Table 5.
Open in new tab

Results of Cox proportional hazards models and C-index (standard error) in different groups

GroupLandmark Time, yResponder or NonresponderPProgressor or NonprogressorP
HR95% CI (%)C-index (SE)HR95% CI (%)C-index (SE)
HGG (n = 78)0.5 1.0 1.50.147 0.204 0.2070.063–0.343 0.091–0.460 0.080–0.5350.625 (0.035) 0.637 (0.048) 0.667 (0.047)<0.001 <0.001 0.0014.128 7.783 14.1662.246–7.588 3.398–17.826 4.218–47.5740.579 (0.064) 0.540 (0.046) 0.597 (0.066)<0.001 <0.001 <0.001
Non-HGG (n = 191)0.5 1.0 1.50.112 0.076 0.1010.054–0.231 0.034–0.172 0.044–0.2360.516 (0.017) 0.502 (0.016) 0.511 (0.019)<0.001 <0.001 <0.00114.844 8.691 15.3126.969–31.619 3.794–19.910 6.483–36.1620.500 (0.010) 0.509 (0.014) 0.500 (0.012)<0.001 <0.001 <0.001
MBL (n = 87)0.5 1.0 1.50.121 0.126 0.1370.047–0.308 0.045–0.353 0.045–0.4140.517 (0.025) 0.512 (0.025) 0.505 (0.029)<0.001 <0.001 <0.0018.485 5.798 12.9103.150–22.861 1.929–17.426 3.614–46.1110.507 (0.019) 0.511 (0.021) 0.508 (0.016)<0.001 0.002 <0.001
Embryonal tumors (n = 41)0.5 1.0 1.50.176 0.085 0.2180.054–0.574 0.021–0.338 0.061–0.7760.532 (0.052) 0.529 (0.053) 0.541 (0.048)0.004 <0.001 0.0199.355 4.194 6.8972.706–32.336 1.173–14.998 1.927–24.6840.517 (0.033) 0.517 (0.046) 0.515 (0.046)<0.001 0.027 0.003
Chemotherapy only (n = 61)0.5 1.0 1.50.030 0.051 0.1130.006–0.136 0.011–0.243 0.027–0.4730.537 (0.041) 0.540 (0.038) 0.544 (0.045)<0.001 <0.001 0.00343.242 20.989 12.1087.901–236.665 5.065–86.982 3.065–47.8270.533 (0.031) 0.518 (0.032) 0.534 (0.024)<0.001 <0.001 <0.001
Radiotherapy only (n = 44)0.5 1.0 1.50.042 0.049 0.0460.005–0.329 0.006–0.429 0.005–0.4080.500 (0.019) 0.545 (0.048) 0.571 (0.050)0.003 0.006 0.00660.979 15.096 20.1217.258–512.318 2.388–95.437 3.641–111.1820.518 (0.025) 0.533 (0.032) 0.528 (0.036)<0.001 0.004 0.001
Chemoradiotherapy (n = 164)0.5 1.0 1.50.141 0.112 0.1750.079–0.252 0.058–0.213 0.087–0.3510.500 (0.026) 0.528 (0.024) 0.538 (0.028)<0.001 <0.001 <0.0016.601 7.636 8.1363.785–11.511 4.034–14.453 3.853–17.1770.506 (0.018) 0.500 (0.015) 0.532 (0.022)<0.001 <0.001 <0.001
With leptomeningeal seeding (n = 66)0.5 1.0 1.50.205 0.165 0.3010.092–0.455 0.068–0.403 0.125–0.7260.531 (0.061) 0.540 (0.065) 0.579 (0.062)<0.001 <0.001 00.0074.764 3.079 4.8202.122–10.694 1.416–6.695 2.124–10.9410.596 (0.053) 0.547 (0.061) 0.516 (0.062)<0.001 0.005 <0.001
Without leptomeningeal seeding (n = 203)0.5 1.0 1.50.067 0.077 0.0970.033–0.132 0.036–0.162 0.040–0.2310.504 (0.019) 0.514 (0.016) 0.528 (0.018)<0.001 <0.001 <0.00117.827 21.048 23.6449.613–33.061 9.803–45.196 8.945–62.4970.510 (0.011) 0.500 (0.008) 0.529 (0.014)<0.001 <0.001 <0.001
All (N = 269)0.5 1.0 1.50.088 0.079 0.1060.053–0.148 0.045–0.140 0.058–0.1950.500 (0.020) 0.521 (0.019) 0.527 (0.021)<0.001 <0.001 <0.00110.539 10.192 14.4906.594–16.843 5.954–17.447 7.787–26.9650.510 (0.014) 0.503 (0.013) 0.520 (0.015)<0.001 <0.001 <0.001
