Table 1. Open in new tab Overview of...

Phenotype	EHR data source	Validation evidence
Disease or syndrome
AAA	●	●	●	●		●	●
AMI	●	●	●	●		●	●	●	●
AD	●	●	●	●		●
AF	●	●	●	●		●	●	●
Uveitis	●	●		●
Bleeding	●	●	●	●	●	●	●		●
Bullous disorder	●	●		●		●
CHD	●	●		●		●	●
Depression	●	●		●		●
Diabetes	●	●		●		●
Giant cell arteritis	●	●		●		●
HF	●	●	●	●		●	●
HIV	●	●	●	●		●
Hypertension	●	●		●		●	●
HCM	●	●		●		●
Influenza	●					●
MS	●	●		●		●
PAD	●	●	●	●		●	●
Polymyalgia	●	●		●		●
PBC	●	●		●		●
Psoriasis	●	●		●		●
Dementia NOS	●	●	●	●		●
RA	●	●		●		●
SA	●	●		●		●	●
Intracerebral hemorrhage	●	●	●	●		●	●
Ischemic stroke	●	●	●	●		●	●
SAH	●	●	●	●		●	●
Stroke NOS	●	●	●	●		●	●
SCD	●	●	●	●		●	●
Systemic sclerosis	●	●		●		●
TIA	●	●	●	●		●	●
UCD	●	●	●			●	●
UA	●	●		●		●	●
Vascular dementia	●	●	●	●		●
Obesity	●	●		●		●
Biomarkers
Blood pressure	●					●
Eosinophils	●					●
Heart rate	●					●
Lymphocytes	●					●
Neutrophils	●					●
White blood cells	●					●			●
LDL cholesterol	●					●
HDL cholesterol	●					●
Triglycerides	●					●
BMI	●	●				●
Lifestyle risk factors and other
Alcohol	●					●
Ethnicity	●	●				●
Pregnancy	●	●				●
Sex	●					●
Smoking	●					●
Deprivation	●					●

Phenotype

EHR data source

Validation evidence

Primary care

Secondary care

Death

Cross-source

Case-note review

Prognosis

Etiology

Genetic

Cross-country

Disease or syndrome

AAA

●

AMI

●

Uveitis

●

Bleeding

●

Bullous disorder

●

CHD

●

Depression

●

Diabetes

●

Giant cell arteritis

●

HIV

●

Hypertension

●

HCM

●

Influenza

●

PAD

●

Polymyalgia

●

PBC

●

Psoriasis

●

Dementia NOS

●

Intracerebral hemorrhage

●

Ischemic stroke

●

SAH

●

Stroke NOS

●

SCD

●

Systemic sclerosis

●

TIA

●

UCD

●

Vascular dementia

●

Obesity

●

Biomarkers

Blood pressure

●

Eosinophils

●

Heart rate

●

Lymphocytes

●

Neutrophils

●

White blood cells

●

LDL cholesterol

●

HDL cholesterol

●

Triglycerides

●

BMI

●

Lifestyle risk factors and other

Alcohol

●

Ethnicity

●

Pregnancy

●

Sex

●

Smoking

●

Deprivation

●

Phenotype	EHR data source	Validation evidence
Disease or syndrome
AAA	●	●	●	●		●	●
AMI	●	●	●	●		●	●	●	●
AD	●	●	●	●		●
AF	●	●	●	●		●	●	●
Uveitis	●	●		●
Bleeding	●	●	●	●	●	●	●		●
Bullous disorder	●	●		●		●
CHD	●	●		●		●	●
Depression	●	●		●		●
Diabetes	●	●		●		●
Giant cell arteritis	●	●		●		●
HF	●	●	●	●		●	●
HIV	●	●	●	●		●
Hypertension	●	●		●		●	●
HCM	●	●		●		●
Influenza	●					●
MS	●	●		●		●
PAD	●	●	●	●		●	●
Polymyalgia	●	●		●		●
PBC	●	●		●		●
Psoriasis	●	●		●		●
Dementia NOS	●	●	●	●		●
RA	●	●		●		●
SA	●	●		●		●	●
Intracerebral hemorrhage	●	●	●	●		●	●
Ischemic stroke	●	●	●	●		●	●
SAH	●	●	●	●		●	●
Stroke NOS	●	●	●	●		●	●
SCD	●	●	●	●		●	●
Systemic sclerosis	●	●		●		●
TIA	●	●	●	●		●	●
UCD	●	●	●			●	●
UA	●	●		●		●	●
Vascular dementia	●	●	●	●		●
Obesity	●	●		●		●
Biomarkers
Blood pressure	●					●
Eosinophils	●					●
Heart rate	●					●
Lymphocytes	●					●
Neutrophils	●					●
White blood cells	●					●			●
LDL cholesterol	●					●
HDL cholesterol	●					●
Triglycerides	●					●
BMI	●	●				●
Lifestyle risk factors and other
Alcohol	●					●
Ethnicity	●	●				●
Pregnancy	●	●				●
Sex	●					●
Smoking	●					●
Deprivation	●					●

Table 1.

