Clinical Characteristics of Patients With Carbapenem-Resistant vs Carbapenem-Susceptible Klebsiella pneumonia in Hospital-Acquired and Community-Onset Infections
| Characteristics . | Hospital-Acquired Infection (n = 3477) . | Community-Onset Infection (n = 1926) . | ||||
|---|---|---|---|---|---|---|
| CRKP (n = 601) . | CSKP (n = 2876) . | P Value . | CRKP (n = 149) . | CSKP (n = 1777) . | P Value . | |
| Age (year), mean ± SD | 62.3 ± 20.0 | 61.6 ± 24.1 | .24 | 68.5 ± 17.7 | 65.2 ± 22.4 | 0.31 |
| Female sex | 330 (54.9) | 1639 (57.0) | .35 | 79 (53.0) | 1220 (68.7) | <.001 |
| Hospital | <.001a | .09a | ||||
| 1 (tertiary) | 466 (77.5) | 2134 (74.2) | 106 (71.1) | 1234 (69.4) | ||
| 2 (community) | 112 (18.6) | 430 (15.0) | 40 (26.9) | 429 (24.1) | ||
| 3 (children’s) | 23 (3.8) | 312 (10.8) | 3 (2.0) | 114 (6.4) | ||
| Anatomical site | <.001a | .12a | ||||
| UTI | 372 (61.9) | 1897 (66.0) | 124(83.2) | 1448 (81.5) | ||
| PNU | 148 (24.6) | 473 (16.4) | 13(8.7) | 104 (5.8) | ||
| BSI | 66 (11.0) | 421 (14.6) | 12(8.1) | 225 (12.7) | ||
| SSI | 15 (2.5) | 85 (3.0) | ||||
| Year of infection | <.001a | <.001a | ||||
| 2006 | 102 (17.0) | 294 (10.2) | 30 (20.1) | 190 (10.7) | ||
| 2007 | 101 (16.8) | 308 (10.7) | 35 (23.5) | 224 (12.6) | ||
| 2008 | 89 (14.8) | 283 (9.8) | 29 (19.5) | 165 (9.3) | ||
| 2009 | 62 (10.3) | 390 (13.6) | 16 (10.7) | 237 (13.3) | ||
| 2010 | 40 (6.7) | 355 (12.3) | 16 (10.7) | 220 (12.4) | ||
| 2011 | 48 (8.0) | 236 (8.2) | 4 (2.7) | 122 (6.9) | ||
| 2012 | 49 (8.2) | 333 (11.6) | 5 (3.4) | 185 (10.4) | ||
| 2013 | 72 (12.0) | 352 (12.2) | 7 (4.7) | 216 (12.2) | ||
| 2014 | 38 (6.3) | 325 (11.3) | 7 (4.7) | 218 (12.3) | ||
| Diabetes | 201 (33.4) | 880 (30.6) | .17 | 46 (30.9) | 612 (34.5) | .38 |
| Malignancy | 93 (15.5) | 602 (20.9) | <.01 | 23 (15.4) | 258 (14.5) | .76 |
| Dialysis | 91 (15.1) | 182 (6.3) | <.001 | 6 (4.0) | 64 (3.6) | .79 |
| History of transplant | 28 (4.7) | 123 (4.3) | .68 | 8 (5.4) | 71 (4.0) | .42 |
| Charlson Comorbidity Index, mean ± SD | 2.9 ± 2.4 | 2.9 ± 2.6 | .46 | 2.6 ± 2.5 | 2.5 ± 2.4 | .22 |
| Prior hospitalizationb | 348 (57.9) | 1743 (60.6) | .22 | 69 (46.3) | 979 (55.1) | .04 |
| Hospital LOS before KP infection, mean ± SD | 13.7 ± 18.7 | 9.7 ± 15.2 | <.001 | N/A | N/A | N/A |
| ICU stay before KP infection | 261 (43.4) | 939 (32.7) | <.001 | N/A | N/A | N/A |
| ICU days before KP infection, mean ± SD | 14.9 ± 18.2 | 10.7 ± 16.3 | <.001 | N/A | N/A | N/A |
| Antibiotics before KP infectionc | 382 (63.6) | 1325 (46.1) | <.001 | N/K | N/K | N/K |
| Characteristics . | Hospital-Acquired Infection (n = 3477) . | Community-Onset Infection (n = 1926) . | ||||
|---|---|---|---|---|---|---|
| CRKP (n = 601) . | CSKP (n = 2876) . | P Value . | CRKP (n = 149) . | CSKP (n = 1777) . | P Value . | |