GroupLandmark Time, yResponder or NonresponderPProgressor or NonprogressorP
HR95% CI (%)C-index (SE)HR95% CI (%)C-index (SE)
HGG (n = 78)0.5 1.0 1.50.147 0.204 0.2070.063–0.343 0.091–0.460 0.080–0.5350.625 (0.035) 0.637 (0.048) 0.667 (0.047)<0.001 <0.001 0.0014.128 7.783 14.1662.246–7.588 3.398–17.826 4.218–47.5740.579 (0.064) 0.540 (0.046) 0.597 (0.066)<0.001 <0.001 <0.001
Non-HGG (n = 191)0.5 1.0 1.50.112 0.076 0.1010.054–0.231 0.034–0.172 0.044–0.2360.516 (0.017) 0.502 (0.016) 0.511 (0.019)<0.001 <0.001 <0.00114.844 8.691 15.3126.969–31.619 3.794–19.910 6.483–36.1620.500 (0.010) 0.509 (0.014) 0.500 (0.012)<0.001 <0.001 <0.001
MBL (n = 87)0.5 1.0 1.50.121 0.126 0.1370.047–0.308 0.045–0.353 0.045–0.4140.517 (0.025) 0.512 (0.025) 0.505 (0.029)<0.001 <0.001 <0.0018.485 5.798 12.9103.150–22.861 1.929–17.426 3.614–46.1110.507 (0.019) 0.511 (0.021) 0.508 (0.016)<0.001 0.002 <0.001
Embryonal tumors (n = 41)0.5 1.0 1.50.176 0.085 0.2180.054–0.574 0.021–0.338 0.061–0.7760.532 (0.052) 0.529 (0.053) 0.541 (0.048)0.004 <0.001 0.0199.355 4.194 6.8972.706–32.336 1.173–14.998 1.927–24.6840.517 (0.033) 0.517 (0.046) 0.515 (0.046)<0.001 0.027 0.003
Chemotherapy only (n = 61)0.5 1.0 1.50.030 0.051 0.1130.006–0.136 0.011–0.243 0.027–0.4730.537 (0.041) 0.540 (0.038) 0.544 (0.045)<0.001 <0.001 0.00343.242 20.989 12.1087.901–236.665 5.065–86.982 3.065–47.8270.533 (0.031) 0.518 (0.032) 0.534 (0.024)<0.001 <0.001 <0.001
Radiotherapy only (n = 44)0.5 1.0 1.50.042 0.049 0.0460.005–0.329 0.006–0.429 0.005–0.4080.500 (0.019) 0.545 (0.048) 0.571 (0.050)0.003 0.006 0.00660.979 15.096 20.1217.258–512.318 2.388–95.437 3.641–111.1820.518 (0.025) 0.533 (0.032) 0.528 (0.036)<0.001 0.004 0.001
Chemoradiotherapy (n = 164)0.5 1.0 1.50.141 0.112 0.1750.079–0.252 0.058–0.213 0.087–0.3510.500 (0.026) 0.528 (0.024) 0.538 (0.028)<0.001 <0.001 <0.0016.601 7.636 8.1363.785–11.511 4.034–14.453 3.853–17.1770.506 (0.018) 0.500 (0.015) 0.532 (0.022)<0.001 <0.001 <0.001
With leptomeningeal seeding (n = 66)0.5 1.0 1.50.205 0.165 0.3010.092–0.455 0.068–0.403 0.125–0.7260.531 (0.061) 0.540 (0.065) 0.579 (0.062)<0.001 <0.001 00.0074.764 3.079 4.8202.122–10.694 1.416–6.695 2.124–10.9410.596 (0.053) 0.547 (0.061) 0.516 (0.062)<0.001 0.005 <0.001
Without leptomeningeal seeding (n = 203)0.5 1.0 1.50.067 0.077 0.0970.033–0.132 0.036–0.162 0.040–0.2310.504 (0.019) 0.514 (0.016) 0.528 (0.018)<0.001 <0.001 <0.00117.827 21.048 23.6449.613–33.061 9.803–45.196 8.945–62.4970.510 (0.011) 0.500 (0.008) 0.529 (0.014)<0.001 <0.001 <0.001
All (N = 269)0.5 1.0 1.50.088 0.079 0.1060.053–0.148 0.045–0.140 0.058–0.1950.500 (0.020) 0.521 (0.019) 0.527 (0.021)<0.001 <0.001 <0.00110.539 10.192 14.4906.594–16.843 5.954–17.447 7.787–26.9650.510 (0.014) 0.503 (0.013) 0.520 (0.015)<0.001 <0.001 <0.001
Table 5.
