Cox Proportional Hazards Model to Determine Predictors of Time to Next Pregnancy
| Variable . | Adjusted HR (95% CI) . | . |
|---|---|---|
| . | Model 1: All Potential Pregnancies . | Model 2: Certain and Probable Pregnancies . |
| Age at index pregnancy, y | ||
| 15–19 | 1 | 1 |
| 20–24 | 1.02 (1.01–1.03) | 1.06 (1.04–1.08) |
| 25–29 | 0.88 (.87–.90) | 0.90 (.88–.92) |
| 30–34 | 0.66 (.65–.67) | 0.65 (.64–.67) |
| 35–39 | 0.37 (.36–.38) | 0.35 (.34–.36) |
| 40–44 | 0.15 (.14–.16) | 0.10 (.09–.11) |
| 45–49 | 0.07 (.06–.10) | 0.03 (.01–.05) |
| HIV status, CD4+ T-cell count | ||
| Negative, not applicable | 1 | 1 |
| Positive, ≥500 cells/µL | 0.90 (.88–.92) | 0.91 (.88–.94) |
| Positive, 350–499 cells/µL | 0.86 (.84–.88) | 0.86 (.83–.89) |
| Positive, 200–349 cells/µL | 0.75 (.73–.77) | 0.76 (.73–.79) |
| Positive, <200 cells/µL | 0.51 (.49–.53) | 0.52 (.49–.54) |
| ART status among HIV-positive women | ||
| Naive | 1 | 1 |
| Experienced | 1.63 (1.59–1.67) | 1.42 (1.37–1.46) |
| Outcome of first pregnancy | ||
| Live birth | 1 | 1 |
| Stillbirth | 2.52 (2.44–2.61) | 2.56 (2.48–2.64) |
| Neonatal death | 2.17 (2.06–2.29) | 2.19 (2.08–2.31) |
| Miscarriage | 3.13 (3.00–3.27) | 3.27 (3.14–3.42) |
| Induced abortion | 1.73 (1.67–1.79) | 1.75 (1.70–1.81) |
| Unspecified/ambiguous | 1.01 (1.00–1.03) | 1.16 (1.14–1.19) |
| Population group | ||
| Mixed race | 1 | 1 |
| Black African | 0.86 (.85–.87) | 0.80 (.78–.81) |
| White | 0.45 (.43–.46) | 0.54 (.51–.56) |
| Other/unspecified | 0.21 (.20–.21) | 0.23 (.21–.24) |
| Pregnancies per calendar year after 2007 | 1.07 (1.06–1.07) | 1.07 (1.07–1.07) |
| Variable . | Adjusted HR (95% CI) . | . |
|---|---|---|
| . | Model 1: All Potential Pregnancies . | Model 2: Certain and Probable Pregnancies . |
| Age at index pregnancy, y | ||
| 15–19 | 1 | 1 |
| 20–24 | 1.02 (1.01–1.03) | 1.06 (1.04–1.08) |
| 25–29 | 0.88 (.87–.90) | 0.90 (.88–.92) |
| 30–34 | 0.66 (.65–.67) | 0.65 (.64–.67) |
| 35–39 | 0.37 (.36–.38) | 0.35 (.34–.36) |
| 40–44 | 0.15 (.14–.16) | 0.10 (.09–.11) |
| 45–49 | 0.07 (.06–.10) | 0.03 (.01–.05) |
| HIV status, CD4+ T-cell count | ||
| Negative, not applicable | 1 | 1 |
| Positive, ≥500 cells/µL | 0.90 (.88–.92) | 0.91 (.88–.94) |
| Positive, 350–499 cells/µL | 0.86 (.84–.88) | 0.86 (.83–.89) |
| Positive, 200–349 cells/µL | 0.75 (.73–.77) | 0.76 (.73–.79) |
| Positive, <200 cells/µL | 0.51 (.49–.53) | 0.52 (.49–.54) |
| ART status among HIV-positive women | ||
| Naive | 1 | 1 |
| Experienced | 1.63 (1.59–1.67) | 1.42 (1.37–1.46) |
| Outcome of first pregnancy | ||
| Live birth | 1 | 1 |
| Stillbirth | 2.52 (2.44–2.61) | 2.56 (2.48–2.64) |
| Neonatal death | 2.17 (2.06–2.29) | 2.19 (2.08–2.31) |
| Miscarriage | 3.13 (3.00–3.27) | 3.27 (3.14–3.42) |
| Induced abortion | 1.73 (1.67–1.79) | 1.75 (1.70–1.81) |
| Unspecified/ambiguous | 1.01 (1.00–1.03) | 1.16 (1.14–1.19) |
| Population group | ||
| Mixed race | 1 | 1 |
| Black African | 0.86 (.85–.87) | 0.80 (.78–.81) |
| White | 0.45 (.43–.46) | 0.54 (.51–.56) |
| Other/unspecified | 0.21 (.20–.21) | 0.23 (.21–.24) |
| Pregnancies per calendar year after 2007 | 1.07 (1.06–1.07) | 1.07 (1.07–1.07) |
Abbreviations: ART, antiretroviral therapy; CI, confidence interval; HIV, human immunodeficiency virus.
