Table 4 Open in new tab Construct...

	Age	BASFI	EQ-5D	patient's global assessment of well-being	WPAI, impact on work productivity^a	Impact on daily activities	ASDAS- CRP
All patients (n = 3984)
mSCQ	0.41	0.34	−0.33	0.22	0.21	0.30	0.19
mSCQ + EAMs	0.45	0.32	−0.33	0.19^c	0.16^c	0.26^c	0.16^c
mSCQ + fractures	0.40	0.34	−0.33	0.21	0.20	0.29	0.19
mSCQ + osteoporosis + fracture	0.41	0.34	−0.33	0.22	0.21	0.30	0.19
mSCQ + EAMs + osteoporosis	0.46^c	0.32	−0.33	0.20	0.17^c	0.27	0.16^c
mSCQ + EAMs + fractures	0.45	0.32	−0.33	0.19^c	0.17^c	0.27	0.16^c
mSCQ + EAMs + osteoporosis + fractures	0.45	0.33	−0.33	0.20	0.17^c	0.27	0.17
RDCI^b	0.47^c	0.24^c	−0.21^c	0.12^c	0.09^c	0.17^c	0.10^c
Patients fulfilling ASAS axSpA criteria (n = 2955)
mSCQ	0.38	0.35^d	−0.35^d	0.21^d	0.20^d	0.29^d	0.19^d
mSCQ + EAMs	0.42^c	0.34	−0.34^d	0.20^d	0.17^c^,^d	0.27	0.17^c^,^d
mSCQ + fractures	0.38	0.35^d	−0.34^d	0.21^d	0.20^d	0.30^d	0.18^d
mSCQ + osteoporosis + fracture	0.39	0.35^d	−0.34	0.22^d	0.20^d	0.30^d	0.19^d
mSCQ + EAMs + osteoporosis	0.42^c	0.34	−0.34^d	0.20^d	0.17^c^,^d	0.28	0.18^d
mSCQ + EAMs + fractures	0.42^c	0.34	−0.34^d	0.20^d	0.17^c^,^d	0.27	0.17^c^,^d
mSCQ + EAMs + osteoporosis + fractures	0.42^c	0.34	−0.34^d	0.20^d	0.17^c^,^d	0.28	0.17^c^,^d
RDCI^b	0.44^c	0.25^c^,^d	−0.22^c	0.12^c^,^d	0.08^c^,^d	0.17^c^,^d	0.10^c^,^d
Patients fulfilling ASAS pSpA criteria (n = 415)
mSCQ	0.40	0.46^d	−0.29^d	0.19^d	0.29^d	0.32^d	0.25^d
mSCQ + EAMs	0.45^c	0.35^c	−0.29^d	0.15^c^,^d	0.22^c^,^d	0.27^c	0.19^c^,^d
mSCQ + fractures	0.40	0.41^c^,^d	−0.30^d	0.18^d	0.30^d	0.33^d	0.26^d
mSCQ + osteoporosis + fracture	0.40	0.42^d	−0.31	0.19^d	0.32^c^,^d	0.34^d	0.26^d
mSCQ + EAMs + osteoporosis	0.45^c	0.36^c	−0.27^d	0.16^c^,^d	0.24^c^,^d	0.28	0.19^c
mSCQ + EAMs + fractures	0.45^c	0.37^c	−0.26^c^,^d	0.15^c^,^d	0.24^c^,^d	0.27^c	0.19^c^,^d
mSCQ + EAMs + osteoporosis + fractures	0.46^c	0.37^c	−0.27^d	0.15^c^,^d	0.26^c^,^d	0.29	0.20^c^,^d
RDCI^b	0.42	0.35^c^,^d	−0.23^c	0.16^c^,^d	0.25^c^,^d	0.24^c^,^d	0.22^c^,^d

