Table 1. Open in new tab Evolution of...

	Unit	Reference range	2010	2015	2016	2017	2019
Biochemical markers
Serum calcium colorimetric	mmol/L	2.15–2.5	2.35	2.33	2.4	2.35	2.48
Serum phosphate colorimetric	mmol/L	0.81–1.45	0.93	0.42	0.54	1.25	0.99
P × Ca	–	–	2.19	0.98	1.3	2.94	2.46
1-84 parathyroid hormone electrochemiluminescence	ng/L	15–65	124	96	180		456
25(OH)D₃ electrochemiluminescence	nmol/L	–	66	48	53	101	72
bs-ALP CLIA-Liaison XL Diasorin	µg/L	5.5–22.9	15	70.8	43.6	56.4	20.3
P₁NP chemiluminescence	µg/L	15–80			755.2	2326	1596
DXA measurement
BMD lumbar spine L1–L4	g/cm²	–	1.094		1.079	1.222	1.251
BMD midwrist	g/cm²	–	0.667		0.5	0.543	0.537
BMD-UDR	g/cm²	–	0.360		0.353	0.377	0.403
T-score lumbar spine	–	–	0		0.2	1.2	−1.5
T-score wrist	–	–	−2.8		−5.2	−4.9	−4.3
Z-score lumbar spine	–	–	0.2		0.1	1.5	−1.8
Z-score wrist	–	–	−2.5		−5.6	−4.5	−3.9
Histomorphometry
BV/TV	%	15–22		24.4	15.88	17
OV/BV	%	2 ± 1		56.56	53.54	25.88
OS/BS	%	15 ± 5		54.47	81.43	68.66
ObS/BS	%	4 ± 2		0	6.42	8.21
ES/BS	%	0.88 ± 0.3		6.22	1.66	2.61
N.Oc	n/mm²	0.54 ± 0.05		5.09	1.06	2.19

Unit

Reference range

2010

2015

2016

2017

2019

Biochemical markers

Serum calcium colorimetric

mmol/L

2.15–2.5

2.35

2.33

2.4

2.35

2.48

Serum phosphate colorimetric

mmol/L

0.81–1.45

0.93

0.42

0.54

1.25

0.99

P × Ca

–

2.19

0.98

1.3

2.94

2.46

1-84 parathyroid hormone electrochemiluminescence

ng/L

15–65

124

180

456

25(OH)D₃ electrochemiluminescence

nmol/L

–

101

bs-ALP CLIA-Liaison XL Diasorin

µg/L

5.5–22.9

70.8

43.6

56.4

20.3

P₁NP chemiluminescence

µg/L

15–80

755.2

2326

1596

DXA measurement

BMD lumbar spine L1–L4

g/cm²

–

1.094

1.079

1.222

1.251

BMD midwrist

g/cm²

–

0.667

0.5

0.543

0.537

BMD-UDR

g/cm²

–

0.360

0.353

0.377

0.403

T-score lumbar spine

–

0.2

1.2

−1.5

T-score wrist

–

−2.8

−5.2

−4.9

−4.3

Z-score lumbar spine

–

0.2

0.1

1.5

−1.8

Z-score wrist

–

−2.5

−5.6

−4.5

−3.9

Histomorphometry

BV/TV

15–22

24.4

15.88

OV/BV

2 ± 1

56.56

53.54

25.88

OS/BS

15 ± 5

54.47

81.43

68.66

ObS/BS

4 ± 2

6.42

8.21

ES/BS

0.88 ± 0.3

6.22

1.66

2.61

N.Oc

n/mm²

0.54 ± 0.05

5.09

1.06

2.19

	Unit	Reference range	2010	2015	2016	2017	2019
Biochemical markers
Serum calcium colorimetric	mmol/L	2.15–2.5	2.35	2.33	2.4	2.35	2.48
Serum phosphate colorimetric	mmol/L	0.81–1.45	0.93	0.42	0.54	1.25	0.99
P × Ca	–	–	2.19	0.98	1.3	2.94	2.46
1-84 parathyroid hormone electrochemiluminescence	ng/L	15–65	124	96	180		456
25(OH)D₃ electrochemiluminescence	nmol/L	–	66	48	53	101	72
bs-ALP CLIA-Liaison XL Diasorin	µg/L	5.5–22.9	15	70.8	43.6	56.4	20.3
P₁NP chemiluminescence	µg/L	15–80			755.2	2326	1596
DXA measurement
BMD lumbar spine L1–L4	g/cm²	–	1.094		1.079	1.222	1.251
BMD midwrist	g/cm²	–	0.667		0.5	0.543	0.537
BMD-UDR	g/cm²	–	0.360		0.353	0.377	0.403
T-score lumbar spine	–	–	0		0.2	1.2	−1.5
T-score wrist	–	–	−2.8		−5.2	−4.9	−4.3
Z-score lumbar spine	–	–	0.2		0.1	1.5	−1.8
Z-score wrist	–	–	−2.5		−5.6	−4.5	−3.9
Histomorphometry
BV/TV	%	15–22		24.4	15.88	17
OV/BV	%	2 ± 1		56.56	53.54	25.88
OS/BS	%	15 ± 5		54.47	81.43	68.66
ObS/BS	%	4 ± 2		0	6.42	8.21
ES/BS	%	0.88 ± 0.3		6.22	1.66	2.61
N.Oc	n/mm²	0.54 ± 0.05		5.09	1.06	2.19

Table 1.

