Relative Hazards of Liver Disease Progression Events by HIV Viral Load (Copies/mL)
| Variable . | Person-Years . | Events . | Unadjusted HR (95% CI) . | Adjusteda HR (95% CI) . |
|---|---|---|---|---|
| HIV RNA at entry | ||||
| ≤75 | 469 | 10 | Referent | Referent |
| 76–10 000 | 342 | 5 | 0.66 (0.22, 1.92) | 0.53 (0.18, 1.56) |
| >10 000 | 270 | 8 | 1.35 (0.53, 3.41) | 0.75 (0.28, 2.03) |
| Missing | 75 | 1 | 0.64 (0.08, 5.04) | 0.57 (0.07, 4.57) |
| Time-updated HIV RNA | ||||
| ≤75 | 347 | 10 | Referent | Referent |
| 76–10 000 | 237 | 2 | 0.27 (0.06, 1.23) | 0.25 (0.05, 1.15) |
| >10 000 | 180 | 6 | 1.15 (0.42, 3.18) | 0.87 (0.31, 2.43) |
| Missing | 391 | 6 | 1.20 (0.38, 3.82) | 1.28 (0.40, 4.08) |
| Lagged HIV RNA (3-month) | ||||
| ≤75 | 365 | 9 | Referent | Referent |
| 76–10 000 | 250 | 4 | 0.60 (0.19, 1.97) | 0.53 (0.16, 1.75) |
| >10 000 | 193 | 6 | 1.25 (0.44, 3.51) | 0.93 (0.31, 2.76) |
| Missing | 348 | 5 | 1.22 (0.36, 4.18) | 1.70 (0.47, 6.12) |
| Lagged HIV RNA (6-month) | ||||
| ≤75 | 381 | 9 | Referent | Referent |
| 76–10 000 | 263 | 4 | 0.62 (0.19, 2.01) | 0.54 (0.16, 1.77) |
| >10 000 | 203 | 7 | 1.42 (0.53, 3.81) | 1.06 (0.37, 3.05) |
| Missing | 309 | 4 | 1.01 (0.27, 3.80) | 1.31 (0.34, 5.12) |
| Variable . | Person-Years . | Events . | Unadjusted HR (95% CI) . | Adjusteda HR (95% CI) . |
|---|---|---|---|---|
| HIV RNA at entry | ||||
| ≤75 | 469 | 10 | Referent | Referent |
| 76–10 000 | 342 | 5 | 0.66 (0.22, 1.92) | 0.53 (0.18, 1.56) |
| >10 000 | 270 | 8 | 1.35 (0.53, 3.41) | 0.75 (0.28, 2.03) |
| Missing | 75 | 1 | 0.64 (0.08, 5.04) | 0.57 (0.07, 4.57) |
| Time-updated HIV RNA | ||||
| ≤75 | 347 | 10 | Referent | Referent |
| 76–10 000 | 237 | 2 | 0.27 (0.06, 1.23) | 0.25 (0.05, 1.15) |
| >10 000 | 180 | 6 | 1.15 (0.42, 3.18) | 0.87 (0.31, 2.43) |
| Missing | 391 | 6 | 1.20 (0.38, 3.82) | 1.28 (0.40, 4.08) |
| Lagged HIV RNA (3-month) | ||||
| ≤75 | 365 | 9 | Referent | Referent |
| 76–10 000 | 250 | 4 | 0.60 (0.19, 1.97) | 0.53 (0.16, 1.75) |
| >10 000 | 193 | 6 | 1.25 (0.44, 3.51) | 0.93 (0.31, 2.76) |
| Missing | 348 | 5 | 1.22 (0.36, 4.18) | 1.70 (0.47, 6.12) |
| Lagged HIV RNA (6-month) | ||||
| ≤75 | 381 | 9 | Referent | Referent |
| 76–10 000 | 263 | 4 | 0.62 (0.19, 2.01) | 0.54 (0.16, 1.77) |
| >10 000 | 203 | 7 | 1.42 (0.53, 3.81) | 1.06 (0.37, 3.05) |
| Missing | 309 | 4 | 1.01 (0.27, 3.80) | 1.31 (0.34, 5.12) |
Abbreviations: CI, confidence interval; HIV, human immunodeficiency virus; HR, hazard ratio.
a Final adjusted models are reduced from fully adjusted models, having removed covariates that did not significantly predict liver disease progression and did not substantially change the estimate for the association of interest. The models for baseline and current HIV viral load are adjusted for baseline CD4 (<200, ≥200) only. The models for lagged HIV viral load are adjusted for baseline CD4 (<200, ≥200), HCV viral load (≥106, <106), and age (continuous).
