Table 3 Open in new tab Clinical...

Parameter	Univariate linear regression	Multivariate linear regression
Donor characteristics
Donor age (per year)	−0.003	0.001	0.006	−0.003	0.001	0.01
Donor gender (female)	0.08	0.04	0.02	0.1	0.04	0.002
Heart beating donor/non-heart beating donor^a	0.02	0.05	0.56
Living donor/deceased donor^a	−0.01	0.06	0.84
History of hypertension	−0.01	0.04	0.02	−0.1	0.04	0.03
History of diabetes mellitus^a	0.20	0.21	0.4
History of smoking^a	−0.002	0.04	0.04
Body mass index^a (kg/m²)	−0.002	0.004	0.57
History of cardiovascular events	−0.11	0.03	0.002	−0.12	0.04	0.001
eGFR (mL/min/1.73 m²)	0.00	0.00	0.57
Recipient characteristics
Recipient age^a (years)	−0.003	0.001	0.05
Recipient gender (female)
CMV disease	−0.06	0.05	0.25
Presence of one or more treated acute rejection episodes after transplantation^a	−0.02	0.04	0.6
Biopsy-proven acute cellular rejection	−0.003	0.03	0.9
Acute antibody-mediated rejection	0.01	0.06	0.8
Delayed graft function^b	−0.08	0.05	0.1
Pretransplant donor-specific antibody presence	0.05	0.05	0.4
Immunosuppressive protocol (CsA-MMF-Cs versus TAC-MMF-Cs)	0.1	0.03	0.02
eGFR 3 months after TX (mL/min/1.73 m²)	0.00	0.00	0.5
eGFR at 1 year after TX (mL/min/1.73 m²)	−0.05	0.04	0.1
eGFR at 2 years after TX (mL/min/1.73 m²)	−0.05	0.03	0.2
eGFR 5 years after TX (mL/min/1.73 m²)	0.00	0.002	0.7
Cold ischaemia time^a	−0.01	0.00	0.07
Cardiovascular events after transplantation^a	−0.05	0.04	0.2
Post-transplant diabetes mellitus^a	−0.03	0.03	0.4

Parameter

Univariate linear regression

Multivariate linear regression

Parameter estimate

Standard error

P-value

Parameter estimate

Standard error

P-value

Donor characteristics

Donor age (per year)

−0.003

0.001

0.006

−0.003

0.001

0.01

Donor gender (female)

0.08

0.04

0.02

0.1

0.04

0.002

Heart beating donor/non-heart beating donor^a

0.02

0.05

0.56

Living donor/deceased donor^a

−0.01

0.06

0.84

History of hypertension

−0.01

0.04

0.02

−0.1

0.04

0.03

History of diabetes mellitus^a

0.20

0.21

0.4

History of smoking^a

−0.002

0.04

Body mass index^a (kg/m²)

−0.002

0.004

0.57

History of cardiovascular events

−0.11

0.03

0.002

−0.12

0.04

0.001

eGFR (mL/min/1.73 m²)

0.00

0.57

Recipient characteristics

Recipient age^a (years)

−0.003

0.001

0.05

Recipient gender (female)

CMV disease

−0.06

0.05

0.25

Presence of one or more treated acute rejection episodes after transplantation^a

−0.02

0.04

0.6

Biopsy-proven acute cellular rejection

−0.003

0.03

0.9

Acute antibody-mediated rejection

0.01

0.06

0.8

Delayed graft function^b

−0.08

0.05

0.1

Pretransplant donor-specific antibody presence

0.05

0.4

Immunosuppressive protocol (CsA-MMF-Cs versus TAC-MMF-Cs)

0.1

0.03

0.02

eGFR 3 months after TX (mL/min/1.73 m²)

0.00

0.5

eGFR at 1 year after TX (mL/min/1.73 m²)

−0.05

0.04

0.1

eGFR at 2 years after TX (mL/min/1.73 m²)

−0.05

0.03

0.2

eGFR 5 years after TX (mL/min/1.73 m²)

0.00

0.002

0.7

Cold ischaemia time^a

−0.01

0.00

0.07

Cardiovascular events after transplantation^a

−0.05

0.04

0.2

Post-transplant diabetes mellitus^a

−0.03

0.03

0.4

Parameter	Univariate linear regression	Multivariate linear regression
Donor characteristics
Donor age (per year)	−0.003	0.001	0.006	−0.003	0.001	0.01
Donor gender (female)	0.08	0.04	0.02	0.1	0.04	0.002
Heart beating donor/non-heart beating donor^a	0.02	0.05	0.56
Living donor/deceased donor^a	−0.01	0.06	0.84
History of hypertension	−0.01	0.04	0.02	−0.1	0.04	0.03
History of diabetes mellitus^a	0.20	0.21	0.4
History of smoking^a	−0.002	0.04	0.04
Body mass index^a (kg/m²)	−0.002	0.004	0.57
History of cardiovascular events	−0.11	0.03	0.002	−0.12	0.04	0.001
eGFR (mL/min/1.73 m²)	0.00	0.00	0.57
Recipient characteristics
Recipient age^a (years)	−0.003	0.001	0.05
Recipient gender (female)
CMV disease	−0.06	0.05	0.25
Presence of one or more treated acute rejection episodes after transplantation^a	−0.02	0.04	0.6
Biopsy-proven acute cellular rejection	−0.003	0.03	0.9
Acute antibody-mediated rejection	0.01	0.06	0.8
Delayed graft function^b	−0.08	0.05	0.1
Pretransplant donor-specific antibody presence	0.05	0.05	0.4
Immunosuppressive protocol (CsA-MMF-Cs versus TAC-MMF-Cs)	0.1	0.03	0.02
eGFR 3 months after TX (mL/min/1.73 m²)	0.00	0.00	0.5
eGFR at 1 year after TX (mL/min/1.73 m²)	−0.05	0.04	0.1
eGFR at 2 years after TX (mL/min/1.73 m²)	−0.05	0.03	0.2
eGFR 5 years after TX (mL/min/1.73 m²)	0.00	0.002	0.7
Cold ischaemia time^a	−0.01	0.00	0.07
Cardiovascular events after transplantation^a	−0.05	0.04	0.2
Post-transplant diabetes mellitus^a	−0.03	0.03	0.4