Age

BASFI

EQ-5D

patient's global assessment of well-being

WPAI, impact on work productivity^a

Impact on daily activities

ASDAS- CRP

All patients (n = 3984)

mSCQ

0.41

0.34

−0.33

0.22

0.21

0.30

0.19

mSCQ + EAMs

0.45

0.32

−0.33

0.19^c

0.16^c

0.26^c

0.16^c

mSCQ + fractures

0.40

0.34

−0.33

0.21

0.20

0.29

0.19

mSCQ + osteoporosis + fracture

0.41

0.34

−0.33

0.22

0.21

0.30

0.19

mSCQ + EAMs + osteoporosis

0.46^c

0.32

−0.33

0.20

0.17^c

0.27

0.16^c

mSCQ + EAMs + fractures

0.45

0.32

−0.33

0.19^c

0.17^c

0.27

0.16^c

mSCQ + EAMs + osteoporosis + fractures

0.45

0.33

−0.33

0.20

0.17^c

0.27

0.17

RDCI^b

0.47^c

0.24^c

−0.21^c

0.12^c

0.09^c

0.17^c

0.10^c

Patients fulfilling ASAS axSpA criteria (n = 2955)

mSCQ

0.38

0.35^d

−0.35^d

0.21^d

0.20^d

0.29^d

0.19^d

mSCQ + EAMs

0.42^c

0.34

−0.34^d

0.20^d

0.17^c^,^d

0.27

0.17^c^,^d

mSCQ + fractures

0.38

0.35^d

−0.34^d

0.21^d

0.20^d

0.30^d

0.18^d

mSCQ + osteoporosis + fracture

0.39

0.35^d

−0.34

0.22^d

0.20^d

0.30^d

0.19^d

mSCQ + EAMs + osteoporosis

0.42^c

0.34

−0.34^d

0.20^d

0.17^c^,^d

0.28

0.18^d

mSCQ + EAMs + fractures

0.42^c

0.34

−0.34^d

0.20^d

0.17^c^,^d

0.27

0.17^c^,^d

mSCQ + EAMs + osteoporosis + fractures

0.42^c

0.34

−0.34^d

0.20^d

0.17^c^,^d

0.28

0.17^c^,^d

RDCI^b

0.44^c

0.25^c^,^d

−0.22^c

0.12^c^,^d

0.08^c^,^d

0.17^c^,^d

0.10^c^,^d

Patients fulfilling ASAS pSpA criteria (n = 415)

