Table 1.
Open in new tab

Characteristics of Studies That Examined People Who Inject Drugs Treated With Direct-acting Antivirals for Chronic Hepatitis C

Study and Year
(Reference)		CenterCountryStudy DesignHCV Treatment RegimeTotal Number of PatientsAge (Mean or Median)MalePWIDNon- PWIDDefinition of Active Injecting Drug UseHCV Genotype (1/2/3/4–6)No. of Patients With CirrhosisTreatment Setting
Alimohammadi et al 2016 [36]Single CanadaRetrospective cohort studyNot specified40......150Current injection drug use during DAA treatment.........
Bielen et al 2017 [32] MultipleBelgiumRetrospective cohort studyVarious57952,335918464Injection drug use during DAA treatment413/0/78/82341Hospital-based
Boglione et al 2017 [21] Single ItalyProspective cohort studyVarious163......1630Injection drug use in 12 months prior to starting treatment......Hospital-based
Foster et al 2017 [12]Multiple United KingdomRetrospective case- control studyGLE/PIB166645 900671599Injection drug use in 12 months prior to starting treatment852/245/401/168163...
Grebely et al 2018 [22] MultipleAustraliaProspective cohort studySOF/VEL10348741030Injection drug use in 6 months prior to starting treatment36/5/60/29Community- and hospital-based
Morris et al 2017 [23]MultipleAustraliaProspective cohort studyVarious120…826060Injection drug use in 12 months prior to starting treatmentNANACommunity-based
Read et al 2017 [33]Single AustraliaRetrospective cohort studyVarious7245 485319Injection drug use in 6 months prior to starting treatment47/1/24/07Community- and hospital-based
Schütz et al 2018 [24] Single AustriaProspective cohort studyVarious4038,9292317Injection drug use in 3 months prior to starting treatment40/0/0/00Community- and hospital-based
Sulkowski et al 2017 [29]Single United StatesProspective cohort studySOF/LDV14455 8836108Recent injection drug use prior to starting treatment…16Hospital-based
Study and Year
(Reference)		CenterCountryStudy DesignHCV Treatment RegimeTotal Number of PatientsAge (Mean or Median)MalePWIDNon- PWIDDefinition of Active Injecting Drug UseHCV Genotype (1/2/3/4–6)No. of Patients With CirrhosisTreatment Setting
Alimohammadi et al 2016 [36]Single CanadaRetrospective cohort studyNot specified40......150Current injection drug use during DAA treatment.........
Bielen et al 2017 [32] MultipleBelgiumRetrospective cohort studyVarious57952,335918464Injection drug use during DAA treatment413/0/78/82341Hospital-based
Boglione et al 2017 [21] Single ItalyProspective cohort studyVarious163......1630Injection drug use in 12 months prior to starting treatment......Hospital-based
Foster et al 2017 [12]Multiple United KingdomRetrospective case- control studyGLE/PIB166645 900671599Injection drug use in 12 months prior to starting treatment852/245/401/168163...
Grebely et al 2018 [22] MultipleAustraliaProspective cohort studySOF/VEL10348741030Injection drug use in 6 months prior to starting treatment36/5/60/29Community- and hospital-based
Morris et al 2017 [23]MultipleAustraliaProspective cohort studyVarious120…826060Injection drug use in 12 months prior to starting treatmentNANACommunity-based
Read et al 2017 [33]Single AustraliaRetrospective cohort studyVarious7245 485319Injection drug use in 6 months prior to starting treatment47/1/24/07Community- and hospital-based
Schütz et al 2018 [24] Single AustriaProspective cohort studyVarious4038,9292317Injection drug use in 3 months prior to starting treatment40/0/0/00Community- and hospital-based
Sulkowski et al 2017 [29]Single United StatesProspective cohort studySOF/LDV14455 8836108Recent injection drug use prior to starting treatment…16Hospital-based

Abbreviations: DAA, direct acting antiviral; GLE/PIB, glecaprevir/pibrentasvir; HCV, hepatitis C virus; NA, not available; PWID, people who inject drugs; SOF/LDV, sofosbuvir/ledipasvir.

