Effect of Intensive Versus Standard Anthelminthic Treatment on Metabolic Outcomes in the Metabolic Survey of the Lake Victoria Island Intervention Study on Worms and Allergy-Related Diseases Cluster-Randomized Trial: Cluster-Level Analysis (n = 1853)
| Outcome . | Mean . | Crude Mean Difference or GMR (95% CI) . | P Value . | Adjusted Mean Difference or GMR (95% CI)a . | P Value . | |
|---|---|---|---|---|---|---|
| . | Intensive . | Standard . | . | . | . | . |
| HOMA-IR (glucose × insulin / 22.5) | GM, 1.24b | GM, 1.30b | GMR, 0.96 (.85–1.07)c | .43 | aGMR, 0.96 (.86–1.07)c | .42 |
| Fasting glucose (mmol/L) | 4.78 | 4.76 | 0.02 (−.16 to .20) | .85 | 0.01 (−.17 to .19) | .90 |
| Glycated hemoglobin (mmol/mol) | 30.72 | 30.56 | 0.16 (−2.09 to 2.41) | .88 | 0.14 (−2.11 to 2.40) | .90 |
| Triglycerides (mmol/L) | GM, 0.98b | GM, 0.98b | GMR, 1.00 (.94–1.06)c | .95 | aGMR, 0.97 (.85–1.11)c | .63 |
| Total cholesterol (mmol/L) | 4.52 | 4.33 | 0.19 (−.16 to .54) | .27 | 0.19 (−.16 to .54) | .28 |
| LDL-c (mmol/L) | 2.86 | 2.60 | 0.27 (−.03 to .56) | .08 | 0.26 (−.03 to .56) | .08 |
| HDL-c (mmol/L) | GM, 1.20b | GM, 1.20b | GMR, 1.01 (.87–1.17)c | .94 | aGMR, 1.01 (.87–1.17)c | .94 |
| Systolic BP (mm Hg) | 115.27 | 116.13 | −0.86 (−2.84 to 1.12) | .38 | −1.02 (−2.72 to .68) | .22 |
| Diastolic BP (mm Hg) | 76.40 | 76.37 | 0.03 (−1.25 to 1.31) | .97 | −0.12 (−1.34 to 1.10) | .84 |
| Body mass index (kg/m2) | 23.34 | 23.34 | 0.01 (−.50 to .51) | .99 | −0.08 (−.58 to .42) | .74 |
| Waist circumference (cm) | 80.00 | 80.04 | −0.04 (−1.49 to 1.41) | .95 | −0.32 (−1.70 to 1.07) | .64 |
| Waist-to-hip ratio | 0.85 | 0.85 | 0.00 (.00−.01) | .96 | 0.00 (−.01 to .00) | .72 |
| Outcome . | Mean . | Crude Mean Difference or GMR (95% CI) . | P Value . | Adjusted Mean Difference or GMR (95% CI)a . | P Value . | |
|---|---|---|---|---|---|---|
| . | Intensive . | Standard . | . | . | . | . |
| HOMA-IR (glucose × insulin / 22.5) | GM, 1.24b | GM, 1.30b | GMR, 0.96 (.85–1.07)c | .43 | aGMR, 0.96 (.86–1.07)c | .42 |
| Fasting glucose (mmol/L) | 4.78 | 4.76 | 0.02 (−.16 to .20) | .85 | 0.01 (−.17 to .19) | .90 |
| Glycated hemoglobin (mmol/mol) | 30.72 | 30.56 | 0.16 (−2.09 to 2.41) | .88 | 0.14 (−2.11 to 2.40) | .90 |
| Triglycerides (mmol/L) | GM, 0.98b | GM, 0.98b | GMR, 1.00 (.94–1.06)c | .95 | aGMR, 0.97 (.85–1.11)c | .63 |
| Total cholesterol (mmol/L) | 4.52 | 4.33 | 0.19 (−.16 to .54) | .27 | 0.19 (−.16 to .54) | .28 |
| LDL-c (mmol/L) | 2.86 | 2.60 | 0.27 (−.03 to .56) | .08 | 0.26 (−.03 to .56) | .08 |
| HDL-c (mmol/L) | GM, 1.20b | GM, 1.20b | GMR, 1.01 (.87–1.17)c | .94 | aGMR, 1.01 (.87–1.17)c | .94 |
| Systolic BP (mm Hg) | 115.27 | 116.13 | −0.86 (−2.84 to 1.12) | .38 | −1.02 (−2.72 to .68) | .22 |
| Diastolic BP (mm Hg) | 76.40 | 76.37 | 0.03 (−1.25 to 1.31) | .97 | −0.12 (−1.34 to 1.10) | .84 |
| Body mass index (kg/m2) | 23.34 | 23.34 | 0.01 (−.50 to .51) | .99 | −0.08 (−.58 to .42) | .74 |
| Waist circumference (cm) | 80.00 | 80.04 | −0.04 (−1.49 to 1.41) | .95 | −0.32 (−1.70 to 1.07) | .64 |
| Waist-to-hip ratio | 0.85 | 0.85 | 0.00 (.00−.01) | .96 | 0.00 (−.01 to .00) | .72 |
Abbreviations: aGMR, adjusted geometric mean ratio; BP, blood pressure; CI, confidence interval; GM, geometric mean; GMR, geometric mean ratio; HDL-c, high-density lipoprotein cholesterol; HOMA-IR, homeostatic model assessment of insulin resistance; LDL-c, low-density lipoprotein cholesterol.
aAdjusted for age and sex.
bGeometric means used because of skewed cluster-specific means.
cGMRs used because of skewed cluster-specific means.
