Table 1

Demographic and baseline characteristics according to antithrombotic therapy at baseline discharge

No antithrombotic (N = 586)Only antiplatelet drugs (N = 681)Only VKA (N = 4066)Only NOACs (N = 3167)Antiplatelet drugs + OAC (N = 1163)P-value
Demographics
Age (years), median (IQR)61 (51–73)72 (62–78)71 (64–78)70 (62–77)72 (65–78)<0.0001
Female, n (%)223 (38.1)289 (42.4)1729 (42.5)1272 (40.2)374 (32.2)<0.0001
Type of AF, n (%)<0.0001
 First diagnosed136 (23.9)127 (19.2)386 (9.6)626 (20.0)189 (16.7)
 Paroxysmal231 (40.7)285 (43.1)821 (20.5)844 (27.0)288 (25.4)
 Persistent78 (13.7)80 (12.1)711 (17.7)814 (26.0)215 (19.0)
 LS persistent9 (1.6)18 (2.7)206 (5.1)158 (5.1)35 (3.1)
 Permanent114 (20.1)151 (22.8)1884 (47.0)683 (21.9)405 (35.8)
Concomitant diseases, n (%)
 Hypertension188 (32.5)412 (61.1)2631 (65.2)1897 (60.4)791 (68.5)<0.0001
 CAD91 (16.2)334 (52.8)850 (22.3)498 (16.4)834 (76.3)<0.0001
 Previous MI40 (44.0)160 (47.9)325 (38.2)194 (39.0)432 (51.8)<0.0001
 Heart failure135 (23.4)323 (47.9)1735 (42.9)934 (29.8)590 (51.1)<0.0001
 Valvular disease157 (27.4)305 (46.0)2362 (59.1)1316 (42.5)625 (54.6)<0.0001
 Dilated cardiomyopathy24 (4.2)54 (8.0)419 (10.4)185 (5.9)142 (12.4)<0.0001
 Hypertrophic cardiomyopathy9 (1.6)16 (2.4)154 (3.8)76 (2.4)41 (3.6)0.0007
 Restrictive cardiomyopathy2 (0.3)1 (0.1)11 (0.3)4 (0.1)2 (0.2)0.5788
 Other cardiomyopathy12 (2.1)24 (3.6)161 (4.0)97 (3.1)56 (4.8)0.0102
 Congenital heart disease6 (1.0)9 (1.3)50 (1.2)25 (0.8)12 (1.0)0.3852
 PAH21 (3.7)53 (8.0)345 (8.6)128 (4.1)93 (8.1)<0.0001
Cardiovascular risk factors, n (%)
Diabetes mellitus86 (14.8)161 (23.7)943 (23.3)595 (18.9)409 (35.5)<0.0001
Lipid disorder148 (26.6)295 (45.7)1651 (42.5)1138 (37.5)617 (55.1)<0.0001
Current smoker85 (15.5)71 (11.2)305 (8.2)244 (8.2)124 (11.3)<0.0001
 No regular exercise170 (33.4)290 (47.6)1483 (42.5)989 (37.0)525 (50.9)<0.0001
Other comorbidities, n (%)
 Previous stroke14 (2.4)40 (6.0)262 (6.5)189 (6.0)83 (7.2)0.0005
 Previous TIA6 (1.0)18 (2.7)126 (3.1)119 (3.8)41 (3.6)0.0048
 Previous bleedings39 (6.8)59 (8.8)166 (4.1)163 (5.2)68 (5.9)<0.0001
 PAD26 (4.5)84 (12.8)299 (7.5)176 (5.7)175 (15.5)<0.0001
 Chronic kidney disease37 (6.3)123 (18.2)504 (12.5)304 (9.6)223 (19.3)<0.0001
 COPD34 (5.9)60 (8.9)388 (9.6)226 (7.2)147 (12.7)<0.0001
 Malignancy47 (8.0)54 (8.0)285 (7.0)262 (8.3)89 (7.7)0.3309
 Thyroid disease/disorder57 (9.9)75 (11.4)615 (15.4)452 (14.5)166 (14.5)0.0017
Main reason for admission/consultation, n (%)<0.0001
 AF447 (76.3)368 (54.0)2565 (63.1)2557 (80.7)537 (46.2)
 ACS13 (2.2)84 (12.3)36 (0.9)19 (0.6)161 (13.8)