Table 1.
Open in new tab

Characteristics of Studies That Examined People Who Inject Drugs Treated With Direct-acting Antivirals for Chronic Hepatitis C

Study and Year
(Reference)		CenterCountryStudy DesignHCV Treatment RegimeTotal Number of PatientsAge (Mean or Median)MalePWIDNon- PWIDDefinition of Active Injecting Drug UseHCV Genotype (1/2/3/4–6)No. of Patients With CirrhosisTreatment Setting
Alimohammadi et al 2016 [36]Single CanadaRetrospective cohort studyNot specified40......150Current injection drug use during DAA treatment.........
Bielen et al 2017 [32] MultipleBelgiumRetrospective cohort studyVarious57952,335918464Injection drug use during DAA treatment413/0/78/82341Hospital-based
Boglione et al 2017 [21] Single ItalyProspective cohort studyVarious163......1630Injection drug use in 12 months prior to starting treatment......Hospital-based
Foster et al 2017 [12]Multiple United KingdomRetrospective case- control studyGLE/PIB166645 900671599Injection drug use in 12 months prior to starting treatment852/245/401/168163...
Grebely et al 2018 [22] MultipleAustraliaProspective cohort studySOF/VEL10348741030Injection drug use in 6 months prior to starting treatment36/5/60/29Community- and hospital-based
Morris et al 2017 [23]MultipleAustraliaProspective cohort studyVarious120…826060Injection drug use in 12 months prior to starting treatmentNANACommunity-based
Read et al 2017 [33]Single AustraliaRetrospective cohort studyVarious7245 485319Injection drug use in 6 months prior to starting treatment47/1/24/07Community- and hospital-based
Schütz et al 2018 [24] Single AustriaProspective cohort studyVarious4038,9292317Injection drug use in 3 months prior to starting treatment40/0/0/00Community- and hospital-based
Sulkowski et al 2017 [29]Single United StatesProspective cohort studySOF/LDV14455 8836108Recent injection drug use prior to starting treatment…16Hospital-based
Study and Year
(Reference)		CenterCountryStudy DesignHCV Treatment RegimeTotal Number of PatientsAge (Mean or Median)MalePWIDNon- PWIDDefinition of Active Injecting Drug UseHCV Genotype (1/2/3/4–6)No. of Patients With CirrhosisTreatment Setting
Alimohammadi et al 2016 [36]Single CanadaRetrospective cohort studyNot specified40......150Current injection drug use during DAA treatment.........
Bielen et al 2017 [32] MultipleBelgiumRetrospective cohort studyVarious57952,335918464Injection drug use during DAA treatment413/0/78/82341Hospital-based
Boglione et al 2017 [21] Single ItalyProspective cohort studyVarious163......1630Injection drug use in 12 months prior to starting treatment......Hospital-based
Foster et al 2017 [12]Multiple United KingdomRetrospective case- control studyGLE/PIB166645 900671599Injection drug use in 12 months prior to starting treatment852/245/401/168163...
Grebely et al 2018 [22] MultipleAustraliaProspective cohort studySOF/VEL10348741030Injection drug use in 6 months prior to starting treatment36/5/60/29Community- and hospital-based
Morris et al 2017 [23]MultipleAustraliaProspective cohort studyVarious120…826060Injection drug use in 12 months prior to starting treatmentNANACommunity-based
Read et al 2017 [33]Single AustraliaRetrospective cohort studyVarious7245 485319Injection drug use in 6 months prior to starting treatment47/1/24/07Community- and hospital-based
Schütz et al 2018 [24] Single AustriaProspective cohort studyVarious4038,9292317Injection drug use in 3 months prior to starting treatment40/0/0/00Community- and hospital-based
Sulkowski et al 2017 [29]Single United StatesProspective cohort studySOF/LDV14455 8836108Recent injection drug use prior to starting treatment…16Hospital-based

Abbreviations: DAA, direct acting antiviral; GLE/PIB, glecaprevir/pibrentasvir; HCV, hepatitis C virus; NA, not available; PWID, people who inject drugs; SOF/LDV, sofosbuvir/ledipasvir.

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