C-Index of eGFR and proteinuria at 3, 6 and 12 months for the risk of death-censored graft failure
| . | C-index (95% CI) . | P-value . |
|---|---|---|
| eGFR variables | ||
| 3-month eGFR (linear) | 62.6 (57.2–68.1) | <0.0001 |
| 3-month eGFR (splines) | 63.5 (58.2–68.9) | <0.0001 |
| 3-month eGFR (<45) | 59.9 (55.6–64.2) | <0.0001 |
| 6-month eGFR (linear) | 60.3 (54.6–66.0) | 0.0004 |
| 6-month eGFR (splines) | 60.0 (54.0–66.0) | 0.001 |
| 6-month eGFR (<45) | 57.2 (52.6–61.8) | 0.002 |
| 12-month eGFR (linear) | 66.0 (60.1–71.9) | <0.0001 |
| 12-month eGFR (splines) | 67.3 (61.5–73.1) | <0.0001 |
| 12-month eGFR (<45) | 61.3 (56.8–65.8) | <0.0001 |
| Proteinuria variables | ||
| 3-month proteinuria (linear) | 68.4 (63.5–73.4) | <0.0001 |
| 3-month proteinuria (splines) | 68.4 (63.5–73.4) | <0.0001 |
| 3-month proteinuria (>0.5) | 59.5 (55.0–64.0) | <0.0001 |
| 6-month proteinuria (linear) | 70.9 (65.5–76.4) | <0.0001 |
| 6-month proteinuria (splines) | 70.9 (65.5–76.4) | <0.0001 |
| 6-month proteinuria (>0.5) | 63.7 (58.8–68.6) | <0.0001 |
| 12-month proteinuria (linear) | 73.0 (67.9–78.0) | <0.0001 |
| 12-month proteinuria (splines) | 73.0 (67.9–78.0) | <0.0001 |
| 12-month proteinuria (>0.5) | 65.6 (60.7–70.5) | <0.0001 |
| eGFR and proteinuria variables | ||
| 3-month eGFR and proteinuria (linear) | 65.5 (59.7–71.2) | <0.0001 |
| 3-month eGFR and proteinuria (splines) | 70.8 (65.6–75.9) | <0.0001 |
| 3-month eGFR and proteinuria (<45 and >0.5) | 64.7 (59.7–69.7) | <0.0001 |
| 3-month eGFR and proteinuria (3 categoriesa) | 64.1 (59.1–69.0) | <0.0001 |
| 6-month eGFR and proteinuria (linear) | 65.3 (59.2–71.5) | <0.0001 |
| 6-month eGFR and proteinuria (splines) | 71.3 (65.7–76.9) | <0.0001 |
| 6-month eGFR and proteinuria (<45 and >0.5) | 65.1 (59.3–70.9) | <0.0001 |
| 6-month eGFR and proteinuria (3 categoriesa) | 64.2 (58.5–69.9) | <0.0001 |
| 12-month eGFR and proteinuria (linear) | 71.1 (65.2–77.0) | <0.0001 |
| 12-month eGFR and proteinuria (splines) | 74.8 (69.5–80.0) | <0.0001 |
| 12-month eGFR and proteinuria (<45 and >0.5) | 70.2 (64.9–75.4) | <0.0001 |
| 12-month eGFR and proteinuria (3 categoriesa) | 69.4 (64.3–74.5) | <0.0001 |
| . | C-index (95% CI) . | P-value . |
|---|---|---|
| eGFR variables | ||
| 3-month eGFR (linear) | 62.6 (57.2–68.1) | <0.0001 |
| 3-month eGFR (splines) | 63.5 (58.2–68.9) | <0.0001 |
| 3-month eGFR (<45) | 59.9 (55.6–64.2) | <0.0001 |
| 6-month eGFR (linear) | 60.3 (54.6–66.0) | 0.0004 |
| 6-month eGFR (splines) | 60.0 (54.0–66.0) | 0.001 |
| 6-month eGFR (<45) | 57.2 (52.6–61.8) | 0.002 |
| 12-month eGFR (linear) | 66.0 (60.1–71.9) | <0.0001 |
| 12-month eGFR (splines) | 67.3 (61.5–73.1) | <0.0001 |
| 12-month eGFR (<45) | 61.3 (56.8–65.8) | <0.0001 |
| Proteinuria variables | ||
| 3-month proteinuria (linear) | 68.4 (63.5–73.4) | <0.0001 |
| 3-month proteinuria (splines) | 68.4 (63.5–73.4) | <0.0001 |
| 3-month proteinuria (>0.5) | 59.5 (55.0–64.0) | <0.0001 |
| 6-month proteinuria (linear) | 70.9 (65.5–76.4) | <0.0001 |
| 6-month proteinuria (splines) | 70.9 (65.5–76.4) | <0.0001 |
| 6-month proteinuria (>0.5) | 63.7 (58.8–68.6) | <0.0001 |
| 12-month proteinuria (linear) | 73.0 (67.9–78.0) | <0.0001 |
| 12-month proteinuria (splines) | 73.0 (67.9–78.0) | <0.0001 |
