Cox proportional hazards models for time to islet autoimmunity and celiac autoimmunity in cotwins
| Covariate . | Hazard Ratio (95% Confidence Interval) . | P value . |
|---|---|---|
| Time to IA in Dizygotic Cotwins | ||
| Proband’s age at type 1 diabetes diagnosis | 0.88 (0.78-1.00) | 0.047 |
| Proband’s sex | 0.37 (0.08-1.76) | 0.210 |
| DR3 present in proband | 0.95 (0.20-4.42) | 0.945 |
| DR4 present in proband | 0.79 (0.15-4.05) | 0.773 |
| Time to IA in Monozygotic Cotwins | ||
| Proband’s age at type 1 diabetes diagnosis | 0.91 (0.84-0.98) | 0.012 |
| Proband’s sex | 0.97 (0.29-3.28) | 0.962 |
| 0.81 (0.26-2.51) | 0.716 | |
| DR4 present in proband | 1.05 (0.32-3.47) | 0.938 |
| Time to CDA in Dizygotic Cotwins | ||
| Proband’s age at type 1 diabetes diagnosis | 0.85 (0.66-1.08) | 0.187 |
| Proband’s sex | 0.21 (0.02-1.91) | 0.164 |
| DR3 present in proband | 0.43 (0.09-1.93) | 0.268 |
| DR4 present in proband | 0.47 (0.05-4.12) | 0.495 |
| Time to CDA in Monozygotic Cotwins | ||
| Proband’s age at type 1 diabetes diagnosis | 0.79 (0.68-0.91) | 0.001 |
| 0.44 (0.06-3.35) | 0.426 | |
| DR3 present in proband | 0.17 (0.02-1.46) | 0.106 |
| DR4 present in proband | 5.01 (0.38-65.8) | 0.220 |
| Covariate . | Hazard Ratio (95% Confidence Interval) . | P value . |
|---|---|---|
| Time to IA in Dizygotic Cotwins | ||
| Proband’s age at type 1 diabetes diagnosis | 0.88 (0.78-1.00) | 0.047 |
| Proband’s sex | 0.37 (0.08-1.76) | 0.210 |
| DR3 present in proband | 0.95 (0.20-4.42) | 0.945 |
| DR4 present in proband | 0.79 (0.15-4.05) | 0.773 |
| Time to IA in Monozygotic Cotwins | ||
| Proband’s age at type 1 diabetes diagnosis | 0.91 (0.84-0.98) | 0.012 |
| Proband’s sex | 0.97 (0.29-3.28) | 0.962 |
| 0.81 (0.26-2.51) | 0.716 | |
| DR4 present in proband | 1.05 (0.32-3.47) | 0.938 |
| Time to CDA in Dizygotic Cotwins | ||
| Proband’s age at type 1 diabetes diagnosis | 0.85 (0.66-1.08) | 0.187 |
| Proband’s sex | 0.21 (0.02-1.91) | 0.164 |
| DR3 present in proband | 0.43 (0.09-1.93) | 0.268 |
| DR4 present in proband | 0.47 (0.05-4.12) | 0.495 |
| Time to CDA in Monozygotic Cotwins | ||
| Proband’s age at type 1 diabetes diagnosis | 0.79 (0.68-0.91) | 0.001 |
| 0.44 (0.06-3.35) | 0.426 | |
| DR3 present in proband | 0.17 (0.02-1.46) | 0.106 |
| DR4 present in proband | 5.01 (0.38-65.8) | 0.220 |
Abbreviations: IA, islet autoimmunity; CDA, celiac autoimmunity.
Cox proportional hazards models for time to islet autoimmunity and celiac autoimmunity in cotwins
| Covariate . | Hazard Ratio (95% Confidence Interval) . | P value . |
|---|---|---|
| Time to IA in Dizygotic Cotwins | ||
| Proband’s age at type 1 diabetes diagnosis | 0.88 (0.78-1.00) | 0.047 |
| Proband’s sex | 0.37 (0.08-1.76) | 0.210 |
| DR3 present in proband | 0.95 (0.20-4.42) | 0.945 |
| DR4 present in proband | 0.79 (0.15-4.05) | 0.773 |
| Time to IA in Monozygotic Cotwins | ||
| Proband’s age at type 1 diabetes diagnosis | 0.91 (0.84-0.98) | 0.012 |
| Proband’s sex | 0.97 (0.29-3.28) | 0.962 |
| 0.81 (0.26-2.51) | 0.716 | |
| DR4 present in proband | 1.05 (0.32-3.47) | 0.938 |
| Time to CDA in Dizygotic Cotwins | ||
| Proband’s age at type 1 diabetes diagnosis | 0.85 (0.66-1.08) | 0.187 |
| Proband’s sex | 0.21 (0.02-1.91) | 0.164 |
| DR3 present in proband | 0.43 (0.09-1.93) | 0.268 |
| DR4 present in proband | 0.47 (0.05-4.12) | 0.495 |
| Time to CDA in Monozygotic Cotwins | ||
| Proband’s age at type 1 diabetes diagnosis | 0.79 (0.68-0.91) | 0.001 |
| 0.44 (0.06-3.35) | 0.426 | |
| DR3 present in proband | 0.17 (0.02-1.46) | 0.106 |
| DR4 present in proband | 5.01 (0.38-65.8) | 0.220 |
| Covariate . | Hazard Ratio (95% Confidence Interval) . | P value . |
|---|---|---|
| Time to IA in Dizygotic Cotwins | ||
| Proband’s age at type 1 diabetes diagnosis | 0.88 (0.78-1.00) | 0.047 |
| Proband’s sex | 0.37 (0.08-1.76) | 0.210 |
| DR3 present in proband | 0.95 (0.20-4.42) | 0.945 |
| DR4 present in proband | 0.79 (0.15-4.05) | 0.773 |
| Time to IA in Monozygotic Cotwins | ||
| Proband’s age at type 1 diabetes diagnosis | 0.91 (0.84-0.98) | 0.012 |
| Proband’s sex | 0.97 (0.29-3.28) | 0.962 |
| 0.81 (0.26-2.51) | 0.716 | |
| DR4 present in proband | 1.05 (0.32-3.47) | 0.938 |
| Time to CDA in Dizygotic Cotwins | ||
| Proband’s age at type 1 diabetes diagnosis | 0.85 (0.66-1.08) | 0.187 |
| Proband’s sex | 0.21 (0.02-1.91) | 0.164 |
| DR3 present in proband | 0.43 (0.09-1.93) | 0.268 |
| DR4 present in proband | 0.47 (0.05-4.12) | 0.495 |
| Time to CDA in Monozygotic Cotwins | ||
| Proband’s age at type 1 diabetes diagnosis | 0.79 (0.68-0.91) | 0.001 |
| 0.44 (0.06-3.35) | 0.426 | |
| DR3 present in proband | 0.17 (0.02-1.46) | 0.106 |
| DR4 present in proband | 5.01 (0.38-65.8) | 0.220 |
Abbreviations: IA, islet autoimmunity; CDA, celiac autoimmunity.
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