Distribution of Genotypes and Alleles Frequencies of the Single Nucleotide Polymorphisms of IFNG Between Patients With Cutaneous Leishmaniasis and Control Subjects
| SNP . | CL . | Controls . | Comparison . | OR (95% CI) . | P . | s-Value [s = −log2 (P)] . |
|---|---|---|---|---|---|---|
| rs2069705 | n = 630 | n = 615 | ||||
| C/C | 199 (31.6) | 254 (41.3) | TT vs CC | 1.7 (1.3–2.4) | .0008 | 10 |
| C/T | 303 (48.1) | 267 (43.4) | CT vs CC | 1.5 (1.1–1.9) | .0033 | 8 |
| T/T | 128 (20.3) | 94 (15.3) | TT+CT vs CC | 1.5 (1.2–2.0) | .0004 | 11 |
| C | 701 (55.6) | 775 (63.0) | T vs C | 1.4 (1.2–1.6) | .0002 | 12 |
| T | 559 (44.4) | 455 (37.0) | … | … | ||
| rs2430561 | n = 647 | n = 624 | ||||
| A/A | 324 (50.1) | 350 (56.1) | … | … | ||
| A/T | 265 (41.0) | 228 (36.5) | TT+AT vs AA | 1.3 (1.0–1.6) | .0317 | 5 |
| T/T | 58 (8.9) | 46 (7.4) | T vs A | 1.2 (1.0–1.2) | .0319 | 5 |
| A | 913 (70.6) | 928 (74.4) | … | … | ||
| T | 381 (29.4) | 320 (25.6) | … | … | ||
| rs1861494 | n = 626 | n = 616 | ||||
| A/A | 369 (58.9) | 365 (59.3) | … | … | ||
| A/G | 232 (37.1) | 211 (34.2) | AA+AG vs GG | 1.7 (1.0–2.8) | .0479 | 4 |
| G/G | 25 (4.0) | 40 (6.5) | AG vs GG | 1.8 (1.0–3.0) | 0.0362 | 5 |
| A | 970 (77.5) | 941 (76.4) | … | … | ||
| G | 282 (22.5) | 291 (23.6) | … | … | ||
| rs1861493 | n = 626 | n = 616 | ||||
| C/C | 25 (4.0) | 40 (6.5) | … | … | ||
| C/T | 225 (35.9) | 207 (33.6) | TT+CT vs CC | 1.7 (1.0–2.8) | .0479 | 4 |
| T/T | 376 (60.1) | 369 (59.9) | CT vs CC | 1.7 (1.0–3.0) | .0405 | 5 |
| C | 275 (22.0) | 287 (23.3) | … | … | ||
| T | 977 (78.0) | 945 (76.7) | … | … | ||
| rs2069718 | n = 626 | n = 616 | ||||
| T/T | 230 (36.7) | 270 (43.8) | … | … | ||
| T/C | 292 (46.7) | 262 (42.6) | TC vs TT | 1.3 (1.0–1.7) | .0296 | 5 |
| C/C | 104 (16.6) | 84 (13.6) | TT vs CC | 0.7 (0.5–0.9) | .0292 | 5 |
| T | 752 (60.1) | 802 (65.1) | C vs T | 1.2 (1.0–1.5) | .0095 | 7 |
| C | 500 (39.9) | 430 (34.9) | … | … |
| SNP . | CL . | Controls . | Comparison . | OR (95% CI) . | P . | s-Value [s = −log2 (P)] . |
|---|---|---|---|---|---|---|
| rs2069705 | n = 630 | n = 615 | ||||
| C/C | 199 (31.6) | 254 (41.3) | TT vs CC | 1.7 (1.3–2.4) | .0008 | 10 |
| C/T | 303 (48.1) | 267 (43.4) | CT vs CC | 1.5 (1.1–1.9) | .0033 | 8 |
| T/T | 128 (20.3) | 94 (15.3) | TT+CT vs CC | 1.5 (1.2–2.0) | .0004 | 11 |
| C | 701 (55.6) | 775 (63.0) | T vs C | 1.4 (1.2–1.6) | .0002 | 12 |
| T | 559 (44.4) | 455 (37.0) | … | … | ||
| rs2430561 | n = 647 | n = 624 | ||||
| A/A | 324 (50.1) | 350 (56.1) | … | … | ||
| A/T | 265 (41.0) | 228 (36.5) | TT+AT vs AA | 1.3 (1.0–1.6) | .0317 | 5 |