| 12-month proteinuria (>0.5) | 65.6 (60.7–70.5) | <0.0001 |
| eGFR and proteinuria variables | ||
| 3-month eGFR and proteinuria (linear) | 65.5 (59.7–71.2) | <0.0001 |
| 3-month eGFR and proteinuria (splines) | 70.8 (65.6–75.9) | <0.0001 |
| 3-month eGFR and proteinuria (<45 and >0.5) | 64.7 (59.7–69.7) | <0.0001 |
| 3-month eGFR and proteinuria (3 categoriesa) | 64.1 (59.1–69.0) | <0.0001 |
| 6-month eGFR and proteinuria (linear) | 65.3 (59.2–71.5) | <0.0001 |
| 6-month eGFR and proteinuria (splines) | 71.3 (65.7–76.9) | <0.0001 |
| 6-month eGFR and proteinuria (<45 and >0.5) | 65.1 (59.3–70.9) | <0.0001 |
| 6-month eGFR and proteinuria (3 categoriesa) | 64.2 (58.5–69.9) | <0.0001 |
| 12-month eGFR and proteinuria (linear) | 71.1 (65.2–77.0) | <0.0001 |
| 12-month eGFR and proteinuria (splines) | 74.8 (69.5–80.0) | <0.0001 |
| 12-month eGFR and proteinuria (<45 and >0.5) | 70.2 (64.9–75.4) | <0.0001 |
| 12-month eGFR and proteinuria (3 categoriesa) | 69.4 (64.3–74.5) | <0.0001 |
C-indices were calculated from Cox models. When the term ‘linear’ is specified in parentheses, the biological parameter was considered as a continuous variable at the original scale. When the term ‘splines’ is specified, the biological parameter was modelled using a restricted cubic spline with three knots located at the 10th, 50th and 90th percentiles (i.e. one linear component and one cubic component). When a threshold value is specified, the biological parameter was considered as a binary variable.
eGFR > 45 and proteinuria < 0.5 versus eGFR > 45 and proteinuria > 0.5 OR = eGFR < 45 and proteinuria < 0.5 versus eGFR < 45 and proteinuria > 0.5.
C-Index of eGFR and proteinuria at 3, 6 and 12 months for the risk of death-censored graft failure
| . | C-index (95% CI) . | P-value . |
|---|---|---|
| eGFR variables | ||
| 3-month eGFR (linear) | 62.6 (57.2–68.1) | <0.0001 |
| 3-month eGFR (splines) | 63.5 (58.2–68.9) | <0.0001 |
| 3-month eGFR (<45) | 59.9 (55.6–64.2) | <0.0001 |
| 6-month eGFR (linear) | 60.3 (54.6–66.0) | 0.0004 |
| 6-month eGFR (splines) | 60.0 (54.0–66.0) | 0.001 |
| 6-month eGFR (<45) | 57.2 (52.6–61.8) | 0.002 |
| 12-month eGFR (linear) | 66.0 (60.1–71.9) | <0.0001 |
| 12-month eGFR (splines) | 67.3 (61.5–73.1) | <0.0001 |
| 12-month eGFR (<45) | 61.3 (56.8–65.8) | <0.0001 |
| Proteinuria variables | ||
| 3-month proteinuria (linear) | 68.4 (63.5–73.4) | <0.0001 |
| 3-month proteinuria (splines) | 68.4 (63.5–73.4) | <0.0001 |
| 3-month proteinuria (>0.5) | 59.5 (55.0–64.0) | <0.0001 |
| 6-month proteinuria (linear) | 70.9 (65.5–76.4) | <0.0001 |
| 6-month proteinuria (splines) | 70.9 (65.5–76.4) | <0.0001 |
| 6-month proteinuria (>0.5) | 63.7 (58.8–68.6) | <0.0001 |
| 12-month proteinuria (linear) | 73.0 (67.9–78.0) | <0.0001 |
| 12-month proteinuria (splines) | 73.0 (67.9–78.0) | <0.0001 |
| 12-month proteinuria (>0.5) | 65.6 (60.7–70.5) | <0.0001 |
| eGFR and proteinuria variables | ||
| 3-month eGFR and proteinuria (linear) | 65.5 (59.7–71.2) | <0.0001 |
| 3-month eGFR and proteinuria (splines) | 70.8 (65.6–75.9) | <0.0001 |
| 3-month eGFR and proteinuria (<45 and >0.5) | 64.7 (59.7–69.7) | <0.0001 |
| 3-month eGFR and proteinuria (3 categoriesa) | 64.1 (59.1–69.0) | <0.0001 |
| 6-month eGFR and proteinuria (linear) | 65.3 (59.2–71.5) | <0.0001 |
