Multivariable Logistic Regression of Clinical and Microbiological Factors Associated With ICU Admission in Adults With IPD, 2000–2016
| Factor . | Odds Ratio . | 95% CI . | P Value . |
|---|---|---|---|
| Homeless | 0.65 | 0.45 to 0.93 | .020 |
| Male | 0.87 | 0.67 to 1.12 | .283 |
| Alcohol abuse | 2.23 | 1.64 to 3.03 | <.001 |
| Illegal drug use | 1.20 | 0.85 to 1.68 | .298 |
| Serotypes 4, 5, or 8 | 0.69 | 0.51 to 0.94 | .017 |
| Age group | |||
| 18–64 y | Reference group | ||
| 65–84 y | 0.80 | 0.57 to 1.11 | .179 |
| 85+ y | 0.14 | 0.04 to 0.47 | .001 |
| Smoking | |||
| Nonsmoker | Reference group | ||
| Current smoker | 1.46 | 1.01 to 2.12 | .046 |
| Former smoker | 1.29 | 0.85 to 1.96 | .231 |
| Primary diagnosis | |||
| Bacteremia/other | Reference group | ||
| Pneumonia/empyema | 1.65 | 1.05 to 2.60 | .031 |
| Meningitis | 19.64 | 9.76 to 39.49 | <.001 |
| Comorbiditya | |||
| No comorbidity | Reference group | ||
| Immunocompetent comorbidity | 1.38 | 1.03 to 1.85 | .031 |
| Immunocompromising comorbidity | 1.15 | 0.81 to 1.63 | .440 |
| Factor . | Odds Ratio . | 95% CI . | P Value . |
|---|---|---|---|
| Homeless | 0.65 | 0.45 to 0.93 | .020 |
| Male | 0.87 | 0.67 to 1.12 | .283 |
| Alcohol abuse | 2.23 | 1.64 to 3.03 | <.001 |
| Illegal drug use | 1.20 | 0.85 to 1.68 | .298 |
| Serotypes 4, 5, or 8 | 0.69 | 0.51 to 0.94 | .017 |
| Age group | |||
| 18–64 y | Reference group | ||
| 65–84 y | 0.80 | 0.57 to 1.11 | .179 |
| 85+ y | 0.14 | 0.04 to 0.47 | .001 |
| Smoking | |||
| Nonsmoker | Reference group | ||
| Current smoker | 1.46 | 1.01 to 2.12 | .046 |
| Former smoker | 1.29 | 0.85 to 1.96 | .231 |
| Primary diagnosis | |||
| Bacteremia/other | Reference group | ||
| Pneumonia/empyema | 1.65 | 1.05 to 2.60 | .031 |
| Meningitis | 19.64 | 9.76 to 39.49 | <.001 |
| Comorbiditya | |||
| No comorbidity | Reference group | ||
| Immunocompetent comorbidity | 1.38 | 1.03 to 1.85 | .031 |
| Immunocompromising comorbidity | 1.15 | 0.81 to 1.63 | .440 |
Abbreviations: CI, confidence interval; ICU, intensive care unit; IPD, invasive pneumococcal disease.
aProportion of cases with 1 or more immunocompetent or immunocompromising comorbidities [13].
Multivariable Logistic Regression of Clinical and Microbiological Factors Associated With ICU Admission in Adults With IPD, 2000–2016
| Factor . | Odds Ratio . | 95% CI . | P Value . |
|---|---|---|---|
| Homeless | 0.65 | 0.45 to 0.93 | .020 |
| Male | 0.87 | 0.67 to 1.12 | .283 |
| Alcohol abuse | 2.23 | 1.64 to 3.03 | <.001 |
| Illegal drug use | 1.20 | 0.85 to 1.68 | .298 |
| Serotypes 4, 5, or 8 | 0.69 | 0.51 to 0.94 | .017 |
| Age group | |||
| 18–64 y | Reference group | ||
| 65–84 y | 0.80 | 0.57 to 1.11 | .179 |
| 85+ y | 0.14 | 0.04 to 0.47 | .001 |
| Smoking | |||
| Nonsmoker | Reference group | ||
| Current smoker | 1.46 | 1.01 to 2.12 | .046 |
| Former smoker | 1.29 | 0.85 to 1.96 | .231 |
| Primary diagnosis | |||
| Bacteremia/other | Reference group | ||
| Pneumonia/empyema | 1.65 | 1.05 to 2.60 | .031 |
| Meningitis | 19.64 | 9.76 to 39.49 | <.001 |
| Comorbiditya | |||
| No comorbidity | Reference group | ||
| Immunocompetent comorbidity | 1.38 | 1.03 to 1.85 | .031 |
| Immunocompromising comorbidity | 1.15 | 0.81 to 1.63 | .440 |
| Factor . | Odds Ratio . | 95% CI . | P Value . |
|---|---|---|---|
| Homeless | 0.65 | 0.45 to 0.93 | .020 |
| Male | 0.87 | 0.67 to 1.12 | .283 |
| Alcohol abuse | 2.23 | 1.64 to 3.03 | <.001 |
| Illegal drug use | 1.20 | 0.85 to 1.68 | .298 |
| Serotypes 4, 5, or 8 | 0.69 | 0.51 to 0.94 | .017 |
| Age group | |||
| 18–64 y | Reference group | ||
| 65–84 y | 0.80 | 0.57 to 1.11 | .179 |
| 85+ y | 0.14 | 0.04 to 0.47 | .001 |
| Smoking | |||
| Nonsmoker | Reference group | ||
| Current smoker | 1.46 | 1.01 to 2.12 | .046 |
| Former smoker | 1.29 | 0.85 to 1.96 | .231 |
| Primary diagnosis | |||
| Bacteremia/other | Reference group | ||
| Pneumonia/empyema | 1.65 | 1.05 to 2.60 | .031 |
| Meningitis | 19.64 | 9.76 to 39.49 | <.001 |
| Comorbiditya | |||
| No comorbidity | Reference group | ||
| Immunocompetent comorbidity | 1.38 | 1.03 to 1.85 | .031 |
| Immunocompromising comorbidity | 1.15 | 0.81 to 1.63 | .440 |
Abbreviations: CI, confidence interval; ICU, intensive care unit; IPD, invasive pneumococcal disease.
aProportion of cases with 1 or more immunocompetent or immunocompromising comorbidities [13].
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