Table 4.
Open in new tab

Association of 3-, 6- and 12-month eGFR and proteinuria with death-censored graft failure

Univariable
Adjusted
HR (95% CI)P-valueHR (95% CI)P-value
eGFR variables
 3 months
  For 10 mL/min/1.73 m² increase0.76 (0.67–0.85)<0.00010.80 (0.70–0.92)0.001
<0.0001<0.0001
  >60 mL/min/1.73 m² (reference)1.00–1.00–
  45–600.83 (0.51–1.36)0.460.83 (0.50–1.38)0.47
  30–451.29 (0.82–2.03)0.271.14 (0.68–1.91)0.63
  <304.60 (2.78–7.62)<0.00013.65 (2.00–6.65)<0.0001
  <45 mL/min/1.73 m21.98 (1.42–2.74)<0.00011.66 (1.14–2.40)0.008
 6 months
  For 10 mL/min/1.73 m² increase0.80 (0.71–0.91)0.00040.84 (0.74–0.97)0.013
–<0.0001–<0.0001
  >60 mL/min/1.73 m² (reference)1.00–1.00–
  45–600.88 (0.53–1.43)0.600.88 (0.53–1.47)0.63
  30–451.15 (0.72–1.85)0.551.10 (0.66–1.85)0.71
  <303.88 (2.31–6.53)<0.00013.27 (1.76–6.06)0.0002
  <45 mL/min/1.73 m21.73 (1.23–2.43)0.0021.51 (1.04–2.20)0.031
 12 months
  For 10 mL/min/1.73 m² increase0.67 (0.59–0.77)<0.00010.69 (0.60–0.80)<0.0001
–<0.0001–<0.0001
  >60 mL/min/1.73 m² (reference)1.00–1.00–
  45–601.03 (0.60–1.77)0.901.08 (0.62–1.87)0.78
  30–451.46 (0.87–2.45)0.161.41 (0.81–2.47)0.22
  <307.12 (4.13–12.28)<0.00016.86 (3.72–12.67)<0.0001
  <45 mL/min/1.73 m22.21 (1.55–3.13)<0.00011.95 (1.33–2.86)0.0006
Proteinuria variables
 3 months
  For 1 g/day increase1.24 (1.14–1.34)<0.00011.25 (1.14–1.36)<0.0001
–<0.0001–<0.0001
  <0.5 g/day (reference)1.00–1.00–
  0.5–11.89 (1.14–3.12)0.0131.78 (1.06–2.98)0.028
  1–23.64 (1.93–6.87)<0.00012.85 (1.45–5.58)0.002
  >25.31 (2.81–10.02)<0.00014.89 (2.56–9.33)<0.0001
  >0.5 g/day2.69 (1.84–3.94)<0.00012.45 (1.65–3.63)<0.0001
 6 months
  For 1 g/day increase1.41 (1.27–1.57)<0.00011.42 (1.27–1.59)<0.0001
–<0.0001–<0.0001
  <0.5 g/day (reference)1.00–1.00–
  0.5–12.70 (1.63–4.49)0.00012.53 (1.51–4.25)0.0004
  1–27.51 (4.35–12.94)<0.00016.33 (3.61–11.09)<0.0001
  >23.46 (1.49–8.04)0.0043.55 (1.51–8.37)0.004
  >0.5 g/day3.85 (2.59–5.72)<0.00013.56 (2.38–5.34)<0.0001
 12 months
  For 1 g/day increase1.60 (1.43–1.79)<0.00011.57 (1.38–1.77)<0.0001
–<0.0001–<0.0001
  <0.5 g/day (reference)1.00–1.00–
  0.5–13.13 (1.92–5.11)<0.00012.56 (1.53–4.31)0.0004
  1–24.98 (2.86–8.69)<0.00014.34 (2.45–7.70)<0.0001
  >27.29 (3.72–14.30)<0.00015.87 (2.91–11.81)<0.0001
