Table 2.
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Calculated Rat and Human Point of Departure (POD) for the 8 Pyrethroids

ExposureDeltamethrinPermethrinBifenthrinEsfenvalerateCyfluthrinCyhalothrinCyphenothrinNotes
External POD in ratsa (mg/kg/day)1.544.43.10.71.20.66.0cU.S. Environmental Protection Agency (U.S. EPA) DER (D422817) Wolansky et al. (2006)
Brain Cmax (ng/g)b28.31370 (cis-permethrin) 280 (trans-permethrin)219.87.330.617.467.6PND90 simulated
Human Equivalent Dose (mg/kg/day)0.914.1 (cis-permethrin) 8.7 (trans-permethrin)0.90.10.80.42.1Adult simulated
ExposureDeltamethrinPermethrinBifenthrinEsfenvalerateCyfluthrinCyhalothrinCyphenothrinNotes
External POD in ratsa (mg/kg/day)1.544.43.10.71.20.66.0cU.S. Environmental Protection Agency (U.S. EPA) DER (D422817) Wolansky et al. (2006)
Brain Cmax (ng/g)b28.31370 (cis-permethrin) 280 (trans-permethrin)219.87.330.617.467.6PND90 simulated
Human Equivalent Dose (mg/kg/day)0.914.1 (cis-permethrin) 8.7 (trans-permethrin)0.90.10.80.42.1Adult simulated

Estimated adult brain tissue internal dose at the reported benchmark dose lower confidence limit (BMDL) as POD in adult rats from U.S. EPA based on the benchmark dose analysis of the Wolansky et al. (2006) data.

a

External PODs in rats correspond to BMDL values which correspond to a Benchmark Response of 1 SD change from the control mean.

b

Brain Cmax was calculated separately assuming that dosing was with a single permethrin isomer (cis- or trans-permethrin) at the rat POD (44.4 mg/kg/day).

c

No observed adverse effect level for neurological effects as external POD in rats for Cyphenothrin from WIL Laboratories Research (Ashland, Ohio) Functional Observational Battery study used by the Environmental Protection Agency in their risk assessment (Weiner et al., 2009).

Table 2.
Open in new tab

Calculated Rat and Human Point of Departure (POD) for the 8 Pyrethroids

ExposureDeltamethrinPermethrinBifenthrinEsfenvalerateCyfluthrinCyhalothrinCyphenothrinNotes
External POD in ratsa (mg/kg/day)1.544.43.10.71.20.66.0cU.S. Environmental Protection Agency (U.S. EPA) DER (D422817) Wolansky et al. (2006)
Brain Cmax (ng/g)b28.31370 (cis-permethrin) 280 (trans-permethrin)219.87.330.617.467.6PND90 simulated
Human Equivalent Dose (mg/kg/day)0.914.1 (cis-permethrin) 8.7 (trans-permethrin)0.90.10.80.42.1Adult simulated
ExposureDeltamethrinPermethrinBifenthrinEsfenvalerateCyfluthrinCyhalothrinCyphenothrinNotes
External POD in ratsa (mg/kg/day)1.544.43.10.71.20.66.0cU.S. Environmental Protection Agency (U.S. EPA) DER (D422817) Wolansky et al. (2006)
Brain Cmax (ng/g)b28.31370 (cis-permethrin) 280 (trans-permethrin)219.87.330.617.467.6PND90 simulated
Human Equivalent Dose (mg/kg/day)0.914.1 (cis-permethrin) 8.7 (trans-permethrin)0.90.10.80.42.1Adult simulated

Estimated adult brain tissue internal dose at the reported benchmark dose lower confidence limit (BMDL) as POD in adult rats from U.S. EPA based on the benchmark dose analysis of the Wolansky et al. (2006) data.

a

External PODs in rats correspond to BMDL values which correspond to a Benchmark Response of 1 SD change from the control mean.

b

Brain Cmax was calculated separately assuming that dosing was with a single permethrin isomer (cis- or trans-permethrin) at the rat POD (44.4 mg/kg/day).

c

No observed adverse effect level for neurological effects as external POD in rats for Cyphenothrin from WIL Laboratories Research (Ashland, Ohio) Functional Observational Battery study used by the Environmental Protection Agency in their risk assessment (Weiner et al., 2009).

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