mSCQ

0.40

0.46^d

−0.29^d

0.19^d

0.29^d

0.32^d

0.25^d

mSCQ + EAMs

0.45^c

0.35^c

−0.29^d

0.15^c^,^d

0.22^c^,^d

0.27^c

0.19^c^,^d

mSCQ + fractures

0.40

0.41^c^,^d

−0.30^d

0.18^d

0.30^d

0.33^d

0.26^d

mSCQ + osteoporosis + fracture

0.40

0.42^d

−0.31

0.19^d

0.32^c^,^d

0.34^d

0.26^d

mSCQ + EAMs + osteoporosis

0.45^c

0.36^c

−0.27^d

0.16^c^,^d

0.24^c^,^d

0.28

0.19^c

mSCQ + EAMs + fractures

0.45^c

0.37^c

−0.26^c^,^d

0.15^c^,^d

0.24^c^,^d

0.27^c

0.19^c^,^d

mSCQ + EAMs + osteoporosis + fractures

0.46^c

0.37^c

−0.27^d

0.15^c^,^d

0.26^c^,^d

0.29

0.20^c^,^d

RDCI^b

0.42

0.35^c^,^d

−0.23^c

0.16^c^,^d

0.25^c^,^d

0.24^c^,^d

0.22^c^,^d

	Age	BASFI	EQ-5D	patient's global assessment of well-being	WPAI, impact on work productivity^a	Impact on daily activities	ASDAS- CRP
All patients (n = 3984)
mSCQ	0.41	0.34	−0.33	0.22	0.21	0.30	0.19
mSCQ + EAMs	0.45	0.32	−0.33	0.19^c	0.16^c	0.26^c	0.16^c
mSCQ + fractures	0.40	0.34	−0.33	0.21	0.20	0.29	0.19
mSCQ + osteoporosis + fracture	0.41	0.34	−0.33	0.22	0.21	0.30	0.19
mSCQ + EAMs + osteoporosis	0.46^c	0.32	−0.33	0.20	0.17^c	0.27	0.16^c
mSCQ + EAMs + fractures	0.45	0.32	−0.33	0.19^c	0.17^c	0.27	0.16^c
mSCQ + EAMs + osteoporosis + fractures	0.45	0.33	−0.33	0.20	0.17^c	0.27	0.17
RDCI^b	0.47^c	0.24^c	−0.21^c	0.12^c	0.09^c	0.17^c	0.10^c
Patients fulfilling ASAS axSpA criteria (n = 2955)
mSCQ	0.38	0.35^d	−0.35^d	0.21^d	0.20^d	0.29^d	0.19^d
mSCQ + EAMs	0.42^c	0.34	−0.34^d	0.20^d	0.17^c^,^d	0.27	0.17^c^,^d
mSCQ + fractures	0.38	0.35^d	−0.34^d	0.21^d	0.20^d	0.30^d	0.18^d
mSCQ + osteoporosis + fracture	0.39	0.35^d	−0.34	0.22^d	0.20^d	0.30^d	0.19^d
mSCQ + EAMs + osteoporosis	0.42^c	0.34	−0.34^d	0.20^d	0.17^c^,^d	0.28	0.18^d
mSCQ + EAMs + fractures	0.42^c	0.34	−0.34^d	0.20^d	0.17^c^,^d	0.27	0.17^c^,^d
mSCQ + EAMs + osteoporosis + fractures	0.42^c	0.34	−0.34^d	0.20^d	0.17^c^,^d	0.28	0.17^c^,^d
RDCI^b	0.44^c	0.25^c^,^d	−0.22^c	0.12^c^,^d	0.08^c^,^d	0.17^c^,^d	0.10^c^,^d
Patients fulfilling ASAS pSpA criteria (n = 415)
mSCQ	0.40	0.46^d	−0.29^d	0.19^d	0.29^d	0.32^d	0.25^d
mSCQ + EAMs	0.45^c	0.35^c	−0.29^d	0.15^c^,^d	0.22^c^,^d	0.27^c	0.19^c^,^d
mSCQ + fractures	0.40	0.41^c^,^d	−0.30^d	0.18^d	0.30^d	0.33^d	0.26^d
mSCQ + osteoporosis + fracture	0.40	0.42^d	−0.31	0.19^d	0.32^c^,^d	0.34^d	0.26^d
mSCQ + EAMs + osteoporosis	0.45^c	0.36^c	−0.27^d	0.16^c^,^d	0.24^c^,^d	0.28	0.19^c
mSCQ + EAMs + fractures	0.45^c	0.37^c	−0.26^c^,^d	0.15^c^,^d	0.24^c^,^d	0.27^c	0.19^c^,^d
mSCQ + EAMs + osteoporosis + fractures	0.46^c	0.37^c	−0.27^d	0.15^c^,^d	0.26^c^,^d	0.29	0.20^c^,^d
RDCI^b	0.42	0.35^c^,^d	−0.23^c	0.16^c^,^d	0.25^c^,^d	0.24^c^,^d	0.22^c^,^d

Table 4

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Construct validity of different modifications of the mSCQ and the RDCI with health outcomes in all patients, and subgroups of patients with axSpA and pSpA

