Table 3.

Spectrum of PTD after ifosfamide therapy

Proximal dysfunction featuresOverall, n = 23Overall, nIfosfamideOverall, nIfosfamide + cisplatinP-value
Hypokalaemia, n (%)20 (87.0)1411 (78.6)99 (100)NS
Metabolic acidosis, n (%)12 (52.2)126 (50)86 (75)NS
Hypophosphataemia, n (%)14 (61.0)148 (57.1)86 (75)NS
TmPO4²/eGFR < 0.80, n (%)9 (39.1)66 (100)33 (100)NS
Hypouricaemia, n (%)9 (39.1)115 (45.4)54 (80)NS
UAFE > 10%, n (%)5 (21.7)33 (100)22 (100)NS
Low weight proteinuria, n (%)10 (43.5)107 (70)63 (50)NS
Proximal dysfunction featuresOverall, n = 23Overall, nIfosfamideOverall, nIfosfamide + cisplatinP-value
Hypokalaemia, n (%)20 (87.0)1411 (78.6)99 (100)NS
Metabolic acidosis, n (%)12 (52.2)126 (50)86 (75)NS
Hypophosphataemia, n (%)14 (61.0)148 (57.1)86 (75)NS
TmPO4²/eGFR < 0.80, n (%)9 (39.1)66 (100)33 (100)NS
Hypouricaemia, n (%)9 (39.1)115 (45.4)54 (80)NS
UAFE > 10%, n (%)5 (21.7)33 (100)22 (100)NS
Low weight proteinuria, n (%)10 (43.5)107 (70)63 (50)NS

NS, not significant.

Table 3.

Spectrum of PTD after ifosfamide therapy

Proximal dysfunction featuresOverall, n = 23Overall, nIfosfamideOverall, nIfosfamide + cisplatinP-value
Hypokalaemia, n (%)20 (87.0)1411 (78.6)99 (100)NS
Metabolic acidosis, n (%)12 (52.2)126 (50)86 (75)NS
Hypophosphataemia, n (%)14 (61.0)148 (57.1)86 (75)NS
TmPO4²/eGFR < 0.80, n (%)9 (39.1)66 (100)33 (100)NS
Hypouricaemia, n (%)9 (39.1)115 (45.4)54 (80)NS
UAFE > 10%, n (%)5 (21.7)33 (100)22 (100)NS
Low weight proteinuria, n (%)10 (43.5)107 (70)63 (50)NS
Proximal dysfunction featuresOverall, n = 23Overall, nIfosfamideOverall, nIfosfamide + cisplatinP-value
Hypokalaemia, n (%)20 (87.0)1411 (78.6)99 (100)NS
Metabolic acidosis, n (%)12 (52.2)126 (50)86 (75)NS
Hypophosphataemia, n (%)14 (61.0)148 (57.1)86 (75)NS
TmPO4²/eGFR < 0.80, n (%)9 (39.1)66 (100)33 (100)NS
Hypouricaemia, n (%)9 (39.1)115 (45.4)54 (80)NS
UAFE > 10%, n (%)5 (21.7)33 (100)22 (100)NS
Low weight proteinuria, n (%)10 (43.5)107 (70)63 (50)NS

NS, not significant.

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