Relative Hazards of Liver Disease Progression Events by HIV Viral Load (Copies/mL)
| Variable . | Person-Years . | Events . | Unadjusted HR (95% CI) . | Adjusteda HR (95% CI) . |
|---|---|---|---|---|
| HIV RNA at entry | ||||
| ≤75 | 469 | 10 | Referent | Referent |
| 76–10 000 | 342 | 5 | 0.66 (0.22, 1.92) | 0.53 (0.18, 1.56) |
| >10 000 | 270 | 8 | 1.35 (0.53, 3.41) | 0.75 (0.28, 2.03) |
| Missing | 75 | 1 | 0.64 (0.08, 5.04) | 0.57 (0.07, 4.57) |
| Time-updated HIV RNA | ||||
| ≤75 | 347 | 10 | Referent | Referent |
| 76–10 000 | 237 | 2 | 0.27 (0.06, 1.23) | 0.25 (0.05, 1.15) |
| >10 000 | 180 | 6 | 1.15 (0.42, 3.18) | 0.87 (0.31, 2.43) |
| Missing | 391 | 6 | 1.20 (0.38, 3.82) | 1.28 (0.40, 4.08) |
| Lagged HIV RNA (3-month) | ||||
| ≤75 | 365 | 9 | Referent | Referent |
| 76–10 000 | 250 | 4 | 0.60 (0.19, 1.97) | 0.53 (0.16, 1.75) |
| >10 000 | 193 | 6 | 1.25 (0.44, 3.51) | 0.93 (0.31, 2.76) |
| Missing | 348 | 5 | 1.22 (0.36, 4.18) | 1.70 (0.47, 6.12) |
| Lagged HIV RNA (6-month) | ||||
| ≤75 | 381 | 9 | Referent | Referent |
| 76–10 000 | 263 | 4 | 0.62 (0.19, 2.01) | 0.54 (0.16, 1.77) |
| >10 000 | 203 | 7 | 1.42 (0.53, 3.81) | 1.06 (0.37, 3.05) |
| Missing | 309 | 4 | 1.01 (0.27, 3.80) | 1.31 (0.34, 5.12) |
| Variable . | Person-Years . | Events . | Unadjusted HR (95% CI) . | Adjusteda HR (95% CI) . |
|---|---|---|---|---|
| HIV RNA at entry | ||||
| ≤75 | 469 | 10 | Referent | Referent |
| 76–10 000 | 342 | 5 | 0.66 (0.22, 1.92) | 0.53 (0.18, 1.56) |
| >10 000 | 270 | 8 | 1.35 (0.53, 3.41) | 0.75 (0.28, 2.03) |
| Missing | 75 | 1 | 0.64 (0.08, 5.04) | 0.57 (0.07, 4.57) |
| Time-updated HIV RNA | ||||
| ≤75 | 347 | 10 | Referent | Referent |
| 76–10 000 | 237 | 2 | 0.27 (0.06, 1.23) | 0.25 (0.05, 1.15) |
| >10 000 | 180 | 6 | 1.15 (0.42, 3.18) | 0.87 (0.31, 2.43) |
| Missing | 391 | 6 | 1.20 (0.38, 3.82) | 1.28 (0.40, 4.08) |
| Lagged HIV RNA (3-month) | ||||
| ≤75 | 365 | 9 | Referent | Referent |
| 76–10 000 | 250 | 4 | 0.60 (0.19, 1.97) | 0.53 (0.16, 1.75) |
| >10 000 | 193 | 6 | 1.25 (0.44, 3.51) | 0.93 (0.31, 2.76) |
| Missing | 348 | 5 | 1.22 (0.36, 4.18) | 1.70 (0.47, 6.12) |
| Lagged HIV RNA (6-month) | ||||
| ≤75 | 381 | 9 | Referent | Referent |
| 76–10 000 | 263 | 4 | 0.62 (0.19, 2.01) | 0.54 (0.16, 1.77) |
| >10 000 | 203 | 7 | 1.42 (0.53, 3.81) | 1.06 (0.37, 3.05) |
| Missing | 309 | 4 | 1.01 (0.27, 3.80) | 1.31 (0.34, 5.12) |
Abbreviations: CI, confidence interval; HIV, human immunodeficiency virus; HR, hazard ratio.
a Final adjusted models are reduced from fully adjusted models, having removed covariates that did not significantly predict liver disease progression and did not substantially change the estimate for the association of interest. The models for baseline and current HIV viral load are adjusted for baseline CD4 (<200, ≥200) only. The models for lagged HIV viral load are adjusted for baseline CD4 (<200, ≥200), HCV viral load (≥106, <106), and age (continuous).
This PDF is available to Subscribers Only
View Article Abstract & Purchase OptionsFor full access to this pdf, sign in to an existing account, or purchase an annual subscription.