| T/T | 58 (8.9) | 46 (7.4) | T vs A | 1.2 (1.0–1.2) | .0319 | 5 |
| A | 913 (70.6) | 928 (74.4) | … | … | ||
| T | 381 (29.4) | 320 (25.6) | … | … | ||
| rs1861494 | n = 626 | n = 616 | ||||
| A/A | 369 (58.9) | 365 (59.3) | … | … | ||
| A/G | 232 (37.1) | 211 (34.2) | AA+AG vs GG | 1.7 (1.0–2.8) | .0479 | 4 |
| G/G | 25 (4.0) | 40 (6.5) | AG vs GG | 1.8 (1.0–3.0) | 0.0362 | 5 |
| A | 970 (77.5) | 941 (76.4) | … | … | ||
| G | 282 (22.5) | 291 (23.6) | … | … | ||
| rs1861493 | n = 626 | n = 616 | ||||
| C/C | 25 (4.0) | 40 (6.5) | … | … | ||
| C/T | 225 (35.9) | 207 (33.6) | TT+CT vs CC | 1.7 (1.0–2.8) | .0479 | 4 |
| T/T | 376 (60.1) | 369 (59.9) | CT vs CC | 1.7 (1.0–3.0) | .0405 | 5 |
| C | 275 (22.0) | 287 (23.3) | … | … | ||
| T | 977 (78.0) | 945 (76.7) | … | … | ||
| rs2069718 | n = 626 | n = 616 | ||||
| T/T | 230 (36.7) | 270 (43.8) | … | … | ||
| T/C | 292 (46.7) | 262 (42.6) | TC vs TT | 1.3 (1.0–1.7) | .0296 | 5 |
| C/C | 104 (16.6) | 84 (13.6) | TT vs CC | 0.7 (0.5–0.9) | .0292 | 5 |
| T | 752 (60.1) | 802 (65.1) | C vs T | 1.2 (1.0–1.5) | .0095 | 7 |
| C | 500 (39.9) | 430 (34.9) | … | … |
Abbreviations: CI, confidence interval; CL, cutaneous leishmaniasis; IFNG, interferon-γ gene; OR, odds ratio; SNP, single nucleotide polymorphism.
Distribution of Genotypes and Alleles Frequencies of the Single Nucleotide Polymorphisms of IFNG Between Patients With Cutaneous Leishmaniasis and Control Subjects
| SNP . | CL . | Controls . | Comparison . | OR (95% CI) . | P . | s-Value [s = −log2 (P)] . |
|---|---|---|---|---|---|---|
| rs2069705 | n = 630 | n = 615 | ||||
| C/C | 199 (31.6) | 254 (41.3) | TT vs CC | 1.7 (1.3–2.4) | .0008 | 10 |
| C/T | 303 (48.1) | 267 (43.4) | CT vs CC | 1.5 (1.1–1.9) | .0033 | 8 |
| T/T | 128 (20.3) | 94 (15.3) | TT+CT vs CC | 1.5 (1.2–2.0) | .0004 | 11 |
| C | 701 (55.6) | 775 (63.0) | T vs C | 1.4 (1.2–1.6) | .0002 | 12 |
| T | 559 (44.4) | 455 (37.0) | … | … | ||
| rs2430561 | n = 647 | n = 624 | ||||
| A/A | 324 (50.1) | 350 (56.1) | … | … | ||
| A/T | 265 (41.0) | 228 (36.5) | TT+AT vs AA | 1.3 (1.0–1.6) | .0317 | 5 |
| T/T | 58 (8.9) | 46 (7.4) | T vs A | 1.2 (1.0–1.2) | .0319 | 5 |
| A | 913 (70.6) | 928 (74.4) | … | … | ||
| T | 381 (29.4) | 320 (25.6) | … | … | ||
| rs1861494 | n = 626 | n = 616 | ||||
| A/A | 369 (58.9) | 365 (59.3) | … | … | ||
| A/G | 232 (37.1) | 211 (34.2) | AA+AG vs GG | 1.7 (1.0–2.8) | .0479 | 4 |
| G/G | 25 (4.0) | 40 (6.5) | AG vs GG | 1.8 (1.0–3.0) | 0.0362 | 5 |
| A | 970 (77.5) | 941 (76.4) | … | … | ||
| G | 282 (22.5) | 291 (23.6) | … | … | ||
| rs1861493 | n = 626 | n = 616 | ||||
