Tissue samples were collected from five separate sources: Brigham and Women’s Hospital (Boston, MA, USA); Mayo Clinic (Jacksonville, FL, USA); Massachusetts General Hospital/Massachusetts Alzheimer’s Disease Research Center (Boston, MA, USA); Newcastle Brain Tissue Resource (Newcastle upon Tyne, UK); and Queen Square Brain Bank for Neurological Disorders (London, UK)
| Case # . | Source . | Diagnosis . | Age . | Sex . | Duration of disease (years) . | PMI (h) . |
|---|---|---|---|---|---|---|
| 20060025 | Newcastle | Probable DLB | 76 | M | 8 | 13 |
| 20050022 | Newcastle | PD with DLB | 68 | F | 9 | 69 |
| 20070105 | Newcastle | Probable DLB | 71 | M | 7 | 8 |
| 20040085 | Newcastle | Probable DLB | 77 | M | 2 | 29 |
| 20100353 | Newcastle | Cog. normal control | 74 | F | NA | 53 |
| 20100150 | Newcastle | Cog. normal control | 77 | M | NA | 83 |
| A01-064 | Brigham and Women's | Interstitial pneumonitis | 49 | F | NA | 25.5 |
| A01-111 | Brigham and Women's | Cog. normal control | 43 | F | NA | 23.5 |
| A01-213 | Brigham and Women's | DLB | 83 | M | 8 | 54 |
| BN14D00074 | Brigham and Women's | DLB | 82 | M | 5 | <24 |
| P80/10 | Queen Square | DLB | 67 | M | 7 | 40 |
| P11/11 | Queen Square | DLB | 60 | M | 8 | 24 |
| P20/14 | Queen Square | DLB | 75 | M | 16 | 57 |
| P48/07 | Queen Square | Cog. normal control | F | NA | 39 | |
| 1687 | MGH | DLB | 73 | M | 24 | |
| 1650 | MGH | DLB | 76 | M | 10 | |
| 1594 | MGH | DLB | 81 | F | 8 | |
| 1590 | MGH | DLB | 62 | M | <24 | |
| 1504 | MGH | DLB | 79 | F | 12 | |
| 1751 | MGH | DLB | 87 | F | 6 | |
| 1901 | MGH | Control | 54 | M | NA | 6 |
| 1887 | MGH | Control | 60 | M | NA | 14 |
| CON 1 | Mayo Clinic | PA/CAA | 81 | F | NA | |
| CON 2 | Mayo Clinic | PA | 75 | F | NA | |
| CON 3 | Mayo Clinic | PA | 81 | F | NA | 22 |
| CON 4 | Mayo Clinic | PA/lacune (pseudo-dementia) | 75 | F | NA | |
| CON 5 | Mayo Clinic | PA | 81 | M | NA | |
| CON 6 | Mayo Clinic | PA | 78 | M | NA | 13 |
| CON 7 | Mayo Clinic | SC/VaD | 79 | F | NA | 8 |
| CON 8 | Mayo Clinic | SC | 70 | M | NA | 20 |
| CON 9 | Mayo Clinic | Normal (pseudo-dementia) | 63 | M | NA | 3 |
| CON 10 | Mayo Clinic | PA | 87 | F | NA | 21 |
| CON 11 | Mayo Clinic | PA | 88 | F | NA | 6 |
| Syn1 | Mayo Clinic | DLB | 81 | F | ||
| Syn2 | Mayo Clinic | DLB | 67 | F | ||
| Syn3 | Mayo Clinic | DLB | 68 | F | 11 | |
| Syn4 | Mayo Clinic | DLB | 66 | F | 16 | |
| Syn5 | Mayo Clinic | DLB | 79 | M | ||
| Syn6 | Mayo Clinic | DLB | 54 | M | 5 | |
| Syn7 | Mayo Clinic | DLB | 62 | F | 7 |
| Case # . | Source . | Diagnosis . | Age . | Sex . | Duration of disease (years) . | PMI (h) . |
|---|---|---|---|---|---|---|
| 20060025 | Newcastle | Probable DLB | 76 | M | 8 | 13 |
| 20050022 | Newcastle | PD with DLB | 68 | F | 9 | 69 |
| 20070105 | Newcastle | Probable DLB | 71 | M | 7 | 8 |
| 20040085 | Newcastle | Probable DLB | 77 | M | 2 | 29 |
| 20100353 | Newcastle | Cog. normal control | 74 | F | NA | 53 |
| 20100150 | Newcastle | Cog. normal control | 77 | M | NA | 83 |
| A01-064 | Brigham and Women's | Interstitial pneumonitis | 49 | F | NA | 25.5 |
| A01-111 | Brigham and Women's | Cog. normal control | 43 | F | NA | 23.5 |
| A01-213 | Brigham and Women's | DLB | 83 | M | 8 | 54 |
| BN14D00074 | Brigham and Women's | DLB | 82 | M | 5 | <24 |
| P80/10 | Queen Square | DLB | 67 | M | 7 | 40 |