| Age (year), mean ± SD | 62.3 ± 20.0 | 61.6 ± 24.1 | .24 | 68.5 ± 17.7 | 65.2 ± 22.4 | 0.31 |
| Female sex | 330 (54.9) | 1639 (57.0) | .35 | 79 (53.0) | 1220 (68.7) | <.001 |
| Hospital | <.001a | .09a | ||||
| 1 (tertiary) | 466 (77.5) | 2134 (74.2) | 106 (71.1) | 1234 (69.4) | ||
| 2 (community) | 112 (18.6) | 430 (15.0) | 40 (26.9) | 429 (24.1) | ||
| 3 (children’s) | 23 (3.8) | 312 (10.8) | 3 (2.0) | 114 (6.4) | ||
| Anatomical site | <.001a | .12a | ||||
| UTI | 372 (61.9) | 1897 (66.0) | 124(83.2) | 1448 (81.5) | ||
| PNU | 148 (24.6) | 473 (16.4) | 13(8.7) | 104 (5.8) | ||
| BSI | 66 (11.0) | 421 (14.6) | 12(8.1) | 225 (12.7) | ||
| SSI | 15 (2.5) | 85 (3.0) | ||||
| Year of infection | <.001a | <.001a | ||||
| 2006 | 102 (17.0) | 294 (10.2) | 30 (20.1) | 190 (10.7) | ||
| 2007 | 101 (16.8) | 308 (10.7) | 35 (23.5) | 224 (12.6) | ||
| 2008 | 89 (14.8) | 283 (9.8) | 29 (19.5) | 165 (9.3) | ||
| 2009 | 62 (10.3) | 390 (13.6) | 16 (10.7) | 237 (13.3) | ||
| 2010 | 40 (6.7) | 355 (12.3) | 16 (10.7) | 220 (12.4) | ||
| 2011 | 48 (8.0) | 236 (8.2) | 4 (2.7) | 122 (6.9) | ||
| 2012 | 49 (8.2) | 333 (11.6) | 5 (3.4) | 185 (10.4) | ||
| 2013 | 72 (12.0) | 352 (12.2) | 7 (4.7) | 216 (12.2) | ||
| 2014 | 38 (6.3) | 325 (11.3) | 7 (4.7) | 218 (12.3) | ||
| Diabetes | 201 (33.4) | 880 (30.6) | .17 | 46 (30.9) | 612 (34.5) | .38 |
| Malignancy | 93 (15.5) | 602 (20.9) | <.01 | 23 (15.4) | 258 (14.5) | .76 |
| Dialysis | 91 (15.1) | 182 (6.3) | <.001 | 6 (4.0) | 64 (3.6) | .79 |
| History of transplant | 28 (4.7) | 123 (4.3) | .68 | 8 (5.4) | 71 (4.0) | .42 |
| Charlson Comorbidity Index, mean ± SD | 2.9 ± 2.4 | 2.9 ± 2.6 | .46 | 2.6 ± 2.5 | 2.5 ± 2.4 | .22 |
| Prior hospitalizationb | 348 (57.9) | 1743 (60.6) | .22 | 69 (46.3) | 979 (55.1) | .04 |
| Hospital LOS before KP infection, mean ± SD | 13.7 ± 18.7 | 9.7 ± 15.2 | <.001 | N/A | N/A | N/A |
| ICU stay before KP infection | 261 (43.4) | 939 (32.7) | <.001 | N/A | N/A | N/A |
| ICU days before KP infection, mean ± SD | 14.9 ± 18.2 | 10.7 ± 16.3 | <.001 | N/A | N/A | N/A |
| Antibiotics before KP infectionc | 382 (63.6) | 1325 (46.1) | <.001 | N/K | N/K | N/K |
Abbreviations: BSI, blood stream infection; CRKP, carbapenem-resistant K pneumoniae; CSKP, carbapenem-susceptible K pneumoniae; ICU, intensive care unit; LOS, length of stay; N/A, not applicable; N/K, not known; PNU, pneumonia; SD, standard deviation; SSI, surgical site infection; UTI, urinary tract infection.
Note: Data are No. (%), unless indicated. P values were obtained from bivariate analyses.
aOverall P value for a variable with multiple categories.
bPrior hospitalization at the study in New York City hospitals.
cLonger than 1 day of any oral or parenteral antibiotic use including β-lactams, β-lactam-β-lactamase inhibitor, fluoroquinolones, and aminoglycosides.