Open in new tab

Overview of published, peer-reviewed EHR phenotypes derived from the CALIBER platform and the approaches of validation evidence - More information available on the CALIBER Portal https://www.caliberresearch.org/portal/phenotypes

Phenotype	EHR data source			Validation evidence
	Primary care	Secondary care	Death	Cross-source	Case-note review	Prognosis	Etiology	Genetic	Cross-country
Disease or syndrome
AAA	●	●	●	●		●	●
AMI	●	●	●	●		●	●	●	●
AD	●	●	●	●		●
AF	●	●	●	●		●	●	●
Uveitis	●	●		●
Bleeding	●	●	●	●	●	●	●		●
Bullous disorder	●	●		●		●
CHD	●	●		●		●	●
Depression	●	●		●		●
Diabetes	●	●		●		●
Giant cell arteritis	●	●		●		●
HF	●	●	●	●		●	●
HIV	●	●	●	●		●
Hypertension	●	●		●		●	●
HCM	●	●		●		●
Influenza	●					●
MS	●	●		●		●
PAD	●	●	●	●		●	●
Polymyalgia	●	●		●		●
PBC	●	●		●		●
Psoriasis	●	●		●		●
Dementia NOS	●	●	●	●		●
RA	●	●		●		●
SA	●	●		●		●	●
Intracerebral hemorrhage	●	●	●	●		●	●
Ischemic stroke	●	●	●	●		●	●
SAH	●	●	●	●		●	●
Stroke NOS	●	●	●	●		●	●
SCD	●	●	●	●		●	●
Systemic sclerosis	●	●		●		●
TIA	●	●	●	●		●	●
UCD	●	●	●			●	●
UA	●	●		●		●	●
Vascular dementia	●	●	●	●		●
Obesity	●	●		●		●
Biomarkers
Blood pressure	●					●
Eosinophils	●					●
Heart rate	●					●
Lymphocytes	●					●
Neutrophils	●					●
White blood cells	●					●			●
LDL cholesterol	●					●
HDL cholesterol	●					●
Triglycerides	●					●
BMI	●	●				●
Lifestyle risk factors and other
Alcohol	●					●
Ethnicity	●	●				●
Pregnancy	●	●				●
Sex	●					●
Smoking	●					●
Deprivation	●					●

Phenotype	EHR data source			Validation evidence
	Primary care	Secondary care	Death	Cross-source	Case-note review	Prognosis	Etiology	Genetic	Cross-country
Disease or syndrome
AAA	●	●	●	●		●	●
AMI	●	●	●	●		●	●	●	●
AD	●	●	●	●		●
AF	●	●	●	●		●	●	●
Uveitis	●	●		●
Bleeding	●	●	●	●	●	●	●		●
Bullous disorder	●	●		●		●
CHD	●	●		●		●	●
Depression	●	●		●		●
Diabetes	●	●		●		●
Giant cell arteritis	●	●		●		●
HF	●	●	●	●		●	●
HIV	●	●	●	●		●
Hypertension	●	●		●		●	●
HCM	●	●		●		●
Influenza	●					●
MS	●	●		●		●
PAD	●	●	●	●		●	●
Polymyalgia	●	●		●		●
PBC	●	●		●		●
Psoriasis	●	●		●		●
Dementia NOS	●	●	●	●		●
RA	●	●		●		●
SA	●	●		●		●	●
Intracerebral hemorrhage	●	●	●	●		●	●
Ischemic stroke	●	●	●	●		●	●
SAH	●	●	●	●		●	●
Stroke NOS	●	●	●	●		●	●
SCD	●	●	●	●		●	●
Systemic sclerosis	●	●		●		●
TIA	●	●	●	●		●	●
UCD	●	●	●			●	●
UA	●	●		●		●	●
Vascular dementia	●	●	●	●		●
Obesity	●	●		●		●
Biomarkers
Blood pressure	●					●
Eosinophils	●					●
Heart rate	●					●
Lymphocytes	●					●
Neutrophils	●					●
White blood cells	●					●			●
LDL cholesterol	●					●
HDL cholesterol	●					●
Triglycerides	●					●
BMI	●	●				●
Lifestyle risk factors and other
Alcohol	●					●
Ethnicity	●	●				●
Pregnancy	●	●				●
Sex	●					●
Smoking	●					●
Deprivation	●					●

AAA: abdominal aortic aneurysm; AD: Alzheimer’s disease; AF: atrial fibrillation; AMI: acute myocardial infarction; BMI: body mass index; CHD: coronary heart disease; EHR: electronic health record; HCM: hypertrophic cardiomyopathy; HDL: high-density lipoprotein; HF: heart failure; HIV: human immunodeficiency virus; LDL: low-density lipoprotein; MS: multiple sclerosis; NOS: not otherwise specified; PAD: peripheral arterial disease; PBC: primary biliary cirrhosis; RA: rheumatoid arthritis; SA: stable angina; SAH: subarachnoid hemorrhage; SCD: sudden cardiac death; TIA: transient ischemic attack; UA: unstable angina; UCD: unheralded coronary death.

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