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A. Normalized for nicotine levels, analysis from a THS2.2 batch used in this study (3R4F was measured in a previous study but is considered representative of the actual batches used during this study).

ISO parametersTHS2.23R4F
1. Carbon monoxidemg/mg nicotine0.437 ± 0.03114.8 ± 0.715
2. Nicotinemg/mg nicotine1 ± 0.0451 ± 0.0542
3. Tarmg/mg nicotine6.304 ± 1.21414.3 ± 0.717
4. TPMmg/mg nicotine34.72 ± 1.39622.2 ± 1.2
5. Watermg/mg nicotine27.41 ± 1.9377.01 ± 0.673
Aliphatic dienes
6. 1,3-Butadieneµg/mg nicotine0.298 ± 0.05336.7 ± 3.6
7. Isopreneµg/mg nicotine2.483 ± 0.335427 ± 36.4
Carbonyls
8. Acetaldehydeµg/mg nicotine157.9 ± 15.78719 ± 50.1
9. Acetoneµg/mg nicotine29.35 ± 3.463323 ± 11.9
10. Acroleinµg/mg nicotine8.165 ± 1.18977 ± 5.51
11. Butyraldehydeµg/mg nicotine20.32 ± 2.02441.7 ± 3.64
12. Crotonaldehydeµg/mg nicotine2.809 ± 0.33340.5 ± 4.31
13. Formaldehydeµg/mg nicotine2.623 ± 0.27128.3 ± 3.48
14. Methyl ethyl ketoneµg/mg nicotine5.986 ± 0.9191.9 ± 5.79
15. Propionaldehydeµg/mg nicotine11.75 ± 1.48358.1 ± 2.68
Acid derivatives
16. Acetamideµg/mg nicotine3.063 ± 0.2837.17 ± 0.399
17. Acrylamideµg/mg nicotine1.918 ± 0.1882.03 ± 0.157
18. Acrylonitrileµg/mg nicotine0.166 ± 0.01314.4 ± 0.894
Epoxides
19. Ethylene oxideµg/mg nicotine0.167 ± 0.01112.9 ± 0.998
20. Propylene oxideµg/mg nicotine0.094 ± 0.0080.723 ± 0.0234
Nitro compounds
21. NitrobenzeneN.D.N.D.
Aromatic Amines
22. 1-Aminonaphthaleneng/mg nicotine0.065 ± 0.0079.95 ± 0.6
23. 2-Aminonaphthaleneng/mg nicotine3/4 < 0.0245.11 ± 0.186
24. 3-Aminobiphenylng/mg nicotine0.043 ± 0.0051.64 ± 0.213
25. 4-Aminobiphenylng/mg nicotine4/4 < 0.0321.31 ± 0.115
26. o-Toluidineng/mg nicotine0.962 ± 0.07643.5 ± 1.45
27. Benzidineng/mg nicotine4/4 < 7E-4N.D.
N-Heterocyclic aromatics
28. Pyridineµg/mg nicotine6.343 ± 0.28318 ± 0.833
29. Quinolineµg/mg nicotine0.016 ± 0.0010.273 ± 0.0276
Halogen compounds
30. Vinyl chlorideng/mg nicotine4/4 < 2.47750.2 ± 2.75
Inorganic compounds
31. Ammoniaµg/mg nicotine10.18 ± 0.61119.4 ± 0.847
32. Hydrogen cyanideµg/mg nicotine2.905 ± 0.201215 ± 17.2
33. Nitric oxideµg/mg nicotine11.37 ± 0.521218 ± 10.3
34. Nitrogen oxidesµg/mg nicotine11.48 ± 0.516240 ± 12.3
Monocyclic aromatics
35. Benzeneµg/mg nicotine0.538 ± 0.03746.8 ± 1.7
36. Styreneµg/mg nicotine0.578 ± 0.04811.9 ± 0.497
37. Tolueneµg/mg nicotine2.172 ± 0.23197.8 ± 3.8
N-nitrosamines
38. N-Nitrosoanabasine (NAB)ng/mg nicotine4/4 < 2.17318 ± 1.24
39. N-Nitrosoanatabine (NAT)ng/mg nicotine11.67 ± 1.224173 ± 10.1
40. 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK)ng/mg nicotine4.631 ± 0.387117 ± 5.56
