Drugs potentially interacting with statins metabolized by cytochrome P450 3A4 leading to increased risk of myopathy and rhabdomyolysis
| Anti-infective agents . | Calcium antagonists . | Other . |
|---|---|---|
| Itraconazole | Verapamil | Ciclosporin |
| Ketoconazole | Diltiazem | Danazol |
| Posaconazole | Amlodipine | Amiodarone |
| Erythromycin | Ranolazine | |
| Clarithromycin | Grapefruit juice | |
| Telithromycin | Nefazodone | |
| HIV protease inhibitors | Gemfibrozil |
| Anti-infective agents . | Calcium antagonists . | Other . |
|---|---|---|
| Itraconazole | Verapamil | Ciclosporin |
| Ketoconazole | Diltiazem | Danazol |
| Posaconazole | Amlodipine | Amiodarone |
| Erythromycin | Ranolazine | |
| Clarithromycin | Grapefruit juice | |
| Telithromycin | Nefazodone | |
| HIV protease inhibitors | Gemfibrozil |
Adapted from Egan and Colman,257 and Wiklund et al.258
HIV = human immunodeficiency virus.
Drugs potentially interacting with statins metabolized by cytochrome P450 3A4 leading to increased risk of myopathy and rhabdomyolysis
| Anti-infective agents . | Calcium antagonists . | Other . |
|---|---|---|
| Itraconazole | Verapamil | Ciclosporin |
| Ketoconazole | Diltiazem | Danazol |
| Posaconazole | Amlodipine | Amiodarone |
| Erythromycin | Ranolazine | |
| Clarithromycin | Grapefruit juice | |
| Telithromycin | Nefazodone | |
| HIV protease inhibitors | Gemfibrozil |
| Anti-infective agents . | Calcium antagonists . | Other . |
|---|---|---|
| Itraconazole | Verapamil | Ciclosporin |
| Ketoconazole | Diltiazem | Danazol |
| Posaconazole | Amlodipine | Amiodarone |
| Erythromycin | Ranolazine | |
| Clarithromycin | Grapefruit juice | |
| Telithromycin | Nefazodone | |
| HIV protease inhibitors | Gemfibrozil |
Adapted from Egan and Colman,257 and Wiklund et al.258
HIV = human immunodeficiency virus.
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