Open in new tab

Results of Cox proportional hazards models and C-index (standard error) in different groups

GroupLandmark Time, yResponder or NonresponderPProgressor or NonprogressorP
HR95% CI (%)C-index (SE)HR95% CI (%)C-index (SE)
HGG (n = 78)0.5 1.0 1.50.147 0.204 0.2070.063–0.343 0.091–0.460 0.080–0.5350.625 (0.035) 0.637 (0.048) 0.667 (0.047)<0.001 <0.001 0.0014.128 7.783 14.1662.246–7.588 3.398–17.826 4.218–47.5740.579 (0.064) 0.540 (0.046) 0.597 (0.066)<0.001 <0.001 <0.001
Non-HGG (n = 191)0.5 1.0 1.50.112 0.076 0.1010.054–0.231 0.034–0.172 0.044–0.2360.516 (0.017) 0.502 (0.016) 0.511 (0.019)<0.001 <0.001 <0.00114.844 8.691 15.3126.969–31.619 3.794–19.910 6.483–36.1620.500 (0.010) 0.509 (0.014) 0.500 (0.012)<0.001 <0.001 <0.001
MBL (n = 87)0.5 1.0 1.50.121 0.126 0.1370.047–0.308 0.045–0.353 0.045–0.4140.517 (0.025) 0.512 (0.025) 0.505 (0.029)<0.001 <0.001 <0.0018.485 5.798 12.9103.150–22.861 1.929–17.426 3.614–46.1110.507 (0.019) 0.511 (0.021) 0.508 (0.016)<0.001 0.002 <0.001
Embryonal tumors (n = 41)0.5 1.0 1.50.176 0.085 0.2180.054–0.574 0.021–0.338 0.061–0.7760.532 (0.052) 0.529 (0.053) 0.541 (0.048)0.004 <0.001 0.0199.355 4.194 6.8972.706–32.336 1.173–14.998 1.927–24.6840.517 (0.033) 0.517 (0.046) 0.515 (0.046)<0.001 0.027 0.003
Chemotherapy only (n = 61)0.5 1.0 1.50.030 0.051 0.1130.006–0.136 0.011–0.243 0.027–0.4730.537 (0.041) 0.540 (0.038) 0.544 (0.045)<0.001 <0.001 0.00343.242 20.989 12.1087.901–236.665 5.065–86.982 3.065–47.8270.533 (0.031) 0.518 (0.032) 0.534 (0.024)<0.001 <0.001 <0.001
Radiotherapy only (n = 44)0.5 1.0 1.50.042 0.049 0.0460.005–0.329 0.006–0.429 0.005–0.4080.500 (0.019) 0.545 (0.048) 0.571 (0.050)0.003 0.006 0.00660.979 15.096 20.1217.258–512.318 2.388–95.437 3.641–111.1820.518 (0.025) 0.533 (0.032) 0.528 (0.036)<0.001 0.004 0.001
Chemoradiotherapy (n = 164)0.5 1.0 1.50.141 0.112 0.1750.079–0.252 0.058–0.213 0.087–0.3510.500 (0.026) 0.528 (0.024) 0.538 (0.028)<0.001 <0.001 <0.0016.601 7.636 8.1363.785–11.511 4.034–14.453 3.853–17.1770.506 (0.018) 0.500 (0.015) 0.532 (0.022)<0.001 <0.001 <0.001
With leptomeningeal seeding (n = 66)0.5 1.0 1.50.205 0.165 0.3010.092–0.455 0.068–0.403 0.125–0.7260.531 (0.061) 0.540 (0.065) 0.579 (0.062)<0.001 <0.001 00.0074.764 3.079 4.8202.122–10.694 1.416–6.695 2.124–10.9410.596 (0.053) 0.547 (0.061) 0.516 (0.062)<0.001 0.005 <0.001
Without leptomeningeal seeding (n = 203)0.5 1.0 1.50.067 0.077 0.0970.033–0.132 0.036–0.162 0.040–0.2310.504 (0.019) 0.514 (0.016) 0.528 (0.018)<0.001 <0.001 <0.00117.827 21.048 23.6449.613–33.061 9.803–45.196 8.945–62.4970.510 (0.011) 0.500 (0.008) 0.529 (0.014)<0.001 <0.001 <0.001
All (N = 269)0.5 1.0 1.50.088 0.079 0.1060.053–0.148 0.045–0.140 0.058–0.1950.500 (0.020) 0.521 (0.019) 0.527 (0.021)<0.001 <0.001 <0.00110.539 10.192 14.4906.594–16.843 5.954–17.447 7.787–26.9650.510 (0.014) 0.503 (0.013) 0.520 (0.015)<0.001 <0.001 <0.001