41. N-Nitrosonornicotine (NNN)ng/mg nicotine10.37 ± 1.039155 ± 4.31
Phenols
42. Catecholµg/mg nicotine15.53 ± 1.69843.8 ± 2.17
43. m+p-cresolµg/mg nicotine0.123 ± 0.026.04 ± 0.448
44. o-cresolµg/mg nicotine0.102 ± 0.0142.08 ± 0.18
45. Hydroquinoneµg/mg nicotine6.614 ± 0.85940.2 ± 1.85
46. Phenolµg/mg nicotine1.617 ± 0.2696.59 ± 0.497
47. Resorcinolµg/mg nicotine0.049 ± 0.0040.894 ± 0.0364
PAHs
48. Benzo[a]pyreneng/mg nicotine3/4 < 0.6964.66 ± 1.87
49. Benz[a]anthraceneng/mg nicotine1.078 ± 0.0519.21 ± 3.19
50. Dibenz[a,h]anthraceneng/mg nicotine4/4 < 0.073/8 < 0
51. Pyreneng/mg nicotine4.085 ± 0.2425.5 ± 15.2
Metals/Elements
52. Arsenicng/mg nicotine3/3 < 0.7873.32 ± 0.209
53. Cadmiumng/mg nicotine0.371 ± 0.00863.7 ± 3.28
54. Chromiumng/mg nicotine3/3 < 0.1184/4 < 0.257
55. Leadng/mg nicotine3/3 < 2.33214.8 ± 0.773
56. Mercuryng/mg nicotine1.024 ± 0.1051.86 ± 0.0981
57. Nickelng/mg nicotine2/3 < 0.1184/4 < 0.257
58. Seleniumng/mg nicotine3/3 < 0.3830.687 ± 0.126
ISO parametersTHS2.23R4F
1. Carbon monoxidemg/mg nicotine0.437 ± 0.03114.8 ± 0.715
2. Nicotinemg/mg nicotine1 ± 0.0451 ± 0.0542
3. Tarmg/mg nicotine6.304 ± 1.21414.3 ± 0.717
4. TPMmg/mg nicotine34.72 ± 1.39622.2 ± 1.2
5. Watermg/mg nicotine27.41 ± 1.9377.01 ± 0.673
Aliphatic dienes
6. 1,3-Butadieneµg/mg nicotine0.298 ± 0.05336.7 ± 3.6
7. Isopreneµg/mg nicotine2.483 ± 0.335427 ± 36.4
Carbonyls
8. Acetaldehydeµg/mg nicotine157.9 ± 15.78719 ± 50.1
9. Acetoneµg/mg nicotine29.35 ± 3.463323 ± 11.9
10. Acroleinµg/mg nicotine8.165 ± 1.18977 ± 5.51
11. Butyraldehydeµg/mg nicotine20.32 ± 2.02441.7 ± 3.64
12. Crotonaldehydeµg/mg nicotine2.809 ± 0.33340.5 ± 4.31
13. Formaldehydeµg/mg nicotine2.623 ± 0.27128.3 ± 3.48
14. Methyl ethyl ketoneµg/mg nicotine5.986 ± 0.9191.9 ± 5.79
15. Propionaldehydeµg/mg nicotine11.75 ± 1.48358.1 ± 2.68
Acid derivatives
16. Acetamideµg/mg nicotine3.063 ± 0.2837.17 ± 0.399
17. Acrylamideµg/mg nicotine1.918 ± 0.1882.03 ± 0.157
18. Acrylonitrileµg/mg nicotine0.166 ± 0.01314.4 ± 0.894
Epoxides
19. Ethylene oxideµg/mg nicotine0.167 ± 0.01112.9 ± 0.998
20. Propylene oxideµg/mg nicotine0.094 ± 0.0080.723 ± 0.0234
Nitro compounds
21. NitrobenzeneN.D.N.D.
Aromatic Amines
22. 1-Aminonaphthaleneng/mg nicotine0.065 ± 0.0079.95 ± 0.6
23. 2-Aminonaphthaleneng/mg nicotine3/4 < 0.0245.11 ± 0.186