Open in new tab

Evolution of biological, BMD and histomorphometric parameters

	Unit	Reference range	2010	2015	2016	2017	2019
Biochemical markers
Serum calcium colorimetric	mmol/L	2.15–2.5	2.35	2.33	2.4	2.35	2.48
Serum phosphate colorimetric	mmol/L	0.81–1.45	0.93	0.42	0.54	1.25	0.99
P × Ca	–	–	2.19	0.98	1.3	2.94	2.46
1-84 parathyroid hormone electrochemiluminescence	ng/L	15–65	124	96	180		456
25(OH)D₃ electrochemiluminescence	nmol/L	–	66	48	53	101	72
bs-ALP CLIA-Liaison XL Diasorin	µg/L	5.5–22.9	15	70.8	43.6	56.4	20.3
P₁NP chemiluminescence	µg/L	15–80			755.2	2326	1596
DXA measurement
BMD lumbar spine L1–L4	g/cm²	–	1.094		1.079	1.222	1.251
BMD midwrist	g/cm²	–	0.667		0.5	0.543	0.537
BMD-UDR	g/cm²	–	0.360		0.353	0.377	0.403
T-score lumbar spine	–	–	0		0.2	1.2	−1.5
T-score wrist	–	–	−2.8		−5.2	−4.9	−4.3
Z-score lumbar spine	–	–	0.2		0.1	1.5	−1.8
Z-score wrist	–	–	−2.5		−5.6	−4.5	−3.9
Histomorphometry
BV/TV	%	15–22		24.4	15.88	17
OV/BV	%	2 ± 1		56.56	53.54	25.88
OS/BS	%	15 ± 5		54.47	81.43	68.66
ObS/BS	%	4 ± 2		0	6.42	8.21
ES/BS	%	0.88 ± 0.3		6.22	1.66	2.61
N.Oc	n/mm²	0.54 ± 0.05		5.09	1.06	2.19

	Unit	Reference range	2010	2015	2016	2017	2019
Biochemical markers
Serum calcium colorimetric	mmol/L	2.15–2.5	2.35	2.33	2.4	2.35	2.48
Serum phosphate colorimetric	mmol/L	0.81–1.45	0.93	0.42	0.54	1.25	0.99
P × Ca	–	–	2.19	0.98	1.3	2.94	2.46
1-84 parathyroid hormone electrochemiluminescence	ng/L	15–65	124	96	180		456
25(OH)D₃ electrochemiluminescence	nmol/L	–	66	48	53	101	72
bs-ALP CLIA-Liaison XL Diasorin	µg/L	5.5–22.9	15	70.8	43.6	56.4	20.3
P₁NP chemiluminescence	µg/L	15–80			755.2	2326	1596
DXA measurement
BMD lumbar spine L1–L4	g/cm²	–	1.094		1.079	1.222	1.251
BMD midwrist	g/cm²	–	0.667		0.5	0.543	0.537
BMD-UDR	g/cm²	–	0.360		0.353	0.377	0.403
T-score lumbar spine	–	–	0		0.2	1.2	−1.5
T-score wrist	–	–	−2.8		−5.2	−4.9	−4.3
Z-score lumbar spine	–	–	0.2		0.1	1.5	−1.8
Z-score wrist	–	–	−2.5		−5.6	−4.5	−3.9
Histomorphometry
BV/TV	%	15–22		24.4	15.88	17
OV/BV	%	2 ± 1		56.56	53.54	25.88
OS/BS	%	15 ± 5		54.47	81.43	68.66
ObS/BS	%	4 ± 2		0	6.42	8.21
ES/BS	%	0.88 ± 0.3		6.22	1.66	2.61
N.Oc	n/mm²	0.54 ± 0.05		5.09	1.06	2.19

BMD-UDR, bone mineral density at the ultradistal radius; BV/TV, bone volume/total volume; DXA, dual-energy X-ray absorptiometry; ES/BS, eroded surface/bone surface; N.Oc, number of osteoclasts; OV/BV, osteoid volume/bone volume; OS/BS, osteoid surface/bone surface; ObS/BS, osteoblast surface/bone surface; P × Ca, calcium–phosphate product.

The arrow indicates the time of the introduction of phosphorus supplementation.

This Feature Is Available To Subscribers Only