| P11/11 | Queen Square | DLB | 60 | M | 8 | 24 |
| P20/14 | Queen Square | DLB | 75 | M | 16 | 57 |
| P48/07 | Queen Square | Cog. normal control | F | NA | 39 | |
| 1687 | MGH | DLB | 73 | M | 24 | |
| 1650 | MGH | DLB | 76 | M | 10 | |
| 1594 | MGH | DLB | 81 | F | 8 | |
| 1590 | MGH | DLB | 62 | M | <24 | |
| 1504 | MGH | DLB | 79 | F | 12 | |
| 1751 | MGH | DLB | 87 | F | 6 | |
| 1901 | MGH | Control | 54 | M | NA | 6 |
| 1887 | MGH | Control | 60 | M | NA | 14 |
| CON 1 | Mayo Clinic | PA/CAA | 81 | F | NA | |
| CON 2 | Mayo Clinic | PA | 75 | F | NA | |
| CON 3 | Mayo Clinic | PA | 81 | F | NA | 22 |
| CON 4 | Mayo Clinic | PA/lacune (pseudo-dementia) | 75 | F | NA | |
| CON 5 | Mayo Clinic | PA | 81 | M | NA | |
| CON 6 | Mayo Clinic | PA | 78 | M | NA | 13 |
| CON 7 | Mayo Clinic | SC/VaD | 79 | F | NA | 8 |
| CON 8 | Mayo Clinic | SC | 70 | M | NA | 20 |
| CON 9 | Mayo Clinic | Normal (pseudo-dementia) | 63 | M | NA | 3 |
| CON 10 | Mayo Clinic | PA | 87 | F | NA | 21 |
| CON 11 | Mayo Clinic | PA | 88 | F | NA | 6 |
| Syn1 | Mayo Clinic | DLB | 81 | F | ||
| Syn2 | Mayo Clinic | DLB | 67 | F | ||
| Syn3 | Mayo Clinic | DLB | 68 | F | 11 | |
| Syn4 | Mayo Clinic | DLB | 66 | F | 16 | |
| Syn5 | Mayo Clinic | DLB | 79 | M | ||
| Syn6 | Mayo Clinic | DLB | 54 | M | 5 | |
| Syn7 | Mayo Clinic | DLB | 62 | F | 7 |
Frontal cortex grey matter was analysed from DLB patients and corresponding controls.
CAA: cerebral amyloid angiopathy; F: female; M: male; MGH: Massachusetts General Hospital; NA: not applicable; PA: pathological aging; PMI: post-mortem interval; SC: senile changes; VaD: vascular dementia.
Tissue samples were collected from five separate sources: Brigham and Women’s Hospital (Boston, MA, USA); Mayo Clinic (Jacksonville, FL, USA); Massachusetts General Hospital/Massachusetts Alzheimer’s Disease Research Center (Boston, MA, USA); Newcastle Brain Tissue Resource (Newcastle upon Tyne, UK); and Queen Square Brain Bank for Neurological Disorders (London, UK)
| Case # . | Source . | Diagnosis . | Age . | Sex . | Duration of disease (years) . | PMI (h) . |
|---|---|---|---|---|---|---|
| 20060025 | Newcastle | Probable DLB | 76 | M | 8 | 13 |
| 20050022 | Newcastle | PD with DLB | 68 | F | 9 | 69 |
| 20070105 | Newcastle | Probable DLB | 71 | M | 7 | 8 |
| 20040085 | Newcastle | Probable DLB | 77 | M | 2 | 29 |
| 20100353 | Newcastle | Cog. normal control | 74 | F | NA | 53 |
| 20100150 | Newcastle | Cog. normal control | 77 | M | NA | 83 |
| A01-064 | Brigham and Women's | Interstitial pneumonitis | 49 | F | NA | 25.5 |
| A01-111 | Brigham and Women's | Cog. normal control | 43 | F | NA | 23.5 |
| A01-213 | Brigham and Women's | DLB | 83 | M | 8 | 54 |
| BN14D00074 | Brigham and Women's | DLB | 82 | M | 5 | <24 |
| P80/10 | Queen Square | DLB | 67 | M | 7 | 40 |
| P11/11 | Queen Square | DLB | 60 | M | 8 | 24 |
| P20/14 | Queen Square | DLB | 75 | M | 16 | 57 |
| P48/07 | Queen Square | Cog. normal control | F | NA | 39 | |
| 1687 | MGH | DLB | 73 | M | 24 | |
| 1650 | MGH | DLB | 76 | M | 10 | |
| 1594 | MGH | DLB | 81 | F | 8 | |
| 1590 | MGH | DLB | 62 | M | <24 | |
| 1504 | MGH | DLB | 79 | F | 12 | |
| 1751 | MGH | DLB | 87 | F | 6 | |
| 1901 | MGH | Control | 54 | M | NA | 6 |
| 1887 | MGH | Control | 60 | M | NA | 14 |
| CON 1 | Mayo Clinic | PA/CAA | 81 | F | NA | |