24. 3-Aminobiphenylng/mg nicotine0.043 ± 0.0051.64 ± 0.213
25. 4-Aminobiphenylng/mg nicotine4/4 < 0.0321.31 ± 0.115
26. o-Toluidineng/mg nicotine0.962 ± 0.07643.5 ± 1.45
27. Benzidineng/mg nicotine4/4 < 7E-4N.D.
N-Heterocyclic aromatics
28. Pyridineµg/mg nicotine6.343 ± 0.28318 ± 0.833
29. Quinolineµg/mg nicotine0.016 ± 0.0010.273 ± 0.0276
Halogen compounds
30. Vinyl chlorideng/mg nicotine4/4 < 2.47750.2 ± 2.75
Inorganic compounds
31. Ammoniaµg/mg nicotine10.18 ± 0.61119.4 ± 0.847
32. Hydrogen cyanideµg/mg nicotine2.905 ± 0.201215 ± 17.2
33. Nitric oxideµg/mg nicotine11.37 ± 0.521218 ± 10.3
34. Nitrogen oxidesµg/mg nicotine11.48 ± 0.516240 ± 12.3
Monocyclic aromatics
35. Benzeneµg/mg nicotine0.538 ± 0.03746.8 ± 1.7
36. Styreneµg/mg nicotine0.578 ± 0.04811.9 ± 0.497
37. Tolueneµg/mg nicotine2.172 ± 0.23197.8 ± 3.8
N-nitrosamines
38. N-Nitrosoanabasine (NAB)ng/mg nicotine4/4 < 2.17318 ± 1.24
39. N-Nitrosoanatabine (NAT)ng/mg nicotine11.67 ± 1.224173 ± 10.1
40. 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK)ng/mg nicotine4.631 ± 0.387117 ± 5.56
41. N-Nitrosonornicotine (NNN)ng/mg nicotine10.37 ± 1.039155 ± 4.31
Phenols
42. Catecholµg/mg nicotine15.53 ± 1.69843.8 ± 2.17
43. m+p-cresolµg/mg nicotine0.123 ± 0.026.04 ± 0.448
44. o-cresolµg/mg nicotine0.102 ± 0.0142.08 ± 0.18
45. Hydroquinoneµg/mg nicotine6.614 ± 0.85940.2 ± 1.85
46. Phenolµg/mg nicotine1.617 ± 0.2696.59 ± 0.497
47. Resorcinolµg/mg nicotine0.049 ± 0.0040.894 ± 0.0364
PAHs
48. Benzo[a]pyreneng/mg nicotine3/4 < 0.6964.66 ± 1.87
49. Benz[a]anthraceneng/mg nicotine1.078 ± 0.0519.21 ± 3.19
50. Dibenz[a,h]anthraceneng/mg nicotine4/4 < 0.073/8 < 0
51. Pyreneng/mg nicotine4.085 ± 0.2425.5 ± 15.2
Metals/Elements
52. Arsenicng/mg nicotine3/3 < 0.7873.32 ± 0.209
53. Cadmiumng/mg nicotine0.371 ± 0.00863.7 ± 3.28
54. Chromiumng/mg nicotine3/3 < 0.1184/4 < 0.257
55. Leadng/mg nicotine3/3 < 2.33214.8 ± 0.773
56. Mercuryng/mg nicotine1.024 ± 0.1051.86 ± 0.0981
57. Nickelng/mg nicotine2/3 < 0.1184/4 < 0.257
58. Seleniumng/mg nicotine3/3 < 0.3830.687 ± 0.126
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A. Normalized for nicotine levels, analysis from a THS2.2 batch used in this study (3R4F was measured in a previous study but is considered representative of the actual batches used during this study).