  >0.5 g/day4.04 (2.75–5.92)<0.00013.39 (2.25–5.11)<0.0001
Univariable
Adjusted
HR (95% CI)P-valueHR (95% CI)P-value
eGFR variables
 3 months
  For 10 mL/min/1.73 m² increase0.76 (0.67–0.85)<0.00010.80 (0.70–0.92)0.001
<0.0001<0.0001
  >60 mL/min/1.73 m² (reference)1.00–1.00–
  45–600.83 (0.51–1.36)0.460.83 (0.50–1.38)0.47
  30–451.29 (0.82–2.03)0.271.14 (0.68–1.91)0.63
  <304.60 (2.78–7.62)<0.00013.65 (2.00–6.65)<0.0001
  <45 mL/min/1.73 m21.98 (1.42–2.74)<0.00011.66 (1.14–2.40)0.008
 6 months
  For 10 mL/min/1.73 m² increase0.80 (0.71–0.91)0.00040.84 (0.74–0.97)0.013
–<0.0001–<0.0001
  >60 mL/min/1.73 m² (reference)1.00–1.00–
  45–600.88 (0.53–1.43)0.600.88 (0.53–1.47)0.63
  30–451.15 (0.72–1.85)0.551.10 (0.66–1.85)0.71
  <303.88 (2.31–6.53)<0.00013.27 (1.76–6.06)0.0002
  <45 mL/min/1.73 m21.73 (1.23–2.43)0.0021.51 (1.04–2.20)0.031
 12 months
  For 10 mL/min/1.73 m² increase0.67 (0.59–0.77)<0.00010.69 (0.60–0.80)<0.0001
–<0.0001–<0.0001
  >60 mL/min/1.73 m² (reference)1.00–1.00–
  45–601.03 (0.60–1.77)0.901.08 (0.62–1.87)0.78
  30–451.46 (0.87–2.45)0.161.41 (0.81–2.47)0.22
  <307.12 (4.13–12.28)<0.00016.86 (3.72–12.67)<0.0001
  <45 mL/min/1.73 m22.21 (1.55–3.13)<0.00011.95 (1.33–2.86)0.0006
Proteinuria variables
 3 months
  For 1 g/day increase1.24 (1.14–1.34)<0.00011.25 (1.14–1.36)<0.0001
–<0.0001–<0.0001
  <0.5 g/day (reference)1.00–1.00–
  0.5–11.89 (1.14–3.12)0.0131.78 (1.06–2.98)0.028
  1–23.64 (1.93–6.87)<0.00012.85 (1.45–5.58)0.002
  >25.31 (2.81–10.02)<0.00014.89 (2.56–9.33)<0.0001
  >0.5 g/day2.69 (1.84–3.94)<0.00012.45 (1.65–3.63)<0.0001
 6 months
  For 1 g/day increase1.41 (1.27–1.57)<0.00011.42 (1.27–1.59)<0.0001
–<0.0001–<0.0001
  <0.5 g/day (reference)1.00–1.00–
  0.5–12.70 (1.63–4.49)0.00012.53 (1.51–4.25)0.0004
  1–27.51 (4.35–12.94)<0.00016.33 (3.61–11.09)<0.0001
  >23.46 (1.49–8.04)0.0043.55 (1.51–8.37)0.004
  >0.5 g/day3.85 (2.59–5.72)<0.00013.56 (2.38–5.34)<0.0001
 12 months
  For 1 g/day increase1.60 (1.43–1.79)<0.00011.57 (1.38–1.77)<0.0001
–<0.0001–<0.0001
  <0.5 g/day (reference)1.00–1.00–
  0.5–13.13 (1.92–5.11)<0.00012.56 (1.53–4.31)0.0004
  1–24.98 (2.86–8.69)<0.00014.34 (2.45–7.70)<0.0001
  >27.29 (3.72–14.30)<0.00015.87 (2.91–11.81)<0.0001
  >0.5 g/day4.04 (2.75–5.92)<0.00013.39 (2.25–5.11)<0.0001