 Valvular disease9 (1.5)19 (2.8)177 (4.4)17 (0.5)52 (4.5)
 Hypertension21 (3.6)10 (1.5)94 (2.3)51 (1.6)19 (1.6)
 Heart failure22 (3.8)67 (9.8)502 (12.3)207 (6.5)142 (12.2)
 Other CAD8 (1.4)41 (6.0)80 (2.0)36 (1.1)96 (8.3)
 Other CV28 (4.8)65 (9.5)363 (8.9)159 (5.0)105 (9.0)
 Other non-CV38 (6.5)27 (4.0)248 (6.1)121 (3.8)51 (4.4)
Symptomatic status, n (%)<0.0001
 EHRA I261 (44.5)337 (49.5)1942 (47.8)1328 (41.9)519 (44.6)
 EHRA II–III–IV325 (55.5)344 (50.5)2124 (52.2)1839 (58.1)644 (55.4)
No antithrombotic (N = 586)Only antiplatelet drugs (N = 681)Only VKA (N = 4066)Only NOACs (N = 3167)Antiplatelet drugs + OAC (N = 1163)P-value
Demographics
Age (years), median (IQR)61 (51–73)72 (62–78)71 (64–78)70 (62–77)72 (65–78)<0.0001
Female, n (%)223 (38.1)289 (42.4)1729 (42.5)1272 (40.2)374 (32.2)<0.0001
Type of AF, n (%)<0.0001
 First diagnosed136 (23.9)127 (19.2)386 (9.6)626 (20.0)189 (16.7)
 Paroxysmal231 (40.7)285 (43.1)821 (20.5)844 (27.0)288 (25.4)
 Persistent78 (13.7)80 (12.1)711 (17.7)814 (26.0)215 (19.0)
 LS persistent9 (1.6)18 (2.7)206 (5.1)158 (5.1)35 (3.1)
 Permanent114 (20.1)151 (22.8)1884 (47.0)683 (21.9)405 (35.8)
Concomitant diseases, n (%)
 Hypertension188 (32.5)412 (61.1)2631 (65.2)1897 (60.4)791 (68.5)<0.0001
 CAD91 (16.2)334 (52.8)850 (22.3)498 (16.4)834 (76.3)<0.0001
 Previous MI40 (44.0)160 (47.9)325 (38.2)194 (39.0)432 (51.8)<0.0001
 Heart failure135 (23.4)323 (47.9)1735 (42.9)934 (29.8)590 (51.1)<0.0001
 Valvular disease157 (27.4)305 (46.0)2362 (59.1)1316 (42.5)625 (54.6)<0.0001
 Dilated cardiomyopathy24 (4.2)54 (8.0)419 (10.4)185 (5.9)142 (12.4)<0.0001
 Hypertrophic cardiomyopathy9 (1.6)16 (2.4)154 (3.8)76 (2.4)41 (3.6)0.0007
 Restrictive cardiomyopathy2 (0.3)1 (0.1)11 (0.3)4 (0.1)2 (0.2)0.5788
 Other cardiomyopathy12 (2.1)24 (3.6)161 (4.0)97 (3.1)56 (4.8)0.0102
 Congenital heart disease6 (1.0)9 (1.3)50 (1.2)25 (0.8)12 (1.0)0.3852
 PAH21 (3.7)53 (8.0)345 (8.6)128 (4.1)93 (8.1)<0.0001
Cardiovascular risk factors, n (%)
Diabetes mellitus86 (14.8)161 (23.7)943 (23.3)595 (18.9)409 (35.5)<0.0001
Lipid disorder148 (26.6)295 (45.7)1651 (42.5)1138 (37.5)617 (55.1)<0.0001
Current smoker85 (15.5)71 (11.2)305 (8.2)244 (8.2)124 (11.3)<0.0001
 No regular exercise170 (33.4)290 (47.6)1483 (42.5)989 (37.0)525 (50.9)<0.0001
Other comorbidities, n (%)
 Previous stroke14 (2.4)40 (6.0)262 (6.5)189 (6.0)83 (7.2)0.0005
 Previous TIA6 (1.0)18 (2.7)126 (3.1)119 (3.8)41 (3.6)0.0048
 Previous bleedings39 (6.8)59 (8.8)166 (4.1)163 (5.2)68 (5.9)<0.0001
 PAD26 (4.5)84 (12.8)299 (7.5)176 (5.7)175 (15.5)<0.0001
 Chronic kidney disease37 (6.3)123 (18.2)504 (12.5)304 (9.6)223 (19.3)<0.0001
