Table 3. Open in new tab Data-derived...

Dose	Age	Deltamethrin	cis-Permethrin	trans-Permethrin	Esfenvalerate
HED	5 vs 25	0.82	0.73	1.08	0.94	0.83	0.73	1.13	0.92
+10-fold HED	0.82	0.76	1.17	0.96	0.78	0.70	1.14	0.92
−10-fold HED	0.90	0.78	1.13	0.97	0.85	0.72	1.07	0.86
HED	1 vs 25	0.86	0.68	1.13	0.94	0.82	0.65	1.23	0.95
+10-fold HED	0.86	0.71	1.17	0.94	0.79	0.67	1.19	0.90
−10-fold HED	0.94	0.76	1.20	0.96	0.85	0.68	1.09	0.86
HED	0.5 vs 25	0.81	0.66	1.21	0.97	0.82	0.65	1.25	0.93
+10-fold HED	0.82	0.65	1.22	1.00	0.80	0.65	1.23	0.90
−10-fold HED	0.92	0.69	1.18	0.96	0.87	0.69	1.14	0.86

Dose	Age	Deltamethrin	cis-Permethrin	trans-Permethrin	Esfenvalerate
HED	5 vs 25	0.82	0.73	1.08	0.94	0.83	0.73	1.13	0.92
+10-fold HED	0.82	0.76	1.17	0.96	0.78	0.70	1.14	0.92
−10-fold HED	0.90	0.78	1.13	0.97	0.85	0.72	1.07	0.86
HED	1 vs 25	0.86	0.68	1.13	0.94	0.82	0.65	1.23	0.95
+10-fold HED	0.86	0.71	1.17	0.94	0.79	0.67	1.19	0.90
−10-fold HED	0.94	0.76	1.20	0.96	0.85	0.68	1.09	0.86
HED	0.5 vs 25	0.81	0.66	1.21	0.97	0.82	0.65	1.25	0.93
+10-fold HED	0.82	0.65	1.22	1.00	0.80	0.65	1.23	0.90
−10-fold HED	0.92	0.69	1.18	0.96	0.87	0.69	1.14	0.86

Table 3.

Data-derived Extrapolation Factors at 3 Different Ages in Human Males for Deltamethrin, cis-Permethrin, trans-Permethrin, and Esfenvalerate in Brain and Plasma

Dose	Age	Deltamethrin		cis-Permethrin		trans-Permethrin		Esfenvalerate
Dose	Age	Plasma C_max	Brain C_max	Plasma C_max	Brain C_max	Plasma C_max	Brain C_max	Plasma C_max	Brain C_max
HED	5 vs 25	0.82	0.73	1.08	0.94	0.83	0.73	1.13	0.92
+10-fold HED		0.82	0.76	1.17	0.96	0.78	0.70	1.14	0.92
−10-fold HED		0.90	0.78	1.13	0.97	0.85	0.72	1.07	0.86
HED	1 vs 25	0.86	0.68	1.13	0.94	0.82	0.65	1.23	0.95
+10-fold HED		0.86	0.71	1.17	0.94	0.79	0.67	1.19	0.90
−10-fold HED		0.94	0.76	1.20	0.96	0.85	0.68	1.09	0.86
HED	0.5 vs 25	0.81	0.66	1.21	0.97	0.82	0.65	1.25	0.93
+10-fold HED		0.82	0.65	1.22	1.00	0.80	0.65	1.23	0.90
−10-fold HED		0.92	0.69	1.18	0.96	0.87	0.69	1.14	0.86

Dose	Age	Deltamethrin		cis-Permethrin		trans-Permethrin		Esfenvalerate
Dose	Age	Plasma C_max	Brain C_max	Plasma C_max	Brain C_max	Plasma C_max	Brain C_max	Plasma C_max	Brain C_max
HED	5 vs 25	0.82	0.73	1.08	0.94	0.83	0.73	1.13	0.92
+10-fold HED		0.82	0.76	1.17	0.96	0.78	0.70	1.14	0.92
−10-fold HED		0.90	0.78	1.13	0.97	0.85	0.72	1.07	0.86
HED	1 vs 25	0.86	0.68	1.13	0.94	0.82	0.65	1.23	0.95
+10-fold HED		0.86	0.71	1.17	0.94	0.79	0.67	1.19	0.90
−10-fold HED		0.94	0.76	1.20	0.96	0.85	0.68	1.09	0.86
HED	0.5 vs 25	0.81	0.66	1.21	0.97	0.82	0.65	1.25	0.93
+10-fold HED		0.82	0.65	1.22	1.00	0.80	0.65	1.23	0.90
−10-fold HED		0.92	0.69	1.18	0.96	0.87	0.69	1.14	0.86

The main value in the table is the results of the equation: Juvenile C_{max_50th percentile}/Adult C_{max_50th percentile}.

Human Equivalent Dose (HED) 0.85, 14.1, 8.73, and 0.1136 mg/kg/day for deltamethrin, cis-permethrin, trans-permethrin, and esfenvalerate, respectively; +10-fold HED indicates the use of a 10-fold higher dose than the HED; −10-fold HED indicates the use of a 10-fold lower dose than the HED.

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