Models were adjusted for recipient age, history of heart failure, donor type, DGF, immunization, HLA incompatibilities, induction treatment and graft rejection (prior to the considered variable, i.e. prior to 3, 6 or 12 months).

Table 4.
Open in new tab

Association of 3-, 6- and 12-month eGFR and proteinuria with death-censored graft failure

Univariable
Adjusted
HR (95% CI)P-valueHR (95% CI)P-value
eGFR variables
 3 months
  For 10 mL/min/1.73 m² increase0.76 (0.67–0.85)<0.00010.80 (0.70–0.92)0.001
<0.0001<0.0001
  >60 mL/min/1.73 m² (reference)1.00–1.00–
  45–600.83 (0.51–1.36)0.460.83 (0.50–1.38)0.47
  30–451.29 (0.82–2.03)0.271.14 (0.68–1.91)0.63
  <304.60 (2.78–7.62)<0.00013.65 (2.00–6.65)<0.0001
  <45 mL/min/1.73 m21.98 (1.42–2.74)<0.00011.66 (1.14–2.40)0.008
 6 months
  For 10 mL/min/1.73 m² increase0.80 (0.71–0.91)0.00040.84 (0.74–0.97)0.013
–<0.0001–<0.0001
  >60 mL/min/1.73 m² (reference)1.00–1.00–
  45–600.88 (0.53–1.43)0.600.88 (0.53–1.47)0.63
  30–451.15 (0.72–1.85)0.551.10 (0.66–1.85)0.71
  <303.88 (2.31–6.53)<0.00013.27 (1.76–6.06)0.0002
  <45 mL/min/1.73 m21.73 (1.23–2.43)0.0021.51 (1.04–2.20)0.031
 12 months
  For 10 mL/min/1.73 m² increase0.67 (0.59–0.77)<0.00010.69 (0.60–0.80)<0.0001
–<0.0001–<0.0001
  >60 mL/min/1.73 m² (reference)1.00–1.00–
  45–601.03 (0.60–1.77)0.901.08 (0.62–1.87)0.78
  30–451.46 (0.87–2.45)0.161.41 (0.81–2.47)0.22
  <307.12 (4.13–12.28)<0.00016.86 (3.72–12.67)<0.0001
  <45 mL/min/1.73 m22.21 (1.55–3.13)<0.00011.95 (1.33–2.86)0.0006
Proteinuria variables
 3 months
  For 1 g/day increase1.24 (1.14–1.34)<0.00011.25 (1.14–1.36)<0.0001
–<0.0001–<0.0001
  <0.5 g/day (reference)1.00–1.00–
  0.5–11.89 (1.14–3.12)0.0131.78 (1.06–2.98)0.028
  1–23.64 (1.93–6.87)<0.00012.85 (1.45–5.58)0.002
  >25.31 (2.81–10.02)<0.00014.89 (2.56–9.33)<0.0001
  >0.5 g/day2.69 (1.84–3.94)<0.00012.45 (1.65–3.63)<0.0001
 6 months
  For 1 g/day increase1.41 (1.27–1.57)<0.00011.42 (1.27–1.59)<0.0001
–<0.0001–<0.0001
  <0.5 g/day (reference)1.00–1.00–
  0.5–12.70 (1.63–4.49)0.00012.53 (1.51–4.25)0.0004
  1–27.51 (4.35–12.94)<0.00016.33 (3.61–11.09)<0.0001
  >23.46 (1.49–8.04)0.0043.55 (1.51–8.37)0.004
  >0.5 g/day3.85 (2.59–5.72)<0.00013.56 (2.38–5.34)<0.0001
 12 months
  For 1 g/day increase1.60 (1.43–1.79)<0.00011.57 (1.38–1.77)<0.0001
–<0.0001–<0.0001
  <0.5 g/day (reference)1.00–1.00–
  0.5–13.13 (1.92–5.11)<0.00012.56 (1.53–4.31)0.0004
  1–24.98 (2.86–8.69)<0.00014.34 (2.45–7.70)<0.0001
  >27.29 (3.72–14.30)<0.00015.87 (2.91–11.81)<0.0001