ISO parametersTHS2.23R4F
1. Carbon monoxidemg/mg nicotine0.437 ± 0.03114.8 ± 0.715
2. Nicotinemg/mg nicotine1 ± 0.0451 ± 0.0542
3. Tarmg/mg nicotine6.304 ± 1.21414.3 ± 0.717
4. TPMmg/mg nicotine34.72 ± 1.39622.2 ± 1.2
5. Watermg/mg nicotine27.41 ± 1.9377.01 ± 0.673
Aliphatic dienes
6. 1,3-Butadieneµg/mg nicotine0.298 ± 0.05336.7 ± 3.6
7. Isopreneµg/mg nicotine2.483 ± 0.335427 ± 36.4
Carbonyls
8. Acetaldehydeµg/mg nicotine157.9 ± 15.78719 ± 50.1
9. Acetoneµg/mg nicotine29.35 ± 3.463323 ± 11.9
10. Acroleinµg/mg nicotine8.165 ± 1.18977 ± 5.51
11. Butyraldehydeµg/mg nicotine20.32 ± 2.02441.7 ± 3.64
12. Crotonaldehydeµg/mg nicotine2.809 ± 0.33340.5 ± 4.31
13. Formaldehydeµg/mg nicotine2.623 ± 0.27128.3 ± 3.48
14. Methyl ethyl ketoneµg/mg nicotine5.986 ± 0.9191.9 ± 5.79
15. Propionaldehydeµg/mg nicotine11.75 ± 1.48358.1 ± 2.68
Acid derivatives
16. Acetamideµg/mg nicotine3.063 ± 0.2837.17 ± 0.399
17. Acrylamideµg/mg nicotine1.918 ± 0.1882.03 ± 0.157
18. Acrylonitrileµg/mg nicotine0.166 ± 0.01314.4 ± 0.894
Epoxides
19. Ethylene oxideµg/mg nicotine0.167 ± 0.01112.9 ± 0.998
20. Propylene oxideµg/mg nicotine0.094 ± 0.0080.723 ± 0.0234
Nitro compounds
21. NitrobenzeneN.D.N.D.
Aromatic Amines
22. 1-Aminonaphthaleneng/mg nicotine0.065 ± 0.0079.95 ± 0.6
23. 2-Aminonaphthaleneng/mg nicotine3/4 < 0.0245.11 ± 0.186
24. 3-Aminobiphenylng/mg nicotine0.043 ± 0.0051.64 ± 0.213
25. 4-Aminobiphenylng/mg nicotine4/4 < 0.0321.31 ± 0.115
26. o-Toluidineng/mg nicotine0.962 ± 0.07643.5 ± 1.45
27. Benzidineng/mg nicotine4/4 < 7E-4N.D.
N-Heterocyclic aromatics
28. Pyridineµg/mg nicotine6.343 ± 0.28318 ± 0.833
29. Quinolineµg/mg nicotine0.016 ± 0.0010.273 ± 0.0276
Halogen compounds
30. Vinyl chlorideng/mg nicotine4/4 < 2.47750.2 ± 2.75
Inorganic compounds
31. Ammoniaµg/mg nicotine10.18 ± 0.61119.4 ± 0.847
32. Hydrogen cyanideµg/mg nicotine2.905 ± 0.201215 ± 17.2
33. Nitric oxideµg/mg nicotine11.37 ± 0.521218 ± 10.3
34. Nitrogen oxidesµg/mg nicotine11.48 ± 0.516240 ± 12.3
Monocyclic aromatics
35. Benzeneµg/mg nicotine0.538 ± 0.03746.8 ± 1.7
36. Styreneµg/mg nicotine0.578 ± 0.04811.9 ± 0.497
37. Tolueneµg/mg nicotine2.172 ± 0.23197.8 ± 3.8
N-nitrosamines
38. N-Nitrosoanabasine (NAB)ng/mg nicotine4/4 < 2.17318 ± 1.24
39. N-Nitrosoanatabine (NAT)ng/mg nicotine11.67 ± 1.224173 ± 10.1
40. 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK)ng/mg nicotine4.631 ± 0.387117 ± 5.56