| C/C | 25 (4.0) | 40 (6.5) | … | … | ||
| C/T | 225 (35.9) | 207 (33.6) | TT+CT vs CC | 1.7 (1.0–2.8) | .0479 | 4 |
| T/T | 376 (60.1) | 369 (59.9) | CT vs CC | 1.7 (1.0–3.0) | .0405 | 5 |
| C | 275 (22.0) | 287 (23.3) | … | … | ||
| T | 977 (78.0) | 945 (76.7) | … | … | ||
| rs2069718 | n = 626 | n = 616 | ||||
| T/T | 230 (36.7) | 270 (43.8) | … | … | ||
| T/C | 292 (46.7) | 262 (42.6) | TC vs TT | 1.3 (1.0–1.7) | .0296 | 5 |
| C/C | 104 (16.6) | 84 (13.6) | TT vs CC | 0.7 (0.5–0.9) | .0292 | 5 |
| T | 752 (60.1) | 802 (65.1) | C vs T | 1.2 (1.0–1.5) | .0095 | 7 |
| C | 500 (39.9) | 430 (34.9) | … | … |
| SNP . | CL . | Controls . | Comparison . | OR (95% CI) . | P . | s-Value [s = −log2 (P)] . |
|---|---|---|---|---|---|---|
| rs2069705 | n = 630 | n = 615 | ||||
| C/C | 199 (31.6) | 254 (41.3) | TT vs CC | 1.7 (1.3–2.4) | .0008 | 10 |
| C/T | 303 (48.1) | 267 (43.4) | CT vs CC | 1.5 (1.1–1.9) | .0033 | 8 |
| T/T | 128 (20.3) | 94 (15.3) | TT+CT vs CC | 1.5 (1.2–2.0) | .0004 | 11 |
| C | 701 (55.6) | 775 (63.0) | T vs C | 1.4 (1.2–1.6) | .0002 | 12 |
| T | 559 (44.4) | 455 (37.0) | … | … | ||
| rs2430561 | n = 647 | n = 624 | ||||
| A/A | 324 (50.1) | 350 (56.1) | … | … | ||
| A/T | 265 (41.0) | 228 (36.5) | TT+AT vs AA | 1.3 (1.0–1.6) | .0317 | 5 |
| T/T | 58 (8.9) | 46 (7.4) | T vs A | 1.2 (1.0–1.2) | .0319 | 5 |
| A | 913 (70.6) | 928 (74.4) | … | … | ||
| T | 381 (29.4) | 320 (25.6) | … | … | ||
| rs1861494 | n = 626 | n = 616 | ||||
| A/A | 369 (58.9) | 365 (59.3) | … | … | ||
| A/G | 232 (37.1) | 211 (34.2) | AA+AG vs GG | 1.7 (1.0–2.8) | .0479 | 4 |
| G/G | 25 (4.0) | 40 (6.5) | AG vs GG | 1.8 (1.0–3.0) | 0.0362 | 5 |
| A | 970 (77.5) | 941 (76.4) | … | … | ||
| G | 282 (22.5) | 291 (23.6) | … | … | ||
| rs1861493 | n = 626 | n = 616 | ||||
| C/C | 25 (4.0) | 40 (6.5) | … | … | ||
| C/T | 225 (35.9) | 207 (33.6) | TT+CT vs CC | 1.7 (1.0–2.8) | .0479 | 4 |
| T/T | 376 (60.1) | 369 (59.9) | CT vs CC | 1.7 (1.0–3.0) | .0405 | 5 |
| C | 275 (22.0) | 287 (23.3) | … | … | ||
| T | 977 (78.0) | 945 (76.7) | … | … | ||
| rs2069718 | n = 626 | n = 616 | ||||
| T/T | 230 (36.7) | 270 (43.8) | … | … | ||
| T/C | 292 (46.7) | 262 (42.6) | TC vs TT | 1.3 (1.0–1.7) | .0296 | 5 |
| C/C | 104 (16.6) | 84 (13.6) | TT vs CC | 0.7 (0.5–0.9) | .0292 | 5 |
| T | 752 (60.1) | 802 (65.1) | C vs T | 1.2 (1.0–1.5) | .0095 | 7 |
| C | 500 (39.9) | 430 (34.9) | … | … |
Abbreviations: CI, confidence interval; CL, cutaneous leishmaniasis; IFNG, interferon-γ gene; OR, odds ratio; SNP, single nucleotide polymorphism.
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