  >0.5 g/day4.04 (2.75–5.92)<0.00013.39 (2.25–5.11)<0.0001
Univariable
Adjusted
HR (95% CI)P-valueHR (95% CI)P-value
eGFR variables
 3 months
  For 10 mL/min/1.73 m² increase0.76 (0.67–0.85)<0.00010.80 (0.70–0.92)0.001
<0.0001<0.0001
  >60 mL/min/1.73 m² (reference)1.00–1.00–
  45–600.83 (0.51–1.36)0.460.83 (0.50–1.38)0.47
  30–451.29 (0.82–2.03)0.271.14 (0.68–1.91)0.63
  <304.60 (2.78–7.62)<0.00013.65 (2.00–6.65)<0.0001
  <45 mL/min/1.73 m21.98 (1.42–2.74)<0.00011.66 (1.14–2.40)0.008
 6 months
  For 10 mL/min/1.73 m² increase0.80 (0.71–0.91)0.00040.84 (0.74–0.97)0.013
–<0.0001–<0.0001
  >60 mL/min/1.73 m² (reference)1.00–1.00–
  45–600.88 (0.53–1.43)0.600.88 (0.53–1.47)0.63
  30–451.15 (0.72–1.85)0.551.10 (0.66–1.85)0.71
  <303.88 (2.31–6.53)<0.00013.27 (1.76–6.06)0.0002
  <45 mL/min/1.73 m21.73 (1.23–2.43)0.0021.51 (1.04–2.20)0.031
 12 months
  For 10 mL/min/1.73 m² increase0.67 (0.59–0.77)<0.00010.69 (0.60–0.80)<0.0001
–<0.0001–<0.0001
  >60 mL/min/1.73 m² (reference)1.00–1.00–
  45–601.03 (0.60–1.77)0.901.08 (0.62–1.87)0.78
  30–451.46 (0.87–2.45)0.161.41 (0.81–2.47)0.22
  <307.12 (4.13–12.28)<0.00016.86 (3.72–12.67)<0.0001
  <45 mL/min/1.73 m22.21 (1.55–3.13)<0.00011.95 (1.33–2.86)0.0006
Proteinuria variables
 3 months
  For 1 g/day increase1.24 (1.14–1.34)<0.00011.25 (1.14–1.36)<0.0001
–<0.0001–<0.0001
  <0.5 g/day (reference)1.00–1.00–
  0.5–11.89 (1.14–3.12)0.0131.78 (1.06–2.98)0.028
  1–23.64 (1.93–6.87)<0.00012.85 (1.45–5.58)0.002
  >25.31 (2.81–10.02)<0.00014.89 (2.56–9.33)<0.0001
  >0.5 g/day2.69 (1.84–3.94)<0.00012.45 (1.65–3.63)<0.0001
 6 months
  For 1 g/day increase1.41 (1.27–1.57)<0.00011.42 (1.27–1.59)<0.0001
–<0.0001–<0.0001
  <0.5 g/day (reference)1.00–1.00–
  0.5–12.70 (1.63–4.49)0.00012.53 (1.51–4.25)0.0004
  1–27.51 (4.35–12.94)<0.00016.33 (3.61–11.09)<0.0001
  >23.46 (1.49–8.04)0.0043.55 (1.51–8.37)0.004
  >0.5 g/day3.85 (2.59–5.72)<0.00013.56 (2.38–5.34)<0.0001
 12 months
  For 1 g/day increase1.60 (1.43–1.79)<0.00011.57 (1.38–1.77)<0.0001
–<0.0001–<0.0001
  <0.5 g/day (reference)1.00–1.00–
  0.5–13.13 (1.92–5.11)<0.00012.56 (1.53–4.31)0.0004
  1–24.98 (2.86–8.69)<0.00014.34 (2.45–7.70)<0.0001
  >27.29 (3.72–14.30)<0.00015.87 (2.91–11.81)<0.0001
  >0.5 g/day4.04 (2.75–5.92)<0.00013.39 (2.25–5.11)<0.0001

Models were adjusted for recipient age, history of heart failure, donor type, DGF, immunization, HLA incompatibilities, induction treatment and graft rejection (prior to the considered variable, i.e. prior to 3, 6 or 12 months).

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