	Age	BASFI	EQ-5D	patient's global assessment of well-being	WPAI, impact on work productivity^a	Impact on daily activities	ASDAS- CRP
All patients (n = 3984)
mSCQ	0.41	0.34	−0.33	0.22	0.21	0.30	0.19
mSCQ + EAMs	0.45	0.32	−0.33	0.19^c	0.16^c	0.26^c	0.16^c
mSCQ + fractures	0.40	0.34	−0.33	0.21	0.20	0.29	0.19
mSCQ + osteoporosis + fracture	0.41	0.34	−0.33	0.22	0.21	0.30	0.19
mSCQ + EAMs + osteoporosis	0.46^c	0.32	−0.33	0.20	0.17^c	0.27	0.16^c
mSCQ + EAMs + fractures	0.45	0.32	−0.33	0.19^c	0.17^c	0.27	0.16^c
mSCQ + EAMs + osteoporosis + fractures	0.45	0.33	−0.33	0.20	0.17^c	0.27	0.17
RDCI^b	0.47^c	0.24^c	−0.21^c	0.12^c	0.09^c	0.17^c	0.10^c
Patients fulfilling ASAS axSpA criteria (n = 2955)
mSCQ	0.38	0.35^d	−0.35^d	0.21^d	0.20^d	0.29^d	0.19^d
mSCQ + EAMs	0.42^c	0.34	−0.34^d	0.20^d	0.17^c^,^d	0.27	0.17^c^,^d
mSCQ + fractures	0.38	0.35^d	−0.34^d	0.21^d	0.20^d	0.30^d	0.18^d
mSCQ + osteoporosis + fracture	0.39	0.35^d	−0.34	0.22^d	0.20^d	0.30^d	0.19^d
mSCQ + EAMs + osteoporosis	0.42^c	0.34	−0.34^d	0.20^d	0.17^c^,^d	0.28	0.18^d
mSCQ + EAMs + fractures	0.42^c	0.34	−0.34^d	0.20^d	0.17^c^,^d	0.27	0.17^c^,^d
mSCQ + EAMs + osteoporosis + fractures	0.42^c	0.34	−0.34^d	0.20^d	0.17^c^,^d	0.28	0.17^c^,^d
RDCI^b	0.44^c	0.25^c^,^d	−0.22^c	0.12^c^,^d	0.08^c^,^d	0.17^c^,^d	0.10^c^,^d
Patients fulfilling ASAS pSpA criteria (n = 415)
mSCQ	0.40	0.46^d	−0.29^d	0.19^d	0.29^d	0.32^d	0.25^d
mSCQ + EAMs	0.45^c	0.35^c	−0.29^d	0.15^c^,^d	0.22^c^,^d	0.27^c	0.19^c^,^d
mSCQ + fractures	0.40	0.41^c^,^d	−0.30^d	0.18^d	0.30^d	0.33^d	0.26^d
mSCQ + osteoporosis + fracture	0.40	0.42^d	−0.31	0.19^d	0.32^c^,^d	0.34^d	0.26^d
mSCQ + EAMs + osteoporosis	0.45^c	0.36^c	−0.27^d	0.16^c^,^d	0.24^c^,^d	0.28	0.19^c
mSCQ + EAMs + fractures	0.45^c	0.37^c	−0.26^c^,^d	0.15^c^,^d	0.24^c^,^d	0.27^c	0.19^c^,^d
mSCQ + EAMs + osteoporosis + fractures	0.46^c	0.37^c	−0.27^d	0.15^c^,^d	0.26^c^,^d	0.29	0.20^c^,^d
RDCI^b	0.42	0.35^c^,^d	−0.23^c	0.16^c^,^d	0.25^c^,^d	0.24^c^,^d	0.22^c^,^d

