Table 2. Open in new tab Multivariable...

	Non-CP-CRE vs Uninfected	Susceptible Enterobacteriaceae vs Uninfected
ICU stay in the prior 3 months	3.3 (1.4–7.7)	.006
Received antibiotics in preceding 3 months before event^a	3.1 (1.0–10.3)	.05
Chronic skin ulcers^b	11.6 (4.3–30.8)	<.001
Impaired functional status upon admission to hospital			3.9 (1.7–9.2)	.002
Past MDRO^c in preceding 3 months before event^a	52.3 (11.7–233.9)	<.001	258.3 (32.4–2058.0)	<.001
Time at risk^d			0.96 (0.93–1.0)	.04
McCabe score [39]			2.3 (1.2–4.4)	.008
Received cephalosporins in preceding 3 months before event^a			0.2 (0.1–0.5)	<.001

Non-CP-CRE vs Uninfected

Susceptible Enterobacteriaceae vs Uninfected

Parameter

Odds Ratio (95% CI)

P Value

Odds Ratio (95% CI)

P Value

ICU stay in the prior 3 months

3.3 (1.4–7.7)

.006

Received antibiotics in preceding 3 months before event^a

3.1 (1.0–10.3)

.05

Chronic skin ulcers^b

11.6 (4.3–30.8)

<.001

Impaired functional status upon admission to hospital

3.9 (1.7–9.2)

.002

Past MDRO^c in preceding 3 months before event^a

52.3 (11.7–233.9)

<.001

258.3 (32.4–2058.0)

<.001

Time at risk^d

0.96 (0.93–1.0)

.04

McCabe score [39]

2.3 (1.2–4.4)

.008

Received cephalosporins in preceding 3 months before event^a

0.2 (0.1–0.5)

<.001

	Non-CP-CRE vs Uninfected	Susceptible Enterobacteriaceae vs Uninfected
ICU stay in the prior 3 months	3.3 (1.4–7.7)	.006
Received antibiotics in preceding 3 months before event^a	3.1 (1.0–10.3)	.05
Chronic skin ulcers^b	11.6 (4.3–30.8)	<.001
Impaired functional status upon admission to hospital			3.9 (1.7–9.2)	.002
Past MDRO^c in preceding 3 months before event^a	52.3 (11.7–233.9)	<.001	258.3 (32.4–2058.0)	<.001
Time at risk^d			0.96 (0.93–1.0)	.04
McCabe score [39]			2.3 (1.2–4.4)	.008
Received cephalosporins in preceding 3 months before event^a			0.2 (0.1–0.5)	<.001

Table 2.

Open in new tab

Multivariable Models of Risk Factors for Non-CP-CRE and Carbapenem-Susceptible Enterobacteriaceae Acquisitions

	Non-CP-CRE vs Uninfected		Susceptible Enterobacteriaceae vs Uninfected
Parameter	Odds Ratio (95% CI)	P Value	Odds Ratio (95% CI)	P Value
ICU stay in the prior 3 months	3.3 (1.4–7.7)	.006
Received antibiotics in preceding 3 months before event^a	3.1 (1.0–10.3)	.05
Chronic skin ulcers^b	11.6 (4.3–30.8)	<.001
Impaired functional status upon admission to hospital			3.9 (1.7–9.2)	.002
Past MDRO^c in preceding 3 months before event^a	52.3 (11.7–233.9)	<.001	258.3 (32.4–2058.0)	<.001
Time at risk^d			0.96 (0.93–1.0)	.04
McCabe score [39]			2.3 (1.2–4.4)	.008
Received cephalosporins in preceding 3 months before event^a			0.2 (0.1–0.5)	<.001

	Non-CP-CRE vs Uninfected		Susceptible Enterobacteriaceae vs Uninfected
Parameter	Odds Ratio (95% CI)	P Value	Odds Ratio (95% CI)	P Value
ICU stay in the prior 3 months	3.3 (1.4–7.7)	.006
Received antibiotics in preceding 3 months before event^a	3.1 (1.0–10.3)	.05
Chronic skin ulcers^b	11.6 (4.3–30.8)	<.001
Impaired functional status upon admission to hospital			3.9 (1.7–9.2)	.002
Past MDRO^c in preceding 3 months before event^a	52.3 (11.7–233.9)	<.001	258.3 (32.4–2058.0)	<.001
Time at risk^d			0.96 (0.93–1.0)	.04
McCabe score [39]			2.3 (1.2–4.4)	.008
Received cephalosporins in preceding 3 months before event^a			0.2 (0.1–0.5)	<.001

Abbreviations: CI, confidence interval; CP, carbapenemase producing; CRE, carbapenem-resistant Enterobacteriaceae; ICU, intensive care unit; MDRO, multidrug-resistant organism; OR, odds ratio.

^aEvent was defined as bacterial isolation for the patients who acquired non-CP-CRE or susceptible Enterobacteriaceae and as patients’ discharge date for uninfected patients.

^bLower limb diabetic foot wounds, decubitus ulcers, dwelling wound surrounding PEG insertion, surgical-site wounds, surrounding catheters.

^cIncludes methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus, extended-spectrum beta lactamase-producing Enterobacteriaceae, Acinetobacter baumannii, and Pseudomonas aeruginosa.

^dFor both resistant and susceptible case patients, time at risk was defined as the length of stay from admission to culture. For uninfected control patients, the time at risk was adjusted by multiplying the total length of stay by a random number between 0 and 1 (Excel; Microsoft).

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