutathione |
| Spot urine: albumin, creatinine, chloride, sodium, potassium, uromodullin,† trace elements† (among others selenium, palladium, lithium, lead, mercury, cadmium, copper, zinc, iron, manganese), nitrite,† nitrate,† symmetric and asymmetric dimethylarginines (SDMA, ADMA),† dimethylamine,† malondialdehyde.† Omics include proteomics/peptidomics,† metabolomics |
| 24-Hour urine: volume, sodium, potassium (estimated salt intake calculated), chloride, albumin, creatinine, iodine, marinobufagenin† |
| Selected genotyping† |
| Biomarker laboratory analyses performed in South Africa and in international laboratories |
| Serum: albumin, total protein, liver enzymes, billirubin, uric acid, apolipoprotein A and B, calcium, chloride, cholesterol (high density, low density), triglycerides, creatinine, cystatin C, C-reactive protein, interleukin-6, tumour necrosis factor-α, iron, potassium, magnesium, sodium, phosphate, selenium, urea, cotinine, renin, aldosterone, testosterone, dehydroepiandrosterone sulfate, human sex hormone-binding globulin, cortisol, N-terminal prohormone B-type natriuretic peptide, MB isoenzyme of creatinine kinase, insulin, parathyroid hormone, 25-hydroxyvitamin D, angiotensin-converting enzyme, adiponectin, leptin, glutathione reductase, total antioxidant status, reactive oxygen species (serum peroxides), myeloperoxidase, cellular adhesion molecules, p-selectin, ADAMTS13, growth differentiating factor-15, insulin-like growth factor 1, insulin-like growth factor binding protein-3, tetrahydrobiopterin, renin–angiotensin system-Fingerprint including 10 peptides† |
| Sodium fluoride plasma: glucose |
| Citrated plasma: Von Willbrand factor, plasma clot turbidimetry and lysis |
| Stabilyte plasma: total fibrinogen, γ′ fibrinogen, plasminogen activator inhibitor-1 |
| EDTA plasma: prorenin, monocyte chemotactic protein-1, symmetric and asymmetric dimethylarginines (SDMA, ADMA),† arginine,† homoarginine,† 21-multiplex T-cell inflammatory cytokines† |
| EDTA whole blood: full blood count, blood group, glycated haemoglobin, superoxide dismutase, glutathione peroxidase, total glutathione |
| Spot urine: albumin, creatinine, chloride, sodium, potassium, uromodullin,† trace elements† (among others selenium, palladium, lithium, lead, mercury, cadmium, copper, zinc, iron, manganese), nitrite,† nitrate,† symmetric and asymmetric dimethylarginines (SDMA, ADMA),† dimethylamine,† malondialdehyde.† Omics include proteomics/peptidomics,† metabolomics |
| 24-Hour urine: volume, sodium, potassium (estimated salt intake calculated), chloride, albumin, creatinine, iodine, marinobufagenin† |
| Selected genotyping† |
†indicates analyses performed in international laboratories.
Overview of analytes included as part of biomarker analyses for the African-PREDICT study, Potchefstroom, South Africa, 2013–2017.