Clinical Characteristics of Patients With Carbapenem-Resistant vs Carbapenem-Susceptible Klebsiella pneumonia in Hospital-Acquired and Community-Onset Infections
| Characteristics . | Hospital-Acquired Infection (n = 3477) . | Community-Onset Infection (n = 1926) . | ||||
|---|---|---|---|---|---|---|
| CRKP (n = 601) . | CSKP (n = 2876) . | P Value . | CRKP (n = 149) . | CSKP (n = 1777) . | P Value . | |
| Age (year), mean ± SD | 62.3 ± 20.0 | 61.6 ± 24.1 | .24 | 68.5 ± 17.7 | 65.2 ± 22.4 | 0.31 |
| Female sex | 330 (54.9) | 1639 (57.0) | .35 | 79 (53.0) | 1220 (68.7) | <.001 |
| Hospital | <.001a | .09a | ||||
| 1 (tertiary) | 466 (77.5) | 2134 (74.2) | 106 (71.1) | 1234 (69.4) | ||
| 2 (community) | 112 (18.6) | 430 (15.0) | 40 (26.9) | 429 (24.1) | ||
| 3 (children’s) | 23 (3.8) | 312 (10.8) | 3 (2.0) | 114 (6.4) | ||
| Anatomical site | <.001a | .12a | ||||
| UTI | 372 (61.9) | 1897 (66.0) | 124(83.2) | 1448 (81.5) | ||
| PNU | 148 (24.6) | 473 (16.4) | 13(8.7) | 104 (5.8) | ||
| BSI | 66 (11.0) | 421 (14.6) | 12(8.1) | 225 (12.7) | ||
| SSI | 15 (2.5) | 85 (3.0) | ||||
| Year of infection | <.001a | <.001a | ||||
| 2006 | 102 (17.0) | 294 (10.2) | 30 (20.1) | 190 (10.7) | ||
| 2007 | 101 (16.8) | 308 (10.7) | 35 (23.5) | 224 (12.6) | ||
| 2008 | 89 (14.8) | 283 (9.8) | 29 (19.5) | 165 (9.3) | ||
| 2009 | 62 (10.3) | 390 (13.6) | 16 (10.7) | 237 (13.3) | ||
| 2010 | 40 (6.7) | 355 (12.3) | 16 (10.7) | 220 (12.4) | ||
| 2011 | 48 (8.0) | 236 (8.2) | 4 (2.7) | 122 (6.9) | ||
| 2012 | 49 (8.2) | 333 (11.6) | 5 (3.4) | 185 (10.4) | ||
| 2013 | 72 (12.0) | 352 (12.2) | 7 (4.7) | 216 (12.2) | ||
| 2014 | 38 (6.3) | 325 (11.3) | 7 (4.7) | 218 (12.3) | ||
| Diabetes | 201 (33.4) | 880 (30.6) | .17 | 46 (30.9) | 612 (34.5) | .38 |
| Malignancy | 93 (15.5) | 602 (20.9) | <.01 | 23 (15.4) | 258 (14.5) | .76 |
| Dialysis | 91 (15.1) | 182 (6.3) | <.001 | 6 (4.0) | 64 (3.6) | .79 |
| History of transplant | 28 (4.7) | 123 (4.3) | .68 | 8 (5.4) | 71 (4.0) | .42 |
| Charlson Comorbidity Index, mean ± SD | 2.9 ± 2.4 | 2.9 ± 2.6 | .46 | 2.6 ± 2.5 | 2.5 ± 2.4 | .22 |
| Prior hospitalizationb | 348 (57.9) | 1743 (60.6) | .22 | 69 (46.3) | 979 (55.1) | .04 |
| Hospital LOS before KP infection, mean ± SD | 13.7 ± 18.7 | 9.7 ± 15.2 | <.001 | N/A | N/A | N/A |
| ICU stay before KP infection | 261 (43.4) | 939 (32.7) | <.001 | N/A | N/A | N/A |
| ICU days before KP infection, mean ± SD | 14.9 ± 18.2 | 10.7 ± 16.3 | <.001 | N/A | N/A | N/A |
| Antibiotics before KP infectionc | 382 (63.6) | 1325 (46.1) | <.001 | N/K | N/K | N/K |
| Characteristics . | Hospital-Acquired Infection (n = 3477) . | Community-Onset Infection (n = 1926) . | ||||
|---|---|---|---|---|---|---|
| CRKP (n = 601) . | CSKP (n = 2876) . | P Value . | CRKP (n = 149) . | CSKP (n = 1777) . | P Value . | |