 COPD34 (5.9)60 (8.9)388 (9.6)226 (7.2)147 (12.7)<0.0001
 Malignancy47 (8.0)54 (8.0)285 (7.0)262 (8.3)89 (7.7)0.3309
 Thyroid disease/disorder57 (9.9)75 (11.4)615 (15.4)452 (14.5)166 (14.5)0.0017
Main reason for admission/consultation, n (%)<0.0001
 AF447 (76.3)368 (54.0)2565 (63.1)2557 (80.7)537 (46.2)
 ACS13 (2.2)84 (12.3)36 (0.9)19 (0.6)161 (13.8)
 Valvular disease9 (1.5)19 (2.8)177 (4.4)17 (0.5)52 (4.5)
 Hypertension21 (3.6)10 (1.5)94 (2.3)51 (1.6)19 (1.6)
 Heart failure22 (3.8)67 (9.8)502 (12.3)207 (6.5)142 (12.2)
 Other CAD8 (1.4)41 (6.0)80 (2.0)36 (1.1)96 (8.3)
 Other CV28 (4.8)65 (9.5)363 (8.9)159 (5.0)105 (9.0)
 Other non-CV38 (6.5)27 (4.0)248 (6.1)121 (3.8)51 (4.4)
Symptomatic status, n (%)<0.0001
 EHRA I261 (44.5)337 (49.5)1942 (47.8)1328 (41.9)519 (44.6)
 EHRA II–III–IV325 (55.5)344 (50.5)2124 (52.2)1839 (58.1)644 (55.4)

ACS, acute coronary syndrome; AF, atrial fibrillation; CAD, coronary artery disease; COPD, chronic obstructive pulmonary disease; CV, cardiovascular; EHRA, European Heart Rhythm Association; IQR, interquartile range; MI, myocardial infarction; NOACs, non-vitamin K antagonist oral anticoagulants; OAC, oral anticoagulants; PAD, peripheral artery disease; PAH, pulmonary artery hypertension; TIA, transient ischaemic attack; VKA, vitamin K antagonist.

Table 1

Demographic and baseline characteristics according to antithrombotic therapy at baseline discharge

No antithrombotic (N = 586)Only antiplatelet drugs (N = 681)Only VKA (N = 4066)Only NOACs (N = 3167)Antiplatelet drugs + OAC (N = 1163)P-value
Demographics
Age (years), median (IQR)61 (51–73)72 (62–78)71 (64–78)70 (62–77)72 (65–78)<0.0001
Female, n (%)223 (38.1)289 (42.4)1729 (42.5)1272 (40.2)374 (32.2)<0.0001
Type of AF, n (%)<0.0001
 First diagnosed136 (23.9)127 (19.2)386 (9.6)626 (20.0)189 (16.7)
 Paroxysmal231 (40.7)285 (43.1)821 (20.5)844 (27.0)288 (25.4)
 Persistent78 (13.7)80 (12.1)711 (17.7)814 (26.0)215 (19.0)
 LS persistent9 (1.6)18 (2.7)206 (5.1)158 (5.1)35 (3.1)
 Permanent114 (20.1)151 (22.8)1884 (47.0)683 (21.9)405 (35.8)
Concomitant diseases, n (%)
 Hypertension188 (32.5)412 (61.1)2631 (65.2)1897 (60.4)791 (68.5)<0.0001
 CAD91 (16.2)334 (52.8)850 (22.3)498 (16.4)834 (76.3)<0.0001
 Previous MI40 (44.0)160 (47.9)325 (38.2)194 (39.0)432 (51.8)<0.0001
 Heart failure135 (23.4)323 (47.9)1735 (42.9)934 (29.8)590 (51.1)<0.0001
 Valvular disease157 (27.4)305 (46.0)2362 (59.1)1316 (42.5)625 (54.6)<0.0001
 Dilated cardiomyopathy24 (4.2)54 (8.0)419 (10.4)185 (5.9)142 (12.4)<0.0001
 Hypertrophic cardiomyopathy9 (1.6)16 (2.4)154 (3.8)76 (2.4)41 (3.6)0.0007
 Restrictive cardiomyopathy2 (0.3)1 (0.1)11 (0.3)4 (0.1)2 (0.2)0.5788
