Table 2. Open in new tab Top 20 AEs...

Rank

Oxycodone

Hydrocodone

Morphine

Fentanyl

Codeine

Drug abuse

Completed suicide

Drug hypersensitivity

Drug abuse

Drug hypersensitivity

Cardiorespiratory arrest

Drug abuse

Hypersensitivity

Product quality issue

Drug abuse

Cardiac arrest

Cardiorespiratory arrest

Lethargy

Toxicity to various agents

Hypersensitivity

Constipation

Back pain

Toxicity to various agents

Emotional distress

Overdose

Completed suicide

Gastroesophageal reflux disease

Drug abuse

Drug effect decreased

Toxicity to various agents

Sinusitis

Anxiety

Cardiac arrest

Hallucination

Toxicity to various agents

Emotional distress

Somnolence

Overdose

Emotional distress

Back pain

Sinusitis

Overdose

Hyperhidrosis

Bronchitis

Dehydration

Cardiac arrest

Respiratory failure

Back pain

Completed suicide

Neuropathy peripheral

Pulmonary embolism

Hallucination

Depression

Deep vein thrombosis

Disease progression

Amnesia

General physical health deterioration

Drug ineffective

Epistaxis

Pulmonary embolism

Depression

Back pain

Constipation

Joint swelling

Injury

Diabetes mellitus

Pulmonary embolism

Respiratory failure

Sinusitis

Decreased appetite

Cardiac failure congestive

Death

Amnesia

Dysphagia

Pleural effusion

Arthralgia

Completed suicide

Injury

Drug interaction

Abdominal pain

Deep vein thrombosis

Disease progression

Renal impairment

Rheumatoid arthritis

Depression

Neuropathy peripheral

Constipation

Renal failure

Hyperhidrosis

Hypokalemia

Hypoesthesia

Depression

Loss of consciousness

Cerebrovascular accident

Emotional distress

Weight increased

Vomiting

Cardiorespiratory arrest

Thrombosis

Memory impairment

Gait disturbance

Loss of consciousness

Urinary tract infection

Cardiorespiratory arrest

Table 2.

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Top 20 AEs ranked by odds ratios for the most frequent opioids

Rank	Oxycodone	Hydrocodone	Morphine	Fentanyl	Codeine
1	Drug abuse	Completed suicide	Drug hypersensitivity	Drug abuse	Drug hypersensitivity
2	Cardiorespiratory arrest	Drug abuse	Hypersensitivity	Product quality issue	Drug abuse
3	Cardiac arrest	Cardiorespiratory arrest	Lethargy	Toxicity to various agents	Hypersensitivity
4	Constipation	Back pain	Toxicity to various agents	Emotional distress	Overdose
5	Completed suicide	Gastroesophageal reflux disease	Drug abuse	Drug effect decreased	Toxicity to various agents
6	Sinusitis	Anxiety	Cardiac arrest	Cardiac arrest	Hallucination
7	Toxicity to various agents	Emotional distress	Somnolence	Overdose	Emotional distress
8	Back pain	Sinusitis	Overdose	Hyperhidrosis	Bronchitis
9	Dehydration	Cardiac arrest	Respiratory failure	Back pain	Completed suicide
10	Neuropathy peripheral	Pulmonary embolism	Hallucination	Depression	Deep vein thrombosis
11	Disease progression	Amnesia	General physical health deterioration	Drug ineffective	Epistaxis
12	Pulmonary embolism	Depression	Back pain	Constipation	Joint swelling
13	Injury	Diabetes mellitus	Pulmonary embolism	Respiratory failure	Sinusitis
14	Decreased appetite	Cardiac failure congestive	Death	Amnesia	Dysphagia
15	Pleural effusion	Arthralgia	Completed suicide	Injury	Drug interaction
16	Abdominal pain	Deep vein thrombosis	Disease progression	Renal impairment	Rheumatoid arthritis
17	Depression	Neuropathy peripheral	Constipation	Renal failure	Hyperhidrosis
18	Hypokalemia	Hypoesthesia	Depression	Loss of consciousness	Cerebrovascular accident
19	Emotional distress	Weight increased	Vomiting	Cardiorespiratory arrest	Thrombosis
20	Memory impairment	Gait disturbance	Loss of consciousness	Urinary tract infection	Cardiorespiratory arrest

Rank	Oxycodone	Hydrocodone	Morphine	Fentanyl	Codeine
1	Drug abuse	Completed suicide	Drug hypersensitivity	Drug abuse	Drug hypersensitivity
2	Cardiorespiratory arrest	Drug abuse	Hypersensitivity	Product quality issue	Drug abuse
3	Cardiac arrest	Cardiorespiratory arrest	Lethargy	Toxicity to various agents	Hypersensitivity
4	Constipation	Back pain	Toxicity to various agents	Emotional distress	Overdose
5	Completed suicide	Gastroesophageal reflux disease	Drug abuse	Drug effect decreased	Toxicity to various agents
6	Sinusitis	Anxiety	Cardiac arrest	Cardiac arrest	Hallucination
7	Toxicity to various agents	Emotional distress	Somnolence	Overdose	Emotional distress
8	Back pain	Sinusitis	Overdose	Hyperhidrosis	Bronchitis
9	Dehydration	Cardiac arrest	Respiratory failure	Back pain	Completed suicide
10	Neuropathy peripheral	Pulmonary embolism	Hallucination	Depression	Deep vein thrombosis
11	Disease progression	Amnesia	General physical health deterioration	Drug ineffective	Epistaxis
12	Pulmonary embolism	Depression	Back pain	Constipation	Joint swelling
13	Injury	Diabetes mellitus	Pulmonary embolism	Respiratory failure	Sinusitis
14	Decreased appetite	Cardiac failure congestive	Death	Amnesia	Dysphagia
15	Pleural effusion	Arthralgia	Completed suicide	Injury	Drug interaction
16	Abdominal pain	Deep vein thrombosis	Disease progression	Renal impairment	Rheumatoid arthritis
17	Depression	Neuropathy peripheral	Constipation	Renal failure	Hyperhidrosis
18	Hypokalemia	Hypoesthesia	Depression	Loss of consciousness	Cerebrovascular accident
19	Emotional distress	Weight increased	Vomiting	Cardiorespiratory arrest	Thrombosis
20	Memory impairment	Gait disturbance	Loss of consciousness	Urinary tract infection	Cardiorespiratory arrest

Abbreviations: AE: adverse events.

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