| Biomarker laboratory analyses performed in South Africa and in international laboratories |
| Serum: albumin, total protein, liver enzymes, billirubin, uric acid, apolipoprotein A and B, calcium, chloride, cholesterol (high density, low density), triglycerides, creatinine, cystatin C, C-reactive protein, interleukin-6, tumour necrosis factor-α, iron, potassium, magnesium, sodium, phosphate, selenium, urea, cotinine, renin, aldosterone, testosterone, dehydroepiandrosterone sulfate, human sex hormone-binding globulin, cortisol, N-terminal prohormone B-type natriuretic peptide, MB isoenzyme of creatinine kinase, insulin, parathyroid hormone, 25-hydroxyvitamin D, angiotensin-converting enzyme, adiponectin, leptin, glutathione reductase, total antioxidant status, reactive oxygen species (serum peroxides), myeloperoxidase, cellular adhesion molecules, p-selectin, ADAMTS13, growth differentiating factor-15, insulin-like growth factor 1, insulin-like growth factor binding protein-3, tetrahydrobiopterin, renin–angiotensin system-Fingerprint including 10 peptides† |
| Sodium fluoride plasma: glucose |
| Citrated plasma: Von Willbrand factor, plasma clot turbidimetry and lysis |
| Stabilyte plasma: total fibrinogen, γ′ fibrinogen, plasminogen activator inhibitor-1 |
| EDTA plasma: prorenin, monocyte chemotactic protein-1, symmetric and asymmetric dimethylarginines (SDMA, ADMA),† arginine,† homoarginine,† 21-multiplex T-cell inflammatory cytokines† |
| EDTA whole blood: full blood count, blood group, glycated haemoglobin, superoxide dismutase, glutathione peroxidase, total glutathione |
| Spot urine: albumin, creatinine, chloride, sodium, potassium, uromodullin,† trace elements† (among others selenium, palladium, lithium, lead, mercury, cadmium, copper, zinc, iron, manganese), nitrite,† nitrate,† symmetric and asymmetric dimethylarginines (SDMA, ADMA),† dimethylamine,† malondialdehyde.† Omics include proteomics/peptidomics,† metabolomics |
| 24-Hour urine: volume, sodium, potassium (estimated salt intake calculated), chloride, albumin, creatinine, iodine, marinobufagenin† |
| Selected genotyping† |
| Biomarker laboratory analyses performed in South Africa and in international laboratories |
| Serum: albumin, total protein, liver enzymes, billirubin, uric acid, apolipoprotein A and B, calcium, chloride, cholesterol (high density, low density), triglycerides, creatinine, cystatin C, C-reactive protein, interleukin-6, tumour necrosis factor-α, iron, potassium, magnesium, sodium, phosphate, selenium, urea, cotinine, renin, aldosterone, testosterone, dehydroepiandrosterone sulfate, human sex hormone-binding globulin, cortisol, N-terminal prohormone B-type natriuretic peptide, MB isoenzyme of creatinine kinase, insulin, parathyroid hormone, 25-hydroxyvitamin D, angiotensin-converting enzyme, adiponectin, leptin, glutathione reductase, total antioxidant status, reactive oxygen species (serum peroxides), myeloperoxidase, cellular adhesion molecules, p-selectin, ADAMTS13, growth differentiating factor-15, insulin-like growth factor 1, insulin-like growth factor binding protein-3, tetrahydrobiopterin, renin–angiotensin system-Fingerprint including 10 peptides† |
| Sodium fluoride plasma: glucose |
| Citrated plasma: Von Willbrand factor, plasma clot turbidimetry and lysis |
| Stabilyte plasma: total fibrinogen, γ′ fibrinogen, plasminogen activator inhibitor-1 |
| EDTA plasma: prorenin, monocyte chemotactic protein-1, symmetric and asymmetric dimethylarginines (SDMA, ADMA),† arginine,† homoarginine,† 21-multiplex T-cell inflammatory cytokines† |
| EDTA whole blood: full blood count, blood group, glycated haemoglobin, superoxide dismutase, glutathione peroxidase, total glutathione |
| Spot urine: albumin, creatinine, chloride, sodium, potassium, uromodullin,† trace elements† (among others selenium, palladium, lithium, lead, mercury, cadmium, copper, zinc, iron, manganese), nitrite,† nitrate,† symmetric and asymmetric dimethylarginines (SDMA, ADMA),† dimethylamine,† malondialdehyde.† Omics include proteomics/peptidomics,† metabolomics |
| 24-Hour urine: volume, sodium, potassium (estimated salt intake calculated), chloride, albumin, creatinine, iodine, marinobufagenin† |
| Selected genotyping† |
†indicates analyses performed in international laboratories.
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