GroupLandmark Time, yResponder or NonresponderPProgressor or NonprogressorP
HR95% CI (%)C-index (SE)HR95% CI (%)C-index (SE)
HGG (n = 78)0.5 1.0 1.50.147 0.204 0.2070.063–0.343 0.091–0.460 0.080–0.5350.625 (0.035) 0.637 (0.048) 0.667 (0.047)<0.001 <0.001 0.0014.128 7.783 14.1662.246–7.588 3.398–17.826 4.218–47.5740.579 (0.064) 0.540 (0.046) 0.597 (0.066)<0.001 <0.001 <0.001
Non-HGG (n = 191)0.5 1.0 1.50.112 0.076 0.1010.054–0.231 0.034–0.172 0.044–0.2360.516 (0.017) 0.502 (0.016) 0.511 (0.019)<0.001 <0.001 <0.00114.844 8.691 15.3126.969–31.619 3.794–19.910 6.483–36.1620.500 (0.010) 0.509 (0.014) 0.500 (0.012)<0.001 <0.001 <0.001
MBL (n = 87)0.5 1.0 1.50.121 0.126 0.1370.047–0.308 0.045–0.353 0.045–0.4140.517 (0.025) 0.512 (0.025) 0.505 (0.029)<0.001 <0.001 <0.0018.485 5.798 12.9103.150–22.861 1.929–17.426 3.614–46.1110.507 (0.019) 0.511 (0.021) 0.508 (0.016)<0.001 0.002 <0.001
Embryonal tumors (n = 41)0.5 1.0 1.50.176 0.085 0.2180.054–0.574 0.021–0.338 0.061–0.7760.532 (0.052) 0.529 (0.053) 0.541 (0.048)0.004 <0.001 0.0199.355 4.194 6.8972.706–32.336 1.173–14.998 1.927–24.6840.517 (0.033) 0.517 (0.046) 0.515 (0.046)<0.001 0.027 0.003
Chemotherapy only (n = 61)0.5 1.0 1.50.030 0.051 0.1130.006–0.136 0.011–0.243 0.027–0.4730.537 (0.041) 0.540 (0.038) 0.544 (0.045)<0.001 <0.001 0.00343.242 20.989 12.1087.901–236.665 5.065–86.982 3.065–47.8270.533 (0.031) 0.518 (0.032) 0.534 (0.024)<0.001 <0.001 <0.001
Radiotherapy only (n = 44)0.5 1.0 1.50.042 0.049 0.0460.005–0.329 0.006–0.429 0.005–0.4080.500 (0.019) 0.545 (0.048) 0.571 (0.050)0.003 0.006 0.00660.979 15.096 20.1217.258–512.318 2.388–95.437 3.641–111.1820.518 (0.025) 0.533 (0.032) 0.528 (0.036)<0.001 0.004 0.001
Chemoradiotherapy (n = 164)0.5 1.0 1.50.141 0.112 0.1750.079–0.252 0.058–0.213 0.087–0.3510.500 (0.026) 0.528 (0.024) 0.538 (0.028)<0.001 <0.001 <0.0016.601 7.636 8.1363.785–11.511 4.034–14.453 3.853–17.1770.506 (0.018) 0.500 (0.015) 0.532 (0.022)<0.001 <0.001 <0.001
With leptomeningeal seeding (n = 66)0.5 1.0 1.50.205 0.165 0.3010.092–0.455 0.068–0.403 0.125–0.7260.531 (0.061) 0.540 (0.065) 0.579 (0.062)<0.001 <0.001 00.0074.764 3.079 4.8202.122–10.694 1.416–6.695 2.124–10.9410.596 (0.053) 0.547 (0.061) 0.516 (0.062)<0.001 0.005 <0.001
Without leptomeningeal seeding (n = 203)0.5 1.0 1.50.067 0.077 0.0970.033–0.132 0.036–0.162 0.040–0.2310.504 (0.019) 0.514 (0.016) 0.528 (0.018)<0.001 <0.001 <0.00117.827 21.048 23.6449.613–33.061 9.803–45.196 8.945–62.4970.510 (0.011) 0.500 (0.008) 0.529 (0.014)<0.001 <0.001 <0.001
All (N = 269)0.5 1.0 1.50.088 0.079 0.1060.053–0.148 0.045–0.140 0.058–0.1950.500 (0.020) 0.521 (0.019) 0.527 (0.021)<0.001 <0.001 <0.00110.539 10.192 14.4906.594–16.843 5.954–17.447 7.787–26.9650.510 (0.014) 0.503 (0.013) 0.520 (0.015)<0.001 <0.001 <0.001
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