 Other cardiomyopathy12 (2.1)24 (3.6)161 (4.0)97 (3.1)56 (4.8)0.0102
 Congenital heart disease6 (1.0)9 (1.3)50 (1.2)25 (0.8)12 (1.0)0.3852
 PAH21 (3.7)53 (8.0)345 (8.6)128 (4.1)93 (8.1)<0.0001
Cardiovascular risk factors, n (%)
Diabetes mellitus86 (14.8)161 (23.7)943 (23.3)595 (18.9)409 (35.5)<0.0001
Lipid disorder148 (26.6)295 (45.7)1651 (42.5)1138 (37.5)617 (55.1)<0.0001
Current smoker85 (15.5)71 (11.2)305 (8.2)244 (8.2)124 (11.3)<0.0001
 No regular exercise170 (33.4)290 (47.6)1483 (42.5)989 (37.0)525 (50.9)<0.0001
Other comorbidities, n (%)
 Previous stroke14 (2.4)40 (6.0)262 (6.5)189 (6.0)83 (7.2)0.0005
 Previous TIA6 (1.0)18 (2.7)126 (3.1)119 (3.8)41 (3.6)0.0048
 Previous bleedings39 (6.8)59 (8.8)166 (4.1)163 (5.2)68 (5.9)<0.0001
 PAD26 (4.5)84 (12.8)299 (7.5)176 (5.7)175 (15.5)<0.0001
 Chronic kidney disease37 (6.3)123 (18.2)504 (12.5)304 (9.6)223 (19.3)<0.0001
 COPD34 (5.9)60 (8.9)388 (9.6)226 (7.2)147 (12.7)<0.0001
 Malignancy47 (8.0)54 (8.0)285 (7.0)262 (8.3)89 (7.7)0.3309
 Thyroid disease/disorder57 (9.9)75 (11.4)615 (15.4)452 (14.5)166 (14.5)0.0017
Main reason for admission/consultation, n (%)<0.0001
 AF447 (76.3)368 (54.0)2565 (63.1)2557 (80.7)537 (46.2)
 ACS13 (2.2)84 (12.3)36 (0.9)19 (0.6)161 (13.8)
 Valvular disease9 (1.5)19 (2.8)177 (4.4)17 (0.5)52 (4.5)
 Hypertension21 (3.6)10 (1.5)94 (2.3)51 (1.6)19 (1.6)
 Heart failure22 (3.8)67 (9.8)502 (12.3)207 (6.5)142 (12.2)
 Other CAD8 (1.4)41 (6.0)80 (2.0)36 (1.1)96 (8.3)
 Other CV28 (4.8)65 (9.5)363 (8.9)159 (5.0)105 (9.0)
 Other non-CV38 (6.5)27 (4.0)248 (6.1)121 (3.8)51 (4.4)
Symptomatic status, n (%)<0.0001
 EHRA I261 (44.5)337 (49.5)1942 (47.8)1328 (41.9)519 (44.6)
 EHRA II–III–IV325 (55.5)344 (50.5)2124 (52.2)1839 (58.1)644 (55.4)
No antithrombotic (N = 586)Only antiplatelet drugs (N = 681)Only VKA (N = 4066)Only NOACs (N = 3167)Antiplatelet drugs + OAC (N = 1163)P-value
Demographics
Age (years), median (IQR)61 (51–73)72 (62–78)71 (64–78)70 (62–77)72 (65–78)<0.0001
Female, n (%)223 (38.1)289 (42.4)1729 (42.5)1272 (40.2)374 (32.2)<0.0001
Type of AF, n (%)<0.0001
 First diagnosed136 (23.9)127 (19.2)386 (9.6)626 (20.0)189 (16.7)
 Paroxysmal231 (40.7)285 (43.1)821 (20.5)844 (27.0)288 (25.4)
 Persistent78 (13.7)80 (12.1)711 (17.7)814 (26.0)215 (19.0)
 LS persistent9 (1.6)18 (2.7)206 (5.1)158 (5.1)35 (3.1)
 Permanent114 (20.1)151 (22.8)1884 (47.0)683 (21.9)405 (35.8)
Concomitant diseases, n (%)
 Hypertension188 (32.5)412 (61.1)2631 (65.2)1897 (60.4)791 (68.5)<0.0001
 CAD91 (16.2)334 (52.8)850 (22.3)498 (16.4)834 (76.3)<0.0001
 Previous MI40 (44.0)160 (47.9)325 (38.2)194 (39.0)432 (51.8)<0.0001