Table 3

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Clinical determinants of telomere length (log T/S) in 5-year protocol biopsies (n = 134)

Parameter	Univariate linear regression			Multivariate linear regression
Parameter	Parameter estimate	Standard error	P-value	Parameter estimate	Standard error	P-value
Donor characteristics
Donor age (per year)	−0.003	0.001	0.006	−0.003	0.001	0.01
Donor gender (female)	0.08	0.04	0.02	0.1	0.04	0.002
Heart beating donor/non-heart beating donor^a	0.02	0.05	0.56
Living donor/deceased donor^a	−0.01	0.06	0.84
History of hypertension	−0.01	0.04	0.02	−0.1	0.04	0.03
History of diabetes mellitus^a	0.20	0.21	0.4
History of smoking^a	−0.002	0.04	0.04
Body mass index^a (kg/m²)	−0.002	0.004	0.57
History of cardiovascular events	−0.11	0.03	0.002	−0.12	0.04	0.001
eGFR (mL/min/1.73 m²)	0.00	0.00	0.57
Recipient characteristics
Recipient age^a (years)	−0.003	0.001	0.05
Recipient gender (female)
CMV disease	−0.06	0.05	0.25
Presence of one or more treated acute rejection episodes after transplantation^a	−0.02	0.04	0.6
Biopsy-proven acute cellular rejection	−0.003	0.03	0.9
Acute antibody-mediated rejection	0.01	0.06	0.8
Delayed graft function^b	−0.08	0.05	0.1
Pretransplant donor-specific antibody presence	0.05	0.05	0.4
Immunosuppressive protocol (CsA-MMF-Cs versus TAC-MMF-Cs)	0.1	0.03	0.02
eGFR 3 months after TX (mL/min/1.73 m²)	0.00	0.00	0.5
eGFR at 1 year after TX (mL/min/1.73 m²)	−0.05	0.04	0.1
eGFR at 2 years after TX (mL/min/1.73 m²)	−0.05	0.03	0.2
eGFR 5 years after TX (mL/min/1.73 m²)	0.00	0.002	0.7
Cold ischaemia time^a	−0.01	0.00	0.07
Cardiovascular events after transplantation^a	−0.05	0.04	0.2
Post-transplant diabetes mellitus^a	−0.03	0.03	0.4

Parameter	Univariate linear regression			Multivariate linear regression
Parameter	Parameter estimate	Standard error	P-value	Parameter estimate	Standard error	P-value
Donor characteristics
Donor age (per year)	−0.003	0.001	0.006	−0.003	0.001	0.01
Donor gender (female)	0.08	0.04	0.02	0.1	0.04	0.002
Heart beating donor/non-heart beating donor^a	0.02	0.05	0.56
Living donor/deceased donor^a	−0.01	0.06	0.84
History of hypertension	−0.01	0.04	0.02	−0.1	0.04	0.03
History of diabetes mellitus^a	0.20	0.21	0.4
History of smoking^a	−0.002	0.04	0.04
Body mass index^a (kg/m²)	−0.002	0.004	0.57
History of cardiovascular events	−0.11	0.03	0.002	−0.12	0.04	0.001
eGFR (mL/min/1.73 m²)	0.00	0.00	0.57
Recipient characteristics
Recipient age^a (years)	−0.003	0.001	0.05
Recipient gender (female)
CMV disease	−0.06	0.05	0.25
Presence of one or more treated acute rejection episodes after transplantation^a	−0.02	0.04	0.6
Biopsy-proven acute cellular rejection	−0.003	0.03	0.9
Acute antibody-mediated rejection	0.01	0.06	0.8
Delayed graft function^b	−0.08	0.05	0.1
Pretransplant donor-specific antibody presence	0.05	0.05	0.4
Immunosuppressive protocol (CsA-MMF-Cs versus TAC-MMF-Cs)	0.1	0.03	0.02
eGFR 3 months after TX (mL/min/1.73 m²)	0.00	0.00	0.5
eGFR at 1 year after TX (mL/min/1.73 m²)	−0.05	0.04	0.1
eGFR at 2 years after TX (mL/min/1.73 m²)	−0.05	0.03	0.2
eGFR 5 years after TX (mL/min/1.73 m²)	0.00	0.002	0.7
Cold ischaemia time^a	−0.01	0.00	0.07
Cardiovascular events after transplantation^a	−0.05	0.04	0.2
Post-transplant diabetes mellitus^a	−0.03	0.03	0.4

Univariate analyses were assessed by linear regression. Multiple linear regression, with backward parameter selection, was used to model the determinants of telomere length. Effect sizes (SE) express the change in log T/S ratio associated with given changes in parameters.

These parameters were included in the multivariate models but were not retained in the final model after backward parameter selection.

^bThis is defined as the need for dialysis within the first 7 days after transplantation.

CsA, cyclosporine; Cs, corticosteroids; TAC, tacrolimus; TX: transplantation.

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