	Age	BASFI	EQ-5D	patient's global assessment of well-being	WPAI, impact on work productivity^a	Impact on daily activities	ASDAS- CRP
All patients (n = 3984)
mSCQ	0.41	0.34	−0.33	0.22	0.21	0.30	0.19
mSCQ + EAMs	0.45	0.32	−0.33	0.19^c	0.16^c	0.26^c	0.16^c
mSCQ + fractures	0.40	0.34	−0.33	0.21	0.20	0.29	0.19
mSCQ + osteoporosis + fracture	0.41	0.34	−0.33	0.22	0.21	0.30	0.19
mSCQ + EAMs + osteoporosis	0.46^c	0.32	−0.33	0.20	0.17^c	0.27	0.16^c
mSCQ + EAMs + fractures	0.45	0.32	−0.33	0.19^c	0.17^c	0.27	0.16^c
mSCQ + EAMs + osteoporosis + fractures	0.45	0.33	−0.33	0.20	0.17^c	0.27	0.17
RDCI^b	0.47^c	0.24^c	−0.21^c	0.12^c	0.09^c	0.17^c	0.10^c
Patients fulfilling ASAS axSpA criteria (n = 2955)
mSCQ	0.38	0.35^d	−0.35^d	0.21^d	0.20^d	0.29^d	0.19^d
mSCQ + EAMs	0.42^c	0.34	−0.34^d	0.20^d	0.17^c^,^d	0.27	0.17^c^,^d
mSCQ + fractures	0.38	0.35^d	−0.34^d	0.21^d	0.20^d	0.30^d	0.18^d
mSCQ + osteoporosis + fracture	0.39	0.35^d	−0.34	0.22^d	0.20^d	0.30^d	0.19^d
mSCQ + EAMs + osteoporosis	0.42^c	0.34	−0.34^d	0.20^d	0.17^c^,^d	0.28	0.18^d
mSCQ + EAMs + fractures	0.42^c	0.34	−0.34^d	0.20^d	0.17^c^,^d	0.27	0.17^c^,^d
mSCQ + EAMs + osteoporosis + fractures	0.42^c	0.34	−0.34^d	0.20^d	0.17^c^,^d	0.28	0.17^c^,^d
RDCI^b	0.44^c	0.25^c^,^d	−0.22^c	0.12^c^,^d	0.08^c^,^d	0.17^c^,^d	0.10^c^,^d
Patients fulfilling ASAS pSpA criteria (n = 415)
mSCQ	0.40	0.46^d	−0.29^d	0.19^d	0.29^d	0.32^d	0.25^d
mSCQ + EAMs	0.45^c	0.35^c	−0.29^d	0.15^c^,^d	0.22^c^,^d	0.27^c	0.19^c^,^d
mSCQ + fractures	0.40	0.41^c^,^d	−0.30^d	0.18^d	0.30^d	0.33^d	0.26^d
mSCQ + osteoporosis + fracture	0.40	0.42^d	−0.31	0.19^d	0.32^c^,^d	0.34^d	0.26^d
mSCQ + EAMs + osteoporosis	0.45^c	0.36^c	−0.27^d	0.16^c^,^d	0.24^c^,^d	0.28	0.19^c
mSCQ + EAMs + fractures	0.45^c	0.37^c	−0.26^c^,^d	0.15^c^,^d	0.24^c^,^d	0.27^c	0.19^c^,^d
mSCQ + EAMs + osteoporosis + fractures	0.46^c	0.37^c	−0.27^d	0.15^c^,^d	0.26^c^,^d	0.29	0.20^c^,^d
RDCI^b	0.42	0.35^c^,^d	−0.23^c	0.16^c^,^d	0.25^c^,^d	0.24^c^,^d	0.22^c^,^d

Work productivity in those currently employed.

The RDCI was calculated according to the information from the physician, except for depression which was retrieved from the patient.

Difference of comorbidity score with mSCQ score >10%.

Difference on correlation between axSpA and pSpA >10%. EAM: extra-articular manifestations; EQ-5D: Euroqol 5 D; mSCQ: modified self-administered comorbidity index; RDCI: rheumatic disease comorbidity index; WPAI: work productivity and activity impairment.

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