 Heart failure135 (23.4)323 (47.9)1735 (42.9)934 (29.8)590 (51.1)<0.0001
 Valvular disease157 (27.4)305 (46.0)2362 (59.1)1316 (42.5)625 (54.6)<0.0001
 Dilated cardiomyopathy24 (4.2)54 (8.0)419 (10.4)185 (5.9)142 (12.4)<0.0001
 Hypertrophic cardiomyopathy9 (1.6)16 (2.4)154 (3.8)76 (2.4)41 (3.6)0.0007
 Restrictive cardiomyopathy2 (0.3)1 (0.1)11 (0.3)4 (0.1)2 (0.2)0.5788
 Other cardiomyopathy12 (2.1)24 (3.6)161 (4.0)97 (3.1)56 (4.8)0.0102
 Congenital heart disease6 (1.0)9 (1.3)50 (1.2)25 (0.8)12 (1.0)0.3852
 PAH21 (3.7)53 (8.0)345 (8.6)128 (4.1)93 (8.1)<0.0001
Cardiovascular risk factors, n (%)
Diabetes mellitus86 (14.8)161 (23.7)943 (23.3)595 (18.9)409 (35.5)<0.0001
Lipid disorder148 (26.6)295 (45.7)1651 (42.5)1138 (37.5)617 (55.1)<0.0001
Current smoker85 (15.5)71 (11.2)305 (8.2)244 (8.2)124 (11.3)<0.0001
 No regular exercise170 (33.4)290 (47.6)1483 (42.5)989 (37.0)525 (50.9)<0.0001
Other comorbidities, n (%)
 Previous stroke14 (2.4)40 (6.0)262 (6.5)189 (6.0)83 (7.2)0.0005
 Previous TIA6 (1.0)18 (2.7)126 (3.1)119 (3.8)41 (3.6)0.0048
 Previous bleedings39 (6.8)59 (8.8)166 (4.1)163 (5.2)68 (5.9)<0.0001
 PAD26 (4.5)84 (12.8)299 (7.5)176 (5.7)175 (15.5)<0.0001
 Chronic kidney disease37 (6.3)123 (18.2)504 (12.5)304 (9.6)223 (19.3)<0.0001
 COPD34 (5.9)60 (8.9)388 (9.6)226 (7.2)147 (12.7)<0.0001
 Malignancy47 (8.0)54 (8.0)285 (7.0)262 (8.3)89 (7.7)0.3309
 Thyroid disease/disorder57 (9.9)75 (11.4)615 (15.4)452 (14.5)166 (14.5)0.0017
Main reason for admission/consultation, n (%)<0.0001
 AF447 (76.3)368 (54.0)2565 (63.1)2557 (80.7)537 (46.2)
 ACS13 (2.2)84 (12.3)36 (0.9)19 (0.6)161 (13.8)
 Valvular disease9 (1.5)19 (2.8)177 (4.4)17 (0.5)52 (4.5)
 Hypertension21 (3.6)10 (1.5)94 (2.3)51 (1.6)19 (1.6)
 Heart failure22 (3.8)67 (9.8)502 (12.3)207 (6.5)142 (12.2)
 Other CAD8 (1.4)41 (6.0)80 (2.0)36 (1.1)96 (8.3)
 Other CV28 (4.8)65 (9.5)363 (8.9)159 (5.0)105 (9.0)
 Other non-CV38 (6.5)27 (4.0)248 (6.1)121 (3.8)51 (4.4)
Symptomatic status, n (%)<0.0001
 EHRA I261 (44.5)337 (49.5)1942 (47.8)1328 (41.9)519 (44.6)
 EHRA II–III–IV325 (55.5)344 (50.5)2124 (52.2)1839 (58.1)644 (55.4)

ACS, acute coronary syndrome; AF, atrial fibrillation; CAD, coronary artery disease; COPD, chronic obstructive pulmonary disease; CV, cardiovascular; EHRA, European Heart Rhythm Association; IQR, interquartile range; MI, myocardial infarction; NOACs, non-vitamin K antagonist oral anticoagulants; OAC, oral anticoagulants; PAD, peripheral artery disease; PAH, pulmonary artery hypertension; TIA, transient ischaemic attack; VKA, vitamin K antagonist.

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