| 6-month eGFR and proteinuria (splines) | 71.3 (65.7–76.9) | <0.0001 |
| 6-month eGFR and proteinuria (<45 and >0.5) | 65.1 (59.3–70.9) | <0.0001 |
| 6-month eGFR and proteinuria (3 categoriesa) | 64.2 (58.5–69.9) | <0.0001 |
| 12-month eGFR and proteinuria (linear) | 71.1 (65.2–77.0) | <0.0001 |
| 12-month eGFR and proteinuria (splines) | 74.8 (69.5–80.0) | <0.0001 |
| 12-month eGFR and proteinuria (<45 and >0.5) | 70.2 (64.9–75.4) | <0.0001 |
| 12-month eGFR and proteinuria (3 categoriesa) | 69.4 (64.3–74.5) | <0.0001 |
| . | C-index (95% CI) . | P-value . |
|---|---|---|
| eGFR variables | ||
| 3-month eGFR (linear) | 62.6 (57.2–68.1) | <0.0001 |
| 3-month eGFR (splines) | 63.5 (58.2–68.9) | <0.0001 |
| 3-month eGFR (<45) | 59.9 (55.6–64.2) | <0.0001 |
| 6-month eGFR (linear) | 60.3 (54.6–66.0) | 0.0004 |
| 6-month eGFR (splines) | 60.0 (54.0–66.0) | 0.001 |
| 6-month eGFR (<45) | 57.2 (52.6–61.8) | 0.002 |
| 12-month eGFR (linear) | 66.0 (60.1–71.9) | <0.0001 |
| 12-month eGFR (splines) | 67.3 (61.5–73.1) | <0.0001 |
| 12-month eGFR (<45) | 61.3 (56.8–65.8) | <0.0001 |
| Proteinuria variables | ||
| 3-month proteinuria (linear) | 68.4 (63.5–73.4) | <0.0001 |
| 3-month proteinuria (splines) | 68.4 (63.5–73.4) | <0.0001 |
| 3-month proteinuria (>0.5) | 59.5 (55.0–64.0) | <0.0001 |
| 6-month proteinuria (linear) | 70.9 (65.5–76.4) | <0.0001 |
| 6-month proteinuria (splines) | 70.9 (65.5–76.4) | <0.0001 |
| 6-month proteinuria (>0.5) | 63.7 (58.8–68.6) | <0.0001 |
| 12-month proteinuria (linear) | 73.0 (67.9–78.0) | <0.0001 |
| 12-month proteinuria (splines) | 73.0 (67.9–78.0) | <0.0001 |
| 12-month proteinuria (>0.5) | 65.6 (60.7–70.5) | <0.0001 |
| eGFR and proteinuria variables | ||
| 3-month eGFR and proteinuria (linear) | 65.5 (59.7–71.2) | <0.0001 |
| 3-month eGFR and proteinuria (splines) | 70.8 (65.6–75.9) | <0.0001 |
| 3-month eGFR and proteinuria (<45 and >0.5) | 64.7 (59.7–69.7) | <0.0001 |
| 3-month eGFR and proteinuria (3 categoriesa) | 64.1 (59.1–69.0) | <0.0001 |
| 6-month eGFR and proteinuria (linear) | 65.3 (59.2–71.5) | <0.0001 |
| 6-month eGFR and proteinuria (splines) | 71.3 (65.7–76.9) | <0.0001 |
| 6-month eGFR and proteinuria (<45 and >0.5) | 65.1 (59.3–70.9) | <0.0001 |
| 6-month eGFR and proteinuria (3 categoriesa) | 64.2 (58.5–69.9) | <0.0001 |
| 12-month eGFR and proteinuria (linear) | 71.1 (65.2–77.0) | <0.0001 |
| 12-month eGFR and proteinuria (splines) | 74.8 (69.5–80.0) | <0.0001 |
| 12-month eGFR and proteinuria (<45 and >0.5) | 70.2 (64.9–75.4) | <0.0001 |
| 12-month eGFR and proteinuria (3 categoriesa) | 69.4 (64.3–74.5) | <0.0001 |
C-indices were calculated from Cox models. When the term ‘linear’ is specified in parentheses, the biological parameter was considered as a continuous variable at the original scale. When the term ‘splines’ is specified, the biological parameter was modelled using a restricted cubic spline with three knots located at the 10th, 50th and 90th percentiles (i.e. one linear component and one cubic component). When a threshold value is specified, the biological parameter was considered as a binary variable.
eGFR > 45 and proteinuria < 0.5 versus eGFR > 45 and proteinuria > 0.5 OR = eGFR < 45 and proteinuria < 0.5 versus eGFR < 45 and proteinuria > 0.5.
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