| Age (year), mean ± SD | 62.3 ± 20.0 | 61.6 ± 24.1 | .24 | 68.5 ± 17.7 | 65.2 ± 22.4 | 0.31 |
| Female sex | 330 (54.9) | 1639 (57.0) | .35 | 79 (53.0) | 1220 (68.7) | <.001 |
| Hospital | <.001a | .09a | ||||
| 1 (tertiary) | 466 (77.5) | 2134 (74.2) | 106 (71.1) | 1234 (69.4) | ||
| 2 (community) | 112 (18.6) | 430 (15.0) | 40 (26.9) | 429 (24.1) | ||
| 3 (children’s) | 23 (3.8) | 312 (10.8) | 3 (2.0) | 114 (6.4) | ||
| Anatomical site | <.001a | .12a | ||||
| UTI | 372 (61.9) | 1897 (66.0) | 124(83.2) | 1448 (81.5) | ||
| PNU | 148 (24.6) | 473 (16.4) | 13(8.7) | 104 (5.8) | ||
| BSI | 66 (11.0) | 421 (14.6) | 12(8.1) | 225 (12.7) | ||
| SSI | 15 (2.5) | 85 (3.0) | ||||
| Year of infection | <.001a | <.001a | ||||
| 2006 | 102 (17.0) | 294 (10.2) | 30 (20.1) | 190 (10.7) | ||
| 2007 | 101 (16.8) | 308 (10.7) | 35 (23.5) | 224 (12.6) | ||
| 2008 | 89 (14.8) | 283 (9.8) | 29 (19.5) | 165 (9.3) | ||
| 2009 | 62 (10.3) | 390 (13.6) | 16 (10.7) | 237 (13.3) | ||
| 2010 | 40 (6.7) | 355 (12.3) | 16 (10.7) | 220 (12.4) | ||
| 2011 | 48 (8.0) | 236 (8.2) | 4 (2.7) | 122 (6.9) | ||
| 2012 | 49 (8.2) | 333 (11.6) | 5 (3.4) | 185 (10.4) | ||
| 2013 | 72 (12.0) | 352 (12.2) | 7 (4.7) | 216 (12.2) | ||
| 2014 | 38 (6.3) | 325 (11.3) | 7 (4.7) | 218 (12.3) | ||
| Diabetes | 201 (33.4) | 880 (30.6) | .17 | 46 (30.9) | 612 (34.5) | .38 |
| Malignancy | 93 (15.5) | 602 (20.9) | <.01 | 23 (15.4) | 258 (14.5) | .76 |
| Dialysis | 91 (15.1) | 182 (6.3) | <.001 | 6 (4.0) | 64 (3.6) | .79 |
| History of transplant | 28 (4.7) | 123 (4.3) | .68 | 8 (5.4) | 71 (4.0) | .42 |
| Charlson Comorbidity Index, mean ± SD | 2.9 ± 2.4 | 2.9 ± 2.6 | .46 | 2.6 ± 2.5 | 2.5 ± 2.4 | .22 |
| Prior hospitalizationb | 348 (57.9) | 1743 (60.6) | .22 | 69 (46.3) | 979 (55.1) | .04 |
| Hospital LOS before KP infection, mean ± SD | 13.7 ± 18.7 | 9.7 ± 15.2 | <.001 | N/A | N/A | N/A |
| ICU stay before KP infection | 261 (43.4) | 939 (32.7) | <.001 | N/A | N/A | N/A |
| ICU days before KP infection, mean ± SD | 14.9 ± 18.2 | 10.7 ± 16.3 | <.001 | N/A | N/A | N/A |
| Antibiotics before KP infectionc | 382 (63.6) | 1325 (46.1) | <.001 | N/K | N/K | N/K |
Abbreviations: BSI, blood stream infection; CRKP, carbapenem-resistant K pneumoniae; CSKP, carbapenem-susceptible K pneumoniae; ICU, intensive care unit; LOS, length of stay; N/A, not applicable; N/K, not known; PNU, pneumonia; SD, standard deviation; SSI, surgical site infection; UTI, urinary tract infection.
Note: Data are No. (%), unless indicated. P values were obtained from bivariate analyses.
aOverall P value for a variable with multiple categories.
bPrior hospitalization at the study in New York City hospitals.
cLonger than 1 day of any oral or parenteral antibiotic use including β-lactams, β-lactam-β-lactamase inhibitor, fluoroquinolones, and aminoglycosides.
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