41. N-Nitrosonornicotine (NNN)ng/mg nicotine10.37 ± 1.039155 ± 4.31
Phenols
42. Catecholµg/mg nicotine15.53 ± 1.69843.8 ± 2.17
43. m+p-cresolµg/mg nicotine0.123 ± 0.026.04 ± 0.448
44. o-cresolµg/mg nicotine0.102 ± 0.0142.08 ± 0.18
45. Hydroquinoneµg/mg nicotine6.614 ± 0.85940.2 ± 1.85
46. Phenolµg/mg nicotine1.617 ± 0.2696.59 ± 0.497
47. Resorcinolµg/mg nicotine0.049 ± 0.0040.894 ± 0.0364
PAHs
48. Benzo[a]pyreneng/mg nicotine3/4 < 0.6964.66 ± 1.87
49. Benz[a]anthraceneng/mg nicotine1.078 ± 0.0519.21 ± 3.19
50. Dibenz[a,h]anthraceneng/mg nicotine4/4 < 0.073/8 < 0
51. Pyreneng/mg nicotine4.085 ± 0.2425.5 ± 15.2
Metals/Elements
52. Arsenicng/mg nicotine3/3 < 0.7873.32 ± 0.209
53. Cadmiumng/mg nicotine0.371 ± 0.00863.7 ± 3.28
54. Chromiumng/mg nicotine3/3 < 0.1184/4 < 0.257
55. Leadng/mg nicotine3/3 < 2.33214.8 ± 0.773
56. Mercuryng/mg nicotine1.024 ± 0.1051.86 ± 0.0981
57. Nickelng/mg nicotine2/3 < 0.1184/4 < 0.257
58. Seleniumng/mg nicotine3/3 < 0.3830.687 ± 0.126
ISO parametersTHS2.23R4F
1. Carbon monoxidemg/mg nicotine0.437 ± 0.03114.8 ± 0.715
2. Nicotinemg/mg nicotine1 ± 0.0451 ± 0.0542
3. Tarmg/mg nicotine6.304 ± 1.21414.3 ± 0.717
4. TPMmg/mg nicotine34.72 ± 1.39622.2 ± 1.2
5. Watermg/mg nicotine27.41 ± 1.9377.01 ± 0.673
Aliphatic dienes
6. 1,3-Butadieneµg/mg nicotine0.298 ± 0.05336.7 ± 3.6
7. Isopreneµg/mg nicotine2.483 ± 0.335427 ± 36.4
Carbonyls
8. Acetaldehydeµg/mg nicotine157.9 ± 15.78719 ± 50.1
9. Acetoneµg/mg nicotine29.35 ± 3.463323 ± 11.9
10. Acroleinµg/mg nicotine8.165 ± 1.18977 ± 5.51
11. Butyraldehydeµg/mg nicotine20.32 ± 2.02441.7 ± 3.64
12. Crotonaldehydeµg/mg nicotine2.809 ± 0.33340.5 ± 4.31
13. Formaldehydeµg/mg nicotine2.623 ± 0.27128.3 ± 3.48
14. Methyl ethyl ketoneµg/mg nicotine5.986 ± 0.9191.9 ± 5.79
15. Propionaldehydeµg/mg nicotine11.75 ± 1.48358.1 ± 2.68
Acid derivatives
16. Acetamideµg/mg nicotine3.063 ± 0.2837.17 ± 0.399
17. Acrylamideµg/mg nicotine1.918 ± 0.1882.03 ± 0.157
18. Acrylonitrileµg/mg nicotine0.166 ± 0.01314.4 ± 0.894
Epoxides
19. Ethylene oxideµg/mg nicotine0.167 ± 0.01112.9 ± 0.998
20. Propylene oxideµg/mg nicotine0.094 ± 0.0080.723 ± 0.0234
Nitro compounds
21. NitrobenzeneN.D.N.D.
Aromatic Amines