| CON 2 | Mayo Clinic | PA | 75 | F | NA | |
| CON 3 | Mayo Clinic | PA | 81 | F | NA | 22 |
| CON 4 | Mayo Clinic | PA/lacune (pseudo-dementia) | 75 | F | NA | |
| CON 5 | Mayo Clinic | PA | 81 | M | NA | |
| CON 6 | Mayo Clinic | PA | 78 | M | NA | 13 |
| CON 7 | Mayo Clinic | SC/VaD | 79 | F | NA | 8 |
| CON 8 | Mayo Clinic | SC | 70 | M | NA | 20 |
| CON 9 | Mayo Clinic | Normal (pseudo-dementia) | 63 | M | NA | 3 |
| CON 10 | Mayo Clinic | PA | 87 | F | NA | 21 |
| CON 11 | Mayo Clinic | PA | 88 | F | NA | 6 |
| Syn1 | Mayo Clinic | DLB | 81 | F | ||
| Syn2 | Mayo Clinic | DLB | 67 | F | ||
| Syn3 | Mayo Clinic | DLB | 68 | F | 11 | |
| Syn4 | Mayo Clinic | DLB | 66 | F | 16 | |
| Syn5 | Mayo Clinic | DLB | 79 | M | ||
| Syn6 | Mayo Clinic | DLB | 54 | M | 5 | |
| Syn7 | Mayo Clinic | DLB | 62 | F | 7 |
| Case # . | Source . | Diagnosis . | Age . | Sex . | Duration of disease (years) . | PMI (h) . |
|---|---|---|---|---|---|---|
| 20060025 | Newcastle | Probable DLB | 76 | M | 8 | 13 |
| 20050022 | Newcastle | PD with DLB | 68 | F | 9 | 69 |
| 20070105 | Newcastle | Probable DLB | 71 | M | 7 | 8 |
| 20040085 | Newcastle | Probable DLB | 77 | M | 2 | 29 |
| 20100353 | Newcastle | Cog. normal control | 74 | F | NA | 53 |
| 20100150 | Newcastle | Cog. normal control | 77 | M | NA | 83 |
| A01-064 | Brigham and Women's | Interstitial pneumonitis | 49 | F | NA | 25.5 |
| A01-111 | Brigham and Women's | Cog. normal control | 43 | F | NA | 23.5 |
| A01-213 | Brigham and Women's | DLB | 83 | M | 8 | 54 |
| BN14D00074 | Brigham and Women's | DLB | 82 | M | 5 | <24 |
| P80/10 | Queen Square | DLB | 67 | M | 7 | 40 |
| P11/11 | Queen Square | DLB | 60 | M | 8 | 24 |
| P20/14 | Queen Square | DLB | 75 | M | 16 | 57 |
| P48/07 | Queen Square | Cog. normal control | F | NA | 39 | |
| 1687 | MGH | DLB | 73 | M | 24 | |
| 1650 | MGH | DLB | 76 | M | 10 | |
| 1594 | MGH | DLB | 81 | F | 8 | |
| 1590 | MGH | DLB | 62 | M | <24 | |
| 1504 | MGH | DLB | 79 | F | 12 | |
| 1751 | MGH | DLB | 87 | F | 6 | |
| 1901 | MGH | Control | 54 | M | NA | 6 |
| 1887 | MGH | Control | 60 | M | NA | 14 |
| CON 1 | Mayo Clinic | PA/CAA | 81 | F | NA | |
| CON 2 | Mayo Clinic | PA | 75 | F | NA | |
| CON 3 | Mayo Clinic | PA | 81 | F | NA | 22 |
| CON 4 | Mayo Clinic | PA/lacune (pseudo-dementia) | 75 | F | NA | |
| CON 5 | Mayo Clinic | PA | 81 | M | NA | |
| CON 6 | Mayo Clinic | PA | 78 | M | NA | 13 |
| CON 7 | Mayo Clinic | SC/VaD | 79 | F | NA | 8 |
| CON 8 | Mayo Clinic | SC | 70 | M | NA | 20 |
| CON 9 | Mayo Clinic | Normal (pseudo-dementia) | 63 | M | NA | 3 |
| CON 10 | Mayo Clinic | PA | 87 | F | NA | 21 |
| CON 11 | Mayo Clinic | PA | 88 | F | NA | 6 |
| Syn1 | Mayo Clinic | DLB | 81 | F | ||
| Syn2 | Mayo Clinic | DLB | 67 | F | ||
| Syn3 | Mayo Clinic | DLB | 68 | F | 11 | |
| Syn4 | Mayo Clinic | DLB | 66 | F | 16 | |
| Syn5 | Mayo Clinic | DLB | 79 | M | ||
| Syn6 | Mayo Clinic | DLB | 54 | M | 5 | |
| Syn7 | Mayo Clinic | DLB | 62 | F | 7 |
Frontal cortex grey matter was analysed from DLB patients and corresponding controls.
CAA: cerebral amyloid angiopathy; F: female; M: male; MGH: Massachusetts General Hospital; NA: not applicable; PA: pathological aging; PMI: post-mortem interval; SC: senile changes; VaD: vascular dementia.
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