Effect of Intensive Versus Standard Anthelminthic Treatment on Metabolic Outcomes in the Metabolic Survey of the Lake Victoria Island Intervention Study on Worms and Allergy-Related Diseases Cluster-Randomized Trial: Cluster-Level Analysis (n = 1853)
| Outcome . | Mean . | Crude Mean Difference or GMR (95% CI) . | P Value . | Adjusted Mean Difference or GMR (95% CI)a . | P Value . | |
|---|---|---|---|---|---|---|
| . | Intensive . | Standard . | . | . | . | . |
| HOMA-IR (glucose × insulin / 22.5) | GM, 1.24b | GM, 1.30b | GMR, 0.96 (.85–1.07)c | .43 | aGMR, 0.96 (.86–1.07)c | .42 |
| Fasting glucose (mmol/L) | 4.78 | 4.76 | 0.02 (−.16 to .20) | .85 | 0.01 (−.17 to .19) | .90 |
| Glycated hemoglobin (mmol/mol) | 30.72 | 30.56 | 0.16 (−2.09 to 2.41) | .88 | 0.14 (−2.11 to 2.40) | .90 |
| Triglycerides (mmol/L) | GM, 0.98b | GM, 0.98b | GMR, 1.00 (.94–1.06)c | .95 | aGMR, 0.97 (.85–1.11)c | .63 |
| Total cholesterol (mmol/L) | 4.52 | 4.33 | 0.19 (−.16 to .54) | .27 | 0.19 (−.16 to .54) | .28 |
| LDL-c (mmol/L) | 2.86 | 2.60 | 0.27 (−.03 to .56) | .08 | 0.26 (−.03 to .56) | .08 |
| HDL-c (mmol/L) | GM, 1.20b | GM, 1.20b | GMR, 1.01 (.87–1.17)c | .94 | aGMR, 1.01 (.87–1.17)c | .94 |
| Systolic BP (mm Hg) | 115.27 | 116.13 | −0.86 (−2.84 to 1.12) | .38 | −1.02 (−2.72 to .68) | .22 |
| Diastolic BP (mm Hg) | 76.40 | 76.37 | 0.03 (−1.25 to 1.31) | .97 | −0.12 (−1.34 to 1.10) | .84 |
| Body mass index (kg/m2) | 23.34 | 23.34 | 0.01 (−.50 to .51) | .99 | −0.08 (−.58 to .42) | .74 |
| Waist circumference (cm) | 80.00 | 80.04 | −0.04 (−1.49 to 1.41) | .95 | −0.32 (−1.70 to 1.07) | .64 |
| Waist-to-hip ratio | 0.85 | 0.85 | 0.00 (.00−.01) | .96 | 0.00 (−.01 to .00) | .72 |
| Outcome . | Mean . | Crude Mean Difference or GMR (95% CI) . | P Value . | Adjusted Mean Difference or GMR (95% CI)a . | P Value . | |
|---|---|---|---|---|---|---|
| . | Intensive . | Standard . | . | . | . | . |
| HOMA-IR (glucose × insulin / 22.5) | GM, 1.24b | GM, 1.30b | GMR, 0.96 (.85–1.07)c | .43 | aGMR, 0.96 (.86–1.07)c | .42 |
| Fasting glucose (mmol/L) | 4.78 | 4.76 | 0.02 (−.16 to .20) | .85 | 0.01 (−.17 to .19) | .90 |
| Glycated hemoglobin (mmol/mol) | 30.72 | 30.56 | 0.16 (−2.09 to 2.41) | .88 | 0.14 (−2.11 to 2.40) | .90 |
| Triglycerides (mmol/L) | GM, 0.98b | GM, 0.98b | GMR, 1.00 (.94–1.06)c | .95 | aGMR, 0.97 (.85–1.11)c | .63 |
| Total cholesterol (mmol/L) | 4.52 | 4.33 | 0.19 (−.16 to .54) | .27 | 0.19 (−.16 to .54) | .28 |
| LDL-c (mmol/L) | 2.86 | 2.60 | 0.27 (−.03 to .56) | .08 | 0.26 (−.03 to .56) | .08 |
| HDL-c (mmol/L) | GM, 1.20b | GM, 1.20b | GMR, 1.01 (.87–1.17)c | .94 | aGMR, 1.01 (.87–1.17)c | .94 |
| Systolic BP (mm Hg) | 115.27 | 116.13 | −0.86 (−2.84 to 1.12) | .38 | −1.02 (−2.72 to .68) | .22 |
| Diastolic BP (mm Hg) | 76.40 | 76.37 | 0.03 (−1.25 to 1.31) | .97 | −0.12 (−1.34 to 1.10) | .84 |
| Body mass index (kg/m2) | 23.34 | 23.34 | 0.01 (−.50 to .51) | .99 | −0.08 (−.58 to .42) | .74 |
| Waist circumference (cm) | 80.00 | 80.04 | −0.04 (−1.49 to 1.41) | .95 | −0.32 (−1.70 to 1.07) | .64 |
| Waist-to-hip ratio | 0.85 | 0.85 | 0.00 (.00−.01) | .96 | 0.00 (−.01 to .00) | .72 |
Abbreviations: aGMR, adjusted geometric mean ratio; BP, blood pressure; CI, confidence interval; GM, geometric mean; GMR, geometric mean ratio; HDL-c, high-density lipoprotein cholesterol; HOMA-IR, homeostatic model assessment of insulin resistance; LDL-c, low-density lipoprotein cholesterol.
aAdjusted for age and sex.
bGeometric means used because of skewed cluster-specific means.
cGMRs used because of skewed cluster-specific means.
This PDF is available to Subscribers Only
View Article Abstract & Purchase OptionsFor full access to this pdf, sign in to an existing account, or purchase an annual subscription.