22. 1-Aminonaphthaleneng/mg nicotine0.065 ± 0.0079.95 ± 0.6
23. 2-Aminonaphthaleneng/mg nicotine3/4 < 0.0245.11 ± 0.186
24. 3-Aminobiphenylng/mg nicotine0.043 ± 0.0051.64 ± 0.213
25. 4-Aminobiphenylng/mg nicotine4/4 < 0.0321.31 ± 0.115
26. o-Toluidineng/mg nicotine0.962 ± 0.07643.5 ± 1.45
27. Benzidineng/mg nicotine4/4 < 7E-4N.D.
N-Heterocyclic aromatics
28. Pyridineµg/mg nicotine6.343 ± 0.28318 ± 0.833
29. Quinolineµg/mg nicotine0.016 ± 0.0010.273 ± 0.0276
Halogen compounds
30. Vinyl chlorideng/mg nicotine4/4 < 2.47750.2 ± 2.75
Inorganic compounds
31. Ammoniaµg/mg nicotine10.18 ± 0.61119.4 ± 0.847
32. Hydrogen cyanideµg/mg nicotine2.905 ± 0.201215 ± 17.2
33. Nitric oxideµg/mg nicotine11.37 ± 0.521218 ± 10.3
34. Nitrogen oxidesµg/mg nicotine11.48 ± 0.516240 ± 12.3
Monocyclic aromatics
35. Benzeneµg/mg nicotine0.538 ± 0.03746.8 ± 1.7
36. Styreneµg/mg nicotine0.578 ± 0.04811.9 ± 0.497
37. Tolueneµg/mg nicotine2.172 ± 0.23197.8 ± 3.8
N-nitrosamines
38. N-Nitrosoanabasine (NAB)ng/mg nicotine4/4 < 2.17318 ± 1.24
39. N-Nitrosoanatabine (NAT)ng/mg nicotine11.67 ± 1.224173 ± 10.1
40. 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK)ng/mg nicotine4.631 ± 0.387117 ± 5.56
41. N-Nitrosonornicotine (NNN)ng/mg nicotine10.37 ± 1.039155 ± 4.31
Phenols
42. Catecholµg/mg nicotine15.53 ± 1.69843.8 ± 2.17
43. m+p-cresolµg/mg nicotine0.123 ± 0.026.04 ± 0.448
44. o-cresolµg/mg nicotine0.102 ± 0.0142.08 ± 0.18
45. Hydroquinoneµg/mg nicotine6.614 ± 0.85940.2 ± 1.85
46. Phenolµg/mg nicotine1.617 ± 0.2696.59 ± 0.497
47. Resorcinolµg/mg nicotine0.049 ± 0.0040.894 ± 0.0364
PAHs
48. Benzo[a]pyreneng/mg nicotine3/4 < 0.6964.66 ± 1.87
49. Benz[a]anthraceneng/mg nicotine1.078 ± 0.0519.21 ± 3.19
50. Dibenz[a,h]anthraceneng/mg nicotine4/4 < 0.073/8 < 0
51. Pyreneng/mg nicotine4.085 ± 0.2425.5 ± 15.2
Metals/Elements
52. Arsenicng/mg nicotine3/3 < 0.7873.32 ± 0.209
53. Cadmiumng/mg nicotine0.371 ± 0.00863.7 ± 3.28
54. Chromiumng/mg nicotine3/3 < 0.1184/4 < 0.257
55. Leadng/mg nicotine3/3 < 2.33214.8 ± 0.773
56. Mercuryng/mg nicotine1.024 ± 0.1051.86 ± 0.0981
57. Nickelng/mg nicotine2/3 < 0.1184/4 < 0.257
58. Seleniumng/mg nicotine3/3 < 0.3830.687 ± 0.126
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