Cox Proportional Hazards Model to Determine Predictors of Time to Next Pregnancy
| Variable . | Adjusted HR (95% CI) . | . |
|---|---|---|
| . | Model 1: All Potential Pregnancies . | Model 2: Certain and Probable Pregnancies . |
| Age at index pregnancy, y | ||
| 15–19 | 1 | 1 |
| 20–24 | 1.02 (1.01–1.03) | 1.06 (1.04–1.08) |
| 25–29 | 0.88 (.87–.90) | 0.90 (.88–.92) |
| 30–34 | 0.66 (.65–.67) | 0.65 (.64–.67) |
| 35–39 | 0.37 (.36–.38) | 0.35 (.34–.36) |
| 40–44 | 0.15 (.14–.16) | 0.10 (.09–.11) |
| 45–49 | 0.07 (.06–.10) | 0.03 (.01–.05) |
| HIV status, CD4+ T-cell count | ||
| Negative, not applicable | 1 | 1 |
| Positive, ≥500 cells/µL | 0.90 (.88–.92) | 0.91 (.88–.94) |
| Positive, 350–499 cells/µL | 0.86 (.84–.88) | 0.86 (.83–.89) |
| Positive, 200–349 cells/µL | 0.75 (.73–.77) | 0.76 (.73–.79) |
| Positive, <200 cells/µL | 0.51 (.49–.53) | 0.52 (.49–.54) |
| ART status among HIV-positive women | ||
| Naive | 1 | 1 |
| Experienced | 1.63 (1.59–1.67) | 1.42 (1.37–1.46) |
| Outcome of first pregnancy | ||
| Live birth | 1 | 1 |
| Stillbirth | 2.52 (2.44–2.61) | 2.56 (2.48–2.64) |
| Neonatal death | 2.17 (2.06–2.29) | 2.19 (2.08–2.31) |
| Miscarriage | 3.13 (3.00–3.27) | 3.27 (3.14–3.42) |
| Induced abortion | 1.73 (1.67–1.79) | 1.75 (1.70–1.81) |
| Unspecified/ambiguous | 1.01 (1.00–1.03) | 1.16 (1.14–1.19) |
| Population group | ||
| Mixed race | 1 | 1 |
| Black African | 0.86 (.85–.87) | 0.80 (.78–.81) |
| White | 0.45 (.43–.46) | 0.54 (.51–.56) |
| Other/unspecified | 0.21 (.20–.21) | 0.23 (.21–.24) |
| Pregnancies per calendar year after 2007 | 1.07 (1.06–1.07) | 1.07 (1.07–1.07) |
| Variable . | Adjusted HR (95% CI) . | . |
|---|---|---|
| . | Model 1: All Potential Pregnancies . | Model 2: Certain and Probable Pregnancies . |
| Age at index pregnancy, y | ||
| 15–19 | 1 | 1 |
| 20–24 | 1.02 (1.01–1.03) | 1.06 (1.04–1.08) |
| 25–29 | 0.88 (.87–.90) | 0.90 (.88–.92) |
| 30–34 | 0.66 (.65–.67) | 0.65 (.64–.67) |
| 35–39 | 0.37 (.36–.38) | 0.35 (.34–.36) |
| 40–44 | 0.15 (.14–.16) | 0.10 (.09–.11) |
| 45–49 | 0.07 (.06–.10) | 0.03 (.01–.05) |
| HIV status, CD4+ T-cell count | ||
| Negative, not applicable | 1 | 1 |
| Positive, ≥500 cells/µL | 0.90 (.88–.92) | 0.91 (.88–.94) |
| Positive, 350–499 cells/µL | 0.86 (.84–.88) | 0.86 (.83–.89) |
| Positive, 200–349 cells/µL | 0.75 (.73–.77) | 0.76 (.73–.79) |
| Positive, <200 cells/µL | 0.51 (.49–.53) | 0.52 (.49–.54) |
| ART status among HIV-positive women | ||
| Naive | 1 | 1 |
| Experienced | 1.63 (1.59–1.67) | 1.42 (1.37–1.46) |
| Outcome of first pregnancy | ||
| Live birth | 1 | 1 |
| Stillbirth | 2.52 (2.44–2.61) | 2.56 (2.48–2.64) |
| Neonatal death | 2.17 (2.06–2.29) | 2.19 (2.08–2.31) |
| Miscarriage | 3.13 (3.00–3.27) | 3.27 (3.14–3.42) |
| Induced abortion | 1.73 (1.67–1.79) | 1.75 (1.70–1.81) |
| Unspecified/ambiguous | 1.01 (1.00–1.03) | 1.16 (1.14–1.19) |
| Population group | ||
| Mixed race | 1 | 1 |
| Black African | 0.86 (.85–.87) | 0.80 (.78–.81) |
| White | 0.45 (.43–.46) | 0.54 (.51–.56) |
| Other/unspecified | 0.21 (.20–.21) | 0.23 (.21–.24) |
| Pregnancies per calendar year after 2007 | 1.07 (1.06–1.07) | 1.07 (1.07–1.07) |
Abbreviations: ART, antiretroviral therapy; CI, confidence interval; HIV, human immunodeficiency virus.
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